J E Crowe

Summary

Affiliation: Vanderbilt University
Country: USA

Publications

  1. ncbi request reprint Differential regulation of granzyme and perforin in effector and memory T cells following smallpox immunization
    Michael T Rock
    Department of Pediatrics, Vanderbilt University Medical Center, Nashville, TN 37232, USA
    J Immunol 174:3757-64. 2005
  2. ncbi request reprint Progression of respiratory syncytial virus infection monitored by fluorescent quantum dot probes
    Elizabeth L Bentzen
    Department of Chemistry, Vanderbilt University, Station B 351822, Nashville, Tennessee 37235 1822, USA
    Nano Lett 5:591-5. 2005
  3. pmc Human metapneumovirus infection in children hospitalized for wheezing
    John V Williams
    J Allergy Clin Immunol 115:1311-2. 2005
  4. pmc The transmembrane domain of the respiratory syncytial virus F protein is an orientation-independent apical plasma membrane sorting sequence
    Sean C Brock
    Department of Microbiology and Immunology, Vanderbilt University School of Medicine, Nashville, TN 37232, USA
    J Virol 79:12528-35. 2005
  5. pmc Low expression of the interleukin (IL)-4 receptor alpha chain and reduced signalling via the IL-4 receptor complex in human neonatal B cells
    Cuixia Tian
    Department of Pediatrics, Vanderbilt University Medical Center, Nashville, TN 37232 2905, USA
    Immunology 119:54-62. 2006
  6. ncbi request reprint Immune responses of infants to infection with respiratory viruses and live attenuated respiratory virus candidate vaccines
    J E Crowe
    Division of Pediatric Infectious Diseases, Vanderbilt University Medical School, Nashville, TN 37232 2581, USA
    Vaccine 16:1423-32. 1998
  7. ncbi request reprint Monoclonal antibody-resistant mutants selected with a respiratory syncytial virus-neutralizing human antibody fab fragment (Fab 19) define a unique epitope on the fusion (F) glycoprotein
    J E Crowe
    Laboratory of Infectious Diseases, National Institutes of Health, Bethesda, Maryland, 20892 0720, USA
    Virology 252:373-5. 1998
  8. ncbi request reprint The live attenuated subgroup B respiratory syncytial virus vaccine candidate RSV 2B33F is attenuated and immunogenic in chimpanzees, but exhibits partial loss of the ts phenotype following replication in vivo
    J E Crowe
    Respiratory Viruses Section, Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Virus Res 59:13-22. 1999
  9. ncbi request reprint Passively acquired antibodies suppress humoral but not cell-mediated immunity in mice immunized with live attenuated respiratory syncytial virus vaccines
    J E Crowe
    Department of Pediatrics, Division of Pediatric Infectious Diseases, Vanderbilt University Medical Center, 1161 21st Avenue S, Nashville, TN 37232, USA
    J Immunol 167:3910-8. 2001
  10. pmc Addition of a missense mutation present in the L gene of respiratory syncytial virus (RSV) cpts530/1030 to RSV vaccine candidate cpts248/404 increases its attenuation and temperature sensitivity
    S S Whitehead
    Respiratory Viruses Section, Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, Bethesda, Maryland 20892, USA
    J Virol 73:871-7. 1999

Collaborators

Detail Information

Publications69

  1. ncbi request reprint Differential regulation of granzyme and perforin in effector and memory T cells following smallpox immunization
    Michael T Rock
    Department of Pediatrics, Vanderbilt University Medical Center, Nashville, TN 37232, USA
    J Immunol 174:3757-64. 2005
    ..Together, these data suggest an important role for effector CD8+ T cells in controlling poxvirus infection, and have implications for our understanding of human CD8+ T cell differentiation...
  2. ncbi request reprint Progression of respiratory syncytial virus infection monitored by fluorescent quantum dot probes
    Elizabeth L Bentzen
    Department of Chemistry, Vanderbilt University, Station B 351822, Nashville, Tennessee 37235 1822, USA
    Nano Lett 5:591-5. 2005
    ..The implications of these results are that QDs may provide a method for early, rapid detection of viral infection and open the door for future studies of the intricate spatial features cell trafficking of viral proteins...
  3. pmc Human metapneumovirus infection in children hospitalized for wheezing
    John V Williams
    J Allergy Clin Immunol 115:1311-2. 2005
  4. pmc The transmembrane domain of the respiratory syncytial virus F protein is an orientation-independent apical plasma membrane sorting sequence
    Sean C Brock
    Department of Microbiology and Immunology, Vanderbilt University School of Medicine, Nashville, TN 37232, USA
    J Virol 79:12528-35. 2005
    ....
  5. pmc Low expression of the interleukin (IL)-4 receptor alpha chain and reduced signalling via the IL-4 receptor complex in human neonatal B cells
    Cuixia Tian
    Department of Pediatrics, Vanderbilt University Medical Center, Nashville, TN 37232 2905, USA
    Immunology 119:54-62. 2006
    ..These studies suggest a possible mechanism underlying the limited magnitude and durability of neonatal antibody responses...
  6. ncbi request reprint Immune responses of infants to infection with respiratory viruses and live attenuated respiratory virus candidate vaccines
    J E Crowe
    Division of Pediatric Infectious Diseases, Vanderbilt University Medical School, Nashville, TN 37232 2581, USA
    Vaccine 16:1423-32. 1998
    ....
  7. ncbi request reprint Monoclonal antibody-resistant mutants selected with a respiratory syncytial virus-neutralizing human antibody fab fragment (Fab 19) define a unique epitope on the fusion (F) glycoprotein
    J E Crowe
    Laboratory of Infectious Diseases, National Institutes of Health, Bethesda, Maryland, 20892 0720, USA
    Virology 252:373-5. 1998
    ..Here we report the results of our sequence analysis of antibody escape mutants that identified F glycoprotein amino acids critical for binding of human or murine RSV F-neutralizing antibodies...
  8. ncbi request reprint The live attenuated subgroup B respiratory syncytial virus vaccine candidate RSV 2B33F is attenuated and immunogenic in chimpanzees, but exhibits partial loss of the ts phenotype following replication in vivo
    J E Crowe
    Respiratory Viruses Section, Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Virus Res 59:13-22. 1999
    ..The implications of these findings for RSV vaccine development are discussed...
  9. ncbi request reprint Passively acquired antibodies suppress humoral but not cell-mediated immunity in mice immunized with live attenuated respiratory syncytial virus vaccines
    J E Crowe
    Department of Pediatrics, Division of Pediatric Infectious Diseases, Vanderbilt University Medical Center, 1161 21st Avenue S, Nashville, TN 37232, USA
    J Immunol 167:3910-8. 2001
    ..Thus, immunity mediated by CD4+ and CD8+ T cells and Abs can be readily induced in mice by live RSV vaccine candidates in the presence of physiologic levels of RSV neutralizing Abs...
  10. pmc Addition of a missense mutation present in the L gene of respiratory syncytial virus (RSV) cpts530/1030 to RSV vaccine candidate cpts248/404 increases its attenuation and temperature sensitivity
    S S Whitehead
    Respiratory Viruses Section, Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, Bethesda, Maryland 20892, USA
    J Virol 73:871-7. 1999
    ....
  11. ncbi request reprint Isolation of a second recombinant human respiratory syncytial virus monoclonal antibody fragment (Fab RSVF2-5) that exhibits therapeutic efficacy in vivo
    J E Crowe
    Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA
    J Infect Dis 177:1073-6. 1998
    ..The antigen-binding domain of Fab RSVF2-5 offers promise as part of a prophylactic regimen for RSV infection in humans...
  12. pmc The temperature-sensitive (ts) phenotype of a cold-passaged (cp) live attenuated respiratory syncytial virus vaccine candidate, designated cpts530, results from a single amino acid substitution in the L protein
    K Juhasz
    Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, Bethesda, Maryland 20892, USA
    J Virol 71:5814-9. 1997
    ..Furthermore, these findings illustrate the feasibility of using the cDNA-based recovery system to analyze and construct defined attenuated vaccine viruses...
  13. ncbi request reprint Passive IgA monoclonal antibody is no more effective than IgG at protecting mice from mucosal challenge with respiratory syncytial virus
    R G Fisher
    Division of Pediatric Infectious Diseases, Duke University Medical Center, Durham, NC 27710, USA
    J Infect Dis 180:1324-7. 1999
    ..Therefore, topical administration of IgA is no more effective than topically administered IgG and is less effective than systemically administered IgG for protecting against RSV infection...
  14. pmc Human metapneumovirus fusion protein vaccines that are immunogenic and protective in cotton rats
    Gabriella Cseke
    Department of Chemistry, Vanderbilt University Medical Center, D 7235 Medical Center North, 1161 21st Ave South, Nashville, TN 37232 2581, USA
    J Virol 81:698-707. 2007
    ..We conclude that sequence-optimized hMPV F protein protects against hMPV infection when delivered as either a DNA or a protein vaccine in cotton rats...
  15. ncbi request reprint Evaluation of a live, cold-passaged, temperature-sensitive, respiratory syncytial virus vaccine candidate in infancy
    P F Wright
    Division of Infectious Disease, Dept of Pediatrics, Vanderbilt University School of Medicine, Nashville, TN 37232, USA
    J Infect Dis 182:1331-42. 2000
    ..A live attenuated RSV vaccine for the youngest infant will use cpts-248/404 modified by additional attenuating mutations...
  16. pmc An alphavirus replicon-based human metapneumovirus vaccine is immunogenic and protective in mice and cotton rats
    Hoyin Mok
    Departments of Pediatrics, Vanderbilt University Medical Center, Vanderbilt University, Nashville, Tennessee 37232, USA
    J Virol 82:11410-8. 2008
    ..Aberrant cytokine gene expression was not detected in these animals. Together, these results represent an important first step toward the use of VRPs encoding hMPV F proteins as a prophylactic vaccine for hMPV...
  17. ncbi request reprint Immunodominance of the VH1-46 antibody gene segment in the primary repertoire of human rotavirus-specific B cells is reduced in the memory compartment through somatic mutation of nondominant clones
    Cuixia Tian
    Department of Pediatrics, Vanderbilt University Medical Center, Nashville, TN 37232 2905, USA
    J Immunol 180:3279-88. 2008
    ..Increased diversity in the VH gene repertoire of the two memory B cell groups derived from broader usage of VH gene segments, increased junctional diversity that was introduced by differential TdT activities, and somatic hypermutation...
  18. ncbi request reprint Generation of recombinant human monoclonal antibodies to rotavirus from single antigen-specific B cells selected with fluorescent virus-like particles
    Jörn Hendrik Weitkamp
    Department of Pediatrics, Vanderbilt University Medical Center, Nashville, TN 37232 2581, USA
    J Immunol Methods 275:223-37. 2003
    ....
  19. ncbi request reprint Genetic and structural determinants of virus neutralizing antibodies
    J E Crowe
    Department of Pediatrics and Microbiology and Immunology, Vanderbilt University Medical Center, Nashville, TN 37232 2581, USA
    Immunol Res 23:135-45. 2001
    ....
  20. pmc Location and length distribution of somatic hypermutation-associated DNA insertions and deletions reveals regions of antibody structural plasticity
    B S Briney
    Departments of Pathology, Microbiology and Immunology, Vanderbilt University Medical Center, Nashville, TN 37232 0417, USA
    Genes Immun 13:523-9. 2012
    ..Finally, through the analysis of both location and length distribution of SHA indels, we have determined regions of structural plasticity within the antibody protein...
  21. ncbi request reprint Influence of maternal antibodies on neonatal immunization against respiratory viruses
    J E Crowe
    Departments of Pediatrics and Microbiology and Immunology, Vanderbilt University Medical Center, Nashville, TN, USA
    Clin Infect Dis 33:1720-7. 2001
    ..This article explores the current knowledge regarding the effect of maternal Abs on respiratory virus and measles virus immunization, and it reviews the current approaches to overcoming Ab-mediated immunosuppression...
  22. pmc The cotton rat (Sigmodon hispidus) is a permissive small animal model of human metapneumovirus infection, pathogenesis, and protective immunity
    John V Williams
    Department of Pediatrics, Vanderbilt University Medical Center, Nashville, TN 37232 2581, USA
    J Virol 79:10944-51. 2005
    ..This model will allow further in vivo studies of hMPV pathogenesis and evaluation of vaccine candidates...
  23. pmc A prospective study comparing human metapneumovirus with other respiratory viruses in adults with hematologic malignancies and respiratory tract infections
    John V Williams
    Department of Pediatrics, Vanderbilt University Medical Center, Nashville, Tennessee 37232 2581, USA
    J Infect Dis 192:1061-5. 2005
    ..Nine patients with hMPV developed LRI; 3 of these patients died. hMPV is a common cause of respiratory infections in adults with hematologic malignancies, with associated morbidity and mortality...
  24. pmc Human metapneumovirus infection plays an etiologic role in acute asthma exacerbations requiring hospitalization in adults
    John V Williams
    Departments of Pediatric, Vanderbilt University Medical Center, Nashville, TN 37232 8300, USA
    J Infect Dis 192:1149-53. 2005
    ..9-312]; P=.03). None of the patients with hMPV infection at hospitalization tested positive at follow-up, strongly suggesting that hMPV plays a direct etiologic role in acute asthma exacerbations...
  25. pmc The role of human metapneumovirus in upper respiratory tract infections in children: a 20-year experience
    John V Williams
    Department of Pediatrics, Vanderbilt University Medical Center, Nashville, TN 37232, USA
    J Infect Dis 193:387-95. 2006
    ..The role that human metapneumovirus (hMPV) plays in the etiology of upper respiratory tract infections (URIs) in children over a period of many years has not been evaluated previously...
  26. ncbi request reprint Rotavirus-specific CD5+ B cells in young children exhibit a distinct antibody repertoire compared with CD5- B cells
    Jörn Hendrik Weitkamp
    Department of Pediatrics, Vanderbilt University Medical Center, and Monroe Carell Jr Children s Hospital at Vanderbilt, Division of Neonatology, Nashville, TN 37232 9544, USA
    Hum Immunol 67:33-42. 2006
    ....
  27. pmc Recent advances in the study of human antibody responses to influenza virus using optimized human hybridoma approaches
    James E Crowe
    Vanderbilt Vaccine Center, Vanderbilt University School of Medicine, Nashville, TN 37232 2905, USA
    Vaccine 27:G47-51. 2009
    ..These studies also reveal evidence for lifelong persistence of immunity to some influenza viruses...
  28. ncbi request reprint Functional maturation of the human antibody response to rotavirus
    Nicole L Kallewaard
    Departments of Microbiology and Immunology, Vanderbilt University, Vanderbilt University Medical Center, Nashville, TN 37232, USA
    J Immunol 180:3980-9. 2008
    ..These structure-function studies suggest a molecular basis for the poor quality of Abs made in infancy following virus infection or immunization...
  29. pmc Evidence for preferential Ig gene usage and differential TdT and exonuclease activities in human naïve and memory B cells
    Cuixia Tian
    Department of Pediatrics, Vanderbilt University Medical Center, 21st Avenue South, Nashville, TN 37232, USA
    Mol Immunol 44:2173-83. 2007
    ..These data suggest distinct functional mechanisms underlying selection of this unique subset of un-class-switched memory B cells...
  30. pmc A recombinant human monoclonal antibody to human metapneumovirus fusion protein that neutralizes virus in vitro and is effective therapeutically in vivo
    John V Williams
    Pediatric Infectious Diseases, Vanderbilt University Medical Center, D 7235 Medical Center North, 1161 21st Avenue South, Nashville, TN 37232
    J Virol 81:8315-24. 2007
    ..There was a dose-response relationship between the dose of DS7 and virus titer. Human Fab DS7 may have prophylactic or therapeutic potential against severe hMPV infection...
  31. pmc Human metapneumovirus nucleoprotein and phosphoprotein interact and provide the minimal requirements for inclusion body formation
    Aaron Derdowski
    Department of Pediatrics, Vanderbilt University School of Medicine, Nashville, TN 37232, USA
    J Gen Virol 89:2698-708. 2008
    ..This work showed that HMPV N and P proteins provide the minimal viral requirements for HMPV inclusion body formation, which may be a distinguishing characteristic of members of the subfamily Pneumovirinae...
  32. pmc Coronavirus infection and hospitalizations for acute respiratory illness in young children
    H Keipp B Talbot
    Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, USA
    J Med Virol 81:853-6. 2009
    ..2 (95% CI 4.3, 17.6), 4.2 (95% CI 1.9, 6.9), and 0 (95% CI 0, 3.7) in children aged <6 months, 6-23 months, and 24-59 months, respectively. Coronaviruses were identified in a modest number of hospitalized children...
  33. pmc The pediatric burden of human coronaviruses evaluated for twenty years
    H Keipp Talbot
    Division of Infectious Diseases, Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN, USA
    Pediatr Infect Dis J 28:682-7. 2009
    ..The epidemiology of human coronaviruses (HCoVs) has not been established using reverse transcription polymerase chain reaction techniques in a specimen collection that spans decades...
  34. ncbi request reprint Natural evolution of a human virus-specific antibody gene repertoire by somatic hypermutation requires both hotspot-directed and randomly-directed processes
    Jörn Hendrik Weitkamp
    Department of Pediatrics, Vanderbilt University Medical Center, Nashville, TN 37232, USA
    Hum Immunol 66:666-76. 2005
    ..These findings suggest that virus-specific antibodies require both hotspot and randomly-directed processes...
  35. ncbi request reprint Immunology of viral respiratory tract infection in infancy
    James E Crowe
    Department of Pediatrics, Vanderbilt University Medical Center, D 7235 Medical Center North, 1161 21st Avenue South, Nashville, TN 37232 2581, USA
    Paediatr Respir Rev 4:112-9. 2003
    ....
  36. pmc Population-based incidence of human metapneumovirus infection among hospitalized children
    John V Williams
    Department of Pediatrics, Vanderbilt University Schoolof Medicine, and Monroe Carell Jr Children s Hospital at Vanderbilt, Nashville, Tennessee 37232 2581, USA
    J Infect Dis 201:1890-8. 2010
    ..Human metapneumovirus (HMPV) is a leading cause of acute respiratory illness (ARI) in children. Population-based incidence rates and comprehensive clinical characterizations of disease have not been established...
  37. ncbi request reprint Human metapneumovirus as a major cause of human respiratory tract disease
    James E Crowe
    Departments of Pediatrics and Microbiology and Immunology, Vanderbilt University Medical Center, Nashville, TN, USA
    Pediatr Infect Dis J 23:S215-21. 2004
    ..The virus, first isolated in 2001, is a clear cause of lower respiratory tract disease in both the very young and the frail elderly. The virus causes acute wheezing in children or, less commonly, croup or pneumonia...
  38. ncbi request reprint Infant and adult human B cell responses to rotavirus share common immunodominant variable gene repertoires
    Jörn Hendrik Weitkamp
    Department of Pediatrics, Vanderbilt University Medical Center, Nashville, TN 37232 2581, USA
    J Immunol 171:4680-8. 2003
    ..These data suggest that residual fetal bias of the B cell repertoire is not a limiting determinant of the quality of Ab responses to viruses of infants beyond the neonatal period...
  39. ncbi request reprint CD154 regulates primate humoral immunity to influenza
    James E Crowe
    Department of Pediatrics, Vanderbilt University Medical Center, Nashville, TN, USA
    Am J Transplant 3:680-8. 2003
    ..Furthermore, the data suggest that viral Ag stimulation of primates in the absence of CD154 stimulation may have a tolerizing effect on that Ag...
  40. pmc An optimized electrofusion-based protocol for generating virus-specific human monoclonal antibodies
    Xiaocong Yu
    Department of Pediatrics, Vanderbilt University Medical Center, Nashville, TN 37232, USA
    J Immunol Methods 336:142-51. 2008
    ..In conclusion, we have developed an efficient and routine approach for the generation of human hybridomas secreting functional human virus-specific monoclonal antibodies...
  41. ncbi request reprint VH1-46 is the dominant immunoglobulin heavy chain gene segment in rotavirus-specific memory B cells expressing the intestinal homing receptor alpha4beta7
    Jörn Hendrik Weitkamp
    Department of Pediatrics, Vanderbilt University Medical Center, Nashville, TN 37232, USA
    J Immunol 174:3454-60. 2005
    ..Interestingly, RV-specific intestinal homing IgD-/alpha4beta7+ B cells using the VH1-46 gene segment were not mutated, in contrast to systemic RV-specific IgD- B cells...
  42. pmc Genetic diversity and evolution of human metapneumovirus fusion protein over twenty years
    Chin Fen Yang
    Department of Pediatrics, Vanderbilt University School of Medicine, Nashville, TN, USA
    Virol J 6:138. 2009
    ..Human metapneumovirus (HMPV) is an important cause of acute respiratory illness in children. We examined the diversity and molecular evolution of HMPV using 85 full-length F (fusion) gene sequences collected over a 20-year period...
  43. pmc Neutralizing antibodies derived from the B cells of 1918 influenza pandemic survivors
    Xiaocong Yu
    Departments of Pediatrics, Vanderbilt University Medical Center, Nashville, Tennessee 37232, USA
    Nature 455:532-6. 2008
    ....
  44. pmc Human metapneumovirus and lower respiratory tract disease in otherwise healthy infants and children
    John V Williams
    Division of Infectious Diseases, Department of Pediatrics, Vanderbilt University Medical Center, Nashville, TN 37232 2581, USA
    N Engl J Med 350:443-50. 2004
    ..We sought to determine the role of human metapneumovirus in lower respiratory tract illness in previously healthy infants and children...
  45. pmc Naturally occurring human monoclonal antibodies neutralize both 1918 and 2009 pandemic influenza A (H1N1) viruses
    Jens C Krause
    Departments of Pediatrics and of Microbiology and Immunology, Vanderbilt University Medical Center, Nashville, Tennessee 37232, USA
    J Virol 84:3127-30. 2010
    ..These antibodies exhibited high potency against the 2009 virus in vitro, and one exerted a marked therapeutic effect in vivo...
  46. doi request reprint High-throughput antibody sequencing reveals genetic evidence of global regulation of the naïve and memory repertoires that extends across individuals
    B S Briney
    Departments of Pathology, Microbiology and Immunology, Vanderbilt University Medical Center, Nashville, TN 37232 0417, USA
    Genes Immun 13:469-73. 2012
    ....
  47. ncbi request reprint CD40-ligand in primate cardiac allograft and viral immunity
    R N Pierson
    Vanderbilt University Medical Center, Department of Cardiothoracic Surgery, Nashville, TN, USA
    Immunol Res 23:253-62. 2001
    ..However, these findings also indicate that pathogenic allograft responses in primates are probably not entirely CD40L-dependent. As such, additional immunomodulatory strategies are needed to facilitate tolerance to a transplanted organ...
  48. ncbi request reprint Respiratory syncytial virus vaccine development
    J E Crowe
    Department of Pediatrics, Vanderbilt University Medical Center, D 7235 Medical Center North, 1161 21st Avenue South, Nashville, TN 37232 2581, USA
    Vaccine 20:S32-7. 2001
    ..Numerous vaccine candidates are currently in early clinical trials. This paper reviews the significant obstacles to development of RSV vaccines, and the progress made to date...
  49. pmc The human neonatal B cell response to respiratory syncytial virus uses a biased antibody variable gene repertoire that lacks somatic mutations
    John V Williams
    Department of Pediatrics, Nashville, TN 37232, United States
    Mol Immunol 47:407-14. 2009
    ..These biased features of the RSV-specific repertoire likely contribute to the poor functional Ab response in very young infants...
  50. pmc Pseudovirion particles bearing native HIV envelope trimers facilitate a novel method for generating human neutralizing monoclonal antibodies against HIV
    Mark D Hicar
    Department of Pediatrics, Vanderbilt University Medical Center, Nashville, TN 37232 2905, USA
    J Acquir Immune Defic Syndr 54:223-35. 2010
    ..These data demonstrate that Gag-Env pseudovirions recapitulate CD4 and coreceptor binding pocket antigenic structures and can facilitate identification of B-cell clones that secrete neutralizing antibodies...
  51. pmc Venezuelan equine encephalitis virus replicon particles encoding respiratory syncytial virus surface glycoproteins induce protective mucosal responses in mice and cotton rats
    Hoyin Mok
    Department of Pediatrics, Vanderbilt University Medical Center, Vanderbilt University, Nashville, Tennessee 37232, USA
    J Virol 81:13710-22. 2007
    ..These results represent an important first step toward the use of VRPs encoding RSV proteins as a prophylactic vaccine for RSV...
  52. ncbi request reprint Identification of an H-2D(b)-restricted CD8+ cytotoxic T lymphocyte epitope in the matrix protein of respiratory syncytial virus
    John A Rutigliano
    Vaccine Research Center, NIAID, National Institutes of Health, Building 40, Room 2502, 40 Convent Drive, MSC 3017, Bethesda, MD 20892 3017, USA
    Virology 337:335-43. 2005
    ..Furthermore, identification of this H-2b-restricted CTL epitope provides access to genetically modified H-2b mice for more detailed studies of CTL mechanisms in RSV infection...
  53. pmc Identification of a novel human leucocyte antigen-A*01-restricted cytotoxic T-lymphocyte epitope in the respiratory syncytial virus fusion protein
    Michael T Rock
    Departments of Pediatrics, Vanderbilt University Medical Center, Nashville, Tennessee 37205, USA
    Immunology 108:474-80. 2003
    ..An HLA-A*01-restricted CTL epitope detected in three healthy adult subjects is characterized. This is the first RSV-specific memory CTL response identified in the fusion protein of RSV...
  54. pmc Respiratory syncytial virus induces host RNA stress granules to facilitate viral replication
    Michael E Lindquist
    Departments of Microbiology and Immunology, Vanderbilt University Medical Center, Nashville, Tennessee 37232 2905, USA
    J Virol 84:12274-84. 2010
    ..These results suggest that RSV induces a host stress granule response and preferentially replicates in host cells that have committed to a stress response...
  55. pmc Tissue-specific regulation of CD8+ T-lymphocyte immunodominance in respiratory syncytial virus infection
    Sujin Lee
    Department of Pediatrics, Vanderbilt University Medical Center, T 2220 Medical Center North, 1161 21st Avenue South, Nashville, TN 37232 2905, USA
    J Virol 81:2349-58. 2007
    ..These studies will facilitate investigation of the regulation of immunodominance of RSV-specific CTL epitopes...
  56. pmc Amphiregulin-deficient mice develop spasmolytic polypeptide expressing metaplasia and intestinal metaplasia
    Ki Taek Nam
    Nashville Department of Veterans Affairs Medical Center, Nashville, Tennessee 37232 0443, USA
    Gastroenterology 136:1288-96. 2009
    ..We previously determined that loss of amphiregulin (AR) promotes SPEM induced by acute oxyntic atrophy. We have now examined whether SPEM in the AR-/- mouse predisposes the stomach to gastric neoplasia...
  57. pmc A chimeric A2 strain of respiratory syncytial virus (RSV) with the fusion protein of RSV strain line 19 exhibits enhanced viral load, mucus, and airway dysfunction
    Martin L Moore
    Department of Pediatrics, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, USA
    J Virol 83:4185-94. 2009
    ..We identified the F protein of RSV line 19 as a factor that plays a role in pulmonary mucin expression in the setting of RSV infection...
  58. ncbi request reprint Transcriptional control of activation-induced cytidine deaminase and error-prone DNA polymerases is functionally mature in the B cells of infants at birth
    Amber L Bowen
    Department of Microbiology and Immunology, Vanderbilt University Medical Center, 1161 21st Avenue South, Nashville, TN 37232 2905, USA
    Hum Immunol 67:43-6. 2006
    ..These data suggest that the ability to upregulate gene transcription of enzymes mediating SHM is not a limiting determinant of the functional quality of infant antibody responses...
  59. pmc Examination of a fusogenic hexameric core from human metapneumovirus and identification of a potent synthetic peptide inhibitor from the heptad repeat 1 region
    Scott A Miller
    Vanderbilt University, Department of Chemistry, Station B 351822, Nashville, TN 37235 1822, USA
    J Virol 81:141-9. 2007
    ..Our studies provide evidence that hMPV also uses a coiled-coil structure as a major player in the fusion process. Additionally, viral HR-1 peptide sequences may need further investigation as potent fusion inhibitors...
  60. ncbi request reprint Smallpox vaccination does not elevate systemic levels of prothrombotic proteins associated with ischemic cardiac events
    Julia F Shaklee
    Vanderbilt University School of Medicine, Nashville, Tennessee, USA
    J Infect Dis 191:724-30. 2005
    ....
  61. pmc Effect of zinc salts on respiratory syncytial virus replication
    Rahaman O Suara
    Department of Pediatric, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, USA
    Antimicrob Agents Chemother 48:783-90. 2004
    ..The results of this study suggest that zinc mediates antiviral activity on RSV by altering the ability of the cell to support RSV replication...
  62. ncbi request reprint Prevalence of reovirus-specific antibodies in young children in Nashville, Tennessee
    Jennifer H Tai
    Department of Pediatrics, Vanderbilt University School of Medicine, Nashville, Tennessee 37232 2581, USA
    J Infect Dis 191:1221-4. 2005
    ..We observed an age-dependent increase in reovirus-specific antibodies in children 1 year of age and older, peaking at 50.0% in children 5-6 years of age. These findings suggest that reovirus infections are common during early childhood...
  63. ncbi request reprint Vaccination success rate and reaction profile with diluted and undiluted smallpox vaccine: a randomized controlled trial
    Thomas R Talbot
    Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN 37232, USA s
    JAMA 292:1205-12. 2004
    ....
  64. pmc Homing in on acute graft vs. host disease: tissue-specific T regulatory and Th17 cells
    Brian G Engelhardt
    Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA
    Curr Top Microbiol Immunol 341:121-46. 2010
    ..tumor effect while minimizing the potentially fatal side effects of aGVHD. A better understanding of Tregs and their tissue specificity should lead to improvement in the success of HSCT...
  65. pmc Emerging studies of human HIV-specific antibody repertoires
    Mark D Hicar
    Department of Pediatrics, Vanderbilt University Medical Center, Nashville, TN 37232, USA
    Vaccine 28:B18-23. 2010
    ..The rapid isolation of large panels of novel human neutralizing antibodies promises to reveal new insights into the fundamental principles underlying antibody-mediated neutralization of HIV...
  66. pmc Prospective study of the incidence, clinical features, and outcome of symptomatic upper and lower respiratory tract infections by respiratory viruses in adult recipients of hematopoietic stem cell transplants for hematologic malignancies
    Rodrigo Martino
    Department of Clinical Hematology, Hospital de la Santa Creu i Sant Pau, and Autonomous University of Barcelona, Spain
    Biol Blood Marrow Transplant 11:781-96. 2005
    ..In addition, human metapneumovirus should be added to the potentially serious causes of RV infections in HSCT...
  67. pmc Respiratory syncytial virus nucleoprotein-specific cytotoxic T-cell epitopes in a South African population of diverse HLA types are conserved in circulating field strains
    Marietjie Venter
    National Institute for Communicable Diseases, Sandringham, South Africa
    J Virol 77:7319-29. 2003
    ..This work suggests that escape from CTL activity is not common for this acute respiratory infection...
  68. ncbi request reprint Genetic predisposition for adverse events after vaccination
    James E Crowe
    J Infect Dis 196:176-7. 2007
  69. pmc Genetic basis for adverse events after smallpox vaccination
    David M Reif
    Computational Genetics Laboratory, Dartmouth Medical School, Lebanon, New Hampshire, USA
    J Infect Dis 198:16-22. 2008
    ....