Howard C Crawford

Summary

Affiliation: Vanderbilt University
Country: USA

Publications

  1. pmc The PEA3 subfamily of Ets transcription factors synergizes with beta-catenin-LEF-1 to activate matrilysin transcription in intestinal tumors
    H C Crawford
    Department of Cancer Biology, Vanderbilt University School of Medicine, Nashville, Tennessee 37232 2175, USA
    Mol Cell Biol 21:1370-83. 2001
  2. pmc Matrix metalloproteinase-7 is expressed by pancreatic cancer precursors and regulates acinar-to-ductal metaplasia in exocrine pancreas
    Howard C Crawford
    Department of Cancer Biology, Vanderbilt Ingram Cancer Center, Vanderbilt University Medical Center, Nashville, Tennessee, USA
    J Clin Invest 109:1437-44. 2002
  3. ncbi Matrix metalloproteinase 7 mediates mammary epithelial cell tumorigenesis through the ErbB4 receptor
    Conor C Lynch
    Department of Cancer Biology, Vanderbilt University, 23rd and Pierce Avenue, Nashville, TN 37232, USA
    Cancer Res 67:6760-7. 2007
  4. ncbi Tcf binding sequence and position determines beta-catenin and Lef-1 responsiveness of MMP-7 promoters
    Mark D Gustavson
    Department of Cancer Biology, Vanderbilt University, Nashville, TN 37232 6840, USA
    Mol Carcinog 41:125-39. 2004
  5. pmc Keratinocyte expression of MMP3 enhances differentiation and prevents tumor establishment
    Lisa J McCawley
    Vanderbilt University, Department of Cancer Biology, Nashville, TN 37232 6840, USA
    Am J Pathol 173:1528-39. 2008
  6. ncbi Identification of novel matrix metalloproteinase-7 (matrilysin) cleavage sites in murine and human Fas ligand
    Tracy Vargo-Gogola
    Department of Cancer Biology, Vanderbilt University, 736 PRB 23rd and Pierce, Nashville, TN 37232 6840, USA
    Arch Biochem Biophys 408:155-61. 2002
  7. ncbi Epidermal growth factor upregulates matrix metalloproteinase-7 expression through activation of PEA3 transcription factors
    Conor C Lynch
    Department of Cancer Biology, Vanderbilt University, Nashville, TN 37232 6840, USA
    Int J Oncol 24:1565-72. 2004
  8. ncbi Resident stromal cell-derived MMP-9 promotes the growth of colorectal metastases in the liver microenvironment
    D Lee Gorden
    Department of Cancer Biology, Vanderbilt University, Nashville, TN 37232 4753, USA
    Int J Cancer 121:495-500. 2007
  9. pmc A rat monoclonal antibody that recognizes pro- and active MMP-7 indicates polarized expression in vivo
    Barbara Fingleton
    Department of Cancer Biology, Vanderbilt University Medical Center, Nashville, Tennessee 37232 6840, USA
    Hybridoma (Larchmt) 26:22-7. 2007
  10. pmc Macrophage-secreted cytokines drive pancreatic acinar-to-ductal metaplasia through NF-κB and MMPs
    Geou Yarh Liou
    Department of Cancer Biology, Mayo Clinic Comprehensive Cancer Center, Mayo Clinic, Jacksonville, FL 32224, USA
    J Cell Biol 202:563-77. 2013

Collaborators

Detail Information

Publications20

  1. pmc The PEA3 subfamily of Ets transcription factors synergizes with beta-catenin-LEF-1 to activate matrilysin transcription in intestinal tumors
    H C Crawford
    Department of Cancer Biology, Vanderbilt University School of Medicine, Nashville, Tennessee 37232 2175, USA
    Mol Cell Biol 21:1370-83. 2001
    ....
  2. pmc Matrix metalloproteinase-7 is expressed by pancreatic cancer precursors and regulates acinar-to-ductal metaplasia in exocrine pancreas
    Howard C Crawford
    Department of Cancer Biology, Vanderbilt Ingram Cancer Center, Vanderbilt University Medical Center, Nashville, Tennessee, USA
    J Clin Invest 109:1437-44. 2002
    ..Thus, MMP-7 and FasL influence the initiation and maintenance of metaplastic events in pancreatic epithelium, explaining the observed link between metaplasia and apoptosis in pancreas and other gastrointestinal tissues...
  3. ncbi Matrix metalloproteinase 7 mediates mammary epithelial cell tumorigenesis through the ErbB4 receptor
    Conor C Lynch
    Department of Cancer Biology, Vanderbilt University, 23rd and Pierce Avenue, Nashville, TN 37232, USA
    Cancer Res 67:6760-7. 2007
    ..Furthermore, overexpression of the ErbB4 ICD in the c57MG cell line recapitulated the proliferative effects of MMP7 in vitro and in vivo. These data indicate a novel mechanism for mammary epithelial cell transformation by MMP7...
  4. ncbi Tcf binding sequence and position determines beta-catenin and Lef-1 responsiveness of MMP-7 promoters
    Mark D Gustavson
    Department of Cancer Biology, Vanderbilt University, Nashville, TN 37232 6840, USA
    Mol Carcinog 41:125-39. 2004
    ..We concluded that sequence and position of Tcf binding sites can determine the extent of beta-catenin-Lef-1 responsiveness for beta-catenin target genes...
  5. pmc Keratinocyte expression of MMP3 enhances differentiation and prevents tumor establishment
    Lisa J McCawley
    Vanderbilt University, Department of Cancer Biology, Nashville, TN 37232 6840, USA
    Am J Pathol 173:1528-39. 2008
    ..These studies suggest that keratinocyte expression of MMP3 promotes cellular differentiation, impeding tumor establishment during tumorigenesis...
  6. ncbi Identification of novel matrix metalloproteinase-7 (matrilysin) cleavage sites in murine and human Fas ligand
    Tracy Vargo-Gogola
    Department of Cancer Biology, Vanderbilt University, 736 PRB 23rd and Pierce, Nashville, TN 37232 6840, USA
    Arch Biochem Biophys 408:155-61. 2002
    ..We conclude that the controversy regarding the biological activity of sFasL may be explained, in part, by the generation of distinct forms of sFasL as a result of cleavage at specific sequences...
  7. ncbi Epidermal growth factor upregulates matrix metalloproteinase-7 expression through activation of PEA3 transcription factors
    Conor C Lynch
    Department of Cancer Biology, Vanderbilt University, Nashville, TN 37232 6840, USA
    Int J Oncol 24:1565-72. 2004
    ..These data demonstrate for the first time that EGF directly enhances MMP-7 expression via the activation of PEA3 transcription factors...
  8. ncbi Resident stromal cell-derived MMP-9 promotes the growth of colorectal metastases in the liver microenvironment
    D Lee Gorden
    Department of Cancer Biology, Vanderbilt University, Nashville, TN 37232 4753, USA
    Int J Cancer 121:495-500. 2007
    ..Stromal-derived MMP-9 may represent an important target for selective inhibition in the treatment of metastases. (c) 2007 Wiley-Liss, Inc...
  9. pmc A rat monoclonal antibody that recognizes pro- and active MMP-7 indicates polarized expression in vivo
    Barbara Fingleton
    Department of Cancer Biology, Vanderbilt University Medical Center, Nashville, Tennessee 37232 6840, USA
    Hybridoma (Larchmt) 26:22-7. 2007
    ..In contrast, advanced colon tumors show MMP-7 in invading cells at the advancing edge of the tumor...
  10. pmc Macrophage-secreted cytokines drive pancreatic acinar-to-ductal metaplasia through NF-κB and MMPs
    Geou Yarh Liou
    Department of Cancer Biology, Mayo Clinic Comprehensive Cancer Center, Mayo Clinic, Jacksonville, FL 32224, USA
    J Cell Biol 202:563-77. 2013
    ..In particular, we identify matrix metalloproteinases (MMPs) as targets that drive ADM and provide in vivo data suggesting that MMP inhibitors may be efficiently applied to block pancreatitis-induced ADM in therapy. ..
  11. ncbi Matrilysin (matrix metalloproteinase-7) selects for apoptosis-resistant mammary cells in vivo
    Tracy Vargo-Gogola
    Department of Cancer Biology, Vanderbilt University, Nashville, Tennessee 37232 6840, USA
    Cancer Res 62:5559-63. 2002
    ..We propose that matrilysin promotes mammary tumor formation by enhancing the selection of cells that are resistant to apoptosis...
  12. ncbi A protective role for matrix metalloproteinase-3 in squamous cell carcinoma
    Lisa J McCawley
    Department of Cancer Biology, Division of Dermatology, Vanderbilt University, Nashville, Tennessee 37232 6840, USA
    Cancer Res 64:6965-72. 2004
    ..We propose that MMP-3 is expressed as a protective response and plays an important role in host defense during SCC tumorigenesis...
  13. ncbi Metalloproteinases and cell fate: Notch just ADAMs anymore
    Eric T Sawey
    Department of Pharmacological Sciences, Stony Brook University, Stony Brook, New York 11794 8651, USA
    Cell Cycle 7:566-9. 2008
    ..Other approaches for Notch inhibition, including by gamma-secretase and broad-spectrum MMP inhibitors, will be discussed...
  14. pmc Matrix metalloproteinase 7 controls pancreatic acinar cell transdifferentiation by activating the Notch signaling pathway
    Eric T Sawey
    Departments of Pharmacological Sciences and Physiology and Biophysics, Stony Brook University, Stony Brook, NY 11794 8651, USA
    Proc Natl Acad Sci U S A 104:19327-32. 2007
    ....
  15. ncbi Role for ETS domain transcription factors Pea3/Erm in mouse lung development
    Yuru Liu
    Department of Cell Biology, Duke University Medical Center, Durham, NC 27710, USA
    Dev Biol 261:10-24. 2003
    ..Our results provide the first functional evidence that Pea3 subfamily members play a role in epithelial-mesenchymal interactions during lung organogenesis...
  16. ncbi Evaluation of matrix metalloproteinase 7 in plasma and pancreatic juice as a biomarker for pancreatic cancer
    Koert F D Kuhlmann
    Department of Surgery, Academic Medical Center of the University of Amsterdam, Amsterdam, The Netherlands
    Cancer Epidemiol Biomarkers Prev 16:886-91. 2007
    ..The diagnostic accuracy of plasma MMP-7 alone is not sufficient to determine treatment strategy in patients with a periampullary mass, but combined evaluation of plasma MMP-7 with CA19-9 and other markers may be clinically useful...
  17. ncbi Preinvasive and invasive ductal pancreatic cancer and its early detection in the mouse
    Sunil R Hingorani
    Department of Medicine, Abramson Family Cancer Research Institute, Abramson Center at the University of Pennsylvania, Philadelphia, PA 19104, USA
    Cancer Cell 4:437-50. 2003
    ..Finally, mice with PanINs have an identifiable serum proteomic signature, suggesting a means of detecting the preinvasive state in patients...
  18. ncbi Beta-catenin regulates the gene of MMP-26, a novel metalloproteinase expressed both in carcinomas and normal epithelial cells
    Natalia D Marchenko
    Cancer Research Center, The Burnham Institute, 10901 North Torrey Pines Road, La Jolla, CA 92093, USA
    Int J Biochem Cell Biol 36:942-56. 2004
    ..This study brings us a step forward towards a better understanding of the unconventional role, regulation and functions of epithelial cell MMP-26 in physiological conditions and in neoplasms...
  19. ncbi The catenin p120ctn inhibits Kaiso-mediated transcriptional repression of the beta-catenin/TCF target gene matrilysin
    Christopher M Spring
    Department of Biology, LSB 331, McMaster University, 1280 Main Street West, Hamilton, ON, Canada L8S 4K1
    Exp Cell Res 305:253-65. 2005
    ....
  20. ncbi E-cadherin suppression accelerates squamous cell carcinoma progression in three-dimensional, human tissue constructs
    Alexander Margulis
    Division of Cancer Biology and Tissue Engineering, Department of Oral and Maxillofacial Pathology, School of Dental Medicine, Tufts University, Boston, Massachusetts, USA
    Cancer Res 65:1783-91. 2005
    ....