Dana C Crawford

Summary

Affiliation: Vanderbilt University
Country: USA

Publications

  1. ncbi request reprint Prevalence of the fragile X syndrome in African-Americans
    Dana C Crawford
    Department of Human Genetics, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    Am J Med Genet 110:226-33. 2002
  2. pmc Lipid trait-associated genetic variation is associated with gallstone disease in the diverse Third National Health and Nutrition Examination Survey (NHANES III)
    Robert Goodloe
    Center for Human Genetics Research, Vanderbilt University, 2215 Garland Avenue, 519 Light Hall, Nashville, Tennessee 37232, USA
    BMC Med Genet 14:120. 2013
  3. pmc LPA and PLG sequence variation and kringle IV-2 copy number in two populations
    Dana C Crawford
    Department of Molecular Physiology and Biophysics, Center for Human Genetics Research, Vanderbilt University, Nashville, TN 37232, USA
    Hum Hered 66:199-209. 2008
  4. pmc Identifying the genotype behind the phenotype: a role model found in VKORC1 and its association with warfarin dosing
    Dana C Crawford
    Vanderbilt University, Center for Human Genetics Research, 519 Light Hall, Nashville, TN 37232, USA
    Pharmacogenomics 8:487-96. 2007
  5. ncbi request reprint Genetic variation is associated with C-reactive protein levels in the Third National Health and Nutrition Examination Survey
    Dana C Crawford
    Department of Genome Sciences, University of Washington, Seattle, USA
    Circulation 114:2458-65. 2006
  6. pmc VKORC1 common variation and bone mineral density in the Third National Health and Nutrition Examination Survey
    Dana C Crawford
    Center for Human Genetics Research, Department of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, Tennessee, United States of America
    PLoS ONE 5:e15088. 2010
  7. pmc Serum vitamins A and E as modifiers of lipid trait genetics in the National Health and Nutrition Examination Surveys as part of the Population Architecture using Genomics and Epidemiology (PAGE) study
    Logan Dumitrescu
    Center for Human Genetics Research, Vanderbilt University, 2215 Garland Avenue, 515B Light Hall, Nashville, TN 37232, USA
    Hum Genet 131:1699-708. 2012
  8. pmc Robust replication of genotype-phenotype associations across multiple diseases in an electronic medical record
    Marylyn D Ritchie
    Center for Human Genetics Research, Department of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine, Nashville, TN 37232, USA
    Am J Hum Genet 86:560-72. 2010
  9. pmc Genetic risk factors for BMI and obesity in an ethnically diverse population: results from the population architecture using genomics and epidemiology (PAGE) study
    Megan D Fesinmeyer
    Department of Biostatistics and Biomathematics, Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA
    Obesity (Silver Spring) 21:835-46. 2013
  10. pmc Generalization and dilution of association results from European GWAS in populations of non-European ancestry: the PAGE study
    Christopher S Carlson
    Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America
    PLoS Biol 11:e1001661. 2013

Detail Information

Publications59

  1. ncbi request reprint Prevalence of the fragile X syndrome in African-Americans
    Dana C Crawford
    Department of Human Genetics, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    Am J Med Genet 110:226-33. 2002
    ..Further population-based studies in diverse populations are necessary to explore the possibility that the prevalence of the fragile X syndrome differs among world populations...
  2. pmc Lipid trait-associated genetic variation is associated with gallstone disease in the diverse Third National Health and Nutrition Examination Survey (NHANES III)
    Robert Goodloe
    Center for Human Genetics Research, Vanderbilt University, 2215 Garland Avenue, 519 Light Hall, Nashville, Tennessee 37232, USA
    BMC Med Genet 14:120. 2013
    ....
  3. pmc LPA and PLG sequence variation and kringle IV-2 copy number in two populations
    Dana C Crawford
    Department of Molecular Physiology and Biophysics, Center for Human Genetics Research, Vanderbilt University, Nashville, TN 37232, USA
    Hum Hered 66:199-209. 2008
    ..African-descent populations have, on average, higher levels of Lp(a), suggesting other genetic factors contribute to Lp(a) level variability across populations...
  4. pmc Identifying the genotype behind the phenotype: a role model found in VKORC1 and its association with warfarin dosing
    Dana C Crawford
    Vanderbilt University, Center for Human Genetics Research, 519 Light Hall, Nashville, TN 37232, USA
    Pharmacogenomics 8:487-96. 2007
    ..These future avenues will be best explored using diverse approaches encompassing clinical, statistical and genomic methods currently being developed for genotype-phenotype studies in human populations...
  5. ncbi request reprint Genetic variation is associated with C-reactive protein levels in the Third National Health and Nutrition Examination Survey
    Dana C Crawford
    Department of Genome Sciences, University of Washington, Seattle, USA
    Circulation 114:2458-65. 2006
    ..Increased serum C-reactive protein (CRP) is an independent risk factor for cardiovascular disease. Previous studies have suggested that genetic variation within the CRP gene is associated with serum CRP...
  6. pmc VKORC1 common variation and bone mineral density in the Third National Health and Nutrition Examination Survey
    Dana C Crawford
    Center for Human Genetics Research, Department of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, Tennessee, United States of America
    PLoS ONE 5:e15088. 2010
    ..This is the first report of VKORC1 common genetic variation associated with BMD, and one of the few reports available that investigate the genetics of BMD and osteoporosis in diverse populations...
  7. pmc Serum vitamins A and E as modifiers of lipid trait genetics in the National Health and Nutrition Examination Surveys as part of the Population Architecture using Genomics and Epidemiology (PAGE) study
    Logan Dumitrescu
    Center for Human Genetics Research, Vanderbilt University, 2215 Garland Avenue, 515B Light Hall, Nashville, TN 37232, USA
    Hum Genet 131:1699-708. 2012
    ....
  8. pmc Robust replication of genotype-phenotype associations across multiple diseases in an electronic medical record
    Marylyn D Ritchie
    Center for Human Genetics Research, Department of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine, Nashville, TN 37232, USA
    Am J Hum Genet 86:560-72. 2010
    ....
  9. pmc Genetic risk factors for BMI and obesity in an ethnically diverse population: results from the population architecture using genomics and epidemiology (PAGE) study
    Megan D Fesinmeyer
    Department of Biostatistics and Biomathematics, Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA
    Obesity (Silver Spring) 21:835-46. 2013
    ..However, studies of this complex trait have focused on ancestrally European populations, despite the high prevalence of obesity in some minority groups...
  10. pmc Generalization and dilution of association results from European GWAS in populations of non-European ancestry: the PAGE study
    Christopher S Carlson
    Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America
    PLoS Biol 11:e1001661. 2013
    ..Models based directly on functional variation may generalize more robustly, but the identification of functional variants remains challenging. ..
  11. pmc Identifying host genetic risk factors in the context of public health surveillance for invasive pneumococcal disease
    Jairam R Lingappa
    Department of Global Health, University of Washington, Seattle, Washington, United States of America
    PLoS ONE 6:e23413. 2011
    ....
  12. pmc Assessment of a pharmacogenomic marker panel in a polypharmacy population identified from electronic medical records
    Matthew T Oetjens
    Center for Human Genetics Research and Department of Molecular Physiology and Biophysics, Vanderbilt University, 2215 Garland Avenue, 519 Light Hall, Nashville, TN 37232 0700, USA
    Pharmacogenomics 14:735-44. 2013
    ..The ADME Core Panel assays 184 variants across 34 pharmacogenes, many of which are difficult to accurately genotype with standard multiplexing methods...
  13. pmc Genetic variation in the rhythmonome: ethnic variation and haplotype structure in candidate genes for arrhythmias
    William S Bush
    Center for Human Genetics Research and Department of Molecular Physiology and Biophysics, Vanderbilt University Medical Center, Nashville, TN, USA
    Pharmacogenomics 10:1043-53. 2009
    ..Here, we report an evaluation of the variation and haplotype structure in six key components of the rhythmonome...
  14. pmc Predicting warfarin dosage in European-Americans and African-Americans using DNA samples linked to an electronic health record
    Andrea H Ramirez
    Department of Medicine, Vanderbilt University in Nashville, TN 37232, USA
    Pharmacogenomics 13:407-18. 2012
    ..Electronic health record (EHR) systems linked to biobanks may allow for pharmacogenomic analysis, but they have not yet been used for this purpose...
  15. pmc Pitfalls of merging GWAS data: lessons learned in the eMERGE network and quality control procedures to maintain high data quality
    Rebecca L Zuvich
    Center for Human Genetics Research, Department of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, TN, USA
    Genet Epidemiol 35:887-98. 2011
    ..Our experience demonstrates that merging multiple datasets after additional QC can be an efficient use of genotype data despite new challenges that appear in the process...
  16. pmc Assessing the accuracy of observer-reported ancestry in a biorepository linked to electronic medical records
    Logan Dumitrescu
    Department of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, Tennessee, USA
    Genet Med 12:648-50. 2010
    ....
  17. pmc Allelic spectrum of the natural variation in CRP
    Dana C Crawford
    Department of Genome Sciences, University of Washington, 1705 NE Pacific, Seattle, WA 98195 7730, USA
    Hum Genet 119:496-504. 2006
    ..Collectively, these data suggest that several different types re-sequencing and genotyping approaches may be required to fully understand the complete spectrum of alleles that impact human phenotypes...
  18. doi request reprint No evidence of interaction between known lipid-associated genetic variants and smoking in the multi-ethnic PAGE population
    Logan Dumitrescu
    Center for Human Genetics Research, Vanderbilt University, 2215 Garland Avenue, 515B Light Hall, Nashville, TN, 37232, USA
    Hum Genet 132:1427-31. 2013
    ..Despite their biological plausibility, we were unable to detect significant SNP × smoking interactions...
  19. pmc Variation in LPA is associated with Lp(a) levels in three populations from the Third National Health and Nutrition Examination Survey
    Logan Dumitrescu
    Center for Human Genetics Research, Vanderbilt University, Nashville, Tennessee, United States of America
    PLoS ONE 6:e16604. 2011
    ....
  20. pmc Genetic variation associated with circulating monocyte count in the eMERGE Network
    David R Crosslin
    Department of Medicine, Division of Medical Genetics, University of Washington, Seattle, WA, USA
    Hum Mol Genet 22:2119-27. 2013
    ..68×10(-17), β = -0.23) at the integrin, alpha 4 gene on chromosome 2. The novel IRF8 results and further replications provide supporting evidence of genetic regions associated with monocyte count...
  21. pmc Effects of smoking on the genetic risk of obesity: the population architecture using genomics and epidemiology study
    Megan D Fesinmeyer
    Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA 98109 1024, USA
    BMC Med Genet 14:6. 2013
    ..Although smoking behavior is known to affect body mass index (BMI), the potential for smoking to influence genetic associations with BMI is largely unexplored...
  22. doi request reprint Post-Genome-Wide Association Study Challenges for Lipid Traits: Describing Age as a Modifier of Gene-Lipid Associations in the Population Architecture Using Genomics and Epidemiology (PAGE) Study
    Logan Dumitrescu
    Center for Human Genetics Research, Vanderbilt University, Nashville, TN
    Ann Hum Genet 77:416-25. 2013
    ..99). However, none of the suggestive modifying effects survived adjustment for multiple testing, highlighting the challenges of identifying modifiers of modest SNP-trait associations despite large sample sizes. ..
  23. pmc Variants near FOXE1 are associated with hypothyroidism and other thyroid conditions: using electronic medical records for genome- and phenome-wide studies
    Joshua C Denny
    Department of Biomedical Informatics, Vanderbilt University, Nashville, TN 37232, USA
    Am J Hum Genet 89:529-42. 2011
    ..Our findings indicate that EMR-linked genomic data could allow discovery of genes associated with many diseases without additional genotyping cost...
  24. pmc Identification of genomic predictors of atrioventricular conduction: using electronic medical records as a tool for genome science
    Joshua C Denny
    Office of Personalized Medicine, Vanderbilt University School of Medicine, Nashville, TN 37232 0575, USA
    Circulation 122:2016-21. 2010
    ..The extent to which this can be demonstrated in cohorts derived from electronic medical records is unknown...
  25. doi request reprint Genetic variation in donor CTLA-4 regulatory region is a strong predictor of outcome after allogeneic hematopoietic cell transplantation for hematologic malignancies
    Madan Jagasia
    Hematology and Stem Cell Transplantation Section, Division of Hematology Oncology, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN 37232, USA
    Biol Blood Marrow Transplant 18:1069-75. 2012
    ..10-2.71, P = .017) and OS (HR = 1.84, 95% CI 1.13-3.0, P = .015). CTLA-4 SNPs can be used to identify high-risk patient subsets that may benefit from preemptive immunomodulation to decrease relapse rates and improve survival...
  26. pmc Characterization of genome-wide association-identified variants for atrial fibrillation in African Americans
    Jessica T Delaney
    Department of Medicine, Vanderbilt University, Nashville, Tennessee, United States of America
    PLoS ONE 7:e32338. 2012
    ..The contribution of these loci to AF risk in African American is unknown...
  27. doi request reprint Replication and characterisation of genetic variants in the fibrinogen gene cluster with plasma fibrinogen levels and haematological traits in the Third National Health and Nutrition Examination Survey
    Janina M Jeff
    Center for Human Genetics Research, Vanderbilt University, Nashville, Tennessee 37232 0700, USA
    Thromb Haemost 107:458-67. 2012
    ..These data confirm the importance of the fibrinogen gene cluster for plasma fibrinogen levels as well as suggest this gene cluster may have pleiotropic effects on haematological traits...
  28. pmc Facilitating pharmacogenetic studies using electronic health records and natural-language processing: a case study of warfarin
    Hua Xu
    Department of Biomedical Informatics, School of Medicine, Vanderbilt University, Nashville, Tennessee 37232, USA
    J Am Med Inform Assoc 18:387-91. 2011
    ..This study sought to develop natural-language-processing algorithms to extract drug-dose information from clinical text, and to assess the capabilities of such tools to automate the data-extraction process for pharmacogenetic studies...
  29. pmc Evidence for age as a modifier of genetic associations for lipid levels
    Logan Dumitrescu
    Center for Human Genetics Research, Vanderbilt University, Nashville, TN 37232, USA
    Ann Hum Genet 75:589-97. 2011
    ..This finding illustrates the utility of using children to discover novel variants associated with complex phenotypes and the importance of considering age-dependent genetic effects in association studies of lipid levels...
  30. pmc A systematic mapping approach of 16q12.2/FTO and BMI in more than 20,000 African Americans narrows in on the underlying functional variation: results from the Population Architecture using Genomics and Epidemiology (PAGE) study
    Ulrike Peters
    Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America
    PLoS Genet 9:e1003171. 2013
    ..Importantly our study demonstrated that comprehensive fine-mapping in AA provides a powerful approach to narrow in on the functional candidate(s) underlying the initial GWAS findings in European populations...
  31. pmc Genetic variants associated with the white blood cell count in 13,923 subjects in the eMERGE Network
    David R Crosslin
    Department of Medicine, Division of Medical Genetics, University of Washington, Seattle, WA 98195, USA
    Hum Genet 131:639-52. 2012
    ..Variants in this region have been reported to be associated with WBC, neutrophil count, and inflammatory diseases including asthma and Crohn's disease...
  32. pmc Integrating host genomics with surveillance for invasive bacterial diseases
    Dana C Crawford
    Vanderbilt University, Nashville, Tennessee, USA
    Emerg Infect Dis 14:1138-40. 2008
    ..Using nDBS specimens, we resequenced CD46, putative host gene receptor for Neisseria meningitidis, and identified variants associated with susceptibility to this disease...
  33. ncbi request reprint A common VLDLR polymorphism interacts with APOE genotype in the prediction of carotid artery disease risk
    Dana C Crawford
    Department of Molecular Physiology and Biophysics, Center for Human Genetics Research, Vanderbilt University, Nashville, TN, USA
    J Lipid Res 49:588-96. 2008
    ..These findings may further our understanding of VLDLR function, its ligand APOE, and ultimately the pathogenesis of CAAD in the general population...
  34. pmc PheWAS: demonstrating the feasibility of a phenome-wide scan to discover gene-disease associations
    Joshua C Denny
    Department of Biomedical Informatics, Vanderbilt University, Nashville, TN, USA
    Bioinformatics 26:1205-10. 2010
    ..The primary outcome of this study was replication of seven previously known SNP-disease associations for these SNPs...
  35. pmc Haplotype diversity across 100 candidate genes for inflammation, lipid metabolism, and blood pressure regulation in two populations
    Dana C Crawford
    Department of Genome Sciences, University of Washington, Seattle 98195 7730, USA
    Am J Hum Genet 74:610-22. 2004
    ....
  36. pmc Genetic determinants of lipid traits in diverse populations from the population architecture using genomics and epidemiology (PAGE) study
    Logan Dumitrescu
    Center for Human Genetics Research, Vanderbilt University, Nashville, Tennessee, United States of America
    PLoS Genet 7:e1002138. 2011
    ..For the associations that did not generalize, differences in effect sizes, allele frequencies, and linkage disequilibrium offer clues to the next generation of association studies for these traits...
  37. pmc Imputation of coding variants in African Americans: better performance using data from the exome sequencing project
    Qing Duan
    Department of Genetics and Department of Computer Science, University of North Carolina, Chapel Hill, NC 27599, USA, Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA, Department of Biostatistics, University of North Carolina, Chapel Hill, NC 27599, USA, Department of Biostatistics and Center for Statistical Genetics, School of Public Health, University of Michigan, Ann Arbor, MI 48109, USA, Renaissance Computing Institute, University of North Carolina, Chapel Hill, NC 27599, USA, Department of Statistics and Department of Genetics, Rutgers University, Piscataway, NJ 08854, USA, Department of Epidemiology, University of North Carolina, Chapel Hill, NC 27599, USA, Department of Epidemiology, University of Washington, Seattle, WA 98195, USA, Division of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA 15261, USA, Department of Epidemiology and Medicine, University of Iowa, Iowa City, IA 52242, Division of Cardiology, George Washington University School of Medicine and Health Sciences, Washington, DC 20037, USA, Department of Preventive Medicine, Keck School of Medicine, University of Southern California Norris Comprehensive Cancer Center, France
    Bioinformatics 29:2744-9. 2013
    ..We recommend using haplotypes from Exome Sequencing Project alone or concatenation of the two panels over quality score-based post-imputation selection or IMPUTE2's two-panel combination...
  38. pmc Genetic variation in the β1-adrenergic receptor is associated with the risk of atrial fibrillation after cardiac surgery
    Janina M Jeff
    Center for Human Genetics Research, Vanderbilt University, Nashville, TN
    Am Heart J 167:101-108.e1. 2014
    ....
  39. ncbi request reprint Utilization of an emr-biorepository to identify the genetic predictors of calcineurin-inhibitor toxicity in heart transplant recipients
    Matthew Oetjens
    Center for Human Genetics Research, USA
    Pac Symp Biocomput 19:253-64. 2014
    ..02 (coeff(S.E.) = 14.60(6.41)). While larger independent studies will be required to further validate this finding, this study underscores the EMRs usefulness as a resource for longitudinal pharmacogenetic study designs. ..
  40. pmc SCN5A variation is associated with electrocardiographic traits in the Jackson Heart Study
    Janina M Jeff
    Center for Human Genetics Research, Vanderbilt University, Nashville, TN 37232 0700, USA
    Circ Cardiovasc Genet 4:139-44. 2011
    ..Recent genetic association studies of one ECG trait, the QT interval, have identified common variation in European-descent populations, but little is known about the genetic determinants of ECG traits in populations of African descent...
  41. doi request reprint Admixture mapping and subsequent fine-mapping suggests a biologically relevant and novel association on chromosome 11 for type 2 diabetes in african americans
    Janina M Jeff
    Charles Bronfman Institute of Personalized Medicine, Icahn School of Medicine at Mount Sinai, Vanderbilt University, Nashville, Tennessee, United States of America
    PLoS ONE 9:e86931. 2014
    ..We identified 13 independent associations between TCIRG1, CHKA, and ALDH3B1 genes on chromosome 11 and T2D. Our results suggest a novel region on chromosome 11 identified by admixture mapping is associated with T2D in African Americans. ..
  42. pmc Knowledge-driven multi-locus analysis reveals gene-gene interactions influencing HDL cholesterol level in two independent EMR-linked biobanks
    Stephen D Turner
    Department of Molecular Physiology and Biophysics, Center for Human Genetics Research, Vanderbilt University School of Medicine, Nashville, Tennessee, United States of America
    PLoS ONE 6:e19586. 2011
    ..These results demonstrate that gene-gene interactions modulate complex human traits, including HDL cholesterol...
  43. ncbi request reprint The patterns of natural variation in human genes
    Dana C Crawford
    Department of Genome Sciences, University of Washington, Seattle, Washington 98195, USA
    Annu Rev Genomics Hum Genet 6:287-312. 2005
    ..Therefore, many different approaches may be required to identify the elusive genotypes associated with common human phenotypes...
  44. ncbi request reprint Definition and clinical importance of haplotypes
    Dana C Crawford
    Department of Genome Sciences, University of Washington, Seattle, Washington 98195, USA
    Annu Rev Med 56:303-20. 2005
    ..Finally, we discuss the latest concepts for the analysis of haplotypes related to human disease, including haplotype blocks, the International HapMap Project, and the future directions of these resources...
  45. pmc Quality control procedures for genome-wide association studies
    Stephen Turner
    Center for Human Genetics Research, Department of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, Tennessee, USA
    Curr Protoc Hum Genet . 2011
    ..We propose best practices and discuss areas of ongoing and future research...
  46. doi request reprint Single nucleotide polymorphism discovery in TBX1 in individuals with and without 22q11.2 deletion syndrome
    Carrie L Heike
    Department of Pediatrics, Division of Craniofacial Medicine, University of Washington and Seattle Children s Hospital, Seattle, Washington 98105 5371, USA
    Birth Defects Res A Clin Mol Teratol 88:54-63. 2010
    ..The purpose of this study was to further characterize the sequence variability in TBX1 by identifying all common SNPs in this gene...
  47. pmc Pattern of sequence variation across 213 environmental response genes
    Robert J Livingston
    Department of Genome Sciences, University of Washington, Seattle, Washington 98195 7730, USA
    Genome Res 14:1821-31. 2004
    ..The implications for the use of these data in direct and indirect association studies of environmentally induced diseases are discussed...
  48. pmc CRP polymorphisms and progression of chronic kidney disease in African Americans
    Adriana M Hung
    Vanderbilt University Medical Center, 1161 21st Avenue South and Garland, Division of Nephrology, S 3223 MCN, Nashville, TN 37232 2372, USA
    Clin J Am Soc Nephrol 5:24-33. 2010
    ..It is unknown if CRP polymorphisms are associated with CKD progression or modify the effectiveness of anti-hypertensive therapy in delaying CKD progression...
  49. pmc CRP polymorphisms and chronic kidney disease in the third national health and nutrition examination survey
    Adriana M Hung
    Veterans Administration Tennessee Valley Healthcare System Nashville, TN, USA
    BMC Med Genet 12:65. 2011
    ..We recently reported an association between the gene variant rs2808630 and CKD progression in African Americans with hypertensive kidney disease. This association has not been studied in other ethnic groups...
  50. ncbi request reprint Evidence for substantial fine-scale variation in recombination rates across the human genome
    Dana C Crawford
    Department of Genome Sciences, University of Washington, Box 354322, Seattle, Washington 98195, USA
    Nat Genet 36:700-6. 2004
    ..No primary sequence characteristics are consistently associated with precise hot-spot location, although G+C content and nucleotide diversity are correlated with local recombination rate...
  51. pmc Peptide tyrosine tyrosine levels are increased in patients with urea cycle disorders
    Sabrina Mitchell
    Center for Human Genetics Research, Vanderbilt University Medical Center, Nashville, TN 37232, USA
    Mol Genet Metab 106:39-42. 2012
    ..These observations may lead to a better understanding of the development of anorexia in UCD patients...
  52. doi request reprint Genetic variation in recipient B-cell activating factor modulates phenotype of GVHD
    William B Clark
    Hematology and Stem Cell Transplantation Section, Division of Hematology Oncology, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA
    Blood 118:1140-4. 2011
    ..48, P = .009]) were independent predictors of GVHD subtypes, adjusted for conventional predictors of cGVHD. This study shows that genetic variation of BAFF modulates GVHD phenotype after allogeneic stem cell transplantation...
  53. pmc Return of individual research results from genome-wide association studies: experience of the Electronic Medical Records and Genomics (eMERGE) Network
    Stephanie M Fullerton
    University of Washington, Seattle, Washington, USA
    Genet Med 14:424-31. 2012
    ..However, few groups have deliberated on specific results or weighed deliberations against relevant local contextual factors...
  54. doi request reprint Strategies for genotyping
    Dana C Crawford
    Center for Human Genetics Research, Department of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, Tennessee, USA
    Curr Protoc Hum Genet . 2011
    ....
  55. pmc Atopy history and the genomics of wheezing after influenza vaccination in children 6-59 months of age
    E Kathryn Miller
    Department of Pediatrics, Vanderbilt University Medical Center, CCC 5323 Medical Center North, Nashville, TN 37232, USA
    Vaccine 29:3431-7. 2011
    ..We sought to determine whether epidemiologic or genetic factors were associated with these outcomes...
  56. pmc Synthesis-View: visualization and interpretation of SNP association results for multi-cohort, multi-phenotype data and meta-analysis
    Sarah A Pendergrass
    Center for Human Genetics Research, Vanderbilt University Medical Center, Nashville TN, USA
    BioData Min 3:10. 2010
    ....
  57. pmc Paternally transmitted FMR1 alleles are less stable than maternally transmitted alleles in the common and intermediate size range
    Amy K Sullivan
    Department of Human Genetics, Emory University School of Medicine, 615 Michael Street, Atlanta, GA 30322, USA
    Am J Hum Genet 70:1532-44. 2002
    ..This difference that depends on repeat size suggests either a different mutational mechanism of instability or an increase in selection against sperm as their repeat size increases...
  58. ncbi request reprint Characterization of beta-globin haplotypes using blood spots from a population-based cohort of newborns with homozygous HbS
    Dana C Crawford
    National Center on Birth Defects and Developmental Disabilities, Division of Applied Public Health Training, Epidemiology Program Office, Centers for Disease Control and Prevention, Atlanta, GA 30341, USA
    Genet Med 4:328-35. 2002
    ..A population-based cohort from three state newborn screening programs was used to describe beta-globin gene cluster variation...
  59. ncbi request reprint Problems with genome-wide association studies
    Scott M Williams
    Science 316:1840-2. 2007