Ronald L Cowan

Summary

Affiliation: Vanderbilt University
Country: USA

Publications

  1. pmc Neuroimaging in human MDMA (Ecstasy) users
    Ronald L Cowan
    Psychiatric Neuroimaging Program, Vanderbilt University School of Medicine, Nashville, Tennessee, USA
    Ann N Y Acad Sci 1139:291-8. 2008
  2. ncbi request reprint Reduced cortical gray matter density in human MDMA (Ecstasy) users: a voxel-based morphometry study
    Ronald L Cowan
    Brain Imaging Center, Department of Psychiatry, McLean Hospital, Harvard Medical School, Belmont, MA 02478, USA
    Drug Alcohol Depend 72:225-35. 2003
  3. ncbi request reprint MDMA use is associated with increased spatial BOLD fMRI visual cortex activation in human MDMA users
    R L Cowan
    Brain Imaging Center, McLean Hospital, and Department of Psychiatry, Harvard Medical School, MA 02478, USA
    Pharmacol Biochem Behav 84:219-28. 2006
  4. ncbi request reprint Neuroimaging research in human MDMA users: a review
    Ronald L Cowan
    Psychiatric Neuroimaging Program, Department of Psychiatry, Vanderbilt University Medical Center, 1500 21st Avenue South, Suite 3000, Nashville, TN 37212, USA
    Psychopharmacology (Berl) 189:539-56. 2007
  5. pmc Occipital cortical proton MRS at 4 Tesla in human moderate MDMA polydrug users
    Ronald L Cowan
    Psychiatric Neuroimaging Program, Department of Psychiatry, Vanderbilt University Medical Center, 1601 23rd Avenue South, Suite 3057, Nashville, TN 37212, USA
    Psychiatry Res 155:179-88. 2007
  6. doi request reprint N-acetylaspartate (NAA) correlates inversely with cannabis use in a frontal language processing region of neocortex in MDMA (Ecstasy) polydrug users: a 3 T magnetic resonance spectroscopy study
    Ronald L Cowan
    Psychiatric Neuroimaging Program, Nashville, TN 37212, USA
    Pharmacol Biochem Behav 92:105-10. 2009
  7. pmc Dopaminergic network differences in human impulsivity
    Joshua W Buckholtz
    Department of Psychology, Vanderbilt University, Nashville, TN 37240, USA
    Science 329:532. 2010
  8. pmc A thalamocorticostriatal dopamine network for psychostimulant-enhanced human cognitive flexibility
    Gregory R Samanez-Larkin
    Department of Psychology, Vanderbilt University, Nashville, Tennessee Institute of Imaging Science, Vanderbilt University, Nashville, Tennessee 37240, USA
    Biol Psychiatry 74:99-105. 2013
  9. pmc Cannabis cue-induced brain activation correlates with drug craving in limbic and visual salience regions: preliminary results
    Evonne J Charboneau
    Vanderbilt Psychiatric Neuroimaging Program, Vanderbilt University Medical Center, Nashville, TN 37212, United States Vanderbilt Addiction Center, Vanderbilt University Medical Center, Nashville, TN 37212, United States Vanderbilt Department of Psychiatry, Vanderbilt University Medical Center, 1601 23rd Avenue South, Suite 3057, Nashville, TN 37212, United States
    Psychiatry Res 214:122-31. 2013
  10. pmc Dopaminergic mechanisms of individual differences in human effort-based decision-making
    Michael T Treadway
    Department of Psychology, Vanderbilt University, Nashville, Tennessee 37240, USA
    J Neurosci 32:6170-6. 2012

Collaborators

Detail Information

Publications41

  1. pmc Neuroimaging in human MDMA (Ecstasy) users
    Ronald L Cowan
    Psychiatric Neuroimaging Program, Vanderbilt University School of Medicine, Nashville, Tennessee, USA
    Ann N Y Acad Sci 1139:291-8. 2008
    ..This paper reviews existing findings in the context of a cortical model and suggests directions for future research...
  2. ncbi request reprint Reduced cortical gray matter density in human MDMA (Ecstasy) users: a voxel-based morphometry study
    Ronald L Cowan
    Brain Imaging Center, Department of Psychiatry, McLean Hospital, Harvard Medical School, Belmont, MA 02478, USA
    Drug Alcohol Depend 72:225-35. 2003
    ....
  3. ncbi request reprint MDMA use is associated with increased spatial BOLD fMRI visual cortex activation in human MDMA users
    R L Cowan
    Brain Imaging Center, McLean Hospital, and Department of Psychiatry, Harvard Medical School, MA 02478, USA
    Pharmacol Biochem Behav 84:219-28. 2006
    ..Additional research is needed to clarify the origin and significance of the current findings...
  4. ncbi request reprint Neuroimaging research in human MDMA users: a review
    Ronald L Cowan
    Psychiatric Neuroimaging Program, Department of Psychiatry, Vanderbilt University Medical Center, 1500 21st Avenue South, Suite 3000, Nashville, TN 37212, USA
    Psychopharmacology (Berl) 189:539-56. 2007
    ....
  5. pmc Occipital cortical proton MRS at 4 Tesla in human moderate MDMA polydrug users
    Ronald L Cowan
    Psychiatric Neuroimaging Program, Department of Psychiatry, Vanderbilt University Medical Center, 1601 23rd Avenue South, Suite 3057, Nashville, TN 37212, USA
    Psychiatry Res 155:179-88. 2007
    ..These findings are not supportive of MDMA-induced alterations in NAA or MI levels in this small sample of moderate MDMA users. Limitations to this study suggest caution in the interpretation of these results...
  6. doi request reprint N-acetylaspartate (NAA) correlates inversely with cannabis use in a frontal language processing region of neocortex in MDMA (Ecstasy) polydrug users: a 3 T magnetic resonance spectroscopy study
    Ronald L Cowan
    Psychiatric Neuroimaging Program, Nashville, TN 37212, USA
    Pharmacol Biochem Behav 92:105-10. 2009
    ..These findings suggest that cannabis use may contribute to altered neuronal integrity in Ecstasy polydrug users in a brain region associated with verbal memory processing...
  7. pmc Dopaminergic network differences in human impulsivity
    Joshua W Buckholtz
    Department of Psychology, Vanderbilt University, Nashville, TN 37240, USA
    Science 329:532. 2010
    ..Path analysis confirmed that the impact of decreased midbrain D2/D3 autoreceptor availability on trait impulsivity is mediated in part through its effect on stimulated striatal DA release...
  8. pmc A thalamocorticostriatal dopamine network for psychostimulant-enhanced human cognitive flexibility
    Gregory R Samanez-Larkin
    Department of Psychology, Vanderbilt University, Nashville, Tennessee Institute of Imaging Science, Vanderbilt University, Nashville, Tennessee 37240, USA
    Biol Psychiatry 74:99-105. 2013
    ..Everyday life demands continuous flexibility in thought and behavior. We examined whether individual differences in dopamine function are related to variability in the effects of amphetamine on one aspect of flexibility: task switching...
  9. pmc Cannabis cue-induced brain activation correlates with drug craving in limbic and visual salience regions: preliminary results
    Evonne J Charboneau
    Vanderbilt Psychiatric Neuroimaging Program, Vanderbilt University Medical Center, Nashville, TN 37212, United States Vanderbilt Addiction Center, Vanderbilt University Medical Center, Nashville, TN 37212, United States Vanderbilt Department of Psychiatry, Vanderbilt University Medical Center, 1601 23rd Avenue South, Suite 3057, Nashville, TN 37212, United States
    Psychiatry Res 214:122-31. 2013
    ..This study provides preliminary evidence for the neural basis of cue-induced cannabis craving and suggests possible neural targets for interventions targeted at treating cannabis dependence. ..
  10. pmc Dopaminergic mechanisms of individual differences in human effort-based decision-making
    Michael T Treadway
    Department of Psychology, Vanderbilt University, Nashville, Tennessee 37240, USA
    J Neurosci 32:6170-6. 2012
    ..These findings highlight the role of DA signaling in striatal, prefrontal, and insular regions as key neurochemical mechanisms underlying individual differences in cost/benefit decision-making...
  11. pmc Correlation of individual differences in schizotypal personality traits with amphetamine-induced dopamine release in striatal and extrastriatal brain regions
    Neil D Woodward
    Psychiatric Neuroimaging Program, Department of Psychiatry, Vanderbilt University School of Medicine, Nashville, TN, USA
    Am J Psychiatry 168:418-26. 2011
    ..The authors sought to determine whether individual differences in normal variation in schizotypal traits are correlated with dopamine transmission in the striatum and in extrastriatal brain regions...
  12. pmc The interrelationship of dopamine D2-like receptor availability in striatal and extrastriatal brain regions in healthy humans: a principal component analysis of [18F]fallypride binding
    David H Zald
    Department of Psychology, Vanderbilt University, 325 Wilson Hall, 111 21st Ave South, Nashville, TN 37212, USA
    Neuroimage 51:53-62. 2010
    ..This conclusion has significant implications for neuropsychiatric models that posit global or regionally specific relationships between dopaminergic tone and behavior...
  13. pmc Caudate responses to reward anticipation associated with delay discounting behavior in healthy youth
    Margaret M Benningfield
    Department of Psychiatry, Vanderbilt University School of Medicine, 1601 23rd Avenue South, Nashville, TN 37212, United States Department of Pediatrics, Vanderbilt University School of Medicine, 2200 Children s Way, Nashville, TN, 37232, United States Electronic address
    Dev Cogn Neurosci 7:43-52. 2014
    ..Using functional magnetic resonance imaging (fMRI), we tested the hypothesis that individual differences in delay discounting behavior in healthy youth are related to differences in responsiveness to potential reward...
  14. pmc Human ecstasy (MDMA) polydrug users have altered brain activation during semantic processing
    Tristan J Watkins
    Vanderbilt Addiction Center, Vanderbilt University School of Medicine, Nashville, TN 37212, USA
    Psychopharmacology (Berl) 227:41-54. 2013
    ..Studies have correlated long-term MDMA use with altered brain activation in regions that play a role in verbal memory...
  15. pmc Evidence for chronically altered serotonin function in the cerebral cortex of female 3,4-methylenedioxymethamphetamine polydrug users
    Christina R Di Iorio
    Department of Psychiatry, School of Medicine, Vanderbilt University School of Medicine, Nashville, TN 37212, USA
    Arch Gen Psychiatry 69:399-409. 2012
    ..Whether MDMA produces chronic reductions in serotonin signaling in humans remains controversial...
  16. pmc Sustained amygdala response to both novel and newly familiar faces characterizes inhibited temperament
    Jennifer Urbano Blackford
    Department of Psychiatry, Vanderbilt University, Nashville, TN 37212, USA
    Soc Cogn Affect Neurosci 6:621-9. 2011
    ..In individuals with an inhibited temperament, this sustained response may be related to the wariness of social situations that persists beyond initial exposure...
  17. pmc Human Ecstasy use is associated with increased cortical excitability: an fMRI study
    Amy L Bauernfeind
    Psychiatric Neuroimaging Program, Vanderbilt University Medical Center, Nashville, TN 37212, USA
    Neuropsychopharmacology 36:1127-41. 2011
    ..When considered in the context of previous results, cortical hyper-excitability may be a biomarker for MDMA-induced serotonin neurotoxicity...
  18. pmc Mesolimbic dopamine reward system hypersensitivity in individuals with psychopathic traits
    Joshua W Buckholtz
    Department of Psychology, Vanderbilt University, Nashville, Tennessee, USA
    Nat Neurosci 13:419-21. 2010
    ..These findings suggest that neurochemical and neurophysiological hyper-reactivity of the dopaminergic reward system may comprise a neural substrate for impulsive-antisocial behavior and substance abuse in psychopathy...
  19. pmc Amygdala and hippocampus fail to habituate to faces in individuals with an inhibited temperament
    Jennifer Urbano Blackford
    Department of Psychiatry, Psychiatric Neuroimaging Program, Vanderbilt University, 1601 23rd Avenue South, Suite 3057, Nashville, TN 37212, USA
    Soc Cogn Affect Neurosci 8:143-50. 2013
    ..We propose that this failure to habituate reflects a social learning deficit in individuals with an inhibited temperament and provides a possible mechanism for increased risk for social anxiety...
  20. pmc MDMA (Ecstasy) association with impaired fMRI BOLD thalamic coherence and functional connectivity
    Ronald M Salomon
    Psychiatric Neuroimaging Program, Vanderbilt University School of Medicine, Nashville, TN 37212, USA
    Drug Alcohol Depend 120:41-7. 2012
    ..2009). Blood oxygenation level dependent (BOLD) data from that study were reanalyzed for intraregional coherence and for inter-regional temporal correlations between time series, as functional connectivity...
  21. pmc Regulation of novelty seeking by midbrain dopamine D2/D3 signaling and ghrelin is altered in obesity
    Shane W Savage
    Department of Psychiatry, Vanderbilt University School of Medicine, Nashville, Tennessee, USA
    Obesity (Silver Spring) 22:1452-7. 2014
    ..In healthy, NS are negatively associated with DA receptors in the substantia nigra (SN). The influence of obesity on the regulation of NS by DA signaling and AG was hypothesized...
  22. ncbi request reprint Pain and hospice care in nursing home residents with dementia and terminal cancer
    Todd B Monroe
    School of Nursing, Vanderbilt University, Nashville, USA
    Geriatr Gerontol Int 13:1018-25. 2013
    ..The aim of the current pilot study was to examine the association between hospice enrolment, dementia severity and pain among nursing home residents who died from advanced cancer...
  23. ncbi request reprint Amygdala-cingulate intrinsic connectivity is associated with degree of social inhibition
    Jennifer Urbano Blackford
    Department of Psychiatry, Vanderbilt University School of Medicine, Nashville, TN, United States Department of Psychology, Vanderbilt University, Nashville, TN, United States Electronic address
    Biol Psychol 99:15-25. 2014
    ..These findings provide important preliminary evidence that social inhibition reflects differences in the underlying intrinsic connectivity of the brain in the absence of social stimuli or stressors. ..
  24. ncbi request reprint Differential effects of D-amphetamine on red and blue light-induced photic activation: A novel BOLD fMRI assay of human dopamine function
    Ronald L Cowan
    Department of Psychiatry, Psychiatric Neuroimaging Program, Vanderbilt University Medical Center, Nashville, Tennessee 37212, USA
    Synapse 62:268-72. 2008
    ....
  25. pmc Midbrain dopamine receptor availability is inversely associated with novelty-seeking traits in humans
    David H Zald
    Department of Psychology, Vanderbilt University Nashville, Tennessee 37240, USA
    J Neurosci 28:14372-8. 2008
    ..We speculate that the lower midbrain (auto)receptor availability seen in high novelty seekers leads to accentuated dopaminergic responses to novelty and other conditions that induce dopamine release...
  26. pmc Ethical and legal issues in pain research in cognitively impaired older adults
    Todd B Monroe
    School of Nursing, Vanderbilt University, Institute of Imaging Science, Vanderbilt University, 461 21st Avenue South, Nashville, TN 37240, USA
    Int J Nurs Stud 50:1283-7. 2013
    ..The aims of this paper are to provide an overview of major ethical challenges that can occur in pain research in cognitively impaired populations and to present potential solutions when preparing study protocols. ..
  27. pmc Oscillatory serotonin function in depression
    Ronald M Salomon
    Department of Psychiatry, Vanderbilt University School of Medicine, Nashville, Tennessee, 37212
    Synapse 67:801-20. 2013
    ..5HT oscillatory dysfunction may define illness subtypes and predict responses to serotonergic agents. Further studies of 5HT oscillations in depression are indicated...
  28. ncbi request reprint Changes in dopamine release and dopamine D2/3 receptor levels with the development of mild obesity
    Robert M Kessler
    Department of Radiology, Vanderbilt University School of Medicine, Nashville, Tennessee, 37232
    Synapse 68:317-20. 2014
    ..Significant, positive correlations of BMI with DA release were seen; correlations with DA D2/3 levels were negative and of borderline significance. ..
  29. pmc Time series fMRI measures detect changes in pontine raphé following acute tryptophan depletion
    Ronald M Salomon
    Psychiatric Neuroimaging Program, Vanderbilt University School of Medicine, Nashville, TN, USA
    Psychiatry Res 191:112-21. 2011
    ..05). This preliminarily supports using fMRI time-series features to assess pontine raphé function. Whether, and how, high frequency activity oscillations interfere with low frequency signaling requires further study...
  30. pmc Prior MDMA (Ecstasy) use is associated with increased basal ganglia-thalamocortical circuit activation during motor task performance in humans: an fMRI study
    John Karageorgiou
    Psychiatric Neuroimaging Program, Vanderbilt University School of Medicine, Nashville, TN 37072, USA
    Neuroimage 46:817-26. 2009
    ..Further studies examining behavioral correlates and the specific neurophysiological basis of the observed findings are warranted...
  31. pmc Decreased dopamine type 2 receptor availability after bariatric surgery: preliminary findings
    Julia P Dunn
    Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN 37232, USA
    Brain Res 1350:123-30. 2010
    ....
  32. pmc Aerobic exercise training reduces cannabis craving and use in non-treatment seeking cannabis-dependent adults
    Maciej S Buchowski
    Energy Balance Laboratory, Division of Gastroenterology, Hepatology and Nutrition, Department of Medicine, Vanderbilt University, Nashville, Tennessee, United States of America
    PLoS ONE 6:e17465. 2011
    ..Cannabis dependence is a significant public health problem. Because there are no approved medications for this condition, treatment must rely on behavioral approaches empirically complemented by such lifestyle change as exercise...
  33. pmc Expectation and temperament moderate amygdala and dorsal anterior cingulate cortex responses to fear faces
    Jacqueline A Clauss
    Vanderbilt Medical School Department of Psychiatry, 1601 23rd Avenue South, Suite 3057J, Nashville, TN 37212, USA
    Cogn Affect Behav Neurosci 11:13-21. 2011
    ..Enhanced amygdala sensitivity coupled with weak inhibitory control from the dACC may form a neural circuit mediating behaviors characteristic of inhibited temperament and risk for anxiety disorders...
  34. ncbi request reprint Pain reports and pain medication treatment in nursing home residents with and without dementia
    Todd B Monroe
    School of Nursing, Vanderbilt University, Nashville, Tennessee, USA Institute of Imaging Science, Vanderbilt University, Nashville, Tennessee, USA
    Geriatr Gerontol Int 14:541-8. 2014
    ..The purpose of this pilot study was to determine if a diagnosis of dementia influenced pain self-reports and pain medication use in a group of verbally communicative nursing home (NH) residents...
  35. pmc Response of neural reward regions to food cues in autism spectrum disorders
    Carissa J Cascio
    Department of Psychiatry, Vanderbilt University, 1601 23rd Ave South, Suite 3057, Nashville, TN 37212, USA
    J Neurodev Disord 4:9. 2012
    ..abstract:..
  36. pmc Persistent dose-dependent changes in brain structure in young adults with low-to-moderate alcohol exposure in utero
    Kristen L Eckstrand
    Department of Radiology and Radiological Sciences, Vanderbilt University Medical Center, Nashville, TN, USA
    Alcohol Clin Exp Res 36:1892-902. 2012
    ..Many children with heavy exposure to alcohol in utero display characteristic alterations in brain size and structure. However, the long-term effects of low-to-moderate alcohol exposure on these outcomes are unknown...
  37. doi request reprint The prevalence of employed nurses identified or enrolled in substance use monitoring programs
    Todd B Monroe
    School of Nursing, Vanderbilt University, Nashville, TN 37209, USA
    Nurs Res 62:10-5. 2013
    ....
  38. doi request reprint Pain in people with Alzheimer disease: potential applications for psychophysical and neurophysiological research
    Todd B Monroe
    School of Nursing, Vanderbilt University, Nashville, TN 37240, USA
    J Geriatr Psychiatry Neurol 25:240-55. 2012
    ....
  39. pmc Cerebral morphology and dopamine D2/D3 receptor distribution in humans: a combined [18F]fallypride and voxel-based morphometry study
    Neil D Woodward
    Psychiatric Neuroimaging Program, Vanderbilt Psychiatric Hospital, Suite 3057, 1601 23rd Ave S, Nashville, TN 37212, USA
    Neuroimage 46:31-8. 2009
    ..Clinical studies comparing dopamine receptor availability between clinical and control groups may benefit by accounting for potential differences in cerebral morphology that exist even after spatial normalization...
  40. ncbi request reprint Sex differences in response to red and blue light in human primary visual cortex: a bold fMRI study
    R L Cowan
    Brain Imaging Center and Behavioral Neuropsychopharmacology Laboratory, Consolidated Department of Psychiatry, Harvard Medical School, McLean Hospital, Belmont, MA 02478, USA
    Psychiatry Res 100:129-38. 2000
    ....
  41. pmc MDMA (ecstasy) use is associated with reduced BOLD signal change during semantic recognition in abstinent human polydrug users: a preliminary fMRI study
    V Raj
    Department of Psychiatry, Vanderbilt University School of Medicine, Nashville, TN 37072, USA
    J Psychopharmacol 24:187-201. 2010
    ..These findings partially overlap with previous structural evidence for reduced grey matter in MDMA users and may, in part, explain the consistent verbal memory impairments observed in other studies of MDMA users...

Research Grants8

  1. High-Field Functional MRI of Human Euphoria
    Ronald Cowan; Fiscal Year: 2003
    ..Eventually, we believe that a better understanding of the brain structures that allow us to get high, and become addicted, will lead to improved awareness and treatment for substance abuse. ..
  2. MR Analysis of Persistent CNS Damage in Human MDMA Users
    Ronald Cowan; Fiscal Year: 2004
    ..abstract_text> ..
  3. MR Analysis of Persistent CNS Damage in Human MDMA Users
    Ronald Cowan; Fiscal Year: 2005
    ..abstract_text> ..
  4. MR Analysis of Persistent CNS Damage in Human MDMA Users
    Ronald Cowan; Fiscal Year: 2006
    ..abstract_text> ..
  5. SERT polymorphisms and human cortical 5-HT2A receptors
    Ronald Cowan; Fiscal Year: 2007
    ..Because the rate of depression is greater in females than males, and because regulation of the 5-HT2A receptor is influenced by estrogen, we have chosen to study the effects of having SS or L-A L-A genotype in female subjects. ..
  6. Genetic Factors in Human MDMA Toxicity: A PET Study
    Ronald Cowan; Fiscal Year: 2007
    ..Exploratory analyses will examine for potential interactions of 5-HT2A receptor and 5-HT transporter genotype with the degree of MDMA exposure and outcome measures of 5-HT2A levels and brain volume. ..