ROGER COLBRAN

Summary

Affiliation: Vanderbilt University
Country: USA

Publications

  1. pmc CaMKII regulates diacylglycerol lipase-α and striatal endocannabinoid signaling
    Brian C Shonesy
    Department of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine, Nashville, Tennessee, USA
    Nat Neurosci 16:456-63. 2013
  2. ncbi request reprint Protein phosphatases and calcium/calmodulin-dependent protein kinase II-dependent synaptic plasticity
    Roger J Colbran
    Department of Molecular Physiology and Biophysics, The Center for Molecular Neuroscience, Vanderbilt University School of Medicine, Nashville, Tennessee 37232 0615, USA
    J Neurosci 24:8404-9. 2004
  3. pmc Targeting of calcium/calmodulin-dependent protein kinase II
    Roger J Colbran
    Department of Molecular Physiology and Biophysics, The Center for Molecular Neuroscience, Vanderbilt University School of Medicine, Nashville, TN 37232, USA
    Biochem J 378:1-16. 2004
  4. ncbi request reprint Calcium/calmodulin-dependent protein kinase II and synaptic plasticity
    Roger J Colbran
    Vanderbilt University Medical Center, Nashville, Tennessee 37232 0615, USA
    Curr Opin Neurobiol 14:318-27. 2004
  5. ncbi request reprint Multivalent interactions of calcium/calmodulin-dependent protein kinase II with the postsynaptic density proteins NR2B, densin-180, and alpha-actinin-2
    A J Robison
    Department of Molecular Physiology and Biophysics, Center for Molecular Neuroscience, Vanderbilt Kennedy Center for Research on Human Development, Vanderbilt University, Nashville, Tennessee 37232 0615, USA
    J Biol Chem 280:35329-36. 2005
  6. ncbi request reprint Dopamine depletion alters phosphorylation of striatal proteins in a model of Parkinsonism
    Abigail M Brown
    Department of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine, Nashville, TN 37232 0615, USA
    Eur J Neurosci 22:247-56. 2005
  7. ncbi request reprint A protein phosphatase-1gamma1 isoform selectivity determinant in dendritic spine-associated neurabin
    Leigh C Carmody
    Department of Molecular Physiology and Biophysics, The Center for Molecular Neuroscience, and The Vanderbilt Kennedy Center for Research on Human Development, Vanderbilt University School of Medicine, Nashville, Tennessee 37232 0615, USA
    J Biol Chem 279:21714-23. 2004
  8. doi request reprint Striatal plasticity and medium spiny neuron dendritic remodeling in parkinsonism
    Ariel Y Deutch
    Department of Psychiatry, Vanderbilt University Medical Center, Nashville, TN 37212, USA
    Parkinsonism Relat Disord 13:S251-8. 2007
  9. pmc Localization of myocyte enhancer factor 2 in the rodent forebrain: regionally-specific cytoplasmic expression of MEF2A
    M Diana Neely
    Department of Psychiatry, Vanderbilt University Medical Center, Nashville, TN 37212, USA
    Brain Res 1274:55-65. 2009
  10. pmc Identification and validation of novel spinophilin-associated proteins in rodent striatum using an enhanced ex vivo shotgun proteomics approach
    Anthony J Baucum
    Department of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, Tennessee 37232 0615, USA
    Mol Cell Proteomics 9:1243-59. 2010

Research Grants

  1. Mechanisms of CaM Kinase II Signal Transduction
    ROGER COLBRAN; Fiscal Year: 2007
  2. Mechanisms of CaM Kinase II Signal Transduction
    ROGER COLBRAN; Fiscal Year: 2005
  3. TARGETING OF BRAIN PROTEIN PHOSPHATASE 1
    ROGER COLBRAN; Fiscal Year: 2002
  4. Mechanisms of CaM Kinase II Signal Transduction
    Roger J Colbran; Fiscal Year: 2010

Collaborators

  • Anthony J Baucum
  • ARIEL DEUTCH
  • Danny Winder
  • Kevin Erreger
  • Y Honse
  • E C Muly
  • Michael Bubser
  • Qin Wang
  • Kevin F Haas
  • DAVID TABB
  • STEVEN TAVALIN
  • M D Neely
  • E N Olson
  • ROBIN E REED
  • P B Allen
  • R D Blakely
  • Margaret Gnegy
  • Peter J Mohler
  • K S Campbell
  • David M Lovinger
  • A J Robison
  • Martha A Bass
  • Leigh C Carmody
  • Chad E Grueter
  • Sunday A Abiria
  • Yuxia Jiao
  • Abigail M Brown
  • Erica Bowton
  • Mark E Anderson
  • Ryan K Bartlett
  • Brian C Shonesy
  • Richard M Gustin
  • Yelyzaveta A Nikandrova
  • Aurelio Galli
  • Jonathan A Javitch
  • Namita Sen
  • Thomas L Kash
  • Ryan T Terry-Lorenzo
  • Francesca Binda
  • Yuejin Wu
  • Michelle S C Khoo
  • Suzanne Sessoms-Sikes
  • Jill R Bordelon
  • Eric D Norman
  • Brian E Wadzinski
  • Paul Greengard
  • Ashley E Brady
  • Susanne Kloeker
  • Carey J Oliver
  • Shi Li
  • Shirish Shenolikar
  • Teniel S Ramikie
  • Nidhi Jalan-Sakrikar
  • Ken Mackie
  • Tyler Rentz
  • Xiaohan Wang
  • Victoria S Cavener
  • Sachin Patel
  • Kristie L Rose
  • Davit Mrelashvili
  • Dhananjay Sakrikar
  • Christine Saunders
  • Edwin J Weeber
  • Jennifer Daily
  • Irina Filonova
  • Terry Jo Bichell
  • Heinrich J Matthies
  • Tammy Jessen
  • Marc G Caron
  • KELLY L CONRAD
  • Ulrik Gether
  • Jacob U Fog
  • Brandon J Lute
  • Concetta Dipace
  • Minjia Zhang
  • Yunji Wu
  • Sabrina D Robertson
  • Martha Bass
  • Rey J Gomez
  • Lisa Mendes
  • Ernest C Madu
  • Yingbo Yang
  • Rong Zhang
  • Igor Dzhura
  • Xiaoqun Guan
  • Prince Kannankeril
  • Jinying Yang
  • Carmine V Oddis
  • Amy Joan L Ham
  • Gemin Ni

Detail Information

Publications32

  1. pmc CaMKII regulates diacylglycerol lipase-α and striatal endocannabinoid signaling
    Brian C Shonesy
    Department of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine, Nashville, Tennessee, USA
    Nat Neurosci 16:456-63. 2013
    ..These findings provide mechanistic insights into the molecular regulation of striatal endocannabinoid signaling with implications for physiological control of motor function...
  2. ncbi request reprint Protein phosphatases and calcium/calmodulin-dependent protein kinase II-dependent synaptic plasticity
    Roger J Colbran
    Department of Molecular Physiology and Biophysics, The Center for Molecular Neuroscience, Vanderbilt University School of Medicine, Nashville, Tennessee 37232 0615, USA
    J Neurosci 24:8404-9. 2004
  3. pmc Targeting of calcium/calmodulin-dependent protein kinase II
    Roger J Colbran
    Department of Molecular Physiology and Biophysics, The Center for Molecular Neuroscience, Vanderbilt University School of Medicine, Nashville, TN 37232, USA
    Biochem J 378:1-16. 2004
    ..These studies have revealed fundamental regulatory mechanisms that are probably important for controlling CaMKII functions in many cell types...
  4. ncbi request reprint Calcium/calmodulin-dependent protein kinase II and synaptic plasticity
    Roger J Colbran
    Vanderbilt University Medical Center, Nashville, Tennessee 37232 0615, USA
    Curr Opin Neurobiol 14:318-27. 2004
    ..Recent progress brings us closer to understanding the regulation of dendritic CaMKII activity, localization, and expression, and its role in modulating synaptic transmission and cell morphology...
  5. ncbi request reprint Multivalent interactions of calcium/calmodulin-dependent protein kinase II with the postsynaptic density proteins NR2B, densin-180, and alpha-actinin-2
    A J Robison
    Department of Molecular Physiology and Biophysics, Center for Molecular Neuroscience, Vanderbilt Kennedy Center for Research on Human Development, Vanderbilt University, Nashville, Tennessee 37232 0615, USA
    J Biol Chem 280:35329-36. 2005
    ....
  6. ncbi request reprint Dopamine depletion alters phosphorylation of striatal proteins in a model of Parkinsonism
    Abigail M Brown
    Department of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine, Nashville, TN 37232 0615, USA
    Eur J Neurosci 22:247-56. 2005
    ..These evolving changes may impact striatal synaptic plasticity, Parkinson's disease progression and the changing efficacy and side-effects associated with dopamine replacement therapy...
  7. ncbi request reprint A protein phosphatase-1gamma1 isoform selectivity determinant in dendritic spine-associated neurabin
    Leigh C Carmody
    Department of Molecular Physiology and Biophysics, The Center for Molecular Neuroscience, and The Vanderbilt Kennedy Center for Research on Human Development, Vanderbilt University School of Medicine, Nashville, Tennessee 37232 0615, USA
    J Biol Chem 279:21714-23. 2004
    ..In combination, these data identify a novel PP1gamma1-selective interaction domain in neurabin that may allow for selective regulation and/or subcellular targeting of PP1 isoforms...
  8. doi request reprint Striatal plasticity and medium spiny neuron dendritic remodeling in parkinsonism
    Ariel Y Deutch
    Department of Psychiatry, Vanderbilt University Medical Center, Nashville, TN 37212, USA
    Parkinsonism Relat Disord 13:S251-8. 2007
    ....
  9. pmc Localization of myocyte enhancer factor 2 in the rodent forebrain: regionally-specific cytoplasmic expression of MEF2A
    M Diana Neely
    Department of Psychiatry, Vanderbilt University Medical Center, Nashville, TN 37212, USA
    Brain Res 1274:55-65. 2009
    ..The extranuclear localization of MEF2A suggests novel roles for MEF2A in specific neuronal populations...
  10. pmc Identification and validation of novel spinophilin-associated proteins in rodent striatum using an enhanced ex vivo shotgun proteomics approach
    Anthony J Baucum
    Department of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, Tennessee 37232 0615, USA
    Mol Cell Proteomics 9:1243-59. 2010
    ....
  11. pmc Association of protein phosphatase 1 gamma 1 with spinophilin suppresses phosphatase activity in a Parkinson disease model
    Abigail M Brown
    Department of Molecular Physiology and Biophysics, Center for Molecular Neuroscience, Vanderbilt Kennedy Center for Research on Human Development, Vanderbilt University, Nashville, TN 37232, USA
    J Biol Chem 283:14286-94. 2008
    ....
  12. pmc Ca2+/calmodulin-dependent protein kinase II binds to and phosphorylates a specific SAP97 splice variant to disrupt association with AKAP79/150 and modulate alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid-type glutamate receptor (AMPAR) activity
    Yelyzaveta A Nikandrova
    Department of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, Tennessee 37232, USA
    J Biol Chem 285:923-34. 2010
    ....
  13. pmc Alcohol exposure alters NMDAR function in the bed nucleus of the stria terminalis
    Thomas L Kash
    Department of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine, Nashville, TN, USA
    Neuropsychopharmacology 34:2420-9. 2009
    ....
  14. ncbi request reprint Parallel purification of three catalytic subunits of the protein serine/threonine phosphatase 2A family (PP2A(C), PP4(C), and PP6(C)) and analysis of the interaction of PP2A(C) with alpha4 protein
    Susanne Kloeker
    Department of Pharmacology, Vanderbilt University Medical Center, Nashville, TN 37232, USA
    Protein Expr Purif 31:19-33. 2003
    ..Together, these findings increase our understanding of the biochemistry of alpha4/phosphatase complexes and suggest that the alpha4 binding site within PP2A may include the phosphatase catalytic domain...
  15. pmc Tissue-specific variation of Ube3a protein expression in rodents and in a mouse model of Angelman syndrome
    Richard M Gustin
    Department of Pharmacology, Vanderbilt University Medical Center, Nashville, TN, USA
    Neurobiol Dis 39:283-91. 2010
    ..These findings suggest that neuronal function throughout the brain is compromised in AS...
  16. pmc Oxidation of calmodulin alters activation and regulation of CaMKII
    A J Robison
    Department of Molecular Physiology and Biophysics, Vanderbilt University Medical Center, Nashville, TN 37232 0615, USA
    Biochem Biophys Res Commun 356:97-101. 2007
    ..When taken together, these data suggest that oxidative stress may perturb neuronal and cardiac function via a decreased ability of oxidized calmodulin to bind, activate, and regulate the interactions of CaMKII...
  17. ncbi request reprint Analysis of specific interactions of native protein phosphatase 1 isoforms with targeting subunits
    Roger J Colbran
    Room 702, Light Hall, Vanderbilt University Medical Center, Nashville, Tennessee 37232 0615, USA
    Methods Enzymol 366:156-75. 2003
    ..Similar strategies may also be used to explore interactions of protein phosphatase catalytic subunits with other proteins...
  18. pmc Selective targeting of the gamma1 isoform of protein phosphatase 1 to F-actin in intact cells requires multiple domains in spinophilin and neurabin
    Leigh C Carmody
    Department of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine, Nashville, Tennessee, USA
    FASEB J 22:1660-71. 2008
    ..Thus, selective targeting of PP1gamma1 to F-actin by neurabins in intact cells requires both the canonical PP1-binding motif and an auxiliary PP1gamma1-selectivity determinant...
  19. ncbi request reprint Spinophilin stabilizes cell surface expression of alpha 2B-adrenergic receptors
    Ashley E Brady
    Department of Pharmacology, Center for Molecular Neuroscience, Vanderbilt University Medical Center, Nashville, Tennessee 37232 6600, USA
    J Biol Chem 278:32405-12. 2003
    ....
  20. pmc CaMKII associates with CaV1.2 L-type calcium channels via selected beta subunits to enhance regulatory phosphorylation
    Sunday A Abiria
    Brain Institute, Vanderbilt University, Nashville, Tennessee, USA
    J Neurochem 112:150-61. 2010
    ..2alpha(1) and beta subunits. These findings demonstrate a biochemical mechanism underlying LTCC facilitation by CaMKII...
  21. ncbi request reprint CaMKIIalpha enhances the desensitization of NR2B-containing NMDA receptors by an autophosphorylation-dependent mechanism
    Suzanne Sessoms-Sikes
    Department of Molecular Physiology and Biophysics, The Center for Molecular Neuroscience, Vanderbilt University School of Medicine, Nashville, TN 37232, USA
    Mol Cell Neurosci 29:139-47. 2005
    ..These data suggest a novel mechanism for Ca2+-dependent negative-feedback regulation of NR2B-containing NMDARs in a CaMKII activity- and autophosphorylation-dependent manner that may modulate NMDAR-mediated synaptic plasticity...
  22. ncbi request reprint Differential modulation of Ca2+/calmodulin-dependent protein kinase II activity by regulated interactions with N-methyl-D-aspartate receptor NR2B subunits and alpha-actinin
    A J Robison
    Department of Molecular Physiology and Biophysics, Center for Molecular Neurosciences and The Vanderbilt Kennedy Center for Research on Human Development, Vanderbilt University School of Medicine, Nashville, Tennessee 37232 0615, USA
    J Biol Chem 280:39316-23. 2005
    ..In combination, these data suggest that dynamically regulated interactions with CaMKII-associated proteins could play pleiotropic roles in finetuning CaMKII signaling in defined subcellular compartments...
  23. pmc Syntaxin 1A interaction with the dopamine transporter promotes amphetamine-induced dopamine efflux
    Francesca Binda
    Department of Molecular Physiology and Biophysics, Center for Molecular Neuroscience, Kennedy Centerfor Research on Human Development, Vanderbilt University, 7124 MRBIII, 465 21st Avenue S, Nashville, TN 37232, USA
    Mol Pharmacol 74:1101-8. 2008
    ..These data suggest that AMPH activation of CaMKII supports DAT/SYN1A association, resulting in a mode of DAT capable of DA efflux...
  24. pmc Dysregulation of dopamine transporters via dopamine D2 autoreceptors triggers anomalous dopamine efflux associated with attention-deficit hyperactivity disorder
    Erica Bowton
    Department of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine, Nashville, Tennessee 37232 8548, USA
    J Neurosci 30:6048-57. 2010
    ..These studies identify a signaling network downstream of D(2)R activation, normally constraining DA action at synapses, that may be altered by DAT mutation to impact risk for DA-related disorders...
  25. pmc Developmentally regulated alternative splicing of densin modulates protein-protein interaction and subcellular localization
    Yuxia Jiao
    Department of Molecular Physiology and Biophysics, Center for Molecular Neuroscience, Vanderbilt Kennedy Center for Research on Human Development, Vanderbilt University School of Medicine, Nashville, Tennesse 37232 0615, USA
    J Neurochem 105:1746-60. 2008
    ..In combination, these data show that densin splice variants have distinct functional characteristics suggesting multiple roles during neuronal development...
  26. pmc Differential regulated interactions of calcium/calmodulin-dependent protein kinase II with isoforms of voltage-gated calcium channel beta subunits
    Chad E Grueter
    Department of Molecular Physiology and Biophysics, Vanderbilt University Medical Center, Nashville, Tennessee 37232, USA
    Biochemistry 47:1760-7. 2008
    ..In combination, these data show that phosphorylation dynamically regulates the interactions of specific isoforms of the Ca2+ channel beta subunits with CaMKII...
  27. ncbi request reprint Death, cardiac dysfunction, and arrhythmias are increased by calmodulin kinase II in calcineurin cardiomyopathy
    Michelle S C Khoo
    Department of Medicine, Vanderbilt University, Nashville, Tenn, USA
    Circulation 114:1352-9. 2006
    ....
  28. ncbi request reprint L-type Ca2+ channel facilitation mediated by phosphorylation of the beta subunit by CaMKII
    Chad E Grueter
    Department of Molecular Physiology and Biophysics, Vanderbilt University Medical Center, Nashville, Tennessee 37232, USA
    Mol Cell 23:641-50. 2006
    ..These findings reveal a molecular mechanism for targeting CaMKII to LTCCs and facilitating I(Ca) that may modulate Ca(2+) entry in diverse cell types coexpressing CaMKII and the beta(2a) subunit...
  29. ncbi request reprint A potassium channel blocker induces a long-lasting enhancement of corticostriatal responses
    Eric D Norman
    Department of Molecular Physiology and Biophysics, Vanderbilt University Medical Center, Nashville, TN 37232 0615, USA
    Neuropharmacology 48:311-21. 2005
    ..Collectively, these findings demonstrate a novel form of L-type calcium channel-dependent plasticity in the adult dorsal striatum that is induced in the absence of dopaminergic input...
  30. pmc Differential localization of protein phosphatase-1alpha, beta and gamma1 isoforms in primate prefrontal cortex
    Jill R Bordelon
    Division of Neuroscience, Yerkes National Primate Research Center, and Department of Neurology, Emory University, Atlanta, GA 30322, USA
    Cereb Cortex 15:1928-37. 2005
    ....
  31. pmc Targeting protein phosphatase 1 (PP1) to the actin cytoskeleton: the neurabin I/PP1 complex regulates cell morphology
    Carey J Oliver
    Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, North Carolina 27710, USA
    Mol Cell Biol 22:4690-701. 2002
    ..These studies provided new insights into the assembly and regulation of a neurabin I/PP1 complex that controls actin rearrangement to promote spine development in mammalian neurons...
  32. ncbi request reprint The neuronal actin-binding proteins, neurabin I and neurabin II, recruit specific isoforms of protein phosphatase-1 catalytic subunits
    Ryan T Terry-Lorenzo
    Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, North Carolina 27710, USA
    J Biol Chem 277:27716-24. 2002
    ..These studies identified some of the structural determinants in PP1 and neurabins that together contribute to preferential targeting of PP1gamma1 and PP1alpha to the mammalian synapse...

Research Grants15

  1. Mechanisms of CaM Kinase II Signal Transduction
    ROGER COLBRAN; Fiscal Year: 2007
    ..Consequently, these mechanistic studies will improve our fundamental understanding of the role of CaMKII in regulating synaptic transmission, providing insight into potential new strategies for treatment of multiple brain disorders. ..
  2. Mechanisms of CaM Kinase II Signal Transduction
    ROGER COLBRAN; Fiscal Year: 2005
    ..Reagents that block these protein.protein interactions also have potential for development as therapeutic compounds to treat mental disorders, such as schizophrenia or depression, and possibly brain injuries. ..
  3. TARGETING OF BRAIN PROTEIN PHOSPHATASE 1
    ROGER COLBRAN; Fiscal Year: 2002
    ..These Aims provide novel insights into the physiological regulation of PP1, a key modulator of synaptic function. ..
  4. Mechanisms of CaM Kinase II Signal Transduction
    Roger J Colbran; Fiscal Year: 2010
    ..Consequently, these mechanistic studies will improve our fundamental understanding of the role of CaMKII in regulating synaptic transmission, providing insight into potential new strategies for treatment of multiple brain disorders. ..