Affiliation: Vanderbilt University
Marks C, Shonesy B, Wang X, Stephenson J, Niswender C, Colbran R. Activated CaMKIIα Binds to the mGlu5 Metabotropic Glutamate Receptor and Modulates Calcium Mobilization. Mol Pharmacol. 2018;94:1352-1362 pubmed publisher
..These findings provide new insights into the physical and functional coupling of these key regulators of postsynaptic signaling. ..
Carlson G, Dienel G, Colbran R. Introduction to the Thematic Minireview Series: Brain glycogen metabolism. J Biol Chem. 2018;293:7087-7088 pubmed publisher
..Recent studies unexpectedly linking some forms of epilepsy to mutations in two poorly understood proteins involved in glycogen metabolism are also reviewed. ..
Shonesy B, Winder D, Patel S, Colbran R. The initiation of synaptic 2-AG mobilization requires both an increased supply of diacylglycerol precursor and increased postsynaptic calcium. Neuropharmacology. 2015;91:57-62 pubmed publisher
..These data show that increasing substrate availability alone is insufficient to drive 2-AG mobilization and that DGL-dependent synaptic depression via CB1R activation requires postsynaptic Ca(2+) signals. ..
Pasek J, Wang X, Colbran R. Differential CaMKII regulation by voltage-gated calcium channels in the striatum. Mol Cell Neurosci. 2015;68:234-43 pubmed publisher
..Our findings indicate that CaMKII activity is dynamically regulated by multiple calcium channels in the striatum thus coupling calcium entry to key downstream substrates. ..
Colbran R. Thematic Minireview Series: Molecular Mechanisms of Synaptic Plasticity. J Biol Chem. 2015;290:28594-5 pubmed publisher
..This series of minireviews will focus on recent advances in our understanding of the molecular and cellular mechanisms that control synaptic plasticity. ..
Stephenson J, Wang X, Perfitt T, Parrish W, Shonesy B, Marks C, et al
. A Novel Human CAMK2A Mutation Disrupts Dendritic Morphology and Synaptic Transmission, and Causes ASD-Related Behaviors. J Neurosci. 2017;37:2216-2233 pubmed publisher
Wang X, Marks C, Perfitt T, Nakagawa T, Lee A, Jacobson D, et al
. A novel mechanism for Ca2+/calmodulin-dependent protein kinase II targeting to L-type Ca2+ channels that initiates long-range signaling to the nucleus. J Biol Chem. 2017;292:17324-17336 pubmed publisher
..Taken together, our findings define a novel molecular interaction with the neuronal LTCC that is required for the initiation of a long-range signal to the nucleus that is critical for learning and memory. ..