Cheryl M Coffin

Summary

Affiliation: Vanderbilt University
Country: USA

Publications

  1. doi request reprint Some general considerations about the clinicopathologic aspects of soft tissue tumors in children and adolescents
    Cheryl M Coffin
    Department of Pathology, Microbiology, and Immunology, Vanderbilt University, Nashville, TN, USA
    Pediatr Dev Pathol 15:11-25. 2012
  2. doi request reprint Fibroblastic and myofibroblastic tumors in children and adolescents
    Cheryl M Coffin
    Department of Pathology, Microbiology, and Immunology, Vanderbilt University, Nashville, TN, USA
    Pediatr Dev Pathol 15:127-80. 2012
  3. doi request reprint Fibrohistiocytic tumors and related neoplasms in children and adolescents
    Jennifer Black
    Department of Pathology, Microbiology, and Immunology, Vanderbilt University, Nashville, TN, USA
    Pediatr Dev Pathol 15:181-210. 2012
  4. doi request reprint Adipose and myxoid tumors of childhood and adolescence
    Cheryl M Coffin
    Department of Pathology, Microbiology, and Immunology, Vanderbilt University, Nashville, TN, USA
    Pediatr Dev Pathol 15:239-54. 2012
  5. doi request reprint Soft tissue tumors of uncertain origin
    Rita Alaggio
    Department of Pathology, University of Padova, Padova, Italy
    Pediatr Dev Pathol 15:267-305. 2012
  6. doi request reprint Lipoblastoma (LPB): a clinicopathologic and immunohistochemical analysis of 59 cases
    Cheryl M Coffin
    Department of Pathology, Vanderbilt University, Nashville, TN 37232 2561, USA
    Am J Surg Pathol 33:1705-12. 2009
  7. doi request reprint Morphologic Overlap between Infantile Myofibromatosis and Infantile Fibrosarcoma: A Pitfall in Diagnosis
    Rita Alaggio
    Dipartimento di Scienze Oncologiche e Chirurgiche Azienda Ospedaliera Università di Padova, Padova, Italy
    Pediatr Dev Pathol 11:355-62. 2008
  8. ncbi request reprint Spindle cell tumor with EWS-WT1 transcript and a favorable clinical course: a variant of DSCT, a variant of leiomyosarcoma, or a new entity? Report of 2 pediatric cases
    Rita Alaggio
    Dipartimento di Scienze Oncologiche e Chirurgiche Università di Padova and IOV Istituto Oncologico Veneto, Padova, Italy
    Am J Surg Pathol 31:454-9. 2007
  9. doi request reprint Nuclear p63 expression in osteoblastic tumors
    Michael E Kallen
    Department of Pathology, Microbiology and Immunology, Vanderbilt University Medical Center, Medical Center North, C 3322, 1161 21st Ave South, Nashville, TN 37232, USA
    Tumour Biol 33:1639-44. 2012
  10. doi request reprint Signal transduction pathway analysis in fibromatosis: receptor and nonreceptor tyrosine kinases
    Justin M M Cates
    Department of Pathology, Microbiology and Immunology, Vanderbilt University Medical Center, Nashville, TN 37232, USA
    Hum Pathol 43:1711-8. 2012

Collaborators

Detail Information

Publications49

  1. doi request reprint Some general considerations about the clinicopathologic aspects of soft tissue tumors in children and adolescents
    Cheryl M Coffin
    Department of Pathology, Microbiology, and Immunology, Vanderbilt University, Nashville, TN, USA
    Pediatr Dev Pathol 15:11-25. 2012
    ....
  2. doi request reprint Fibroblastic and myofibroblastic tumors in children and adolescents
    Cheryl M Coffin
    Department of Pathology, Microbiology, and Immunology, Vanderbilt University, Nashville, TN, USA
    Pediatr Dev Pathol 15:127-80. 2012
    ....
  3. doi request reprint Fibrohistiocytic tumors and related neoplasms in children and adolescents
    Jennifer Black
    Department of Pathology, Microbiology, and Immunology, Vanderbilt University, Nashville, TN, USA
    Pediatr Dev Pathol 15:181-210. 2012
    ..Possibly the entire histogenetic concept of FHTs should be reconsidered in light of current studies...
  4. doi request reprint Adipose and myxoid tumors of childhood and adolescence
    Cheryl M Coffin
    Department of Pathology, Microbiology, and Immunology, Vanderbilt University, Nashville, TN, USA
    Pediatr Dev Pathol 15:239-54. 2012
    ..This article reviews the clinicopathologic features of adipose and myxoid tumors with an emphasis on the unique aspects of these neoplasms in children and adolescents and the differential diagnosis...
  5. doi request reprint Soft tissue tumors of uncertain origin
    Rita Alaggio
    Department of Pathology, University of Padova, Padova, Italy
    Pediatr Dev Pathol 15:267-305. 2012
    ....
  6. doi request reprint Lipoblastoma (LPB): a clinicopathologic and immunohistochemical analysis of 59 cases
    Cheryl M Coffin
    Department of Pathology, Vanderbilt University, Nashville, TN 37232 2561, USA
    Am J Surg Pathol 33:1705-12. 2009
    ..These observations raise the question of whether predisposing genetic or other constitutional factors contribute to the development of LPB or whether LPB is indicative of a syndrome...
  7. doi request reprint Morphologic Overlap between Infantile Myofibromatosis and Infantile Fibrosarcoma: A Pitfall in Diagnosis
    Rita Alaggio
    Dipartimento di Scienze Oncologiche e Chirurgiche Azienda Ospedaliera Università di Padova, Padova, Italy
    Pediatr Dev Pathol 11:355-62. 2008
    ..Careful histologic evaluation to detect the typical features of IM is essential to avoid classification as IF. Molecular analysis for the ETV6-NTRK3 gene fusion is an important diagnostic tool in this group of lesions...
  8. ncbi request reprint Spindle cell tumor with EWS-WT1 transcript and a favorable clinical course: a variant of DSCT, a variant of leiomyosarcoma, or a new entity? Report of 2 pediatric cases
    Rita Alaggio
    Dipartimento di Scienze Oncologiche e Chirurgiche Università di Padova and IOV Istituto Oncologico Veneto, Padova, Italy
    Am J Surg Pathol 31:454-9. 2007
    ..Alternatively, they could represent an unrecognized subgroup of tumors with spindle cell morphology, bearing the same translocation as desmoplastic small round cell tumor, but characterized by a more favorable clinical course...
  9. doi request reprint Nuclear p63 expression in osteoblastic tumors
    Michael E Kallen
    Department of Pathology, Microbiology and Immunology, Vanderbilt University Medical Center, Medical Center North, C 3322, 1161 21st Ave South, Nashville, TN 37232, USA
    Tumour Biol 33:1639-44. 2012
    ..The relatively low prevalence of p63 expression in osteosarcoma would also seem to preclude its use as a marker of osteoblastic differentiation in skeletal sarcomas...
  10. doi request reprint Signal transduction pathway analysis in fibromatosis: receptor and nonreceptor tyrosine kinases
    Justin M M Cates
    Department of Pathology, Microbiology and Immunology, Vanderbilt University Medical Center, Nashville, TN 37232, USA
    Hum Pathol 43:1711-8. 2012
    ..Although platelet-derived growth factor receptor, β type, is expressed ubiquitously in desmoids, the kinases driving cell proliferation in desmoids remain unresolved...
  11. ncbi request reprint Critical values in pediatric surgical pathology: definition, implementation, and reporting in a children's hospital
    Cheryl M Coffin
    Department of Pathology, Primary Children s Medical Center and University of Utah, Salt Lake City, UT 84113, USA
    Am J Clin Pathol 128:1035-40. 2007
    ..Although the term critical values has become embedded in the surgical pathology literature, we would propose an alternative term for significant or unexpected findings that require timely communication and documentation...
  12. doi request reprint Signal transduction pathway analysis in desmoid-type fibromatosis: transforming growth factor-β, COX2 and sex steroid receptors
    Nicholas A Mignemi
    Department of Orthopaedics and Rehabilitation, Vanderbilt Orthopaedic Institute, Nashville, Tennessee, USA
    Cancer Sci 103:2173-80. 2012
    ....
  13. doi request reprint Morphologic and immunophenotypic analysis of desmoid-type fibromatosis after radiation therapy
    Justin M M Cates
    Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, TN 37232, USA
    Hum Pathol 43:1418-24. 2012
    ..Lesser degrees of nuclear atypia seen in isolation do not necessarily indicate a poor prognosis in irradiated desmoid-type fibromatosis...
  14. doi request reprint ALK expression in rhabdomyosarcomas: correlation with histologic subtype and fusion status
    Diana A Corao
    Department of Pathology, A I duPont Hospital for Children, Wilmington, DE, USA
    Pediatr Dev Pathol 12:275-83. 2009
    ..We conclude that there is ALK overexpression in RMS, more commonly in ARMS than in ERMS, most likely independent of fusion status. Amplification or upregulation of ALK may underlie ALK protein overexpression...
  15. doi request reprint Epithelioid inflammatory myofibroblastic sarcoma: An aggressive intra-abdominal variant of inflammatory myofibroblastic tumor with nuclear membrane or perinuclear ALK
    Adrian Mariño-Enríquez
    Department of Pathology, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
    Am J Surg Pathol 35:135-44. 2011
    ..We propose the designation "epithelioid inflammatory myofibroblastic sarcoma" to convey both the malignant behavior of these tumors and their close relationship with IMT...
  16. ncbi request reprint Treatment effects in pediatric soft tissue and bone tumors: practical considerations for the pathologist
    Cheryl M Coffin
    Department of Pathology, University of Utah School of Medicine, Salt Lake City, 84113 1100, USA
    Am J Clin Pathol 123:75-90. 2005
    ....
  17. doi request reprint Liposarcomas in young patients: a study of 82 cases occurring in patients younger than 22 years of age
    Rita Alaggio
    Department of Pathology, University of Padova, Padova, Italy
    Am J Surg Pathol 33:645-58. 2009
    ..Additional study of such cases will be necessary for definitive classification...
  18. ncbi request reprint Inflammatory myofibroblastic tumor: comparison of clinicopathologic, histologic, and immunohistochemical features including ALK expression in atypical and aggressive cases
    Cheryl M Coffin
    Department of Pathology, Division of Pediatric Pathology, University of Utah School of Medicine, Primary Children s Medical Center, Salt Lake City, UT 84113, USA
    Am J Surg Pathol 31:509-20. 2007
    ..Other proliferative, apoptotic, and prognostic markers did not correlate well with morphology or outcome. Thus, ALK reactivity may be a favorable prognostic indicator in IMT and abdominopelvic IMTs recur more frequently...
  19. ncbi request reprint Primitive myxoid mesenchymal tumor of infancy: a clinicopathologic report of 6 cases
    Rita Alaggio
    Department of Oncology and Surgery, Section of Pathology, University of Padova, Padova, Italy
    Am J Surg Pathol 30:388-94. 2006
    ....
  20. doi request reprint Myxoinflammatory fibroblastic sarcoma: report of a case and review of the literature
    Rita Alaggio
    Department of Diagnostic Medical Sciences and Special Therapies, University of Padova, Padova, Italy
    Pediatr Dev Pathol 15:254-8. 2012
    ..Fine-needle aspiration cytology is a safe and useful tool for the diagnosis of pediatric patients with MIFS and is important for an accurate and precise preoperative workup to optimize subsequent management and treatment...
  21. doi request reprint Foamy cell angiosarcoma: a rare and deceptively bland variant of cutaneous angiosarcoma
    Amy D Tatsas
    Department of Pathology, Vanderbilt University Medical Center, Nashville, TN 37232, USA
    J Cutan Pathol 37:901-6. 2010
    ..Critical features for diagnosis include the presence of a deep, permeative, sometimes 'scaffolding' growth pattern and subtle areas of vascular formation...
  22. doi request reprint Undifferentiated high-grade pleomorphic sarcomas in children: a clinicopathologic study of 10 cases and review of literature
    Rita Alaggio
    Department of Pathology, University of Padova, Padua, Italy
    Pediatr Dev Pathol 13:209-17. 2010
    ..In summary, UHGPS is rare in children and frequently located in the head. A more favorable outcome is associated with superficial location. Foci of epithelioid cell may portend an aggressive behavior...
  23. ncbi request reprint Pediatric surgical pathology: pitfalls and strategies for error prevention
    Cheryl M Coffin
    Department of Pathology, Primary Children s Medical Center, University of Utah School of Medicine, Salt Lake City, UT, USA
    Arch Pathol Lab Med 130:610-2. 2006
    ..Few data exist regarding quality measures for pediatric surgical pathology, types of errors, or how error-prone situations and diagnostic pitfalls can be minimized...
  24. ncbi request reprint Gardner fibroma: a clinicopathologic and immunohistochemical analysis of 45 patients with 57 fibromas
    Cheryl M Coffin
    Department of Pathology, Primary Children s Medical Center and University of Utah School of Medicine, Salt Lake City, Utah, USA
    Am J Surg Pathol 31:410-6. 2007
    ..The proportion of sporadic GAFs that have APC mutation remains to be determined...
  25. ncbi request reprint Malignant peripheral nerve sheath tumor: a comparison of grade, immunophenotype, and cell cycle/growth activation marker expression in sporadic and neurofibromatosis 1-related lesions
    Holly Zhou
    Department of Pathology, Primary Children s Medical Center, 100 N Medical Drive, Salt Lake City, UT 84113, USA
    Am J Surg Pathol 27:1337-45. 2003
    ..Combining immunohistochemical stains with histologic grading with careful examination of mitotic activity may provide insight into the progression of peripheral nerve sheath tumors...
  26. doi request reprint Predicting dedifferentiation in liposarcoma: a proteomic approach
    Colt M McClain
    Department of Pathology, Microbiology and Immunology, Vanderbilt University Medical Center, 1161 21st Ave South, Nashville, TN 37232, USA
    Virchows Arch 463:85-92. 2013
    ..Expression of SELENBP1 is decreased in the well-differentiated component of DDL compared to ALT. However, variability in the staining patterns in liposarcoma precludes its use as a predictive marker for dedifferentiation...
  27. doi request reprint Composite uterine neoplasm with embryonal rhabdomyosarcoma and primitive neuroectodermal tumor components: rhabdomyosarcoma with divergent differentiation, variant of primitive neuroectodermal tumor, or unique entity?
    Frances Cate
    Department of Pathology, Microbiology and Immunology, Vanderbilt University Medical Center, Nashville, TN 37232, USA
    Hum Pathol 44:656-63. 2013
    ..A variety of clinicopathologic arguments are presented that support the notion that the current neoplasm is an embryonal rhabdomyosarcoma with divergent neuroectodermal and cartilaginous differentiation...
  28. ncbi request reprint Expression of ALK1 and p80 in inflammatory myofibroblastic tumor and its mesenchymal mimics: a study of 135 cases
    Melissa H Cessna
    Department of Pathology, Primary Children s Medical Center and University of Utah School of Medicine, Salt Lake City, Utah 84132, USA
    Mod Pathol 15:931-8. 2002
    ..In IMT, immunohistochemistry for ALK1 and p80 is useful as an indicator of a 2p23 abnormality, but it must be interpreted in the context of histologic and other clinicopathologic data if used as an adjunct to differential diagnosis...
  29. doi request reprint Utility of immunohistochemical staining with FLI1, D2-40, CD31, and CD34 in the diagnosis of acquired immunodeficiency syndrome-related and non-acquired immunodeficiency syndrome-related Kaposi sarcoma
    Flavia G Nunes Rosado
    Department of Pathology, Vanderbilt University Medical Center, Nashville, Tennessee, USA
    Arch Pathol Lab Med 136:301-4. 2012
    ....
  30. pmc Grading of nonrhabdomyosarcoma soft tissue sarcoma in children and adolescents: a comparison of parameters used for the Fédération Nationale des Centers de Lutte Contre le Cancer and Pediatric Oncology Group Systems
    Joseph D Khoury
    Department of Pathology, St Jude Children s Research Hospital, Memphis, Tennessee, USA
    Cancer 116:2266-74. 2010
    ..The applicability and prognostic utility of the FNCLCC system in pediatric NRSTS has not been assessed or compared with the POG system...
  31. ncbi request reprint Pediatric inflammatory myofibroblastic tumor with late metastasis to the lung: case report and review of the literature
    Raffaella A Morotti
    Department of Pathology, Box 1194, Mount Sinai Medical Center, One Gustave L Levy Place, New York, NY 10029, USA
    Pediatr Dev Pathol 8:224-9. 2005
    ..We describe the clinical and pathologic features of this patient and review the characteristics of extrapulmonary IMTs with distant metastasis reported in the literature...
  32. doi request reprint Composite pheochromocytoma: a clinicopathologic and molecular comparison with ordinary pheochromocytoma and neuroblastoma
    Jessica M Comstock
    Department of Pathology, Division of Pediatric Pathology, University of Utah School of Medicine, Salt Lake City, UT 84113, USA
    Am J Clin Pathol 132:69-73. 2009
    ..These findings suggest that composite pheochromocytoma may be regarded as a histologic variant of classic pheochromocytoma...
  33. ncbi request reprint Human herpesvirus 8 and iron staining are useful in differentiating Kaposi sarcoma from interstitial granuloma annulare
    David A Wada
    Department of Pathology, University of Utah Health Sciences Center, Salt Lake City, UT 84132 2409, USA
    Am J Clin Pathol 127:263-70. 2007
    ..This study provides novel data characterizing iron staining in KS and details the use of iron staining, HHV-8, and MIB-1 to distinguish KS from GA...
  34. ncbi request reprint Classic adamantinoma with osteofibrous dysplasia-like foci and secondary aneurysmal bone cyst
    Angelica Putnam
    Department of Pathology, University of Utah School of Medicine, 50 North Medical Drive, Salt Lake City, UT 84132 2501, USA
    Pediatr Dev Pathol 6:173-8. 2003
    ..To our knowledge, the association of adamantinoma with secondary aneurysmal bone cyst has not been previously reported...
  35. ncbi request reprint Non-neurogenic sarcomas in four children and young adults with neurofibromatosis type 1
    Cheryl M Coffin
    Department of Pathology, The University of Utah School of Medicine, 100 North Medical Drive, Salt Lake City, UT 84113, USA
    Am J Med Genet A 127:40-3. 2004
    ..The purpose is to emphasize that early diagnosis of NF1 and recognition of potential manifestations of non-neurogenic sarcomas are important for clinical care of these patients and their families...
  36. ncbi request reprint USCAP Specialty Conference: case 3
    Cheryl M Coffin
    Department of Pathology, Division of Pediatric Pathology, Primary Children s Hospital, 100 North Medical Drive, Salt Lake City, UT 84113 1100, USA
    Pediatr Dev Pathol 8:74-6. 2005
  37. doi request reprint Myxoinflammatory fibroblastic sarcoma in children and adolescents: clinicopathologic aspects of a rare neoplasm
    Vivian L Weiss
    1 Department of Pathology, Microbiology, and Immunology, Vanderbilt University, Nashville, TN, USA
    Pediatr Dev Pathol 16:425-31. 2013
    ..The differential diagnosis and importance of recognizing this rare neoplasm in young patients are discussed. ..
  38. pmc Survivin Expression and Prognostic Significance in Pediatric Malignant Peripheral Nerve Sheath Tumors (MPNST)
    Rita Alaggio
    Department of Medicine, University of Padova, Padova, Italy
    PLoS ONE 8:e80456. 2013
    ..0038). Overall, these data support the concept that survivin can be regarded as a useful prognostic marker for pediatric MPNST and a promising target for therapeutic interventions. ..
  39. doi request reprint Neurogenic tumors of soft tissue
    Justin M M Cates
    Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, TN, USA
    Pediatr Dev Pathol 15:62-107. 2012
    ..This article reviews the clinicopathologic features and differential diagnosis of neurogenic tumors in the first two decades of life, and highlights use of selected ancillary methods for diagnosis...
  40. doi request reprint Extraskeletal cartilaginous, osseous, and chordoid tumors in children and adolescents
    Justin M M Cates
    Department of Pathology, Microbiology, and Immunology, Vanderbilt University, Nashville, TN, USA
    Pediatr Dev Pathol 15:255-66. 2012
    ..This article reviews the clinicopathologic features and differential diagnosis of extraskeletal cartilaginous, osseous, and chordoid neoplasms in the first two decades of life and highlights the use of diagnostic adjuncts...
  41. doi request reprint Myogenic tumors in children and adolescents
    David M Parham
    Department of Pathology, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA
    Pediatr Dev Pathol 15:211-38. 2012
    ..This article reviews the clinicopathologic features of striated and smooth muscle tumors with an emphasis on the unique aspects of these neoplasms in children and adolescents and the differential diagnosis...
  42. pmc Proteomic identification of oncogenic chromosomal translocation partners encoding chimeric anaplastic lymphoma kinase fusion proteins
    Kojo S J Elenitoba-Johnson
    Department of Pathology, University of Utah School of Medicine, Salt Lake City, UT 84132, USA
    Proc Natl Acad Sci U S A 103:7402-7. 2006
    ..This strategy can be adapted for the identification of known and unknown translocation partners of chimeric ALK fusion proteins involved in oncogenesis...
  43. ncbi request reprint How the pediatric autopsy yields valuable information in a vertically integrated health care system
    David Newton
    Department of Pathology, University of Utah School of Medicine and Primary Children s Medical Center, Salt Lake City 84113, USA
    Arch Pathol Lab Med 128:1239-46. 2004
    ..A recent review of autopsy series showed a decline in the number of serious errors likely to have affected clinical outcome detected at autopsy during the past 46 years, with a current major error rate of 8.4% to 24.4%...
  44. ncbi request reprint Frozen section diagnosis in pediatric surgical pathology: a decade's experience in a children's hospital
    Cheryl M Coffin
    Division of Pediatric Pathology, Department of Pathology, Primary Children s Medical Center, University of Utah, Salt Lake City, USA
    Arch Pathol Lab Med 129:1619-25. 2005
    ..Little data exists about the use, frequency, and type of discrepancies and deferral rates of FS diagnoses in pediatric and adolescent surgical pathology...
  45. ncbi request reprint Teaching pediatric laboratory medicine to pathology residents
    Theodore J Pysher
    Division of Pediatric Pathology, Department of Pathology, Primary Children s Medical Center and University of Utah School of Medicine, Salt Lake City 84113, USA
    Arch Pathol Lab Med 130:1031-8. 2006
    ..Therefore, pathology residents should receive training in pediatric laboratory medicine...
  46. ncbi request reprint Her-2/neu expression in osteosarcoma increases risk of lung metastasis and can be associated with gene amplification
    Holly Zhou
    Department of Pathology, University of Utah, Salt Lake City, UT, USA
    J Pediatr Hematol Oncol 25:27-32. 2003
    ..Whether Her-2/neu expression influences outcome needs to be examined further in a prospective fashion. The hope is that Her-2/neu expression will identify patients who may benefit from the addition of directed biologic therapy...
  47. doi request reprint Methylthioadenosine phosphorylase and activated insulin-like growth factor-1 receptor/insulin receptor: potential therapeutic targets in chordoma
    Josh Sommer
    Chordoma Foundation, Greensboro, NC, USA, and Division of Medical Oncology, Department of Medicine, Duke University Medical Center and Durham Veterans Affairs Medical Center, Durham, NC, USA
    J Pathol 220:608-17. 2010
    ..Aberrant signalling cascades and disrupted metabolic pathways such as these may represent opportunities for novel targeted therapeutic approaches for the treatment of chordoma...
  48. ncbi request reprint Gastrointestinal polyposis in childhood: clinicopathologic and genetic features
    Amy Lowichik
    Department of Pathology, University of Utah Health Sciences Center, 30 N 1900 E, Salt Lake City, UT 84132 2501, USA
    Pediatr Dev Pathol 6:371-91. 2003
    ..This article reviews the gross and microscopic features of polyposis syndromes of childhood and summarizes the molecular/genetic advances in this field. Clinical management is also briefly discussed...
  49. doi request reprint IgG4 plasma cells in inflammatory myofibroblastic tumor: inflammatory marker or pathogenic link?
    Shahrazadb T Saab
    Department of Pathology, Vanderbilt University Medical Center, Nashville, TN 37232 2561, USA
    Mod Pathol 24:606-12. 2011
    ..Therefore, the ratio alone cannot be used as a reliable discriminator between these two entities and other clinical and pathologic features must always be taken into account...