Dai H Chung


Affiliation: Vanderbilt University
Country: USA


  1. Romain C, Paul P, Kim K, Lee S, Qiao J, Chung D. Targeting Aurora kinase-A downregulates cell proliferation and angiogenesis in neuroblastoma. J Pediatr Surg. 2014;49:159-65 pubmed publisher
    ..Targeting AURKA might provide a novel therapeutic strategy in treating aggressive neuroblastomas. ..
  2. Lee S, Craig B, Romain C, Qiao J, Chung D. Silencing of CDC42 inhibits neuroblastoma cell proliferation and transformation. Cancer Lett. 2014;355:210-6 pubmed publisher
    ..In addition, silencing of CDC42 decreased expression of N-myc in BE(2)-C and BE(2)-M17 cells. Our findings suggest that CDC42 may play a role in the regulation of aggressive neuroblastoma behavior. ..
  3. Lee S, Rellinger E, Kim K, Craig B, Romain C, Qiao J, et al. Bromodomain and extraterminal inhibition blocks tumor progression and promotes differentiation in neuroblastoma. Surgery. 2015;158:819-26 pubmed publisher
  4. Starnes J, Unni P, Fathy C, Harms K, Payne S, Chung D. Characterization of pediatric golf cart injuries to guide injury prevention efforts. Am J Emerg Med. 2018;36:1049-1052 pubmed publisher
    ..Increased regulation of driving age as well as driver education may also reduce these injuries. ..
  5. Craig B, Rellinger E, Mettler B, Watkins S, Donahue B, Chung D. Laparoscopic Nissen fundoplication in infants with hypoplastic left heart syndrome. J Pediatr Surg. 2016;51:76-80 pubmed publisher
    ..Laparoscopic approach for fundoplication during the interstage period appears to be a relatively safe option for these patients. ..
  6. request reprint
    Song H, Rellinger E, Park S, Paul P, Qiao J, VASILOPOULOS A, et al. Inhibition of Sirtuin 6 Induces Neuroblastoma Differentiation. Anticancer Res. 2018;38:647-654 pubmed
    ..SIRTs have important oncogenic properties in NB beyond its established functions in aging and genome stability. SIRT6 may represent a novel target for developing future therapeutics for the treatment of aggressive NBs. ..
  7. Zhu Y, Paul P, Lee S, Craig B, Rellinger E, Qiao J, et al. Antioxidant inhibition of steady-state reactive oxygen species and cell growth in neuroblastoma. Surgery. 2015;158:827-36 pubmed publisher
    ..We report a novel observation that shifting the redox balance toward greater ROS levels results in a more aggressive neuroblastoma phenotype. Our data suggest that ROS play a critical role in refractory neuroblastoma. ..
  8. Romain C, Paul P, Lee S, Qiao J, Chung D. Targeting aurora kinase A inhibits hypoxia-mediated neuroblastoma cell tumorigenesis. Anticancer Res. 2014;34:2269-74 pubmed
    ..Hypoxia-induced stimulation of colony formation and migration is, in part, mediated by AURKA. These findings establish that AURKA is a critical regulator of hypoxia-mediated tumor progression in neuroblastoma. ..
  9. Craig B, Rellinger E, Alvarez A, Dusek H, Qiao J, Chung D. Induced differentiation inhibits sphere formation in neuroblastoma. Biochem Biophys Res Commun. 2016;477:255-9 pubmed publisher
    ..Taken together, these data suggest that sphere formation is an accurate method of quantifying the stemness phenotype in neuroblastoma. ..

More Information


  1. Rellinger E, Craig B, Alvarez A, Dusek H, Kim K, Qiao J, et al. FX11 inhibits aerobic glycolysis and growth of neuroblastoma cells. Surgery. 2017;161:747-752 pubmed publisher
    ..Small molecule LDHA inhibition is capable of blocking aerobic glycolysis and growth of neuroblastoma cell lines in vitro and merits further in vivo evaluation of its preclinical efficacy in neuroblastomas. ..
  2. Rellinger E, Padmanabhan C, Qiao J, Appert A, Waterson A, Lindsley C, et al. ML327 induces apoptosis and sensitizes Ewing sarcoma cells to TNF-related apoptosis-inducing ligand. Biochem Biophys Res Commun. 2017;491:463-468 pubmed publisher
    ..Taken together, these findings establish a rationale for further in vivo trials of ML327 in cells of mesenchymal origin both alone and in combination with TRAIL. ..