Research Topics
Genomes and Genes | Christine ChungSummaryAffiliation: Vanderbilt University Country: USA Publications
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Publications
Insulin-like growth factor-1 receptor inhibitor, AMG-479, in cetuximab-refractory head and neck squamous cell carcinomaChristine H Chung
Division of Hematology Oncology, Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee, USA
Head Neck 33:1804-8. 2011..Here, we describe a patient with HNSCC who had complete response to methotrexate (MTX) after progressing on multiple cytotoxic agents, cetuximab, and AMG-479 (monoclonal antibody against insulin-like growth factor-1 receptor [IGF-1R])...
Managing premedications and the risk for reactions to infusional monoclonal antibody therapyChristine H Chung
Division of Hematology Oncology, Department of Medicine and Cancer Biology, Vanderbilt University School of Medicine, 2220 Pierce Avenue, 777 Preston Research Building, Nashville, TN 37232 6307, USA
Oncologist 13:725-32. 2008..Considering the heterogeneity of infusion reactions, clinicians need to recognize the underlying nature of these events in order to identify patients at risk as well as provide optimal prophylactic measures and management of symptoms...- Nuclear factor-kappa B pathway and response in a phase II trial of bortezomib and docetaxel in patients with recurrent and/or metastatic head and neck squamous cell carcinomaC H Chung
Division of Hematology Oncology, Department of Medicine, Vanderbilt University School of Medicine, 2220 Pierce Avenue, Nashville, TN 37232 6307, USA
Ann Oncol 21:864-70. 2010..The combination of bortezomib, an NF-kappaB inhibitor by inhibition of proteasomes, plus docetaxel was assessed for efficacy and toxicity... - Human papillomavirus in head and neck cancer: its role in pathogenesis and clinical implicationsChristine H Chung
Division of Hematology Oncology, Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN 37232 6307 USA
Clin Cancer Res 15:6758-62. 2009..Further understanding of carcinogenesis and clinical behavior of HPV-positive cancers will improve disease prevention, patient care, and surveillance strategies for HNSCC patients... - Detection of tumor epidermal growth factor receptor pathway dependence by serum mass spectrometry in cancer patientsChristine H Chung
Division of Hematology Oncology, Department of Medicine, Vanderbilt Ingram Comprehensive Cancer Center, Vanderbilt University School of Medicine, Nashville, TN 37232 6307, USA
Cancer Epidemiol Biomarkers Prev 19:358-65. 2010.... - Strategic plans to promote head and neck cancer translational research within the radiation therapy oncology group: a report from the translational research programChristine H Chung
Head and Neck Cancer Subcommittee, Translational Research Program, Radiation Therapy Oncology Group Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN 37232 6307, USA
Int J Radiat Oncol Biol Phys 69:S67-78. 2007..In this position paper we outline strategic plans to further promote translational research within the framework of the RTOG... - Gene expression profiles as markers of aggressive disease-EGFR as a factorChristine H Chung
Department of Medicine, Division of Hematology/Oncology, Vanderbilt University School of Medicine, Nashville, TN 37232-6307, USA
Int J Radiat Oncol Biol Phys 69:S102-5. 2007 
Genomics and proteomics: emerging technologies in clinical cancer researchChristine H Chung
Division of Hematology Oncology, Department of Medicine, Vanderbilt Ingram Comprehensive Cancer Center, Vanderbilt University School of Medicine, Nashville, TN 37232 6307, USA
Crit Rev Oncol Hematol 61:1-25. 2007..We will present a framework for future directions of these technologies and how we believe they should be applied in clinical studies...- Increased epidermal growth factor receptor gene copy number is associated with poor prognosis in head and neck squamous cell carcinomasChristine H Chung
Division of Hematology Oncology, Department of Medicine, Vanderbilt Ingram Comprehensive Cancer Center, Vanderbilt University School of Medicine, Nashville, TN 37232 6307, USA
J Clin Oncol 24:4170-6. 2006..A better understanding of the EGFR pathway may improve the use of EGFR inhibitors in HNSCC... - Gene expression profiles identify epithelial-to-mesenchymal transition and activation of nuclear factor-kappaB signaling as characteristics of a high-risk head and neck squamous cell carcinomaChristine H Chung
Division of Hematology Oncology, Department of Medicine, Vanderbilt Ingram Comprehensive Cancer Center, Vanderbilt University School of Medicine, Nashville, TN 37232 6307, USA
Cancer Res 66:8210-8. 2006..The 75-gene list can be used as a prognostic biomarker of recurrence, and our data suggest that the molecular determinants of EMT and NF-kappaB activation can be targeted as the novel therapy in the identified high-risk patients... - Molecular classification of head and neck squamous cell carcinomas using patterns of gene expressionChristine H Chung
Division of Hematology/Oncology, Department of Medicine, Vanderbuilt-Ingram Cancer Center, Vanderbuilt University School of Medicine, Nashville, Tennessee 37232, USA
Cancer Cell 5:489-500. 2004..This work represents an important step toward the identification of clinically significant biomarkers for HNSCC... - Gene expression differences associated with human papillomavirus status in head and neck squamous cell carcinomaRobbert J C Slebos
Department of Cancer Biology, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, Tennessee 37232-6307, USA
Clin Cancer Res 12:701-9. 2006..These properties may be exploited as a target of novel therapeutic agents in HNSCC treatment... - Clinical applications of genomics in head and neck cancerChristine H Chung
Division of Hematology/Oncology, Department of Medicine, Vanderbilt Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, Tennessee 37232-2559, USA
Head Neck 28:360-8. 2006..In this review, we will discuss advances, limitations and future directions of genomics as it applies to HNSCC... - Abrogation of TGF-beta signaling enhances chemokine production and correlates with prognosis in human breast cancerBrian Bierie
Department of Cancer Biology, Vanderbilt University, Nashville, Tennessee, USA
J Clin Invest 119:1571-82. 2009..Together, the results suggest that assessment of TGF-beta signaling pathway status may further stratify the prognosis of ER-positive patients and provide novel therapeutic approaches in the management of breast cancer... - Molecular portraits and the family tree of cancerChristine H Chung
Division of Hematology/Oncology, University of North Carolina at Chapel Hill, CB #7305, 3009 Old Clinic Building, Chapel Hill, North Carolina 27599, USA
Nat Genet 32:533-40. 2002..The early results are painting a detailed portrait of cancer that illustrates the individuality of each tumor and allows familial relationships to be recognized through the identification of cell types sharing common expression patterns... - Transforming growth factor beta engages TACE and ErbB3 to activate phosphatidylinositol-3 kinase/Akt in ErbB2-overexpressing breast cancer and desensitizes cells to trastuzumabShizhen Emily Wang
Department of Cancer Biology, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, USA
Mol Cell Biol 28:5605-20. 2008.... - Phase II trial of irinotecan plus cisplatin in patients with recurrent or metastatic squamous carcinoma of the head and neckJill Gilbert
Division of Hematology and Oncology, Department of Medicine, Vanderbilt University School of Medicine, 2220 Pierce Avenue, 777 PRB, Nashville, TN 37232, USA
Cancer 113:186-92. 2008..Thus, new agents are needed. The authors report the results of a phase II trial of irinotecan and cisplatin in patients with metastatic or recurrent HNC... - Update on molecular diagnostic tests in head and neck cancerKevin T Palka
Division of Hematology Oncology, Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN 37232 6307, USA
Semin Oncol 35:198-210. 2008.... - Reliability and validity of the Vanderbilt Head and Neck Symptom Survey: a tool to assess symptom burden in patients treated with chemoradiationBarbara A Murphy
Department of Medicine, Vanderbilt University Medical Center, USA
Head Neck 32:26-37. 2010.... - Human papillomavirus in early laryngeal carcinomaJessica L Baumann
Department of Cancer Biology, Vanderbilt University School of Medicine, Nashville, Tennessee 37232 6350, USA
Laryngoscope 119:1531-7. 2009..To examine the role of HPV status in the etiology, prognosis, and treatment of head and neck squamous cell carcinoma in early larynx malignancies... - Infusion reactions to monoclonal antibodies for solid tumors: immunologic mechanisms and risk factorsChristine H Chung
Division of Hematology Oncology, Department of Medicine, Vanderbilt University, School of Medicine, Nashville, Tennessee, USA
Oncology (Williston Park) 23:14-7. 2009..The underlying mechanisms of these reactions are not well characterized. In this review, current findings in clinical risk factor assessments and known mechanisms of these infusion reactions are discussed... - Hypothyroidism as a consequence of intensity-modulated radiotherapy with concurrent taxane-based chemotherapy for locally advanced head-and-neck cancerRoberto Diaz
Department of Radiation Oncology, Vanderbilt University Medical Center, Nashville, TN 37232, USA
Int J Radiat Oncol Biol Phys 77:468-76. 2010.... - A feed-forward loop involving protein kinase Calpha and microRNAs regulates tumor cell cycleEzra E W Cohen
Section of Hematology Oncology, Department of Medicine, University of Chicago, Chicago, IL 60637, USA
Cancer Res 69:65-74. 2009.... - Cetuximab-induced anaphylaxis and IgE specific for galactose-alpha-1,3-galactoseChristine H Chung
Division of Hematology Oncology, Department of Medicine, Vanderbilt University School of Medicine, Nashville, USA
N Engl J Med 358:1109-17. 2008..A high prevalence of hypersensitivity reactions to cetuximab has been reported in some areas of the United States... - Comparative shotgun proteomics using spectral count data and quasi-likelihood modelingMing Li
Department of Biostatistics, Biochemistry, Vanderbilt University School of Medicine, Nashville, Tennessee 37232 8575, USA
J Proteome Res 9:4295-305. 2010.... - Evolution of clinical trials in head and neck cancerEddy S Yang
Department of Radiation Oncology, Vanderbilt University Medical Center, Nashville, TN 37232 5671, USA
Crit Rev Oncol Hematol 71:29-42. 2009..Emerging new technologies such as intensity modulated radiation therapy (IMRT) and image-guided radiation therapy (IGRT) will also be reviewed. Functional assessments and quality of life issues will be addressed...
Research Grants
- Molecular signatures of HNSCC in response to targeted therapiesChristine Chung; Fiscal Year: 2007..Ultimately, we expect that the findings from this study will be translated into improved patient selection and optimized treatment benefits from EGFR inhibitors in HNSCC patients. ..
- Molecular signatures of HNSCC in response to targeted therapiesChristine Chung; Fiscal Year: 2009..Ultimately, we expect that the findings from this study will be translated into improved patient selection and optimized treatment benefits from EGFR inhibitors in HNSCC patients. ..