Leena Choi

Summary

Affiliation: Vanderbilt University
Country: USA

Publications

  1. pmc Assessment of wear/nonwear time classification algorithms for triaxial accelerometer
    Leena Choi
    Department of Biostatistics, Vanderbilt University School of Medicine, Nashville, TN 37232 2260, USA
    Med Sci Sports Exerc 44:2009-16. 2012
  2. pmc A survey of the likelihood approach to bioequivalence trials
    Leena Choi
    Department of Biostatistics, School of Medicine, Vanderbilt University, 1161 21st Ave South MCN S 2323, Nashville, TN 37232 2158, USA
    Stat Med 27:4874-94. 2008
  3. pmc A mechanistic latent variable model for estimating drug concentrations in the male genital tract: a case study in drug kinetics
    Leena Choi
    Department of Biostatistics, School of Medicine, Vanderbilt University, Nashville, TN 37232 2158, USA
    Stat Med 27:2697-714. 2008
  4. pmc Distributed lag and spline modeling for predicting energy expenditure from accelerometry in youth
    Leena Choi
    Department of Biostatistics, Vanderbilt University School of Medicine, Nashville, Tennessee, USA
    J Appl Physiol 108:314-27. 2010
  5. pmc Validation of accelerometer wear and nonwear time classification algorithm
    Leena Choi
    Department of Biostatistics, Vanderbilt University School of Medicine, Nashville, TN 37232 2260, USA
    Med Sci Sports Exerc 43:357-64. 2011
  6. pmc A Bayesian hierarchical nonlinear mixture model in the presence of artifactual outliers in a population pharmacokinetic study
    Leena Choi
    Department of Biostatistics, School of Medicine, Vanderbilt University, Nashville, TN, USA
    J Pharmacokinet Pharmacodyn 38:613-36. 2011
  7. pmc CYP2A6 genetic variation and dexmedetomidine disposition
    Utkarsh Kohli
    Departments of Medicine and Pharmacology, Division of Clinical Pharmacology, Vanderbilt University, Nashville, TN, USA
    Eur J Clin Pharmacol 68:937-42. 2012
  8. pmc Sympathetic activation and nitric oxide function in early hypertension
    Alfredo Gamboa
    Department of Medicine, Division of Clinical Pharmacology, Vanderbilt University, Nashville, Tennessee, USA
    Am J Physiol Heart Circ Physiol 302:H1438-43. 2012
  9. pmc A new method to estimate quantitatively seminal vesicle and prostate gland contributions to ejaculate
    Themba T Ndovi
    School of Medicine, Department of Medicine, Division of Clinical Pharmacology, Baltimore, Maryland 21287, USA
    Br J Clin Pharmacol 63:404-20. 2007
  10. pmc Synergistic effect of norepinephrine transporter blockade and α-2 antagonism on blood pressure in autonomic failure
    Luis E Okamoto
    Vanderbilt Autonomic Dysfunction Center, Division of Clinical Pharmacology, Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN, USA
    Hypertension 59:650-6. 2012

Collaborators

Detail Information

Publications25

  1. pmc Assessment of wear/nonwear time classification algorithms for triaxial accelerometer
    Leena Choi
    Department of Biostatistics, Vanderbilt University School of Medicine, Nashville, TN 37232 2260, USA
    Med Sci Sports Exerc 44:2009-16. 2012
    ....
  2. pmc A survey of the likelihood approach to bioequivalence trials
    Leena Choi
    Department of Biostatistics, School of Medicine, Vanderbilt University, 1161 21st Ave South MCN S 2323, Nashville, TN 37232 2158, USA
    Stat Med 27:4874-94. 2008
    ..This simulation study shows that profile likelihoods offer a viable alternative to the (unknown) true likelihood for a range of parameters commensurate with BE research...
  3. pmc A mechanistic latent variable model for estimating drug concentrations in the male genital tract: a case study in drug kinetics
    Leena Choi
    Department of Biostatistics, School of Medicine, Vanderbilt University, Nashville, TN 37232 2158, USA
    Stat Med 27:2697-714. 2008
    ..In particular, unlike existing methods, the proposed model-based approach was not affected by a common form of outliers...
  4. pmc Distributed lag and spline modeling for predicting energy expenditure from accelerometry in youth
    Leena Choi
    Department of Biostatistics, Vanderbilt University School of Medicine, Nashville, Tennessee, USA
    J Appl Physiol 108:314-27. 2010
    ..7 kcal for the TEE, 0.0 +/- 84.2 and 1.3 +/- 104.7 kcal for the PAEE, and -1.1 +/- 97.6 and -0.1 +/- 108.6 MET min for the MET models. We conclude that the DLS approach for accelerometer data improves detailed EE prediction in youth...
  5. pmc Validation of accelerometer wear and nonwear time classification algorithm
    Leena Choi
    Department of Biostatistics, Vanderbilt University School of Medicine, Nashville, TN 37232 2260, USA
    Med Sci Sports Exerc 43:357-64. 2011
    ..A vital step in PA measurement is the classification of daily time into accelerometer wear and nonwear intervals using its recordings (counts) and an accelerometer-specific algorithm...
  6. pmc A Bayesian hierarchical nonlinear mixture model in the presence of artifactual outliers in a population pharmacokinetic study
    Leena Choi
    Department of Biostatistics, School of Medicine, Vanderbilt University, Nashville, TN, USA
    J Pharmacokinet Pharmacodyn 38:613-36. 2011
    ..We also conducted simulation studies with a varying proportion of the outliers. These simulation results showed that the proposed model can accommodate the outliers well so that the estimated PK parameters are less biased...
  7. pmc CYP2A6 genetic variation and dexmedetomidine disposition
    Utkarsh Kohli
    Departments of Medicine and Pharmacology, Division of Clinical Pharmacology, Vanderbilt University, Nashville, TN, USA
    Eur J Clin Pharmacol 68:937-42. 2012
    ..We examined whether CYP2A6 genotypes affect dexmedetomidine disposition...
  8. pmc Sympathetic activation and nitric oxide function in early hypertension
    Alfredo Gamboa
    Department of Medicine, Division of Clinical Pharmacology, Vanderbilt University, Nashville, Tennessee, USA
    Am J Physiol Heart Circ Physiol 302:H1438-43. 2012
    ..If NO deficiency contributes to hypertension, it is likely to be through its modulation of the autonomic nervous system, which was excluded in this study...
  9. pmc A new method to estimate quantitatively seminal vesicle and prostate gland contributions to ejaculate
    Themba T Ndovi
    School of Medicine, Department of Medicine, Division of Clinical Pharmacology, Baltimore, Maryland 21287, USA
    Br J Clin Pharmacol 63:404-20. 2007
    ....
  10. pmc Synergistic effect of norepinephrine transporter blockade and α-2 antagonism on blood pressure in autonomic failure
    Luis E Okamoto
    Vanderbilt Autonomic Dysfunction Center, Division of Clinical Pharmacology, Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN, USA
    Hypertension 59:650-6. 2012
    ..Safety studies are required to address the clinical usefulness of this pharmacological approach...
  11. ncbi request reprint Quantitative assessment of seminal vesicle and prostate drug concentrations by use of a noninvasive method
    Themba T Ndovi
    Department of Medicine, Division of Clinical Pharmacology, School of Medicine, Johns Hopkins University, Baltimore, MD, USA
    Clin Pharmacol Ther 80:146-58. 2006
    ..Understanding the pharmacokinetics in these compartments should inform rational therapeutics involving these glands...
  12. pmc Validity of physical activity intensity predictions by ActiGraph, Actical, and RT3 accelerometers
    Megan P Rothney
    Department of Biomedical Engineering, Vanderbilt University, Nashville, Tennessee, USA
    Obesity (Silver Spring) 16:1946-52. 2008
    ..This study seeks to determine the capabilities of eight previously published regression equations for three commercially available accelerometers to predict summary measures of daily EE...
  13. ncbi request reprint Norepinephrine transporter blockade with atomoxetine induces hypertension in patients with impaired autonomic function
    Cyndya Shibao
    Department of Medicine, Division of Clinical Pharmacology, and the Autonomic Dysfunction Center, Vanderbilt University School of Medicine, Nashville, TN 37212, USA
    Hypertension 50:47-53. 2007
    ..Caution should be exercised when this medication is used in patients with milder form of autonomic impairment...
  14. pmc Validity of a multisensor armband in estimating 24-h energy expenditure in children
    Cindy A Dorminy
    Department of Medicine, Vanderbilt University, Nashville, TN 37232, USA
    Med Sci Sports Exerc 40:699-706. 2008
    ..Algorithms used to predict EE by these monitors are often based on adult populations and may not be accurate for children...
  15. pmc Seasonal changes in amount and patterns of physical activity in women
    Maciej S Buchowski
    Energy Balance Laboratory, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN 37232, USA
    J Phys Act Health 6:252-61. 2009
    ..Environmental factors including seasonal changes are important to guide physical activity (PA) programs to achieve or sustain weight loss. The goal was to determine seasonal variability in the amount and patterns of free-living PA in women...
  16. ncbi request reprint Effect of drug transporter genotypes on pravastatin disposition in European- and African-American participants
    Richard H Ho
    Department of Pediatrics and Pharmacology, Vanderbilt University School of Medicine, Nashville, TN, USA
    Pharmacogenet Genomics 17:647-56. 2007
    ....
  17. pmc Fatigability as a function of physical activity energy expenditure in older adults
    Maciej S Buchowski
    Energy Balance Laboratory, Division of Gastroenterology, Hepatology and Nutrition, Department of Medicine, Vanderbilt University, 1161 21st Avenue South, Nashville, TN 37232, USA
    Age (Dordr) 35:179-87. 2013
    ..We conclude that fatigability severity is a valid measure of PAEE-induced fatigue in older adults...
  18. pmc Resident characteristics related to the lack of morning care provision in long-term care
    Sandra F Simmons
    Division of General Internal Medicine and Public Health, School of Medicine, Vanderbilt University, Center for Quality Aging, Nashville, TN, USA
    Gerontologist 53:151-61. 2013
    ..The purpose of this study was to examine usual long-term care (LTC) practices related to 3 aspects of morning care and determine if there were resident characteristics related to the lack of care...
  19. pmc A controlled trial of an intervention to increase resident choice in long term care
    John F Schnelle
    Vanderbilt University, School of Medicine, Division of General Internal Medicine and Public Health, Center for Quality Aging, Nashville, TN Geriatric Research, Education and Clinical Center, VA Medical Center, Nashville, TN Electronic address
    J Am Med Dir Assoc 14:345-51. 2013
    ..The purpose of this study was to evaluate an intervention to improve staff offers of choice to nursing home residents during morning care...
  20. ncbi request reprint Acarbose, an alpha-glucosidase inhibitor, attenuates postprandial hypotension in autonomic failure
    Cyndya Shibao
    Department of Medicine, Division of Clinical Pharmacology and the Autonomic Dysfunction Center, Vanderbilt University School of Medicine, Nashville, TN 37212, USA
    Hypertension 50:54-61. 2007
    ..In conclusion, 100 mg of acarbose successfully improved postprandial hypotension in patients with severe autonomic failure. This effect is not explained solely by a reduction in insulin levels...
  21. pmc The use of a DNA biobank linked to electronic medical records to characterize pharmacogenomic predictors of tacrolimus dose requirement in kidney transplant recipients
    Kelly A Birdwell
    Division of Nephrology, Vanderbilt University Medical Center, Nashville, Tennesse, USA
    Pharmacogenet Genomics 22:32-42. 2012
    ..The importance of other drug absorption, distribution, metabolism, and elimination (ADME) gene variants has not been well characterized...
  22. ncbi request reprint Effect of the alpha2C-adrenoreceptor deletion322-325 variant on sympathetic activity and cardiovascular measures in healthy subjects
    Daniel Kurnik
    Department of Medicine, Division of Clinical Pharmacology, Vanderbilt University School of Medicine, Nashville, Tennessee 37232 6602, USA
    J Hypertens 25:763-71. 2007
    ..We therefore examined the hypothesis that the ADRA2C deletion variant would alter sympathetic activity and contribute to ethnic differences in blood pressure...
  23. pmc Rapid measurement of total body water to facilitate clinical decision making in hospitalized elderly patients
    James S Powers
    Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN 37232, USA
    J Gerontol A Biol Sci Med Sci 64:664-9. 2009
    ....
  24. ncbi request reprint Estimating treatment efficacy over time: a logistic regression model for binary longitudinal outcomes
    Leena Choi
    Department of Biostatistics, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD 21205, USA
    Stat Med 24:2789-805. 2005
    ....
  25. ncbi request reprint Noninvasive quantitation of drug concentration in prostate and seminal vesicles: improvement and validation with desipramine and aspirin
    Ying Jun Cao
    Department of Medicine, Johns Hopkins University, Baltimore, MD 21287, USA
    J Clin Pharmacol 48:176-83. 2008
    ..91-9.9) for desipramine. We conclude that our quantitative analysis along with the split ejaculate method is sensitive, reproducible, and applicable for the assessment of pharmacokinetics of the accessory glands of the male genital tract...