Research Topics
Genomes and GenesSpecies | Leena ChoiSummaryAffiliation: Vanderbilt University Country: USA Publications
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Publications
Assessment of wear/nonwear time classification algorithms for triaxial accelerometerLeena Choi
Department of Biostatistics, Vanderbilt University School of Medicine, Nashville, TN 37232 2260, USA
Med Sci Sports Exerc 44:2009-16. 2012....- A survey of the likelihood approach to bioequivalence trialsLeena Choi
Department of Biostatistics, School of Medicine, Vanderbilt University, 1161 21st Ave South MCN S 2323, Nashville, TN 37232 2158, USA
Stat Med 27:4874-94. 2008..This simulation study shows that profile likelihoods offer a viable alternative to the (unknown) true likelihood for a range of parameters commensurate with BE research... - Distributed lag and spline modeling for predicting energy expenditure from accelerometry in youthLeena Choi
Department of Biostatistics, Vanderbilt University School of Medicine, Nashville, Tennessee, USA
J Appl Physiol 108:314-27. 2010..7 kcal for the TEE, 0.0 +/- 84.2 and 1.3 +/- 104.7 kcal for the PAEE, and -1.1 +/- 97.6 and -0.1 +/- 108.6 MET min for the MET models. We conclude that the DLS approach for accelerometer data improves detailed EE prediction in youth... - A mechanistic latent variable model for estimating drug concentrations in the male genital tract: a case study in drug kineticsLeena Choi
Department of Biostatistics, School of Medicine, Vanderbilt University, Nashville, TN 37232 2158, USA
Stat Med 27:2697-714. 2008..In particular, unlike existing methods, the proposed model-based approach was not affected by a common form of outliers... - Validation of accelerometer wear and nonwear time classification algorithmLeena Choi
Department of Biostatistics, Vanderbilt University School of Medicine, Nashville, TN 37232 2260, USA
Med Sci Sports Exerc 43:357-64. 2011..A vital step in PA measurement is the classification of daily time into accelerometer wear and nonwear intervals using its recordings (counts) and an accelerometer-specific algorithm... - A Bayesian hierarchical nonlinear mixture model in the presence of artifactual outliers in a population pharmacokinetic studyLeena Choi
Department of Biostatistics, School of Medicine, Vanderbilt University, Nashville, TN, USA
J Pharmacokinet Pharmacodyn 38:613-36. 2011..We also conducted simulation studies with a varying proportion of the outliers. These simulation results showed that the proposed model can accommodate the outliers well so that the estimated PK parameters are less biased... - CYP2A6 genetic variation and dexmedetomidine dispositionUtkarsh Kohli
Departments of Medicine and Pharmacology, Division of Clinical Pharmacology, Vanderbilt University, Nashville, TN, USA
Eur J Clin Pharmacol 68:937-42. 2012..We examined whether CYP2A6 genotypes affect dexmedetomidine disposition... - Sympathetic activation and nitric oxide function in early hypertensionAlfredo Gamboa
Department of Medicine, Division of Clinical Pharmacology, Vanderbilt University, Nashville, Tennessee, USA
Am J Physiol Heart Circ Physiol 302:H1438-43. 2012..If NO deficiency contributes to hypertension, it is likely to be through its modulation of the autonomic nervous system, which was excluded in this study... - A new method to estimate quantitatively seminal vesicle and prostate gland contributions to ejaculateThemba T Ndovi
School of Medicine, Department of Medicine, Division of Clinical Pharmacology, Baltimore, Maryland 21287, USA
Br J Clin Pharmacol 63:404-20. 2007.... - Synergistic effect of norepinephrine transporter blockade and α-2 antagonism on blood pressure in autonomic failureLuis E Okamoto
Vanderbilt Autonomic Dysfunction Center, Division of Clinical Pharmacology, Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN, USA
Hypertension 59:650-6. 2012..Safety studies are required to address the clinical usefulness of this pharmacological approach... 
Quantitative assessment of seminal vesicle and prostate drug concentrations by use of a noninvasive methodThemba T Ndovi
Department of Medicine, Division of Clinical Pharmacology, School of Medicine, Johns Hopkins University, Baltimore, MD, USA
Clin Pharmacol Ther 80:146-58. 2006....- Validity of physical activity intensity predictions by ActiGraph, Actical, and RT3 accelerometersMegan P Rothney
Department of Biomedical Engineering, Vanderbilt University, Nashville, Tennessee, USA
Obesity (Silver Spring) 16:1946-52. 2008..This study seeks to determine the capabilities of eight previously published regression equations for three commercially available accelerometers to predict summary measures of daily EE... - Norepinephrine transporter blockade with atomoxetine induces hypertension in patients with impaired autonomic functionCyndya Shibao
Department of Medicine, Division of Clinical Pharmacology, and the Autonomic Dysfunction Center, Vanderbilt University School of Medicine, Nashville, TN 37212, USA
Hypertension 50:47-53. 2007..Caution should be exercised when this medication is used in patients with milder form of autonomic impairment... - Seasonal changes in amount and patterns of physical activity in womenMaciej S Buchowski
Energy Balance Laboratory, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN 37232, USA
J Phys Act Health 6:252-61. 2009..Environmental factors including seasonal changes are important to guide physical activity (PA) programs to achieve or sustain weight loss. The goal was to determine seasonal variability in the amount and patterns of free-living PA in women... - Effect of drug transporter genotypes on pravastatin disposition in European- and African-American participantsRichard H Ho
Department of Pediatrics and Pharmacology, Vanderbilt University School of Medicine, Nashville, TN, USA
Pharmacogenet Genomics 17:647-56. 2007.... - Validity of a multisensor armband in estimating 24-h energy expenditure in childrenCindy A Dorminy
Department of Medicine, Vanderbilt University, Nashville, TN 37232, USA
Med Sci Sports Exerc 40:699-706. 2008..Algorithms used to predict EE by these monitors are often based on adult populations and may not be accurate for children... 
A controlled trial of an intervention to increase resident choice in long term careJohn F Schnelle
Vanderbilt University, School of Medicine, Division of General Internal Medicine and Public Health, Center for Quality Aging, Nashville, TN Geriatric Research, Education and Clinical Center, VA Medical Center, Nashville, TN Electronic address
J Am Med Dir Assoc 14:345-51. 2013..The purpose of this study was to evaluate an intervention to improve staff offers of choice to nursing home residents during morning care...- Acarbose, an alpha-glucosidase inhibitor, attenuates postprandial hypotension in autonomic failureCyndya Shibao
Department of Medicine, Division of Clinical Pharmacology and the Autonomic Dysfunction Center, Vanderbilt University School of Medicine, Nashville, TN 37212, USA
Hypertension 50:54-61. 2007..In conclusion, 100 mg of acarbose successfully improved postprandial hypotension in patients with severe autonomic failure. This effect is not explained solely by a reduction in insulin levels... - Resident characteristics related to the lack of morning care provision in long-term careSandra F Simmons
Division of General Internal Medicine and Public Health, School of Medicine, Vanderbilt University, Center for Quality Aging, Nashville, TN, USA
Gerontologist 53:151-61. 2013..The purpose of this study was to examine usual long-term care (LTC) practices related to 3 aspects of morning care and determine if there were resident characteristics related to the lack of care... - The use of a DNA biobank linked to electronic medical records to characterize pharmacogenomic predictors of tacrolimus dose requirement in kidney transplant recipientsKelly A Birdwell
Division of Nephrology, Vanderbilt University Medical Center, Nashville, Tennesse, USA
Pharmacogenet Genomics 22:32-42. 2012..The importance of other drug absorption, distribution, metabolism, and elimination (ADME) gene variants has not been well characterized... - Effect of the alpha2C-adrenoreceptor deletion322-325 variant on sympathetic activity and cardiovascular measures in healthy subjectsDaniel Kurnik
Department of Medicine, Division of Clinical Pharmacology, Vanderbilt University School of Medicine, Nashville, Tennessee 37232 6602, USA
J Hypertens 25:763-71. 2007..We therefore examined the hypothesis that the ADRA2C deletion variant would alter sympathetic activity and contribute to ethnic differences in blood pressure... - Rapid measurement of total body water to facilitate clinical decision making in hospitalized elderly patientsJames S Powers
Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN 37232, USA
J Gerontol A Biol Sci Med Sci 64:664-9. 2009.... - Fatigability as a function of physical activity energy expenditure in older adultsMaciej S Buchowski
Energy Balance Laboratory, Division of Gastroenterology, Hepatology and Nutrition, Department of Medicine, Vanderbilt University, 1161 21st Avenue South, Nashville, TN 37232, USA
Age (Dordr) 35:179-87. 2013..We conclude that fatigability severity is a valid measure of PAEE-induced fatigue in older adults... - Estimating treatment efficacy over time: a logistic regression model for binary longitudinal outcomesLeena Choi
Department of Biostatistics, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD 21205, USA
Stat Med 24:2789-805. 2005.... - Noninvasive quantitation of drug concentration in prostate and seminal vesicles: improvement and validation with desipramine and aspirinYing Jun Cao
Department of Medicine, Johns Hopkins University, Baltimore, MD 21287, USA
J Clin Pharmacol 48:176-83. 2008..91-9.9) for desipramine. We conclude that our quantitative analysis along with the split ejaculate method is sensitive, reproducible, and applicable for the assessment of pharmacokinetics of the accessory glands of the male genital tract...