Songhai Chen

Summary

Affiliation: Vanderbilt University
Country: USA

Publications

  1. ncbi request reprint RACK1 binds to a signal transfer region of G betagamma and inhibits phospholipase C beta2 activation
    Songhai Chen
    Department of Pharmacology, Vanderbilt University Medical Center, Nashville, Tennessee 37232 6600, USA
    J Biol Chem 280:33445-52. 2005
  2. pmc RACK1 regulates directional cell migration by acting on G betagamma at the interface with its effectors PLC beta and PI3K gamma
    Songhai Chen
    Department of Pharmacology, Vanderbilt University, Nashville, TN 37232, USA
    Mol Biol Cell 19:3909-22. 2008
  3. ncbi request reprint RACK1 regulates specific functions of Gbetagamma
    Songhai Chen
    Department of Pharmacology, Vanderbilt University Medical Center, Nashville, Tennessee 37232 6600, USA
    J Biol Chem 279:17861-8. 2004
  4. ncbi request reprint Interaction of Gbetagamma with RACK1 and other WD40 repeat proteins
    Songhai Chen
    Department of Pharmacology, Vanderbilt University Medical Center, Room 442, Robinson Research Building, Nashville, TN 37232, USA
    J Mol Cell Cardiol 37:399-406. 2004
  5. pmc Galpha12/13 regulate epiboly by inhibiting E-cadherin activity and modulating the actin cytoskeleton
    Fang Lin
    Department of Pharmacology, Vanderbilt University Medical Center, Nashville, TN 37232, USA
    J Cell Biol 184:909-21. 2009
  6. pmc WDR26 functions as a scaffolding protein to promote Gβγ-mediated phospholipase C β2 (PLCβ2) activation in leukocytes
    Zhizeng Sun
    Department of Pharmacology, Roy J and Lucille A Carver College of Medicine, University of Iowa, Iowa City, Iowa 52242, USA
    J Biol Chem 288:16715-25. 2013
  7. pmc The WD40 repeat protein WDR26 binds Gβγ and promotes Gβγ-dependent signal transduction and leukocyte migration
    Zhizeng Sun
    Department of Pharmacology, Roy J and Lucille A Carver College of Medicine, University of Iowa, Iowa City, IA 52242, USA
    J Biol Chem 286:43902-12. 2011
  8. pmc The Gβ3 splice variant associated with the C825T gene polymorphism is an unstable and functionally inactive protein
    Zhizeng Sun
    Department of Pharmacology, Roy J and Lucille A Carver College of Medicine, University of Iowa, Iowa City, IA 52242, USA
    Cell Signal 24:2349-59. 2012
  9. ncbi request reprint Mutation of a single TMVI residue, Phe(282), in the beta(2)-adrenergic receptor results in structurally distinct activated receptor conformations
    Songhai Chen
    Molecular Cardiology and Biocomputing Units, Victor Chang Cardiac Research Institute, St Vincent s Hospital, Darlinghurst, NSW 2010, Australia
    Biochemistry 41:6045-53. 2002
  10. ncbi request reprint DEP domains: More than just membrane anchors
    Songhai Chen
    Department of Pharmacology, Vanderbilt University Medical Center, Nashville, Tennessee 37232, USA
    Dev Cell 11:436-8. 2006

Collaborators

Detail Information

Publications15

  1. ncbi request reprint RACK1 binds to a signal transfer region of G betagamma and inhibits phospholipase C beta2 activation
    Songhai Chen
    Department of Pharmacology, Vanderbilt University Medical Center, Nashville, Tennessee 37232 6600, USA
    J Biol Chem 280:33445-52. 2005
    ..These data thus demonstrate that RACK1 can regulate the activity of a G betagamma effector by competing for its binding to the signal transfer region of G betagamma...
  2. pmc RACK1 regulates directional cell migration by acting on G betagamma at the interface with its effectors PLC beta and PI3K gamma
    Songhai Chen
    Department of Pharmacology, Vanderbilt University, Nashville, TN 37232, USA
    Mol Biol Cell 19:3909-22. 2008
    ..Taken together, these findings provide a novel mechanism of regulating cell migration, i.e., RACK1-mediated interference with G betagamma-dependent activation of key effectors critical for chemotaxis...
  3. ncbi request reprint RACK1 regulates specific functions of Gbetagamma
    Songhai Chen
    Department of Pharmacology, Vanderbilt University Medical Center, Nashville, Tennessee 37232 6600, USA
    J Biol Chem 279:17861-8. 2004
    ..Similarly, RACK1 does not affect signal transduction through the Galpha subunits of G(i), G(s), or G(q). Collectively, these findings suggest a role of RACK1 in regulating specific functions of Gbetagamma...
  4. ncbi request reprint Interaction of Gbetagamma with RACK1 and other WD40 repeat proteins
    Songhai Chen
    Department of Pharmacology, Vanderbilt University Medical Center, Room 442, Robinson Research Building, Nashville, TN 37232, USA
    J Mol Cell Cardiol 37:399-406. 2004
    ..Here we will describe the molecular mechanism underlying this interaction and the implications of the interaction on the signal transduction of G-protein and RACK1...
  5. pmc Galpha12/13 regulate epiboly by inhibiting E-cadherin activity and modulating the actin cytoskeleton
    Fang Lin
    Department of Pharmacology, Vanderbilt University Medical Center, Nashville, TN 37232, USA
    J Cell Biol 184:909-21. 2009
    ..These results provide the first in vivo evidence that Galpha(12/13) regulate epiboly through two distinct mechanisms: limiting E-cadherin activity and modulating the organization of the actin cytoskeleton...
  6. pmc WDR26 functions as a scaffolding protein to promote Gβγ-mediated phospholipase C β2 (PLCβ2) activation in leukocytes
    Zhizeng Sun
    Department of Pharmacology, Roy J and Lucille A Carver College of Medicine, University of Iowa, Iowa City, Iowa 52242, USA
    J Biol Chem 288:16715-25. 2013
    ..These findings have identified a novel mechanism of regulating Gβγ signaling through a scaffolding protein...
  7. pmc The WD40 repeat protein WDR26 binds Gβγ and promotes Gβγ-dependent signal transduction and leukocyte migration
    Zhizeng Sun
    Department of Pharmacology, Roy J and Lucille A Carver College of Medicine, University of Iowa, Iowa City, IA 52242, USA
    J Biol Chem 286:43902-12. 2011
    ..Collectively, these experiments identify WDR26 as a novel Gβγ-binding protein that is required for the efficacy of Gβγ signaling and leukocyte migration...
  8. pmc The Gβ3 splice variant associated with the C825T gene polymorphism is an unstable and functionally inactive protein
    Zhizeng Sun
    Department of Pharmacology, Roy J and Lucille A Carver College of Medicine, University of Iowa, Iowa City, IA 52242, USA
    Cell Signal 24:2349-59. 2012
    ....
  9. ncbi request reprint Mutation of a single TMVI residue, Phe(282), in the beta(2)-adrenergic receptor results in structurally distinct activated receptor conformations
    Songhai Chen
    Molecular Cardiology and Biocomputing Units, Victor Chang Cardiac Research Institute, St Vincent s Hospital, Darlinghurst, NSW 2010, Australia
    Biochemistry 41:6045-53. 2002
    ....
  10. ncbi request reprint DEP domains: More than just membrane anchors
    Songhai Chen
    Department of Pharmacology, Vanderbilt University Medical Center, Nashville, Tennessee 37232, USA
    Dev Cell 11:436-8. 2006
    ..New findings in yeast, however, demonstrate a major role for a DEP domain in mediating the interaction of an RGS protein to the C-terminal tail of a GPCR, thus placing RGS in close proximity with its substrate G protein alpha subunit...
  11. pmc A critical role of Gbetagamma in tumorigenesis and metastasis of breast cancer
    Xiaoyun Tang
    Department of Pharmacology, Roy J and Lucille A Carver College of Medicine, University of Iowa, Iowa City, Iowa 52242, USA
    J Biol Chem 286:13244-54. 2011
    ..Taken together, our data demonstrate a critical role of Gβγ signaling in promoting breast tumor growth and metastasis and suggest that targeting Gβγ may represent a novel therapeutic approach for breast cancer...
  12. pmc Essential roles of G{alpha}12/13 signaling in distinct cell behaviors driving zebrafish convergence and extension gastrulation movements
    Fang Lin
    Department of Pharmacology, Vanderbilt University Medical Center, Nashville, TN 37232, USA
    J Cell Biol 169:777-87. 2005
    ..These findings provide the first evidence that Galpha(12) and Galpha(13) have overlapping and essential roles in distinct cell behaviors that drive vertebrate gastrulation...
  13. ncbi request reprint Allosteric alpha 1-adrenoreceptor antagonism by the conopeptide rho-TIA
    Iain A Sharpe
    Institute for Molecular Bioscience and the School of Biomedical Sciences, The University of Queensland, St Lucia 4072, Queensland, Australia
    J Biol Chem 278:34451-7. 2003
    ....
  14. ncbi request reprint The betagamma subunit of heterotrimeric G proteins interacts with RACK1 and two other WD repeat proteins
    Edward J Dell
    Institute for Neuroscience and Department of Molecular Pharmacology and Biological Chemistry, Northwestern University Medical School, Chicago, Illinois 60613, USA
    J Biol Chem 277:49888-95. 2002
    ....
  15. ncbi request reprint Phe(303) in TMVI of the alpha(1B)-adrenergic receptor is a key residue coupling TM helical movements to G-protein activation
    Songhai Chen
    Molecular Cardiology Unit, Victor Chang Cardiac Research Institute, St Vincent s Hospital, School of Medicine, Sydney, NSW 2010, Australia
    Biochemistry 41:588-96. 2002
    ..These findings, therefore, confirm and extend our previous data implicating Phe(303) as a key residue coupling TM helical movements to G-protein-activation...