P David Charles
Affiliation: Vanderbilt University
- Depression and intelligence in patients with Parkinson's disease and deep-brain stimulationCourtney R Schadt
School of Medicine, Vanderbilt University Medical Center, Nashville, TN 37212 3375, USA
J Natl Med Assoc 98:1121-5. 2006..These findings suggest that Parkinson's disease patients with lower intelligence test scores and less education benefit more with regards to depressive symptomatology after STN-DBS than patients with higher scores and education...
- Discordance in informed consent response on the basis of demographic factors: brief reportKaren R Nunez-Wallace
Department of Neurology, Baylor College of Medicine, Houston, TX 77030, USA
Intellect Dev Disabil 48:175-9. 2010..This report highlights disparities in surrogate consent giving for individuals with intellectual disabilities and indicates a need for more research to ensure that this vulnerable population has access to appropriate treatments...
- Cervical dystonia and pain: characteristics and treatment patterns from CD PROBE (Cervical Dystonia Patient Registry for Observation of OnabotulinumtoxinA Efficacy)P David Charles
Department of Neurology, Vanderbilt University Medical Center, 1161 21st Ave S, Suite A 1106 MCN, Nashville, TN, 37272, USA
J Neurol 261:1309-19. 2014..Future analyses of CD PROBE will further our understanding of the treatment patterns and outcomes related to onabotulinumtoxinA therapy for this disabling condition. ..
- Subthalamic nucleus deep brain stimulation in early stage Parkinson's diseaseDavid Charles
Department of Neurology, Vanderbilt University Medical Center, USA Electronic address
Parkinsonism Relat Disord 20:731-7. 2014..This manuscript reports the results of a pilot trial investigating preliminary safety and tolerability of DBS in early PD...
- Pilot study assessing the feasibility of applying bilateral subthalamic nucleus deep brain stimulation in very early stage Parkinson's disease: study design and rationaleDavid Charles
Department of Neurology, Vanderbilt University Medical Center, Nashville, TN, USA
J Parkinsons Dis 2:215-23. 2012..Preliminary evidence suggests that subthalamic nucleus stimulation may also be efficacious in early Parkinson's disease, and results of animal studies suggest that it may spare dopaminergic neurons in the substantia nigra...
- Continuation of long-term care for cervical dystonia at an academic movement disorders clinicChandler E Gill
Loyola University, Stritch School of Medicine, 2160 First Avenue South, Maywood, IL 60153, USA
Toxins (Basel) 5:776-83. 2013....
- Efficacy, tolerability, and immunogenicity of onabotulinumtoxina in a randomized, double-blind, placebo-controlled trial for cervical dystoniaDavid Charles
Department of Neurology, Vanderbilt University School of Medicine, Nashville, TN, USA
Clin Neuropharmacol 35:208-14. 2012..To evaluate the efficacy, tolerability, and neutralizing antibodies in the treatment of cervical dystonia with onabotulinumtoxinA (BOTOX)...
- Deep brain stimulation in early Parkinson's disease: enrollment experience from a pilot trialP D Charles
Department of Neurology, Vanderbilt University Medical Center, Nashville, Tennessee 37232, USA
Parkinsonism Relat Disord 18:268-73. 2012..DBS has not been studied in the early stages of PD, but early application should be explored to evaluate safety, efficacy, and the potential to alter disease progression...
- Spasticity treatment facilitates direct care delivery for adults with profound intellectual disabilityP David Charles
Department of Neurology, Vanderbilt University Medical Center, Nashville, Tennessee 37232 2551, USA
Mov Disord 25:466-73. 2010..0006). Transfers trended toward improvement (P = 0.053). This study shows comprehensive spasticity management provides meaningful improvement in ADL care for patients with ID, which may improve quality of life and reduce caregiver burden...
- Botulinum neurotoxin serotype A: a clinical update on non-cosmetic usesP David Charles
Movement Disorders Clinic, Vanderbilt University, Nashville, TN, USA
Am J Health Syst Pharm 61:S11-23. 2004....
- Spasticity in adults living in a developmental centerAlyssa A Pfister
Division of Movement Disorders, Dept of Neurology, Vanderbilt University Medical Center, 2100 Pierce Avenue, Nashville, TN 37212 3375, USA
Arch Phys Med Rehabil 84:1808-12. 2003..To ascertain the prevalence of spasticity among adults living in a developmental center and to document the development of spasticity treatment plans for this population...
- Deep brain stimulation of the subthalamic nucleus reduces antiparkinsonian medication costsP David Charles
The Movement Disorders Clinic, Department of Neurology, Vanderbilt University Medical Center, 2100 Pierce Avenue, Suite 352 MCS, Vanderbilt University, Nashville, TN 37212 3375, USA
Parkinsonism Relat Disord 10:475-9. 2004..DBS patients may experience a significant long-term reduction in the cost of their pharmacologic treatment...
- Clustering of dystonia in some pedigrees with autosomal dominant essential tremor suggests the existence of a distinct subtype of essential tremorPeter Hedera
Department of Neurology, Vanderbilt University, Nashville, TN 37232 8552, USA
BMC Neurol 10:66. 2010..Many patients with clinically definite ET develop dystonia. It remains unknown whether tremor associated with dystonia represent a subtype of ET. We hypothesized that ET with dystonia represents a distinct subtype of ET...
- Botulinum toxin type A therapy during pregnancyWilliam J Newman
School of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee 37212 3375, USA
Mov Disord 19:1384-5. 2004..We present the first case report of clinical Botox treatment during pregnancy. This patient underwent four apparently uncomplicated full-term pregnancies while receiving regular Botox treatments...
- Deep brain stimulation for early-stage Parkinson's disease: an illustrative caseChandler E Gill
Stritch School of Medicine, Loyola University, Maywood, IL, USA
Neuromodulation 14:515-21; discussion 521-2. 2011..We are conducting a randomized pilot trial investigating DBS in early PD. This report describes one participant who received bilateral STN-DBS...
- Rationale and design of a prospective study: Cervical Dystonia Patient Registry for Observation of OnaBotulinumtoxinA Efficacy (CD PROBE)Joseph Jankovic
Baylor College of Medicine, Department of Neurology, Houston, TX, USA
BMC Neurol 11:140. 2011..Irvine, CA, USA). Methods and baseline demographics from an interim analysis are provided...
- Surgical targets for dystonic tremor: considerations between the globus pallidus and ventral intermediate thalamic nucleusPeter Hedera
Department of Neurology, Vanderbilt University, Nashville, TN, USA
Parkinsonism Relat Disord 19:684-6. 2013..We propose that the patients with DT with a mild dystonia should be considered for Vim DBS procedure and the coexistence of severe DT and dystonia may be successfully controlled by combined GPi and Vim DBS surgeries...
- Deep brain stimulation in early stage Parkinson's disease: operative experience from a prospective randomised clinical trialElyne Kahn
School of Medicine, Vanderbilt University, Nashville, Tennessee, USA
J Neurol Neurosurg Psychiatry 83:164-70. 2012..A randomised, prospective study is underway to determine whether STN-DBS in early PD is safe and tolerable...
- Thalamotomy, DBS-Vim, and DBS-GPi for generalized dystonia: a case reportCourtney R Schadt
Vanderbilt University School of Medicine, Nashville, TN 37212 3375, USA
Tenn Med 100:38-9. 2007..His tremor and dystonic symptoms have dramatically improved through combining these surgical interventions...
- Difficulty in securing treatment for degenerative hip disease in a patient with Down syndrome: the gap remains openChandler E Gill
Vanderbilt University Medical Center, 2100 Pierce Ave, Nashville, TN 37212 3375, USA
J Natl Med Assoc 98:93-6. 2006..Finally, we reiterate the surgeon general's call to eradicate preconceptions held in the medical community about the population of persons with mental retardation that result in similar failures to provide adequate care...
- Subthalamic nucleus neuronal firing rate increases with Parkinson's disease progressionMichael S Remple
Department of Neurosurgery, Vanderbilt University Medical Center, Nashville, Tennessee 37212, USA
Mov Disord 26:1657-62. 2011..The results suggest that neuronal firing in the subthalamic nucleus increases with Parkinson's disease progression...
- FUS in familial essential tremor - the search for common causes is still onPeter Hedera
Department of Neurology, Vanderbilt University, 465 21st Avenue South, 6140 MRB III, Nashville, TN 37232 8552, USA
Parkinsonism Relat Disord 19:818-20. 2013..We did not identify a single pathogenic mutation. Our data suggest that FUS mutations are a rare cause of familial ET. ..
- Deep brain stimulation: a new treatment for Parkinson's diseaseMyrandele Damian
Division of Movement Disorders, Department of Neurology, Vanderbilt University Medical Center, Medical Center South, 2100 Pierce Ave, Nashville, TN 37212, USA
Tenn Med 96:33-5. 2003..Levodopa responsiveness, disabling motor fluctuations and dyskinesias, cognition, and concurrent illness are major factors in identifying candidates who will receive the greatest benefit...
- Bilateral globus pallidus internus deep brain stimulation therapy for primary generalized dystoniaBimal B Padaliya
Vanderbilt University School of Medicine, USA
Tenn Med 97:317-8. 2004..This report details the successful treatment of a DYT1-positive 13 year-old boy suffering from PGD...
- Successful treatment of childhood spasticity secondary to cerebral palsy using BotoxChandler Gill
Department of Neurology, Vanderbilt University Medical Center, Suite 304, Medical Center South, Nashville, TN 37212, USA
Tenn Med 96:511-3. 2003..Botox was used in conjunction with a specific physical therapy regimen in order to reach a functional goal of independent ambulation...
- Positive family history of essential tremor influences the motor phenotype of Parkinson's diseasePeter Hedera
Department of Neurology, Vanderbilt University, Nashville, Tennessee 37232 8522, USA
Mov Disord 24:2285-8. 2009..83, P < 0.001). Tremor-dominant subtype of PD in patients with a positive family history of ET suggests that these patients have inherited a genetic susceptibility factor for tremor, which affects the motor phenotype of PD...
- Subthalamic nucleus deep brain stimulation impacts language in early Parkinson's diseaseLara Phillips
Department of Neurology, Vanderbilt University, Nashville, Tennessee, United States of America
PLoS ONE 7:e42829. 2012....
- Pharmacological treatment of disabling tremorCourtney R Schadt
Vanderbilt University, School of Medicine, Nashville, TN, USA
Expert Opin Pharmacother 6:419-28. 2005..This article outlines the available pharmacological agents and treatment considerations for various disabling tremors, including essential tremor and Parkinson's disease...
- The cost of medical education in an ambulatory neurology clinicAnna Abramovitch
School of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA
J Natl Med Assoc 97:1288-90. 2005..78 per half-day clinic. Students spent an average of 49.9 minutes per half-day seeing patients in the absence of an attending physician, an opportunity cost to the clinic of $142.50 per student per half-day...
- Efficacy and safety of botulinum type A toxin (Dysport) in cervical dystonia: results of the first US randomized, double-blind, placebo-controlled studyDaniel Truong
The Parkinson s and Movement Disorders Institute, Fountain Valley, California 92708, USA
Mov Disord 20:783-91. 2005..These results confirm previous reports that Dysport (500 units) is safe, effective, and well-tolerated in patients with cervical dystonia...
- Comparison of botulinum neurotoxin preparations for the treatment of cervical dystoniaMary Ann Chapman
Visage Communications, Inc, Mead, Washington, USA
Clin Ther 29:1325-37. 2007....