J A Canter

Summary

Affiliation: Vanderbilt University
Country: USA

Publications

  1. ncbi request reprint Degree of heteroplasmy reflects oxidant damage in a large family with the mitochondrial DNA A8344G mutation
    Jeffrey A Canter
    Center for Human Genetics Research, Department of Molecular Physiology and Biophysics, Vanderbilt University Medical Center, 519 Light Hall, Nashville, TN 37232 0700, USA
    Free Radic Biol Med 38:678-83. 2005
  2. doi request reprint Personalized medicine: genetic variation and loss of physiologic complexity are associated with mortality in 644 trauma patients
    Patrick R Norris
    Division of Trauma and Surgical Critical Care, Vanderbilt University, Nashville, Tennessee, USA
    Ann Surg 250:524-30. 2009
  3. pmc Specific polymorphic variation in the mitochondrial genome and increased in-hospital mortality after severe trauma
    Jeffrey A Canter
    Center for Human Genetics Research, Department of Molecular Physiology and Biophysics, Vanderbilt University Medical Center, Nashville, Tennessee 37212, USA
    Ann Surg 246:406-11; discussion 411-4. 2007
  4. pmc Genetic variation in the mitochondrial enzyme carbamyl-phosphate synthetase I predisposes children to increased pulmonary artery pressure following surgical repair of congenital heart defects: a validated genetic association study
    Jeffrey A Canter
    Center for Human Genetics Research, Department of Molecular Physiology and Biophysics, Vanderbilt University Medical Center, Nashville, TN, USA
    Mitochondrion 7:204-10. 2007
  5. pmc Mitochondrial DNA polymorphism A4917G is independently associated with age-related macular degeneration
    Jeffrey A Canter
    Center for Human Genetics Research, Department of Molecular Physiology and Biophysics, Vanderbilt University Medical Center, Nashville, Tennessee, United States of America
    PLoS ONE 3:e2091. 2008
  6. ncbi request reprint Mitochondrial DNA G10398A polymorphism and invasive breast cancer in African-American women
    Jeffrey A Canter
    Department of Molecular Physiology and Biophysics, Center for Human Genetics Research, Vanderbilt University Medical Center, Nasshville, Tennessee 37212, USA
    Cancer Res 65:8028-33. 2005
  7. ncbi request reprint The mitochondrial pharmacogenomics of haplogroup T: MTND2*LHON4917G and antiretroviral therapy-associated peripheral neuropathy
    J A Canter
    Center for Human Genetics Research, Department of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine, Nashville, TN 37212, USA
    Pharmacogenomics J 8:71-7. 2008
  8. doi request reprint Genetic variation in the autonomic nervous system affects mortality: a study of 1,095 trauma patients
    John A Morris
    Division of Trauma and Surgical Critical Care, Vanderbilt University Medical Center, Nashville, TN, USA
    J Am Coll Surg 208:663-8; discussion 668-70. 2009
  9. pmc Genetic variation in complement component 2 of the classical complement pathway is associated with increased mortality and infection: a study of 627 patients with trauma
    John A Morris
    Division of Trauma and Surgical Critical Care, Vanderbilt University Medical Center, Nashville, Tennessee, USA
    J Trauma 66:1265-70; discussion 1270-2. 2009
  10. doi request reprint Hemochromatosis gene polymorphisms, mitochondrial haplogroups, and peripheral lipoatrophy during antiretroviral therapy
    Todd Hulgan
    Division of Infectious Diseases, Vanderbilt University School of Medicine, Nashville, Tennessee 37203, USA
    J Infect Dis 197:858-66. 2008

Detail Information

Publications19

  1. ncbi request reprint Degree of heteroplasmy reflects oxidant damage in a large family with the mitochondrial DNA A8344G mutation
    Jeffrey A Canter
    Center for Human Genetics Research, Department of Molecular Physiology and Biophysics, Vanderbilt University Medical Center, 519 Light Hall, Nashville, TN 37232 0700, USA
    Free Radic Biol Med 38:678-83. 2005
    ..The most important novel finding from this family is that some currently asymptomatic individuals with moderate heteroplasmy have evidence of ongoing free-radical mediated oxidant injury...
  2. doi request reprint Personalized medicine: genetic variation and loss of physiologic complexity are associated with mortality in 644 trauma patients
    Patrick R Norris
    Division of Trauma and Surgical Critical Care, Vanderbilt University, Nashville, Tennessee, USA
    Ann Surg 250:524-30. 2009
    ..We hypothesized that variability in ANS receptor proteins (genetics) and loss of complexity (physiology) are independently associated with mortality in critical illness...
  3. pmc Specific polymorphic variation in the mitochondrial genome and increased in-hospital mortality after severe trauma
    Jeffrey A Canter
    Center for Human Genetics Research, Department of Molecular Physiology and Biophysics, Vanderbilt University Medical Center, Nashville, Tennessee 37212, USA
    Ann Surg 246:406-11; discussion 411-4. 2007
    ..To determine whether specific genetic variations in the mtDNA that impact energy production and free-radical generation are potential new risk factors for in-hospital mortality after severe trauma...
  4. pmc Genetic variation in the mitochondrial enzyme carbamyl-phosphate synthetase I predisposes children to increased pulmonary artery pressure following surgical repair of congenital heart defects: a validated genetic association study
    Jeffrey A Canter
    Center for Human Genetics Research, Department of Molecular Physiology and Biophysics, Vanderbilt University Medical Center, Nashville, TN, USA
    Mitochondrion 7:204-10. 2007
    ..In conclusion, the CPSI T1405N genotype appears to be an important new factor in predicting susceptibility to increased PAP following surgical repair of congenital cardiac defects in children...
  5. pmc Mitochondrial DNA polymorphism A4917G is independently associated with age-related macular degeneration
    Jeffrey A Canter
    Center for Human Genetics Research, Department of Molecular Physiology and Biophysics, Vanderbilt University Medical Center, Nashville, Tennessee, United States of America
    PLoS ONE 3:e2091. 2008
    ..20-3.91, p = 0.01). In conclusion, a specific mitochondrial polymorphism previously implicated in other neurodegenerative phenotypes (4917G) appears to convey risk for AMD independent of recently discovered nuclear DNA polymorphisms...
  6. ncbi request reprint Mitochondrial DNA G10398A polymorphism and invasive breast cancer in African-American women
    Jeffrey A Canter
    Department of Molecular Physiology and Biophysics, Center for Human Genetics Research, Vanderbilt University Medical Center, Nasshville, Tennessee 37212, USA
    Cancer Res 65:8028-33. 2005
    ..31; P = 0.81). This study provides novel epidemiologic evidence that the mtDNA 10398A allele influences breast cancer susceptibility in African-American women. mtDNA polymorphisms may be underappreciated factors in breast carcinogenesis...
  7. ncbi request reprint The mitochondrial pharmacogenomics of haplogroup T: MTND2*LHON4917G and antiretroviral therapy-associated peripheral neuropathy
    J A Canter
    Center for Human Genetics Research, Department of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine, Nashville, TN 37212, USA
    Pharmacogenomics J 8:71-7. 2008
    ..5 (95% CI 1.6-18.7) P<0.01). When 4917G individuals were excluded from the analysis, the association with 4216C was no longer seen. The mitochondrial 4917G polymorphism may increase susceptibility to NRTI-associated PN...
  8. doi request reprint Genetic variation in the autonomic nervous system affects mortality: a study of 1,095 trauma patients
    John A Morris
    Division of Trauma and Surgical Critical Care, Vanderbilt University Medical Center, Nashville, TN, USA
    J Am Coll Surg 208:663-8; discussion 668-70. 2009
    ..We have previously demonstrated an unappreciated link between the autonomic nervous system and mortality, heart rate variability, and physiologic complexity...
  9. pmc Genetic variation in complement component 2 of the classical complement pathway is associated with increased mortality and infection: a study of 627 patients with trauma
    John A Morris
    Division of Trauma and Surgical Critical Care, Vanderbilt University Medical Center, Nashville, Tennessee, USA
    J Trauma 66:1265-70; discussion 1270-2. 2009
    ..Consequently, genetic variation in C2 may stratify patient risk and illuminate underlying mechanisms for therapeutic intervention...
  10. doi request reprint Hemochromatosis gene polymorphisms, mitochondrial haplogroups, and peripheral lipoatrophy during antiretroviral therapy
    Todd Hulgan
    Division of Infectious Diseases, Vanderbilt University School of Medicine, Nashville, Tennessee 37203, USA
    J Infect Dis 197:858-66. 2008
    ..Mitochondrial haplogroups and hemochromatosis gene (HFE) polymorphisms have been associated with ART-induced neuropathy. We assessed relationships between these variants and lipoatrophy...
  11. ncbi request reprint Pharmacokinetics and safety of intravenously administered citrulline in children undergoing congenital heart surgery: potential therapy for postoperative pulmonary hypertension
    Frederick E Barr
    Department of Pediatrics, Pediatric Critical Care, Vanderbilt Children s Hospital, Vanderbilt University Medical Center, Nashville, Tenn, USA
    J Thorac Cardiovasc Surg 134:319-26. 2007
    ..In this study, we assessed the safety and pharmacokinetic profile of intravenous citrulline as a potential therapy for postoperative pulmonary hypertension...
  12. pmc African mitochondrial DNA subhaplogroups and peripheral neuropathy during antiretroviral therapy
    Jeffrey A Canter
    Department of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine, 345 24th Ave North, Nashville, TN 37203, USA
    J Infect Dis 201:1703-7. 2010
    ..7 [95% confidence interval, 1.1-12.0]). An African mtDNA subhaplogroup is for the first time implicated in susceptibility to nucleoside reverse-transcriptase inhibitor-associated toxicity...
  13. ncbi request reprint Hemochromatosis (HFE) gene mutations and peripheral neuropathy during antiretroviral therapy
    Asha R Kallianpur
    Department of Medicine, Divisions of General Internal Medicine and Public Health, Nashville, TN, USA
    AIDS 20:1503-13. 2006
    ..Since iron deficiency is associated with some types of PN, and iron is essential for mitochondrial function, we tested the hypothesis that hemochromatosis (HFE) gene mutations influence susceptibility to NRTI-induced PN...
  14. ncbi request reprint Nitric oxide precursors and congenital heart surgery: a randomized controlled trial of oral citrulline
    Heidi A B Smith
    Department of Pediatrics, Vanderbilt University Medical Center, Nashville, Tenn, USA
    J Thorac Cardiovasc Surg 132:58-65. 2006
    ..The study sought to determine whether citrulline supplementation, a precursor to nitric oxide synthesis, is safe and efficacious in increasing plasma citrulline concentrations and decreasing the risk of postoperative pulmonary hypertension...
  15. ncbi request reprint Mitochondrial haplogroups and peripheral neuropathy during antiretroviral therapy: an adult AIDS clinical trials group study
    Todd Hulgan
    Division of Infectious Diseases, Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee 37203, USA
    AIDS 19:1341-9. 2005
    ..The objective of this study was to determine if NRTI-associated peripheral neuropathy is associated with European mitochondrial haplogroups...
  16. ncbi request reprint Mitochondrial DNA deletions serve as biomarkers of aging in the skin, but are typically absent in nonmelanoma skin cancers
    Alex Eshaghian
    VA Tennessee Valley Healthcare System, Vanderbilt University School of Medicine, Nashville, Tennessee 37232 2600, USA
    J Invest Dermatol 126:336-44. 2006
    ..These data support the use of mtDNA mutations as biomarkers of photoaging in the skin...
  17. ncbi request reprint Re: North American white mitochondrial haplogroups in prostate and renal cancer
    Jeffrey A Canter
    J Urol 176:2308-9; author reply 2309. 2006
  18. ncbi request reprint Problems with genome-wide association studies
    Scott M Williams
    Science 316:1840-2. 2007
  19. pmc Overexpression of Akt converts radial growth melanoma to vertical growth melanoma
    Baskaran Govindarajan
    Department of Dermatology, Emory University School of Medicine, and Atlanta Veterans Administration Medical Center, Atlanta, Georgia 30322, USA
    J Clin Invest 117:719-29. 2007
    ..Akt thus serves as a molecular switch that increases angiogenesis and the generation of superoxide, fostering more aggressive tumor behavior. Targeting Akt and ROS may be of therapeutic importance in treatment of advanced melanoma...