Michael Bubser

Summary

Affiliation: Vanderbilt University
Country: USA

Publications

  1. ncbi request reprint Dopaminergic regulation of orexin neurons
    Michael Bubser
    Department of Psychiatry, Vanderbilt University Medical Center, Nashville, TN 37212, USA
    Eur J Neurosci 21:2993-3001. 2005
  2. ncbi request reprint Neurotensin activates GABAergic interneurons in the prefrontal cortex
    Kimberly A Petrie
    Department of Pharmacology, Vanderbilt University Medical Center, Nashville, Tennessee 37212, USA
    J Neurosci 25:1629-36. 2005
  3. ncbi request reprint Differential activation of orexin neurons by antipsychotic drugs associated with weight gain
    Jim Fadel
    Department of Psychiatry and Center for Molecular Neuroscience and Integrative, Vanderbilt University School of Medicine, Nashville, Tennessee 37212, USA
    J Neurosci 22:6742-6. 2002
  4. pmc Novel allosteric agonists of M1 muscarinic acetylcholine receptors induce brain region-specific responses that correspond with behavioral effects in animal models
    Gregory J Digby
    Department of Pharmacology, Vanderbilt University Medical Center, Nashville, Tennessee 37232, USA
    J Neurosci 32:8532-44. 2012
  5. pmc The metabotropic glutamate receptor 8 agonist (S)-3,4-DCPG reverses motor deficits in prolonged but not acute models of Parkinson's disease
    Kari A Johnson
    Department of Pharmacology, Vanderbilt University Medical Center, Nashville, TN, USA
    Neuropharmacology 66:187-95. 2013
  6. pmc The effects of nigrostriatal dopamine depletion on the thalamic parafascicular nucleus
    Sheila V Kusnoor
    Department of Psychiatry, Vanderbilt University Medical Center, Nashville, TN 37212, USA
    Brain Res 1446:46-55. 2012
  7. pmc The orexins/hypocretins and schizophrenia
    Ariel Y Deutch
    Department of Psychiatry, Vanderbilt University Medical Center, Nashville, TN 37212, USA
    Schizophr Bull 33:1277-83. 2007
  8. pmc The metabotropic glutamate receptor 4-positive allosteric modulator VU0364770 produces efficacy alone and in combination with L-DOPA or an adenosine 2A antagonist in preclinical rodent models of Parkinson's disease
    Carrie K Jones
    Vanderbilt Center for Neuroscience Drug Discovery, Department of Pharmacology, Vanderbilt University, Nashville, TN 37212, USA
    J Pharmacol Exp Ther 340:404-21. 2012
  9. ncbi request reprint The neurotensin agonist PD149163 increases Fos expression in the prefrontal cortex of the rat
    Kimberly A Petrie
    Department of Psychiatry, Center for Molecular Neuroscience, Vanderbilt University Medical Center, Nashville, TN, USA
    Neuropsychopharmacology 29:1878-88. 2004
  10. pmc Novel selective allosteric activator of the M1 muscarinic acetylcholine receptor regulates amyloid processing and produces antipsychotic-like activity in rats
    Carrie K Jones
    Department of Pharmacology, Vanderbilt University Medical Center, Nashville, Tennessee 37232 6600, USA
    J Neurosci 28:10422-33. 2008

Collaborators

Detail Information

Publications17

  1. ncbi request reprint Dopaminergic regulation of orexin neurons
    Michael Bubser
    Department of Psychiatry, Vanderbilt University Medical Center, Nashville, TN 37212, USA
    Eur J Neurosci 21:2993-3001. 2005
    ..These data suggest that apomorphine-induced arousal but not accumbens-mediated hyperactivity is required for dopamine to transsynaptically activate orexin neurons...
  2. ncbi request reprint Neurotensin activates GABAergic interneurons in the prefrontal cortex
    Kimberly A Petrie
    Department of Pharmacology, Vanderbilt University Medical Center, Nashville, Tennessee 37212, USA
    J Neurosci 25:1629-36. 2005
    ..These findings suggest that neurotensin plays an important role in regulating prefrontal cortical interneurons and that it may be useful to consider neurotensin agonists as an adjunct in the treatment of schizophrenia...
  3. ncbi request reprint Differential activation of orexin neurons by antipsychotic drugs associated with weight gain
    Jim Fadel
    Department of Psychiatry and Center for Molecular Neuroscience and Integrative, Vanderbilt University School of Medicine, Nashville, Tennessee 37212, USA
    J Neurosci 22:6742-6. 2002
    ..These data suggest that APD-induced weight gain is associated with activation of distinct orexin neurons and emphasize the presence of anatomically and functionally heterogeneous populations of orexin neurons...
  4. pmc Novel allosteric agonists of M1 muscarinic acetylcholine receptors induce brain region-specific responses that correspond with behavioral effects in animal models
    Gregory J Digby
    Department of Pharmacology, Vanderbilt University Medical Center, Nashville, Tennessee 37232, USA
    J Neurosci 32:8532-44. 2012
    ....
  5. pmc The metabotropic glutamate receptor 8 agonist (S)-3,4-DCPG reverses motor deficits in prolonged but not acute models of Parkinson's disease
    Kari A Johnson
    Department of Pharmacology, Vanderbilt University Medical Center, Nashville, TN, USA
    Neuropharmacology 66:187-95. 2013
    ..This article is part of a Special Issue entitled 'Metabotropic Glutamate Receptors'...
  6. pmc The effects of nigrostriatal dopamine depletion on the thalamic parafascicular nucleus
    Sheila V Kusnoor
    Department of Psychiatry, Vanderbilt University Medical Center, Nashville, TN 37212, USA
    Brain Res 1446:46-55. 2012
    ..These data suggest that the loss of thalamostriatal PF neurons in Parkinson's Disease is a primary event rather than secondary to nigrostriatal dopamine degeneration...
  7. pmc The orexins/hypocretins and schizophrenia
    Ariel Y Deutch
    Department of Psychiatry, Vanderbilt University Medical Center, Nashville, TN 37212, USA
    Schizophr Bull 33:1277-83. 2007
    ..This issue of Schizophrenia Bulletin presents several articles that review our current understanding and point to future directions for the study of the orexins/hypocretins in schizophrenia and APD actions...
  8. pmc The metabotropic glutamate receptor 4-positive allosteric modulator VU0364770 produces efficacy alone and in combination with L-DOPA or an adenosine 2A antagonist in preclinical rodent models of Parkinson's disease
    Carrie K Jones
    Vanderbilt Center for Neuroscience Drug Discovery, Department of Pharmacology, Vanderbilt University, Nashville, TN 37212, USA
    J Pharmacol Exp Ther 340:404-21. 2012
    ..The present findings provide exciting support for the potential role of selective mGlu₄ PAMs as a novel approach for the symptomatic treatment of PD and a possible augmentation strategy with either L-DOPA or A2A antagonists...
  9. ncbi request reprint The neurotensin agonist PD149163 increases Fos expression in the prefrontal cortex of the rat
    Kimberly A Petrie
    Department of Psychiatry, Center for Molecular Neuroscience, Vanderbilt University Medical Center, Nashville, TN, USA
    Neuropsychopharmacology 29:1878-88. 2004
    ..Pretreatment with the high-affinity neurotensin antagonist, SR48692, blocked neurotensin agonist-induced Fos expression. These data suggest that neurotensin activates interneurons in the PFC of the rat...
  10. pmc Novel selective allosteric activator of the M1 muscarinic acetylcholine receptor regulates amyloid processing and produces antipsychotic-like activity in rats
    Carrie K Jones
    Department of Pharmacology, Vanderbilt University Medical Center, Nashville, Tennessee 37232 6600, USA
    J Neurosci 28:10422-33. 2008
    ..Together, these data suggest that selective activation of M(1) may provide a novel approach for the treatment of symptoms associated with schizophrenia and Alzheimer's disease...
  11. pmc Tissue-specific variation of Ube3a protein expression in rodents and in a mouse model of Angelman syndrome
    Richard M Gustin
    Department of Pharmacology, Vanderbilt University Medical Center, Nashville, TN, USA
    Neurobiol Dis 39:283-91. 2010
    ..These findings suggest that neuronal function throughout the brain is compromised in AS...
  12. pmc Cortical serotonin and norepinephrine denervation in parkinsonism: preferential loss of the beaded serotonin innervation
    Tultul Nayyar
    Department of Neurobiology and Neurotoxicology, Meharry Medical College, Nashville, TN 37208, USA
    Eur J Neurosci 30:207-16. 2009
    ....
  13. pmc Antipsychotic drug-like effects of the selective M4 muscarinic acetylcholine receptor positive allosteric modulator VU0152100
    NELLIE E BYUN
    1 Vanderbilt Center for Neuroscience Drug Discovery, Vanderbilt University Medical Center, Nashville, TN, USA 2 Department of Pharmacology, Vanderbilt University Medical Center, Nashville, TN, USA 3 Vanderbilt University Institute of Imaging Science, Vanderbilt University Medical Center, Nashville, TN, USA
    Neuropsychopharmacology 39:1578-93. 2014
    ..Taken together, these data support the development of selective M4 PAMs as a new approach to the treatment of psychosis and cognitive impairments associated with psychiatric disorders such as schizophrenia. ..
  14. pmc Muscarinic and nicotinic acetylcholine receptor agonists and allosteric modulators for the treatment of schizophrenia
    Carrie K Jones
    Vanderbilt Center for Neuroscience Drug Discovery, Vanderbilt University Medical Center, Nashville, TN 37232, USA
    Neuropsychopharmacology 37:16-42. 2012
    ....
  15. ncbi request reprint Muscarinic receptor pharmacology and circuitry for the modulation of cognition
    Michael Bubser
    Vanderbilt Center for Neuroscience Drug Discovery, Vanderbilt University, Nashville, TN, 37232, USA
    Handb Exp Pharmacol 208:121-66. 2012
    ..In this chapter, we will review the muscarinic cholinergic circuitry and pharmacology of mAChR agonists and antagonists relevant to the modulation of different aspects of cognition in animals and clinical populations...
  16. ncbi request reprint Differential effects of typical and atypical antipsychotic drugs on striosome and matrix compartments of the striatum
    Michael Bubser
    Departments of Psychiatry and Pharmacology and Center for Molecular Neuroscience, Vanderbilt University Medical Center, Nashville, TN 37212, USA
    Eur J Neurosci 15:713-20. 2002
    ..These data suggest that some characteristics of atypical APDs, such as the lower EPS liability and greater reduction of negative symptoms, may be linked to the coordinate regulation of the striatal striosome and matrix...
  17. ncbi request reprint Addiction and arousal: alternative roles of hypothalamic peptides
    Luis de Lecea
    Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, California 94305, USA
    J Neurosci 26:10372-5. 2006
    ..This review summarizes a Mini-Symposium presented at the 2006 Annual Meeting of the Society for Neuroscience...