Research Topics
Species | John J BrightSummaryAffiliation: Vanderbilt University Country: USA Publications
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Detail Information
Publications
Curcumin inhibits experimental allergic encephalomyelitis by blocking IL-12 signaling through Janus kinase-STAT pathway in T lymphocytesChandramohan Natarajan
Division of Neuroimmunology, Department of Neurology, Vanderbilt University Medical Center, Nashville, TN 37212, USA
J Immunol 168:6506-13. 2002..These findings highlight the fact that curcumin inhibits EAE by blocking IL-12 signaling in T cells and suggest its use in the treatment of MS and other Th1 cell-mediated inflammatory diseases...- 1,25 Dihydroxyvitamin-D3 modulates JAK-STAT pathway in IL-12/IFNgamma axis leading to Th1 response in experimental allergic encephalomyelitisGladson Muthian
Department of Neurology, Vanderbilt University Medical Center, Nashville, Tennessee, USA
J Neurosci Res 83:1299-309. 2006.... - Peroxisome proliferator-activated receptor-gamma-deficient heterozygous mice develop an exacerbated neural antigen-induced Th1 response and experimental allergic encephalomyelitisChandramohan Natarajan
Department of Neurology, Vanderbilt University Medical Center, Nashville, TN 37212, USA
J Immunol 171:5743-50. 2003..These findings suggest that PPARgamma be a critical physiological regulator of CNS inflammation and demyelination in EAE and perhaps multiple sclerosis and other Th1 cell-mediated autoimmune diseases... - PPARgamma antagonists reverse the inhibition of neural antigen-specific Th1 response and experimental allergic encephalomyelitis by Ciglitazone and 15-deoxy-Delta12,14-prostaglandin J2Himanshu P Raikwar
Department of Neurology, Vanderbilt University Medical Center, Nashville, TN 37212, USA
J Neuroimmunol 178:76-86. 2006..These results suggest that Ciglitazone and 15d-PGJ2 ameliorate EAE through PPARgamma-dependent mechanisms and further confirm a physiological role for PPARgamma in the regulation of CNS inflammation and demyelination in EAE... - COX-2 inhibitors modulate IL-12 signaling through JAK-STAT pathway leading to Th1 response in experimental allergic encephalomyelitisGladson Muthian
Department of Neurology, Vanderbilt University Medical Center, Nashville, Tennessee, USA
J Clin Immunol 26:73-85. 2006.... - Setaria digitata secreted filarial lipids modulate IL-12 signaling through JAK-STAT pathway leading to the development of Th1 responseGladson Muthian
Department of Neurology, Vanderbilt University Medical Center, Nashville, TN 37212, USA
Exp Parasitol 114:193-203. 2006..These findings suggest that the SFL modulates Th1 immune response by blocking IL-12 signaling in T cells and thus play a role in host immune evasion of filarial parasites... - Quercetin, a flavonoid phytoestrogen, ameliorates experimental allergic encephalomyelitis by blocking IL-12 signaling through JAK-STAT pathway in T lymphocyteGladson Muthian
Departments of Neurology and Pharmacology, Vanderbilt University Medical Center, Nashville, Tennessee 37212, USA
J Clin Immunol 24:542-52. 2004..These findings highlight the fact that quercetin ameliorates EAE by blocking IL-12 signaling and Th1 differentiation and suggest its use in the treatment of MS and other Th1 cell-mediated autoimmune diseases... - Signaling through JAK2-STAT5 pathway is essential for IL-3-induced activation of microgliaChandramohan Natarajan
Department of Neurology and Pharmacology, Vanderbilt University Medical Center, 1222F VSRH, 2201 Capers Avenue, Nashville, TN 37212, USA
Glia 45:188-96. 2004..These findings highlight the fact that JAK2-STAT5 signaling pathway plays a critical role in mediating IL-3-induced activation of microglia... - PPARgamma antagonists exacerbate neural antigen-specific Th1 response and experimental allergic encephalomyelitisHimanshu P Raikwar
Department of Neurology, Vanderbilt University Medical Center, 1222 VSRH, 2201 Children's way, Nashville, TN 37212, USA
J Neuroimmunol 167:99-107. 2005..These results further suggest that PPARgamma is a critical physiological regulator of CNS inflammation and demyelination in EAE... - Curcumin induces growth-arrest and apoptosis in association with the inhibition of constitutively active JAK-STAT pathway in T cell leukemiaJohnson Rajasingh
Department of Neurology, Vanderbilt University Medical Center, Nashville, TN 37212, USA
Biochem Biophys Res Commun 340:359-68. 2006..The induction of growth-arrest and apoptosis in association with the blockade of constitutively active JAK-STAT pathway suggests this be a mechanism by which curcumin induces antitumor activity in T cell leukemia... - 15-Deoxy-delta12,14-prostaglandin J2 regulates leukemia inhibitory factor signaling through JAK-STAT pathway in mouse embryonic stem cellsJohnson Rajasingh
Department of Neurology, Vanderbilt University Medical Center, Nashville, TN 37212, USA
Exp Cell Res 312:2538-46. 2006..These results suggest that PPARgamma agonists regulate LIF signaling through JAK-STAT pathway leading to growth and self-renewal of ES cells... - Targeting autoimmune diseases through nutraceuticalsJohn J Bright
Department of Neurology, Vanderbilt University School of Medicine, Nashville, Tennessee 37212, USA
Nutrition 20:39-43. 2004 
15-deoxy-Delta(12,14)-prostaglandin J(2) and curcumin modulate the expression of toll-like receptors 4 and 9 in autoimmune T lymphocyteWanida Chearwae
Neuroscience Research Laboratory, Methodist Research Institute at Clarian Health, 1800 North Capitol Avenue, Noyes Building E 504C, Indianapolis, IN 46202, USA
J Clin Immunol 28:558-70. 2008..T lymphocytes also express TLRs and function as costimulatory receptors to upregulate proliferation and cytokine production in response to specific agonists...
Stat4 isoforms differentially regulate inflammation and demyelination in experimental allergic encephalomyelitisCaiqing Mo
Neuroscience Research Laboratory, Methodist Research Institute, Indianapolis, IN 46202, USA
J Immunol 181:5681-90. 2008..This study demonstrates that Stat4 isoforms differentially regulate inflammatory cytokines in association with distinct effects on the onset and severity of EAE...- Curcumin and autoimmune diseaseJohn J Bright
Neuroscience Research Laboratory, Methodist Research Institute, Clarian Health, Indianapolis, IN 46202, USA
Adv Exp Med Biol 595:425-51. 2007..A precise understanding of effective dose, safe regiment, and mechanism of action is required for the use of curcumin in the treatment of human autoimmune diseases...