John J Bright

Summary

Affiliation: Vanderbilt University
Country: USA

Publications

  1. ncbi Curcumin inhibits experimental allergic encephalomyelitis by blocking IL-12 signaling through Janus kinase-STAT pathway in T lymphocytes
    Chandramohan Natarajan
    Division of Neuroimmunology, Department of Neurology, Vanderbilt University Medical Center, Nashville, TN 37212, USA
    J Immunol 168:6506-13. 2002
  2. ncbi 1,25 Dihydroxyvitamin-D3 modulates JAK-STAT pathway in IL-12/IFNgamma axis leading to Th1 response in experimental allergic encephalomyelitis
    Gladson Muthian
    Department of Neurology, Vanderbilt University Medical Center, Nashville, Tennessee, USA
    J Neurosci Res 83:1299-309. 2006
  3. ncbi Peroxisome proliferator-activated receptor-gamma-deficient heterozygous mice develop an exacerbated neural antigen-induced Th1 response and experimental allergic encephalomyelitis
    Chandramohan Natarajan
    Department of Neurology, Vanderbilt University Medical Center, Nashville, TN 37212, USA
    J Immunol 171:5743-50. 2003
  4. ncbi PPARgamma antagonists reverse the inhibition of neural antigen-specific Th1 response and experimental allergic encephalomyelitis by Ciglitazone and 15-deoxy-Delta12,14-prostaglandin J2
    Himanshu P Raikwar
    Department of Neurology, Vanderbilt University Medical Center, Nashville, TN 37212, USA
    J Neuroimmunol 178:76-86. 2006
  5. ncbi COX-2 inhibitors modulate IL-12 signaling through JAK-STAT pathway leading to Th1 response in experimental allergic encephalomyelitis
    Gladson Muthian
    Department of Neurology, Vanderbilt University Medical Center, Nashville, Tennessee, USA
    J Clin Immunol 26:73-85. 2006
  6. ncbi Setaria digitata secreted filarial lipids modulate IL-12 signaling through JAK-STAT pathway leading to the development of Th1 response
    Gladson Muthian
    Department of Neurology, Vanderbilt University Medical Center, Nashville, TN 37212, USA
    Exp Parasitol 114:193-203. 2006
  7. ncbi Quercetin, a flavonoid phytoestrogen, ameliorates experimental allergic encephalomyelitis by blocking IL-12 signaling through JAK-STAT pathway in T lymphocyte
    Gladson Muthian
    Departments of Neurology and Pharmacology, Vanderbilt University Medical Center, Nashville, Tennessee 37212, USA
    J Clin Immunol 24:542-52. 2004
  8. ncbi Signaling through JAK2-STAT5 pathway is essential for IL-3-induced activation of microglia
    Chandramohan Natarajan
    Department of Neurology and Pharmacology, Vanderbilt University Medical Center, 1222F VSRH, 2201 Capers Avenue, Nashville, TN 37212, USA
    Glia 45:188-96. 2004
  9. ncbi PPARgamma antagonists exacerbate neural antigen-specific Th1 response and experimental allergic encephalomyelitis
    Himanshu P Raikwar
    Department of Neurology, Vanderbilt University Medical Center, 1222 VSRH, 2201 Children s way, Nashville, TN 37212, USA
    J Neuroimmunol 167:99-107. 2005
  10. ncbi Curcumin induces growth-arrest and apoptosis in association with the inhibition of constitutively active JAK-STAT pathway in T cell leukemia
    Johnson Rajasingh
    Department of Neurology, Vanderbilt University Medical Center, Nashville, TN 37212, USA
    Biochem Biophys Res Commun 340:359-68. 2006

Collaborators

Detail Information

Publications15

  1. ncbi Curcumin inhibits experimental allergic encephalomyelitis by blocking IL-12 signaling through Janus kinase-STAT pathway in T lymphocytes
    Chandramohan Natarajan
    Division of Neuroimmunology, Department of Neurology, Vanderbilt University Medical Center, Nashville, TN 37212, USA
    J Immunol 168:6506-13. 2002
    ..These findings highlight the fact that curcumin inhibits EAE by blocking IL-12 signaling in T cells and suggest its use in the treatment of MS and other Th1 cell-mediated inflammatory diseases...
  2. ncbi 1,25 Dihydroxyvitamin-D3 modulates JAK-STAT pathway in IL-12/IFNgamma axis leading to Th1 response in experimental allergic encephalomyelitis
    Gladson Muthian
    Department of Neurology, Vanderbilt University Medical Center, Nashville, Tennessee, USA
    J Neurosci Res 83:1299-309. 2006
    ....
  3. ncbi Peroxisome proliferator-activated receptor-gamma-deficient heterozygous mice develop an exacerbated neural antigen-induced Th1 response and experimental allergic encephalomyelitis
    Chandramohan Natarajan
    Department of Neurology, Vanderbilt University Medical Center, Nashville, TN 37212, USA
    J Immunol 171:5743-50. 2003
    ..These findings suggest that PPARgamma be a critical physiological regulator of CNS inflammation and demyelination in EAE and perhaps multiple sclerosis and other Th1 cell-mediated autoimmune diseases...
  4. ncbi PPARgamma antagonists reverse the inhibition of neural antigen-specific Th1 response and experimental allergic encephalomyelitis by Ciglitazone and 15-deoxy-Delta12,14-prostaglandin J2
    Himanshu P Raikwar
    Department of Neurology, Vanderbilt University Medical Center, Nashville, TN 37212, USA
    J Neuroimmunol 178:76-86. 2006
    ..These results suggest that Ciglitazone and 15d-PGJ2 ameliorate EAE through PPARgamma-dependent mechanisms and further confirm a physiological role for PPARgamma in the regulation of CNS inflammation and demyelination in EAE...
  5. ncbi COX-2 inhibitors modulate IL-12 signaling through JAK-STAT pathway leading to Th1 response in experimental allergic encephalomyelitis
    Gladson Muthian
    Department of Neurology, Vanderbilt University Medical Center, Nashville, Tennessee, USA
    J Clin Immunol 26:73-85. 2006
    ....
  6. ncbi Setaria digitata secreted filarial lipids modulate IL-12 signaling through JAK-STAT pathway leading to the development of Th1 response
    Gladson Muthian
    Department of Neurology, Vanderbilt University Medical Center, Nashville, TN 37212, USA
    Exp Parasitol 114:193-203. 2006
    ..These findings suggest that the SFL modulates Th1 immune response by blocking IL-12 signaling in T cells and thus play a role in host immune evasion of filarial parasites...
  7. ncbi Quercetin, a flavonoid phytoestrogen, ameliorates experimental allergic encephalomyelitis by blocking IL-12 signaling through JAK-STAT pathway in T lymphocyte
    Gladson Muthian
    Departments of Neurology and Pharmacology, Vanderbilt University Medical Center, Nashville, Tennessee 37212, USA
    J Clin Immunol 24:542-52. 2004
    ..These findings highlight the fact that quercetin ameliorates EAE by blocking IL-12 signaling and Th1 differentiation and suggest its use in the treatment of MS and other Th1 cell-mediated autoimmune diseases...
  8. ncbi Signaling through JAK2-STAT5 pathway is essential for IL-3-induced activation of microglia
    Chandramohan Natarajan
    Department of Neurology and Pharmacology, Vanderbilt University Medical Center, 1222F VSRH, 2201 Capers Avenue, Nashville, TN 37212, USA
    Glia 45:188-96. 2004
    ..These findings highlight the fact that JAK2-STAT5 signaling pathway plays a critical role in mediating IL-3-induced activation of microglia...
  9. ncbi PPARgamma antagonists exacerbate neural antigen-specific Th1 response and experimental allergic encephalomyelitis
    Himanshu P Raikwar
    Department of Neurology, Vanderbilt University Medical Center, 1222 VSRH, 2201 Children s way, Nashville, TN 37212, USA
    J Neuroimmunol 167:99-107. 2005
    ..These results further suggest that PPARgamma is a critical physiological regulator of CNS inflammation and demyelination in EAE...
  10. ncbi Curcumin induces growth-arrest and apoptosis in association with the inhibition of constitutively active JAK-STAT pathway in T cell leukemia
    Johnson Rajasingh
    Department of Neurology, Vanderbilt University Medical Center, Nashville, TN 37212, USA
    Biochem Biophys Res Commun 340:359-68. 2006
    ..The induction of growth-arrest and apoptosis in association with the blockade of constitutively active JAK-STAT pathway suggests this be a mechanism by which curcumin induces antitumor activity in T cell leukemia...
  11. ncbi 15-Deoxy-delta12,14-prostaglandin J2 regulates leukemia inhibitory factor signaling through JAK-STAT pathway in mouse embryonic stem cells
    Johnson Rajasingh
    Department of Neurology, Vanderbilt University Medical Center, Nashville, TN 37212, USA
    Exp Cell Res 312:2538-46. 2006
    ..These results suggest that PPARgamma agonists regulate LIF signaling through JAK-STAT pathway leading to growth and self-renewal of ES cells...
  12. ncbi Targeting autoimmune diseases through nutraceuticals
    John J Bright
    Department of Neurology, Vanderbilt University School of Medicine, Nashville, Tennessee 37212, USA
    Nutrition 20:39-43. 2004
  13. doi 15-deoxy-Delta(12,14)-prostaglandin J(2) and curcumin modulate the expression of toll-like receptors 4 and 9 in autoimmune T lymphocyte
    Wanida Chearwae
    Neuroscience Research Laboratory, Methodist Research Institute at Clarian Health, 1800 North Capitol Avenue, Noyes Building E 504C, Indianapolis, IN 46202, USA
    J Clin Immunol 28:558-70. 2008
    ..T lymphocytes also express TLRs and function as costimulatory receptors to upregulate proliferation and cytokine production in response to specific agonists...
  14. pmc Stat4 isoforms differentially regulate inflammation and demyelination in experimental allergic encephalomyelitis
    Caiqing Mo
    Neuroscience Research Laboratory, Methodist Research Institute, Indianapolis, IN 46202, USA
    J Immunol 181:5681-90. 2008
    ..This study demonstrates that Stat4 isoforms differentially regulate inflammatory cytokines in association with distinct effects on the onset and severity of EAE...
  15. ncbi Curcumin and autoimmune disease
    John J Bright
    Neuroscience Research Laboratory, Methodist Research Institute, Clarian Health, Indianapolis, IN 46202, USA
    Adv Exp Med Biol 595:425-51. 2007
    ..A precise understanding of effective dose, safe regiment, and mechanism of action is required for the use of curcumin in the treatment of human autoimmune diseases...