Darryl Bornhop

Summary

Affiliation: Vanderbilt University
Country: USA

Publications

  1. ncbi request reprint Preclinical molecular imaging of the translocator protein (TSPO) in a metastases model based on breast cancer xenografts propagated in the murine brain
    Shelby K Wyatt
    Vanderbilt University Institute of Imaging Science, Vanderbilt University Medical Center, Nashville, TN, USA
    Curr Mol Med 12:458-66. 2012
  2. ncbi request reprint Free-solution, label-free molecular interactions studied by back-scattering interferometry
    Darryl J Bornhop
    Department of Chemistry, Vanderbilt Institute of Chemical Biology, Vanderbilt University, VU Station B 351822, Nashville, TN 37235 1822, USA
    Science 317:1732-6. 2007
  3. ncbi request reprint Targeted molecular imaging agents for cellular-scale bimodal imaging
    H Charles Manning
    Department of Chemistry, Vanderbilt University, Nashville, Tennessee 37232, USA
    Bioconjug Chem 15:1488-95. 2004
  4. ncbi request reprint Label-free molecular interaction determinations with nanoscale interferometry
    Dmitry A Markov
    Department of Chemistry, Vanderbilt University, VU Station B 351822, Nashville, Tennessee 37235 1822, USA
    J Am Chem Soc 126:16659-64. 2004
  5. doi request reprint Free-solution interaction assay of carbonic anhydrase to its inhibitors using back-scattering interferometry
    Ereny F Morcos
    Department of Chemistry and Vanderbilt Institute of Chemical Biology, Vanderbilt University, Nashville, TN, USA
    Electrophoresis 31:3691-5. 2010
  6. doi request reprint The potential of backscattering interferometry as an in vitro clinical diagnostic tool for the serological diagnosis of infectious disease
    Amanda Kussrow
    Department of Chemistry and Vanderbilt Institute of Chemical Biology, Vanderbilt University, Nashville, Tennessee, USA
    Analyst 135:1535-7. 2010
  7. ncbi request reprint A novel conjugable translocator protein ligand labeled with a fluorescence dye for in vitro imaging
    Mingfeng Bai
    Department of Chemistry, Vanderbilt University, VU Station B 351822 Nashville, Tennessee 37235 1822, USA
    Bioconjug Chem 18:1118-22. 2007
  8. pmc Measurement of monovalent and polyvalent carbohydrate-lectin binding by back-scattering interferometry
    Amanda Kussrow
    Department of Chemistry and Vanderbilt Institute of Chemical Biology, Vanderbilt University, 4226 Stevenson Center, Nashville, Tennessee 37235, USA
    Anal Chem 81:4889-97. 2009
  9. doi request reprint MBC94, a conjugable ligand for cannabinoid CB 2 receptor imaging
    Mingfeng Bai
    Department of Chemistry, Vanderbilt University, VU Station B 351822, Nashville, Tennessee 37235 1822, USA
    Bioconjug Chem 19:988-92. 2008
  10. doi request reprint Molecular imaging of the translocator protein (TSPO) in a pre-clinical model of breast cancer
    Shelby K Wyatt
    Vanderbilt University Institute of Imaging Science, Vanderbilt University Medical Center, Nashville, TN, USA
    Mol Imaging Biol 12:349-58. 2010

Research Grants

Collaborators

  • HENRY MANNING
  • V Papadopoulos
  • R D Jones
  • D L Cox
  • Hassane McHaourab
  • Mingfeng Bai
  • Shelby K Wyatt
  • Amanda Kussrow
  • Dmitry A Markov
  • Kelly Swinney
  • Ereny F Morcos
  • Joey C Latham
  • Lynn E Samuelson
  • Natasha G Deane
  • Zhanling Wang
  • Reid C Thompson
  • Moneeb Ehtesham
  • Khubaib Y Mapara
  • Stephanie N Bailey
  • Guobin Ma
  • Arnold R Castro
  • Pascal Gallant
  • Ronald C Ballard
  • Carolyn S Enders
  • Laura McIntosh
  • Carolyn Enders
  • Colette R Hunt
  • M G Finn
  • Eiton Kaltgrad
  • Richard A Stein
  • Mary J Cloninger
  • Mark L Wolfenden
  • Madeline J Dukes
  • Jonathan D Casey
  • Michelle Sexton
  • Nephi Stella
  • Robert J Coffey
  • Zeqiu Han
  • A Coe Foutch
  • Malena B Rone
  • Bruce J Aronow
  • Bruce A Aronow
  • M Kay Washington
  • Stephen Dotson
  • Scott Wood

Detail Information

Publications18

  1. ncbi request reprint Preclinical molecular imaging of the translocator protein (TSPO) in a metastases model based on breast cancer xenografts propagated in the murine brain
    Shelby K Wyatt
    Vanderbilt University Institute of Imaging Science, Vanderbilt University Medical Center, Nashville, TN, USA
    Curr Mol Med 12:458-66. 2012
    ....
  2. ncbi request reprint Free-solution, label-free molecular interactions studied by back-scattering interferometry
    Darryl J Bornhop
    Department of Chemistry, Vanderbilt Institute of Chemical Biology, Vanderbilt University, VU Station B 351822, Nashville, TN 37235 1822, USA
    Science 317:1732-6. 2007
    ..The high sensitivity of back-scattering interferometry and small volumes of microfluidics allowed the entire calmodulin assay to be performed with 200 picomoles of solute...
  3. ncbi request reprint Targeted molecular imaging agents for cellular-scale bimodal imaging
    H Charles Manning
    Department of Chemistry, Vanderbilt University, Nashville, Tennessee 37232, USA
    Bioconjug Chem 15:1488-95. 2004
    ....
  4. ncbi request reprint Label-free molecular interaction determinations with nanoscale interferometry
    Dmitry A Markov
    Department of Chemistry, Vanderbilt University, VU Station B 351822, Nashville, Tennessee 37235 1822, USA
    J Am Chem Soc 126:16659-64. 2004
    ....
  5. doi request reprint Free-solution interaction assay of carbonic anhydrase to its inhibitors using back-scattering interferometry
    Ereny F Morcos
    Department of Chemistry and Vanderbilt Institute of Chemical Biology, Vanderbilt University, Nashville, TN, USA
    Electrophoresis 31:3691-5. 2010
    ..BSI has the potential for reducing labor costs, sample consumption, and assay time while providing enhanced reliability over existing techniques...
  6. doi request reprint The potential of backscattering interferometry as an in vitro clinical diagnostic tool for the serological diagnosis of infectious disease
    Amanda Kussrow
    Department of Chemistry and Vanderbilt Institute of Chemical Biology, Vanderbilt University, Nashville, Tennessee, USA
    Analyst 135:1535-7. 2010
    ....
  7. ncbi request reprint A novel conjugable translocator protein ligand labeled with a fluorescence dye for in vitro imaging
    Mingfeng Bai
    Department of Chemistry, Vanderbilt University, VU Station B 351822 Nashville, Tennessee 37235 1822, USA
    Bioconjug Chem 18:1118-22. 2007
    ..These findings suggest that C6Ro5-4864 may provide opportunities in imaging disease states where TSPO levels are affected, such as cancer and neurologic diseases...
  8. pmc Measurement of monovalent and polyvalent carbohydrate-lectin binding by back-scattering interferometry
    Amanda Kussrow
    Department of Chemistry and Vanderbilt Institute of Chemical Biology, Vanderbilt University, 4226 Stevenson Center, Nashville, Tennessee 37235, USA
    Anal Chem 81:4889-97. 2009
    ....
  9. doi request reprint MBC94, a conjugable ligand for cannabinoid CB 2 receptor imaging
    Mingfeng Bai
    Department of Chemistry, Vanderbilt University, VU Station B 351822, Nashville, Tennessee 37235 1822, USA
    Bioconjug Chem 19:988-92. 2008
    ..Preliminary evidence, including in vitro fluorescence imaging and a competition study, showed that NIRmbc94 specifically labeled CB 2-expressing cells...
  10. doi request reprint Molecular imaging of the translocator protein (TSPO) in a pre-clinical model of breast cancer
    Shelby K Wyatt
    Vanderbilt University Institute of Imaging Science, Vanderbilt University Medical Center, Nashville, TN, USA
    Mol Imaging Biol 12:349-58. 2010
    ..To quantitatively evaluate the utility of a translocator protein (TSPO)-targeted near-infrared (NIR) probe (NIR-conPK11195) for in vivo molecular imaging of TSPO in breast cancer...
  11. pmc TSPO targeted dendrimer imaging agent: synthesis, characterization, and cellular internalization
    Lynn E Samuelson
    Department of Chemistry, The Vanderbilt Institute for Chemical Biology and Vanderbilt Ingram Cancer Center, Vanderbilt University, VU Station B 351822 Nashville, Tennessee 37235 1822, USA
    Bioconjug Chem 20:2082-9. 2009
    ..Here, we present the synthesis, characterization, and cellular internalization into C6 rat glioma cells of a TSPO targeted dendrimer imaging agent...
  12. pmc Free-solution label-free detection of alpha-crystallin chaperone interactions by back-scattering interferometry
    Joey C Latham
    Department of Chemistry and The Vanderbilt Institute for Chemical Biology, Vanderbilt University, VU Station B 351822, Nashville, Tennessee 37235 1822, USA
    Anal Chem 81:1865-71. 2009
    ..This work demonstrates that BSI can be extended to screen libraries of disease-related mutants to quantify changes in affinity and/or kinetics of binding...
  13. ncbi request reprint A novel functional translocator protein ligand for cancer imaging
    Mingfeng Bai
    Department of Chemistry, Vanderbilt University, VU Station B 351822, Nashville, TN 37235 1822, USA
    Bioconjug Chem 18:2018-23. 2007
    ..Two fluorescent dye-labeled 6-TSPOmbb732 displayed nanomolar binding affinities to TSPO and were successfully imaged in vitro...
  14. ncbi request reprint Targeted imaging of colonic tumors in smad3-/- mice discriminates cancer and inflammation
    Natasha G Deane
    Department of Surgery and Division of Surgical Oncology, Vanderbilt University, Nashville, TN 37235, USA
    Mol Cancer Res 5:341-9. 2007
    ..Taken together, these results indicate that NIR-conPK11195 is a promising optical molecular imaging tool to rapidly screen for colonic tumors in mice and to discriminate inflammation from cancer...
  15. ncbi request reprint Noninvasive fluid flow measurements in microfluidic channels with backscatter interferometry
    Dmitry A Markov
    Department of Chemistry, Vanderbilt University, Nashville, TN 37235, USA
    Electrophoresis 25:3805-9. 2004
    ..The experiments are performed in the range of 3-6 microL/h with 3sigma detection limits determined to be 0.127 nL/s. Additionally, the RI response of the system is calibrated using temperature changes as well as glycerol solutions...
  16. ncbi request reprint Attomole sensitivity for unlabeled proteins and polypeptides with on-chip capillary electrophoresis and universal detection by interferometric backscatter
    Zhanling Wang
    Department of Chemistry and Biochemistry, Texas Tech University, Lubbock, TX 79409 1061, USA
    Electrophoresis 24:865-73. 2003
    ..This development shows that a universal detector based on backscatter interferometry can be used effectively for on-chip label-free solute analysis...
  17. ncbi request reprint Facile, efficient conjugation of a trifunctional lanthanide chelate to a peripheral benzodiazepine receptor ligand
    H Charles Manning
    Department of Chemistry and Biochemistry, Texas Tech University, Lubbock, Texas 79409, USA
    Org Lett 4:1075-8. 2002
    ..The contrast agent QM-CTMC-PK11195, when chelated with lanthanides, produces bright luminescence and good MRI contrast and can potentially serve as an imaging and demarcation agent for certain types of cancers...
  18. ncbi request reprint Quantification and evaluation of Joule heating in on-chip capillary electrophoresis
    Kelly Swinney
    Department of Chemistry and Biochemistry, Texas Tech University, Lubbock, TX 79409 1061, USA
    Electrophoresis 23:613-20. 2002
    ..Results indicate that heating effects in on-chip CE have been underestimated and there is a need to readdress the theoretical model...

Research Grants4

  1. Interferometric Nano-sensing for Biochemical Analysis
    Darryl Bornhop; Fiscal Year: 2007
    ..This proposal expands on these results, culminating a multiplexed OCIBD for homogeneous (free-solution) molecular interaction assays. ..