Research Topics
| Darryl BornhopSummaryAffiliation: Vanderbilt University Country: USA Publications
Research Grants
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Detail Information
Publications
Preclinical molecular imaging of the translocator protein (TSPO) in a metastases model based on breast cancer xenografts propagated in the murine brainShelby K Wyatt
Vanderbilt University Institute of Imaging Science, Vanderbilt University Medical Center, Nashville, TN, USA
Curr Mol Med 12:458-66. 2012....- Free-solution, label-free molecular interactions studied by back-scattering interferometryDarryl J Bornhop
Department of Chemistry, Vanderbilt Institute of Chemical Biology, Vanderbilt University, VU Station B 351822, Nashville, TN 37235 1822, USA
Science 317:1732-6. 2007..The high sensitivity of back-scattering interferometry and small volumes of microfluidics allowed the entire calmodulin assay to be performed with 200 picomoles of solute... - Targeted molecular imaging agents for cellular-scale bimodal imagingH Charles Manning
Department of Chemistry, Vanderbilt University, Nashville, Tennessee 37232, USA
Bioconjug Chem 15:1488-95. 2004.... - Label-free molecular interaction determinations with nanoscale interferometryDmitry A Markov
Department of Chemistry, Vanderbilt University, VU Station B 351822, Nashville, Tennessee 37235-1822, USA
J Am Chem Soc 126:16659-64. 2004.... 
Free-solution interaction assay of carbonic anhydrase to its inhibitors using back-scattering interferometryEreny F Morcos
Department of Chemistry and Vanderbilt Institute of Chemical Biology, Vanderbilt University, Nashville, TN, USA
Electrophoresis 31:3691-5. 2010..BSI has the potential for reducing labor costs, sample consumption, and assay time while providing enhanced reliability over existing techniques...- The potential of backscattering interferometry as an in vitro clinical diagnostic tool for the serological diagnosis of infectious diseaseAmanda Kussrow
Department of Chemistry and Vanderbilt Institute of Chemical Biology, Vanderbilt University, Nashville, Tennessee, USA
Analyst 135:1535-7. 2010.... - A novel conjugable translocator protein ligand labeled with a fluorescence dye for in vitro imagingMingfeng Bai
Department of Chemistry, Vanderbilt University, VU Station B 351822 Nashville, Tennessee 37235 1822, USA
Bioconjug Chem 18:1118-22. 2007..These findings suggest that C6Ro5-4864 may provide opportunities in imaging disease states where TSPO levels are affected, such as cancer and neurologic diseases... 
Measurement of monovalent and polyvalent carbohydrate-lectin binding by back-scattering interferometryAmanda Kussrow
Department of Chemistry and Vanderbilt Institute of Chemical Biology, Vanderbilt University, 4226 Stevenson Center, Nashville, Tennessee 37235, USA
Anal Chem 81:4889-97. 2009....- MBC94, a conjugable ligand for cannabinoid CB 2 receptor imagingMingfeng Bai
Department of Chemistry, Vanderbilt University, VU Station B 351822, Nashville, Tennessee 37235 1822, USA
Bioconjug Chem 19:988-92. 2008..Preliminary evidence, including in vitro fluorescence imaging and a competition study, showed that NIRmbc94 specifically labeled CB 2-expressing cells... - Molecular imaging of the translocator protein (TSPO) in a pre-clinical model of breast cancerShelby K Wyatt
Vanderbilt University Institute of Imaging Science, Vanderbilt University Medical Center, Nashville, TN, USA
Mol Imaging Biol 12:349-58. 2010..To quantitatively evaluate the utility of a translocator protein (TSPO)-targeted near-infrared (NIR) probe (NIR-conPK11195) for in vivo molecular imaging of TSPO in breast cancer... - TSPO targeted dendrimer imaging agent: synthesis, characterization, and cellular internalizationLynn E Samuelson
Department of Chemistry, The Vanderbilt Institute for Chemical Biology and Vanderbilt Ingram Cancer Center, Vanderbilt University, VU Station B 351822 Nashville, Tennessee 37235 1822, USA
Bioconjug Chem 20:2082-9. 2009..Here, we present the synthesis, characterization, and cellular internalization into C6 rat glioma cells of a TSPO targeted dendrimer imaging agent... - Free-solution label-free detection of alpha-crystallin chaperone interactions by back-scattering interferometryJoey C Latham
Department of Chemistry and The Vanderbilt Institute for Chemical Biology, Vanderbilt University, VU Station B 351822, Nashville, Tennessee 37235 1822, USA
Anal Chem 81:1865-71. 2009..This work demonstrates that BSI can be extended to screen libraries of disease-related mutants to quantify changes in affinity and/or kinetics of binding... - A novel functional translocator protein ligand for cancer imagingMingfeng Bai
Department of Chemistry, Vanderbilt University, VU Station B 351822, Nashville, TN 37235 1822, USA
Bioconjug Chem 18:2018-23. 2007..Two fluorescent dye-labeled 6-TSPOmbb732 displayed nanomolar binding affinities to TSPO and were successfully imaged in vitro... - Targeted imaging of colonic tumors in smad3-/- mice discriminates cancer and inflammationNatasha G Deane
Department of Surgery and Division of Surgical Oncology, Vanderbilt University, Nashville, TN 37235, USA
Mol Cancer Res 5:341-9. 2007..Taken together, these results indicate that NIR-conPK11195 is a promising optical molecular imaging tool to rapidly screen for colonic tumors in mice and to discriminate inflammation from cancer... - Noninvasive fluid flow measurements in microfluidic channels with backscatter interferometryDmitry A Markov
Department of Chemistry, Vanderbilt University, Nashville, TN 37235, USA
Electrophoresis 25:3805-9. 2004..The experiments are performed in the range of 3-6 microL/h with 3sigma detection limits determined to be 0.127 nL/s. Additionally, the RI response of the system is calibrated using temperature changes as well as glycerol solutions... - Attomole sensitivity for unlabeled proteins and polypeptides with on-chip capillary electrophoresis and universal detection by interferometric backscatterZhanling Wang
Department of Chemistry and Biochemistry, Texas Tech University, Lubbock, TX 79409-1061, USA
Electrophoresis 24:865-73. 2003..This development shows that a universal detector based on backscatter interferometry can be used effectively for on-chip label-free solute analysis... - Facile, efficient conjugation of a trifunctional lanthanide chelate to a peripheral benzodiazepine receptor ligandH Charles Manning
Department of Chemistry and Biochemistry, Texas Tech University, Lubbock, Texas 79409, USA
Org Lett 4:1075-8. 2002..The contrast agent QM-CTMC-PK11195, when chelated with lanthanides, produces bright luminescence and good MRI contrast and can potentially serve as an imaging and demarcation agent for certain types of cancers... - Quantification and evaluation of Joule heating in on-chip capillary electrophoresisKelly Swinney
Department of Chemistry and Biochemistry, Texas Tech University, Lubbock, TX 79409-1061, USA
Electrophoresis 23:613-20. 2002..Results indicate that heating effects in on-chip CE have been underestimated and there is a need to readdress the theoretical model...
Research Grants
- Interferometric Nano-sensing for Biochemical AnalysisDarryl Bornhop; Fiscal Year: 2007..This proposal expands on these results, culminating a multiplexed OCIBD for homogeneous (free-solution) molecular interaction assays. ..