Research Topics | Seth BordensteinSummaryAffiliation: Vanderbilt University Country: USA Publications
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Publications
Insect Innate Immunity Database (IIID): an annotation tool for identifying immune genes in insect genomesRobert M Brucker
Department of Biological Sciences, Vanderbilt University, Nashville, Tennessee, United States of America
PLoS ONE 7:e45125. 2012..While these computational predictions need to be complemented with functional studies, the IIID database can help initiate and augment annotations of the immune system in the plethora of insect genomes that will soon become available...
The roles of host evolutionary relationships (genus: Nasonia) and development in structuring microbial communitiesRobert M Brucker
Department of Biological Sciences, Vanderbilt University, Nashville, Tennessee, USA
Evolution 66:349-62. 2012..These findings highlight the importance of host evolutionary relationships on microbiota composition and have broad implications for future studies of microbial symbiosis and animal speciation...- Phage WO of Wolbachia: lambda of the endosymbiont worldBethany N Kent
Department of Biological Sciences, Vanderbilt University, Nashville, TN 37235, USA
Trends Microbiol 18:173-81. 2010..In this sense, phage WO might be likened to phage lambda of the endosymbiont world... - Parasitism and mutualism in Wolbachia: what the phylogenomic trees can and cannot saySeth R Bordenstein
Josephine Bay Paul Center, Marine Biological Laboratory, Woods Hole, MA, USA
Mol Biol Evol 26:231-41. 2009..We suggest that the ancestry of mutualism and parasitism is not resolvable without more suitable outgroups or complete genome sequences from all Wolbachia supergroups... 
Bacteriophage flux in endosymbionts (Wolbachia): infection frequency, lateral transfer, and recombination ratesSeth R Bordenstein
The Marine Biological Laboratory, Josephine Bay Paul Center for Comparative Molecular Biology and Evolution, Woods Hole, Massachusetts, USA
Mol Biol Evol 21:1981-91. 2004..Gene transfer by bacteriophages could drive significant evolutionary change in the genomes of intracellular bacteria that are typically considered highly stable and prone to genomic degradation...- Evolutionary genomics: transdomain gene transfersSeth R Bordenstein
Josephine Bay Paul Center for Comparative Molecular Biology and Evolution, The Marine Biological Laboratory, Woods Hole, Massachusetts 02543, USA
Curr Biol 17:R935-6. 2007..A new study showing promiscuous insertions of bacterial endosymbiont genes into invertebrate genomes ushers in a shift in this paradigm... - The tripartite associations between bacteriophage, Wolbachia, and arthropodsSeth R Bordenstein
Josephine Bay Paul Center for Comparative Molecular Biology and Evolution, The Marine Biological Laboratory, Woods Hole, Massachusetts, USA
PLoS Pathog 2:e43. 2006..Clarifying the roles of lytic and lysogenic phage development in Wolbachia biology will effectively structure inquiries into this research topic... - Genome evolution in an insect cell: distinct features of an ant-bacterial partnershipJennifer J Wernegreen
Josephine Bay Paul Center for Comparative Molecular Biology and Evolution, 7 MBL Street, Woods Hole, Massachusetts 02543, USA
Biol Bull 204:221-31. 2003..This review describes some recent insights into the evolutionary genetics of obligate insect-bacteria symbioses, with a particular focus on an intriguing association between the bacterial endosymbiont Blochmannia and its ant hosts... - Discovery of a novel Wolbachia super group in IsopteraSeth Bordenstein
The Marine Biological Laboratory, The Josephine Bay Paul Center for Comparative Molecular Biology and Evolution, Woods Hole, MA 02543, USA
Curr Microbiol 51:393-8. 2005..It also suggests that surveys of Wolbachia in more earlier-originating (and under-sampled) groups of arthropods are more apt to reveal novel genetic diversity... - Molecular evolution of the Helicobacter pylori vacuolating toxin gene vacAKelly A Gangwer
Department of Microbiology and Immunology, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, USA
J Bacteriol 192:6126-35. 2010..Taken together, these results indicate that positive selection has shaped the phylogenetic structure of VacA and CagA, and each of these virulence determinants has evolved separately from the core genome... - Mobile DNA in obligate intracellular bacteriaSeth R Bordenstein
Josephine Bay Paul Center for Comparative Molecular Biology and Evolution, The Marine Biological Laboratory, 7 MBL Street, Woods Hole, Massachusetts 02543, USA
Nat Rev Microbiol 3:688-99. 2005..However, recent findings from complete genome sequences of obligate intracellular species and their mobile genetic associates favour the abandonment of these wholesale terms for a more complex and tantalizing picture...
Research Grants
- Molecular Evolution and Life Cycle of Wolbachia BacteriohageSeth Bordenstein; Fiscal Year: 2009..health by increasing knowledge on how to employ the phage as (i) a conduit for spreading transgenic traits into arthropod-borne vectors and (ii) as a therapeutic tool for removing filarial Wolbachia and associated human pathologies ..
- Molecular Evolution and Life Cycle of Wolbachia BacteriophageSeth R Bordenstein; Fiscal Year: 2010..Our preliminary studies suggest their principal role is predation of Wolbachia. ..