Italo Biaggioni

Summary

Affiliation: Vanderbilt University
Country: USA

Publications

  1. ncbi request reprint Vestibular influences on autonomic cardiovascular control in humans
    I Biaggioni
    Department of Medicine, Vanderbilt University, Nashville TN 37232 2135, USA
    J Vestib Res 8:35-41. 1998
  2. ncbi request reprint Hypertension in orthostatic hypotension and autonomic dysfunction
    Italo Biaggioni
    Departments of Medicine and Pharmacology, Division of Clinical Pharmacology, 1500 21st Avenue South, Suite 3500, Vanderbilt University, Nashville, TN 37212, USA
    Cardiol Clin 20:291-301, vii. 2002
  3. pmc Excessive nitric oxide function and blood pressure regulation in patients with autonomic failure
    Alfredo Gamboa
    Department of Medicine, Vanderbilt University, Nashville, Tenn 37212, USA
    Hypertension 51:1531-6. 2008
  4. pmc Sympathetic activation and nitric oxide function in early hypertension
    Alfredo Gamboa
    Department of Medicine, Division of Clinical Pharmacology, Vanderbilt University, Nashville, Tennessee, USA
    Am J Physiol Heart Circ Physiol 302:H1438-43. 2012
  5. ncbi request reprint Clonidine for the treatment of supine hypertension and pressure natriuresis in autonomic failure
    Cyndya Shibao
    Division of Clinical Pharmacology, Department of Medicine and Pharmacology, The Autonomic Dysfunction Center, Vanderbilt University School of Medicine, Nashville, TN, USA
    Hypertension 47:522-6. 2006
  6. ncbi request reprint Autonomic contribution to blood pressure and metabolism in obesity
    Cyndya Shibao
    Division of Clinical Pharmacology and the Autonomic Dysfunction Center, Vanderbilt University School of Medicine, Nashville, TN 37212, USA
    Hypertension 49:27-33. 2007
  7. pmc Renal impairment of pure autonomic failure
    Emily M Garland
    Autonomic Dysfunction Center, Vanderbilt University, Nashville, TN 37232 2195, USA
    Hypertension 54:1057-61. 2009
  8. ncbi request reprint The sympathetic nervous system in hypertension: assessment by blood pressure variability and ganglionic blockade
    Andre Diedrich
    Autonomic Dysfunction Center, Vanderbilt University, Nashville, TN 37232 2195, USA
    J Hypertens 21:1677-86. 2003
  9. pmc Effect of A2B adenosine receptor gene ablation on proinflammatory adenosine signaling in mast cells
    Sergey Ryzhov
    Division of Cardiovascular Medicine, Department of Medicine, Vanderbilt University, Nashville, TN 37232, USA
    J Immunol 180:7212-20. 2008
  10. pmc Nitric oxide and regulation of heart rate in patients with postural tachycardia syndrome and healthy subjects
    Alfredo Gamboa
    Division of Clinical Pharmacology, Vanderbilt University, Nashville, TN, USA
    Hypertension 61:376-81. 2013

Detail Information

Publications101 found, 100 shown here

  1. ncbi request reprint Vestibular influences on autonomic cardiovascular control in humans
    I Biaggioni
    Department of Medicine, Vanderbilt University, Nashville TN 37232 2135, USA
    J Vestib Res 8:35-41. 1998
    ..Several factors may explain the apparent discordance of these results, but more research is needed before we can define the potential importance of vestibular input to cardiovascular regulation and orthostatic tolerance in humans...
  2. ncbi request reprint Hypertension in orthostatic hypotension and autonomic dysfunction
    Italo Biaggioni
    Departments of Medicine and Pharmacology, Division of Clinical Pharmacology, 1500 21st Avenue South, Suite 3500, Vanderbilt University, Nashville, TN 37212, USA
    Cardiol Clin 20:291-301, vii. 2002
    ..Supine hypertension complicates the treatment of these patients but can be managed by overnight administration of antihypertensive medications...
  3. pmc Excessive nitric oxide function and blood pressure regulation in patients with autonomic failure
    Alfredo Gamboa
    Department of Medicine, Vanderbilt University, Nashville, Tenn 37212, USA
    Hypertension 51:1531-6. 2008
    ..Potentiation of NO could be used in the treatment of supine hypertension, and its inhibition offers a novel approach to improve orthostatic hypotension...
  4. pmc Sympathetic activation and nitric oxide function in early hypertension
    Alfredo Gamboa
    Department of Medicine, Division of Clinical Pharmacology, Vanderbilt University, Nashville, Tennessee, USA
    Am J Physiol Heart Circ Physiol 302:H1438-43. 2012
    ..If NO deficiency contributes to hypertension, it is likely to be through its modulation of the autonomic nervous system, which was excluded in this study...
  5. ncbi request reprint Clonidine for the treatment of supine hypertension and pressure natriuresis in autonomic failure
    Cyndya Shibao
    Division of Clinical Pharmacology, Department of Medicine and Pharmacology, The Autonomic Dysfunction Center, Vanderbilt University School of Medicine, Nashville, TN, USA
    Hypertension 47:522-6. 2006
    ..66; P=0.043). These results are consistent with residual sympathetic tone contributing to supine hypertension in autonomic failure, which can be targeted with clonidine to decrease BP and nocturnal natriuresis...
  6. ncbi request reprint Autonomic contribution to blood pressure and metabolism in obesity
    Cyndya Shibao
    Division of Clinical Pharmacology and the Autonomic Dysfunction Center, Vanderbilt University School of Medicine, Nashville, TN 37212, USA
    Hypertension 49:27-33. 2007
    ..These results suggest that the sympathetic nervous system could be targeted in the treatment of obesity-associated hypertension...
  7. pmc Renal impairment of pure autonomic failure
    Emily M Garland
    Autonomic Dysfunction Center, Vanderbilt University, Nashville, TN 37232 2195, USA
    Hypertension 54:1057-61. 2009
    ..73 m2; P=0.022) compared with patients who did not have supine hypertension. These findings may indicate that renal function is diminished in PAF in association with supine hypertension...
  8. ncbi request reprint The sympathetic nervous system in hypertension: assessment by blood pressure variability and ganglionic blockade
    Andre Diedrich
    Autonomic Dysfunction Center, Vanderbilt University, Nashville, TN 37232 2195, USA
    J Hypertens 21:1677-86. 2003
    ....
  9. pmc Effect of A2B adenosine receptor gene ablation on proinflammatory adenosine signaling in mast cells
    Sergey Ryzhov
    Division of Cardiovascular Medicine, Department of Medicine, Vanderbilt University, Nashville, TN 37232, USA
    J Immunol 180:7212-20. 2008
    ..Thus, our study confirmed the proinflammatory role of adenosine signaling via A(2B) receptors and the anti-inflammatory actions of A(2B) antagonists in mouse BMMCs...
  10. pmc Nitric oxide and regulation of heart rate in patients with postural tachycardia syndrome and healthy subjects
    Alfredo Gamboa
    Division of Clinical Pharmacology, Vanderbilt University, Nashville, TN, USA
    Hypertension 61:376-81. 2013
    ..We found no evidence of a primary alteration in NO function in POTS. If NO dysfunction plays a role in POTS, it is through its interaction with the autonomic nervous system...
  11. ncbi request reprint Norepinephrine transporter blockade with atomoxetine induces hypertension in patients with impaired autonomic function
    Cyndya Shibao
    Department of Medicine, Division of Clinical Pharmacology, and the Autonomic Dysfunction Center, Vanderbilt University School of Medicine, Nashville, TN 37212, USA
    Hypertension 50:47-53. 2007
    ..Caution should be exercised when this medication is used in patients with milder form of autonomic impairment...
  12. ncbi request reprint Acarbose, an alpha-glucosidase inhibitor, attenuates postprandial hypotension in autonomic failure
    Cyndya Shibao
    Department of Medicine, Division of Clinical Pharmacology and the Autonomic Dysfunction Center, Vanderbilt University School of Medicine, Nashville, TN 37212, USA
    Hypertension 50:54-61. 2007
    ..In conclusion, 100 mg of acarbose successfully improved postprandial hypotension in patients with severe autonomic failure. This effect is not explained solely by a reduction in insulin levels...
  13. pmc Portal osmopressor mechanism linked to transient receptor potential vanilloid 4 and blood pressure control
    Julia McHugh
    Autonomic Dysfunction Center, Departments of Medicine, Vanderbilt University, Nashville, TN 37232 2195, USA
    Hypertension 55:1438-43. 2010
    ..The same volume of physiological saline does not elicit an increase in BP, suggesting osmolality as the stimulus. The osmopressor response to water, and Trpv4 thus represent new factors now implicated in the physiology of BP regulation...
  14. pmc Angiotensin II, independent of plasma renin activity, contributes to the hypertension of autonomic failure
    Amy C Arnold
    Division of Clinical Pharmacology, Vanderbilt University School of Medicine, Nashville, TN 37232 6602, USA
    Hypertension 61:701-6. 2013
    ..Furthermore, these studies suggest that elevations in Ang II contribute to the hypertension of autonomic failure, and provide rationale for the use of AT(1) receptor blockers for treatment of these patients...
  15. ncbi request reprint Contribution of endothelial nitric oxide to blood pressure in humans
    Alfredo Gamboa
    Department of Medicine, Vanderbilt University, Nashville, TN 37212, USA
    Hypertension 49:170-7. 2007
    ..Our results suggest that eNO is one of the most potent metabolic determinants of BP in humans, tonically restraining it by approximately 30 mm Hg...
  16. pmc Nocturnal blood pressure dipping in the hypertension of autonomic failure
    Luis E Okamoto
    Division of Clinical Pharmacology and Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN, USA
    Hypertension 53:363-9. 2009
    ..Dipping was not associated with increased nocturnal urinary sodium or volume excretion or less severe autonomic failure. Thus, mechanisms independent of autonomic pathways contribute to BP dipping in these patients...
  17. pmc Synergistic effect of norepinephrine transporter blockade and α-2 antagonism on blood pressure in autonomic failure
    Luis E Okamoto
    Vanderbilt Autonomic Dysfunction Center, Division of Clinical Pharmacology, Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN, USA
    Hypertension 59:650-6. 2012
    ..Safety studies are required to address the clinical usefulness of this pharmacological approach...
  18. pmc Attenuation of chronic pulmonary inflammation in A2B adenosine receptor knockout mice
    Rinat Zaynagetdinov
    Division of Cardiovascular Medicine, Vanderbilt University, Nashville, Tennessee 37232 6300, USA
    Am J Respir Cell Mol Biol 42:564-71. 2010
    ..These findings are in agreement with previous pharmacologic studies suggesting a deleterious role for A(2B) receptor signaling in chronic lung inflammation...
  19. pmc Adenosine receptors in regulation of dendritic cell differentiation and function
    Sergey V Novitskiy
    Division of Hematology Oncology, Vanderbilt University, Nashville, TN 37232, USA
    Blood 112:1822-31. 2008
    ..Adenosine signaling through A(2B) receptor is an important factor of aberrant DC differentiation and generation of tolerogenic, angiogenic, and proinflammatory cells...
  20. pmc Host A(2B) adenosine receptors promote carcinoma growth
    Sergey Ryzhov
    Division of Cardiovascular Medicine, Vanderbilt University, Nashville, TN 37232, USA
    Neoplasia 10:987-95. 2008
    ..Thus, our data suggest that tumor cells promote their growth by exploiting A(2B) adenosine receptor-dependent regulation of VEGF in host immune cells...
  21. pmc Diurnal variability in orthostatic tachycardia: implications for the postural tachycardia syndrome
    Jordan A Brewster
    Division of Clinical Pharmacology, Vanderbilt University School of Medicine, AA3228 Medical Center North, 1161 21st Avenue South, Nashville, TN 37232 2195, USA
    Clin Sci (Lond) 122:25-31. 2012
    ..Given the importance of orthostatic tachycardia in diagnosing POTS, this diurnal variability should be considered in the clinic as it may affect the diagnosis of POTS...
  22. pmc Chronic sympathetic attenuation and energy metabolism in autonomic failure
    Cyndya Shibao
    Division of Clinical Pharmacology and Autonomic Dysfunction Center, Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN 37232, USA
    Hypertension 59:985-90. 2012
    ..Our findings suggest that sympathetic tonic support of resting energy expenditure is preserved, at least in part, in pathophysiological models of chronic sympathetic attenuation...
  23. ncbi request reprint Role of adenosine and nitric oxide on the mechanisms of action of dipyridamole
    Alfredo Gamboa
    Division of Clinical Pharmacology, Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN, USA
    Stroke 36:2170-5. 2005
    ..Dipyridamole may act by inhibiting adenosine uptake, thus potentiating its actions. Dipyridamole also inhibits cGMP-specific phosphodiesterases (PDE) and, through this mechanism, could potentiate cGMP-mediated actions of nitric oxide...
  24. pmc Adenosinergic regulation of the expansion and immunosuppressive activity of CD11b+Gr1+ cells
    Sergey Ryzhov
    Division of Cardiovascular Medicine, Vanderbilt University, Nashville, TN 37232 6300, USA
    J Immunol 187:6120-9. 2011
    ..We propose that generation of adenosine by CD73 expressed at high levels on granulocytic MDSCs may promote their expansion and facilitate their immunosuppressive activity...
  25. pmc Role of A2B adenosine receptors in regulation of paracrine functions of stem cell antigen 1-positive cardiac stromal cells
    Sergey Ryzhov
    Division of Cardiovascular Medicine, and Department of Medicine, Vanderbilt University Medical School, Nashville, Tennessee 37232, USA
    J Pharmacol Exp Ther 341:764-74. 2012
    ..Thus, our study identified A(2B) adenosine receptors on cardiac stromal cells as potential targets for up-regulation of proangiogenic factors in the ischemic heart...
  26. pmc Altered systemic hemodynamic and baroreflex response to angiotensin II in postural tachycardia syndrome
    Hossam I Mustafa
    Division of Clinical Pharmacology, Vanderbilt University School of Medicine, Nashville, TN 37232 2195, USA
    Circ Arrhythm Electrophysiol 5:173-80. 2012
    ..In this study, we assess systemic and renal hemodynamic and functional responses to Ang II infusion in patients with POTS compared with healthy controls...
  27. pmc Propranolol decreases tachycardia and improves symptoms in the postural tachycardia syndrome: less is more
    Satish R Raj
    Departments of Medicine, Division of Clinical Pharmacology, Autonomic Dysfunction Center, Vanderbilt University, Nashville, Tenn 37232 2195, USA
    Circulation 120:725-34. 2009
    ..We tested the hypothesis that propranolol will attenuate the tachycardia and improve symptom burden in patients with POTS. In protocol 1, a low dose (20 mg) was compared with placebo, and the dose response was assessed in protocol 2...
  28. pmc Adenosine receptor-mediated adhesion of endothelial progenitors to cardiac microvascular endothelial cells
    Sergey Ryzhov
    Department of Medicine, Vanderbilt University, Nashville, Tenn, USA
    Circ Res 102:356-63. 2008
    ..Our results suggest a role for adenosine in vasculogenesis and its potential use to stimulate engraftment in cell-based therapies...
  29. ncbi request reprint Acetylcholinesterase inhibition improves tachycardia in postural tachycardia syndrome
    Satish R Raj
    Autonomic Dysfunction Center, Division of Clinical Pharmacology, Department of Medicine, Vanderbilt University, 1161 21st Ave South, Nashville, TN 37232 2195, USA
    Circulation 111:2734-40. 2005
    ..The objective of this study was to test the hypothesis that acetylcholinesterase inhibitors will attenuate the tachycardia and improve symptom burden in patients with POTS...
  30. pmc Effects of norepinephrine reuptake inhibition on postural tachycardia syndrome
    Elizabeth A Green
    Autonomic Dysfunction Center, Division of Clinical Pharmacology, Department of Medicine, Vanderbilt University, Nashville, TN
    J Am Heart Assoc 2:e000395. 2013
    ..We sought to determine whether NRI with atomoxetine increases standing tachycardia or worsens the symptom burden in POTS patients...
  31. pmc Desmopressin acutely decreases tachycardia and improves symptoms in the postural tachycardia syndrome
    Samuel T Coffin
    Autonomic Dysfunction Center, Division of Clinical Pharmacology, Department of Medicine, Vanderbilt University, Nashville, Tennessee, USA
    Heart Rhythm 9:1484-90. 2012
    ..Increasing blood volume is a promising approach to this problem...
  32. ncbi request reprint Cross-talk between G(s)- and G(q)-coupled pathways in regulation of interleukin-4 by A(2B) adenosine receptors in human mast cells
    Sergey Ryzhov
    Divisions of Cardiovascular Medicine, Vanderbilt University, Nashville, TN 37232 6300, USA
    Mol Pharmacol 70:727-35. 2006
    ..Both forskolin and stimulation of A(2B) receptors up-regulated NFATc1 protein levels. We conclude that A(2B) receptors up-regulate IL-4 through G(q) signaling that is potentiated via cross-talk with G(s)-coupled pathways...
  33. ncbi request reprint Sodium paradoxically reduces the gastropressor response in patients with orthostatic hypotension
    Satish R Raj
    Autonomic Dysfunction Center, Division of Clinical Pharmacology, Department of Medicine, Vanderbilt University, Nashville, TN, USA
    Hypertension 48:329-34. 2006
    ..These data suggest a potentially important role for gastrointestinal osmolality in the activation of the sympathetic nervous system leading to cardiovascular reflexes responsible for the gastropressor response...
  34. ncbi request reprint Endothelial NO synthase polymorphisms and postural tachycardia syndrome
    Emily M Garland
    Autonomic Dysfunction Center, Vanderbilt University, Nashville, TN 37232 2195, USA
    Hypertension 46:1103-10. 2005
    ..These results indicate that NO may influence the development of POTS and the severity of POTS symptoms...
  35. pmc A simplified two-component model of blood pressure fluctuation
    Robert J Brychta
    Autonomic Dysfunction Center, Division of Clinical Pharmacology, Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee 37232 2195, USA
    Am J Physiol Heart Circ Physiol 292:H1193-203. 2007
    ..We report a simple two-component model using neural sympathetic and mechanical respiratory inputs that can explain the majority of blood pressure fluctuation at rest and during orthostatic stress in healthy subjects...
  36. ncbi request reprint Water potentiates the pressor effect of ephedra alkaloids
    Jens Jordan
    Department of Medicine and Pharmacology, Vanderbilt University, Nashville, Tenn 37212, USA
    Circulation 109:1823-5. 2004
    ..We therefore investigated the effects of ephedra alkaloids in patients with autonomic impairment and explored their potential interaction with water ingestion...
  37. pmc Long-term treatment with rituximab of autoimmune autonomic ganglionopathy in a patient with lymphoma
    Ryan Hollenbeck
    MsCI, Autonomic Dysfunction Center, Division of Clinical Pharmacology, Department of Medicine, Vanderbilt University School of Medicine, AA3228 Medical Center North, 1161 21st Ave S, Nashville, TN 37232 2195, USA
    Arch Neurol 68:372-5. 2011
    ..To report on the response to therapy in a patient with autoimmune autonomic ganglionopathy with a high titer of an autoantibody directed against the α-3 subunit of the nicotinic acetylcholine receptor (nAChR) of the autonomic ganglia...
  38. ncbi request reprint Modulation of QT interval during autonomic nervous system blockade in humans
    Andre Diedrich
    Autonomic Dysfunction Center, Vanderbilt University, Nashville, Tenn 37232 2195, USA
    Circulation 106:2238-43. 2002
    ..We used the alternative approach of interrupting neurotransmission at the level of autonomic ganglia to determine its effect on the QT interval...
  39. pmc Low-dose propranolol and exercise capacity in postural tachycardia syndrome: a randomized study
    Amy C Arnold
    Department of Medicine, Division of Clinical Pharmacology, Vanderbilt University, Nashville, TN, USA
    Neurology 80:1927-33. 2013
    ..To determine the effect of low-dose propranolol on maximal exercise capacity in patients with postural tachycardia syndrome (POTS)...
  40. pmc Diagnosing postural tachycardia syndrome: comparison of tilt testing compared with standing haemodynamics
    Walker B Plash
    Autonomic Dysfunction Center, Vanderbilt University School of Medicine, Nashville, TN 37232 2195, USA
    Clin Sci (Lond) 124:109-14. 2013
    ..The 30 bpm ΔHR criterion is not suitable for 30 min tilt. Diagnosis of POTS should consider orthostatic intolerance criteria and not be based solely on orthostatic tachycardia regardless of test used...
  41. doi request reprint PRNP M129V homozygosity in multiple system atrophy vs. Parkinson's disease
    Cyndya Shibao
    Autonomic Dysfunction Center, Vanderbilt University, Nashville, TN 37232, USA
    Clin Auton Res 18:13-9. 2008
    ..Considering the possibility that the prion protein contributes to the pathogenesis of MSA would require confirmation of these findings in an independent patient population...
  42. ncbi request reprint Management of hypertension in the setting of autonomic failure: a pathophysiological approach
    Cyndya Shibao
    Division of Clinical Pharmacology, Department of Medicine and Pharmacology, and the Autonomic Dysfunction Center, Vanderbilt University School of Medicine, Nashville, Tenn 37212, USA
    Hypertension 45:469-76. 2005
    ..Understanding of the underlying mechanisms of disorders of the autonomic nervous system is fundamental for an effective management of these patients and provides insight into more common disorders such as essential hypertension...
  43. doi request reprint Acute hemodynamic effects of a selective serotonin reuptake inhibitor in postural tachycardia syndrome: A randomized, crossover trial
    Philip L Mar
    1Autonomic Dysfunction Center, Department of Medicine, Vanderbilt University, Nashville, USA
    J Psychopharmacol 28:155-61. 2014
    ..At 4 h, symptoms were worse with sertraline than placebo. Conclusions: Sertraline had a modest pressor effect in POTS patients, but this did not translate into a reduced heart rate or improved symptoms. ..
  44. ncbi request reprint Hyperadrenergic postural tachycardia syndrome in mast cell activation disorders
    Cyndya Shibao
    Division of Clinical Pharmacology, Department of Medicine and Pharmacology, and the Autonomic Dysfunction Center, Vanderbilt University School of Medicine, Nashville, Tenn 37212, USA
    Hypertension 45:385-90. 2005
    ..These patients often present with a typical hyperadrenergic response, but beta-blockers should be used with great caution, if at all, and treatment directed against mast cell mediators may be required...
  45. pmc Comparative efficacy of yohimbine against pyridostigmine for the treatment of orthostatic hypotension in autonomic failure
    Cyndya Shibao
    Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tenn, USA
    Hypertension 56:847-51. 2010
    ..Engaging residual sympathetic tone with yohimbine is a more effective approach to improve orthostatic hypotension as compared with pyridostigmine in patients with severe orthostatic hypotension...
  46. ncbi request reprint Hypoxia modulates adenosine receptors in human endothelial and smooth muscle cells toward an A2B angiogenic phenotype
    Igor Feoktistov
    Division of Cardiovascular Medicine, Vanderbilt University, Nashville, TN 37232 6300, USA
    Hypertension 44:649-54. 2004
    ..In conclusion, hypoxia modulates the expression of adenosine receptors in human endothelial and smooth muscle cells toward an A2B"angiogenic" phenotype...
  47. ncbi request reprint Role of adenosine receptors in the regulation of angiogenic factors and neovascularization in hypoxia
    Sergey Ryzhov
    Department of Medicine, Vanderbilt University, Nashville, TN 37232 6300, USA
    J Pharmacol Exp Ther 320:565-72. 2007
    ..Thus, adenosine receptors represent a potential therapeutic target for regulation of neovascularization...
  48. ncbi request reprint Effect of A2B adenosine receptor gene ablation on adenosine-dependent regulation of proinflammatory cytokines
    Sergey Ryzhov
    Divisions of Cardiovascular Medicine, Vanderbilt University, Nashville, Tennessee, USA
    J Pharmacol Exp Ther 324:694-700. 2008
    ....
  49. pmc Distal sudomotor findings in postural tachycardia syndrome
    Amanda Catherine Peltier
    Autonomic Dysfunction Center, Vanderbilt University School of Medicine, Nashville, USA
    Clin Auton Res 20:93-9. 2010
    ..Norepinephrine levels above 600 pg/ml have also been used to delineate patients with a hyperadrenergic state. This study aims to determine the relationship of sudomotor abnormalities to other aspects of dysautonomia in POTS...
  50. ncbi request reprint Four faces of baroreflex failure: hypertensive crisis, volatile hypertension, orthostatic tachycardia, and malignant vagotonia
    Terry Ketch
    Autonomic Dysfunction Center, Vanderbilt University, Nashville, TN 37232 2195, USA
    Circulation 105:2518-23. 2002
    ..Such excursions may derive from endogenous factors such as stress or drowsiness, which result in quite high and quite low pressures, respectively. They may also derive from exogenous factors such as drugs or environmental influences...
  51. pmc Estimation of sleep disturbances using wrist actigraphy in patients with postural tachycardia syndrome
    Kanika Bagai
    Autonomic Dysfunction Center, Vanderbilt University School of Medicine, Nashville, TN, USA Department of Neurology, Vanderbilt University School of Medicine, Nashville, TN, USA
    Auton Neurosci 177:260-5. 2013
    ..Patients with postural tachycardia syndrome (POTS) commonly complain of fatigue, unrefreshing sleep, daytime sleepiness and diminished quality of life. The study objective was to assess sleep quality in POTS patients using wrist actigraphy...
  52. pmc Role of JunB in Adenosine A2B Receptor-Mediated Vascular Endothelial Growth Factor Production
    Sergey Ryzhov
    Divisions of Cardiovascular Medicine S R, Q Z, I F and Clinical Pharmacology A E G, I B, and Departments of Cancer Biology A B, M M D, Medicine S R, A E G, Q Z, I B, I F, and Pharmacology I B, I F, Vanderbilt University, Nashville, Tennessee
    Mol Pharmacol 85:62-73. 2014
    ..Thus, our data suggest an important role of the A2B receptor-dependent upregulation of JunB in VEGF production and possibly other AP-1-regulated events. ..
  53. pmc Dysautonomia: perioperative implications
    Hossam I Mustafa
    Autonomic Dysfunction Center, Division of Clinical Pharmacology, Department of Medicine, Autonomic Rare Disease Clinical Research Consortium, Vanderbilt University Medical Center, Nashville, Tennessee 37232 2195, USA
    Anesthesiology 116:205-15. 2012
    ....
  54. doi request reprint Coexistent autoimmune autonomic ganglionopathy and myasthenia gravis associated with non-small-cell lung cancer
    Amanda C Peltier
    Department of Neurology, Vanderbilt University School of Medicine, A 0118 Medical Center North, Nashville, Tennessee 37232, USA
    Muscle Nerve 41:416-9. 2010
    ....
  55. ncbi request reprint Water drinking as a treatment for orthostatic syndromes
    John R Shannon
    Nathan Blaser Shy Drager Research Program, Autonomic Dysfunction Center, Vanderbilt University, Nashville, Tennessee, USA
    Am J Med 112:355-60. 2002
    ..We tested the hypothesis that water drinking can be used as a practical treatment for patients with orthostatic and postprandial hypotension, as well as those with orthostatic tachycardia...
  56. pmc Management approaches to hypertension in autonomic failure
    Amy C Arnold
    Division of Clinical Pharmacology, Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee 37232 6602, USA
    Curr Opin Nephrol Hypertens 21:481-5. 2012
    ..This review focuses on nonpharmacologic and pharmacologic approaches to manage hypertension in these patients in the face of disabling orthostatic hypotension...
  57. ncbi request reprint Renin-aldosterone paradox and perturbed blood volume regulation underlying postural tachycardia syndrome
    Satish R Raj
    Division of Clinical Pharmacology, Vanderbilt University, Nashville, Tenn 37232 2195, USA
    Circulation 111:1574-82. 2005
    ..We prospectively tested the hypothesis that patients with POTS are hypovolemic compared with healthy controls and explored the role of plasma renin activity and aldosterone in the regulation of plasma volume...
  58. pmc Differential role of the carboxy-terminus of the A(2B) adenosine receptor in stimulation of adenylate cyclase, phospholipase Cbeta, and interleukin-8
    Sergey Ryzhov
    Division of Cardiovascular Medicine, Department of Medicine, Vanderbilt University, Nashville, USA
    Purinergic Signal 5:289-98. 2009
    ....
  59. ncbi request reprint Blockade of nucleoside transport is required for delivery of intraarterial adenosine into the interstitium: relevance to therapeutic preconditioning in humans
    Alfredo Gamboa
    Department of Medicine, Vanderbilt University, Nashville, Tenn 37212, USA
    Circulation 108:2631-5. 2003
    ....
  60. pmc Abnormalities of angiotensin regulation in postural tachycardia syndrome
    Hossam I Mustafa
    Division of Clinical Pharmacology, Vanderbilt University School of Medicine, Nashville, Tennessee 37232 2195, USA
    Heart Rhythm 8:422-8. 2011
    ..In this study, we sought to more fully characterize the renin-angiotensin-aldosterone system (RAAS) to gain a better understanding of the pathophysiology of POTS...
  61. ncbi request reprint Should we target the sympathetic nervous system in the treatment of obesity-associated hypertension?
    Italo Biaggioni
    Department of Medicine, Vanderbilt University, Nashville, TN 37232, USA
    Hypertension 51:168-71. 2008
  62. pmc Pharmacotherapy of autonomic failure
    Cyndya Shibao
    Department of Medicine, Division of Clinical Pharmacology and the Autonomic Dysfunction Center, Vanderbilt University School of Medicine, Nashville, TN 37212, USA
    Pharmacol Ther 134:279-86. 2012
    ..It is preferable to use short-acting pressor agents that can be taken on as needed basis in preparation for upright activities...
  63. ncbi request reprint The sympathetic nervous system and blood volume regulation: lessons from autonomic failure patients
    Italo Biaggioni
    Department of Medicine, Division of Clinical Pharmacology, and Autonomic Dysfunction Center, Vanderbilt University School of Medicine, Nashville, Tennessee 37212, USA
    Am J Med Sci 334:61-4. 2007
    ..Thus, in both these conditions the feedback mechanisms involving the sympathetic nervous system and volume homeostasis are impaired...
  64. pmc Autonomic/metabolic interactions modulating the exercise pressor reflex: the purinergic hypothesis
    Italo Biaggioni
    Department of Medicine, Division of Clinical Pharmacology, and the Autonomic Dysfunction Center, Vanderbilt University School of Medicine, Nashville, TN 37232 2195, USA
    J Physiol 578:5-6. 2007
  65. ncbi request reprint Orthostatic hypotension-related hospitalizations in the United States
    Cyndya Shibao
    Department of Medicine, Division of Clinical Pharmacology, Vanderbilt University, Nashville, Tenn 37212, USA
    Am J Med 120:975-80. 2007
    ..Nevertheless, the precise burden of this condition in the US is currently unknown...
  66. pmc Sleep disturbances and diminished quality of life in postural tachycardia syndrome
    Kanika Bagai
    Paden Dysautonomia Center and Department of Neurology, Vanderbilt University, Nashville, TN, USA
    J Clin Sleep Med 7:204-10. 2011
    ..This study's objective was to assess the sleep quality and health-related quality of life in patients with POTS as compared with healthy control subjects...
  67. ncbi request reprint Differential expression of adenosine receptors in human endothelial cells: role of A2B receptors in angiogenic factor regulation
    Igor Feoktistov
    Division of Cardiology, Vanderbilt University, Nashville, Tenn 37232 6300, USA
    Circ Res 90:531-8. 2002
    ..A2B receptors, predominantly expressed in human microvascular cells, modulate expression of angiogenic factors via coupling to G(q), and possibly via G12/13...
  68. ncbi request reprint Mast cell-mediated stimulation of angiogenesis: cooperative interaction between A2B and A3 adenosine receptors
    Igor Feoktistov
    Division of Cardiovascular Medicine, Vanderbilt University, Nashville, Tenn 37232 6300, USA
    Circ Res 92:485-92. 2003
    ..Thus, adenosine A2B and A3 receptors act in a functional cooperative fashion to promote angiogenesis by a paracrine mechanism involving the differential expression and secretion of angiogenic factors from human mast cells...
  69. ncbi request reprint Can we diagnose, treat or even understand neurally mediated syncope?
    Satish R Raj
    Division of Clinical Pharmacology, Department of Medicine, Vanderbilt University School of Medicine, Nashville TN 37212, USA
    Clin Sci (Lond) 109:161-3. 2005
    ..However, validation studies applied to an unselected patient population are needed before we can judge how useful this test will be in the diagnosis of NMS...
  70. pmc Role of adenosine A(2B) receptors in inflammation
    Igor Feoktistov
    Department of Medicine, Vanderbilt University, Division of Cardiovascular Medicine, Nashville, Tennessee, USA
    Adv Pharmacol 61:115-44. 2011
    ....
  71. ncbi request reprint Adenosine-activated mast cells induce IgE synthesis by B lymphocytes: an A2B-mediated process involving Th2 cytokines IL-4 and IL-13 with implications for asthma
    Sergey Ryzhov
    Division of Clinical Pharmacology, Department of Pharmacology, Vanderbilt University, 1500 21st Avenue South, Nashville, TN 37232, USA
    J Immunol 172:7726-33. 2004
    ....
  72. pmc Clinical and translational research studios: a multidisciplinary internal support program
    Daniel W Byrne
    Department of Biostatistics, Vanderbilt University School of Medicine, Nashville, TN 37232 2158, USA
    Acad Med 87:1052-9. 2012
    ..Investigators have indicated that their Studios have improved the quality of their science (99%; 121/122 responses), and experts have reported that the Studios have been a valuable use of their time (98%; 398/406 responses)...
  73. ncbi request reprint Sympathetic control of the circulation in hypertension: lessons from autonomic disorders
    Italo Biaggioni
    Department of Medicine and Pharmacology, Division of Clinical Pharmacology, Vanderbilt University, Nashville, Tennessee 37212, USA
    Curr Opin Nephrol Hypertens 12:175-80. 2003
    ..The present review summarizes the recent advances that have been made in our understanding of the role of the sympathetic nervous system in hypertension...
  74. pmc Human muscle sympathetic nerve activity and plasma noradrenaline kinetics in space
    Andrew C Ertl
    Vanderbilt University Medical Center, Nashville, TN, USA
    J Physiol 538:321-9. 2002
    ..Therefore, notwithstanding hypovolaemia, astronauts respond normally to simulated orthostatic stress and are able to maintain their arterial pressures at normal levels...
  75. ncbi request reprint Clinical and molecular pharmacologic characteristics of adenosine-induced vasodilation
    Italo Biaggioni
    Departments of Medicine and Pharmacology, Division of Clinical Pharmacology, Clinical Trials Center, Vanderbilt University, 1500 21st Avenue S, Suite 3500, Nashville, TN 37212, USA
    Clin Pharmacol Ther 75:137-9. 2004
  76. ncbi request reprint Adenosine receptor, protein kinase G, and p38 mitogen-activated protein kinase-dependent up-regulation of serotonin transporters involves both transporter trafficking and activation
    Chong Bin Zhu
    Department of Psychiatry, Vanderbilt School of Medicine, Nashville, Tennessee 37232 8548, USA
    Mol Pharmacol 65:1462-74. 2004
    ..Together, these results reveal two PKG-dependent pathways supporting rapid SERT regulation by A3 ARs, one leading to enhanced SERT surface trafficking, and a separate, p38 MAPK-dependent process augmenting SERT intrinsic activity...
  77. ncbi request reprint Bradykinin and its metabolite bradykinin 1-5 inhibit thrombin-induced platelet aggregation in humans
    Laine J Murphey
    Department of Medicine and Pharmacology, Vanderbilt University, Nashville, TN 37232 6602, USA
    J Pharmacol Exp Ther 318:1287-92. 2006
    ..By inhibiting thrombin-induced platelet aggregation without causing vasodilation, bradykinin 1-5 may provide a model for small molecule substrate-selective thrombin inhibitors...
  78. pmc Clinical research subject recruitment: the Volunteer for Vanderbilt Research Program www.volunteer.mc.vanderbilt.edu
    Paul A Harris
    General Clinical Research Center, Vanderbilt University, Nashville, TN 37212, USA
    J Am Med Inform Assoc 12:608-13. 2005
    ....
  79. ncbi request reprint Neurovascular dissociation with paradoxical forearm vasodilation during systemic tyramine administration
    Giris Jacob
    Jacob Recanati Autonomic Dysfunction Center, Department of Internal Medicine C, Rambam Medical Center, Haifa, Israel
    Circulation 107:2475-9. 2003
    ..To test this hypothesis, we determined the effects of intravenous tyramine on local forearm norepinephrine spillover and vascular resistance...
  80. ncbi request reprint Baroreflex buffering and susceptibility to vasoactive drugs
    Jens Jordan
    Franz Volhard Clinical Research Center and HELIOS Klinikum, Medical Faculty of the Charite, Humboldt University, Berlin, Germany
    Circulation 105:1459-64. 2002
    ..Differences in baroreflex function affect the responsiveness to vasoactive medications, particularly baroreflex buffering of blood pressure; however, the magnitude is not known...
  81. ncbi request reprint Artificial gravity: a possible countermeasure for post-flight orthostatic intolerance
    Steven T Moore
    Department of Neurology, Mount Sinai School of Medicine, New York, NY 10029, USA
    Acta Astronaut 56:867-76. 2005
    ..More data is necessary to evaluate this hypothesis, but if it were proven correct, in-flight short-radius centrifugation may help counteract orthostatic intolerance after space flight...
  82. ncbi request reprint Tyramine-induced vasodilation mediated by dopamine contamination: a paradox resolved
    Giris Jacob
    Jacob Recanati Autonomic Dysfunction Center, Department of Internal Medicine C, Rambam Medical Center, Haifa, Israel
    Hypertension 46:355-9. 2005
    ..The possibility of dopamine contamination needs to be considered when interpreting previously published studies using tyramine as a pharmacological tool to assess sympathetic function, and it must be avoided in future studies...
  83. ncbi request reprint Selective norepinephrine reuptake inhibition as a human model of orthostatic intolerance
    Christoph Schroeder
    Clinical Research Center, Helios Klinkum Berlin, Germany
    Circulation 105:347-53. 2002
    ..Observations in patients with functional mutations of the norepinephrine transporter (NET) gene suggest that impaired norepinephrine uptake may contribute to idiopathic orthostatic intolerance...
  84. pmc Human muscle sympathetic neural and haemodynamic responses to tilt following spaceflight
    Benjamin D Levine
    Institute for Exercise and Environmental Medicine, Presbyterian Hospital of Dallas and the University of Texas Southwestern Medical Center at Dallas, Dallas, TX 75231, USA
    J Physiol 538:331-40. 2002
    ..We conclude that after 16 days of spaceflight, muscle sympathetic nerve responses to upright tilt are normal...
  85. ncbi request reprint Beta2-adrenoceptor genotype and function affect hemodynamic profile heterogeneity in postural tachycardia syndrome
    Giris Jacob
    J Recanati Autonomic Dysfunction Center, Department of Internal Medicine A, Rambam Medical Center and Technion IIT, Haifa, Israel
    Hypertension 47:421-7. 2006
    ..Therefore, both decreased beta2-adrenoceptor-related vasodilation and beta2-AR polymorphisms may contribute to the hemodynamic diversity of patients with POTS...
  86. pmc Influence of microgravity on astronauts' sympathetic and vagal responses to Valsalva's manoeuvre
    James F Cox
    Department of Medicine and Physiology, Hunter Holmes McGuire Veterans Affairs Medical Center and Medical College of Virginia at Virginia Commonwealth University, Richmond, Virginia, USA 23249
    J Physiol 538:309-20. 2002
    ..This and earlier research suggest that exposure of healthy humans to microgravity augments arterial pressure and sympathetic responses to Valsalva straining and differentially reduces vagal, but not sympathetic baroreflex gain...
  87. ncbi request reprint Tachycardia caused by A2A adenosine receptor agonists is mediated by direct sympathoexcitation in awake rats
    Arvinder K Dhalla
    Department of Pharmacology, CV Therapeutics, Palo Alto, CA 94304, USA
    J Pharmacol Exp Ther 316:695-702. 2006
    ....
  88. pmc Human cerebral autoregulation before, during and after spaceflight
    Ken Ichi Iwasaki
    Institute for Exercise and Environmental Medicine, 7232 Greenville Avenue, Suite 435, Dallas, TX 75231, USA
    J Physiol 579:799-810. 2007
    ..We conclude that human cerebral autoregulation is preserved, and possibly even improved, by short-duration spaceflight...
  89. ncbi request reprint Diagnosis and treatment of supine hypertension in autonomic failure patients with orthostatic hypotension
    Jens Jordan
    Hypotension and Syncope Unit, Clinical Research Center, Franz Volhard Clinic, Medical Faculty of the Charite, Humboldt University, Berlin, Germany
    J Clin Hypertens (Greenwich) 4:139-45. 2002
    ..During the day, avoiding the supine position is often all that is required. Short-acting vasodilators (e.g., transdermal nitroglycerin) can be used during the night...
  90. ncbi request reprint Spectrum of autonomic cardiovascular neuropathy in diabetes
    Giris Jacob
    J Recanati Autonomic Dysfunction Center, Rambam Medical Center, Haifa, Israel
    Diabetes Care 26:2174-80. 2003
    ..Although the latter is related to overt autonomic neuropathy, the former is proposed to be explained by appropriate autonomic responses. We hypothesize, however, that both conditions are part of a spectrum of autonomic dysfunction...
  91. ncbi request reprint The A2A receptor mediates an endogenous regulatory pathway of cytokine expression in THP-1 cells
    Khaled Bshesh
    Division of Critical Care Medicine, Children s Hospital Medical Center, Cincinnati, Ohio 45229 3039, USA
    J Leukoc Biol 72:1027-36. 2002
    ..Thus, following immune activation with LPS, endogenous adenosine mediates a negative feedback pathway to modulate cytokine expression in THP-1 cells...
  92. ncbi request reprint Adenosine and the exercise pressor reflex: a controversy resolved?
    Italo Biaggioni
    Clin Auton Res 13:7-9. 2003
  93. ncbi request reprint Variations in the dopamine beta-hydroxylase gene are not associated with the autonomic disorders, pure autonomic failure, or multiple system atrophy
    Sonhae Cho
    Molecular Neurobiology Laboratory, McLean Hospital, Harvard Medical School, Belmont, Massachusetts 02478, USA
    Am J Med Genet A 120:234-6. 2003
    ..In addition, no DBH mutation was found that distinguished autonomic disease patients from controls, suggesting that genetic variants of the DBH gene are not associated with the autonomic diseases OI, PAF, and MSA...
  94. pmc Circadian clocks, autonomic rhythms, and blood pressure dipping
    Italo Biaggioni
    Hypertension 52:797-8. 2008
  95. ncbi request reprint Phenotypical evidence for a gender difference in cardiac norepinephrine transporter function
    Christoph Schroeder
    Franz Volhard Clinical Research Center, Haus 129, Medical Faculty of the Charité Campus Buch, Wiltbergstrasse 50, 13125 Berlin, Germany
    Am J Physiol Regul Integr Comp Physiol 286:R851-6. 2004
    ..Our observations suggest that the NET contribution to cardiac norepinephrine turnover may be decreased in women. The gender difference in NET function may not be expressed in tissues that are less NET dependent than the heart...
  96. ncbi request reprint Paradoxical effect of sibutramine on autonomic cardiovascular regulation
    Andreas L Birkenfeld
    Franz Volhard Clinical Research Center, Medical Faculty of the Charite, Humboldt University, Berlin, Germany
    Circulation 106:2459-65. 2002
    ..Norepinephrine reuptake inhibition with sibutramine conceivably could exacerbate arterial hypertension and promote cardiovascular disease...
  97. ncbi request reprint Norepinephrine transporter function and autonomic control of metabolism
    Michael Boschmann
    German Institute of Human Nutrition, 14558 Potsdam, Germany
    J Clin Endocrinol Metab 87:5130-7. 2002
    ..This effect cannot be explained by increased systemic or adipose tissue norepinephrine concentrations. Instead, NET inhibition may sensitize adipose tissue to beta-adrenergic stimulation...
  98. ncbi request reprint Influence of an insertion variant in the 5'UTR of the endothelin-1 gene on orthostatic intolerance
    Robert Winker
    Division of Occupational Medicine, Medical University of Vienna, Vienna, Austria
    Am J Med Sci 330:166-71. 2005
    ..The aim of this study was therefore to ascertain whether this frequent variant of the endothelin-1 gene influences the risk for orthostatic intolerance...
  99. ncbi request reprint Electrical activation of the human vestibulo-sympathetic reflex
    Andrei Voustianiouk
    Mount Sinai School of Medicine, New York, NY, USA
    Exp Brain Res 171:251-61. 2006
    ....
  100. ncbi request reprint AHA/ACCF scientific statement on the evaluation of syncope: from the American Heart Association Councils on Clinical Cardiology, Cardiovascular Nursing, Cardiovascular Disease in the Young, and Stroke, and the Quality of Care and Outcomes Research Interdi
    S Adam Strickberger
    J Am Coll Cardiol 47:473-84. 2006
  101. pmc Cardiovascular and sympathetic neural responses to handgrip and cold pressor stimuli in humans before, during and after spaceflight
    Qi Fu
    Institute for Exercise and Environmental Medicine, Presbyterian Hospital of Dallas, 7232 Greenville Avenue, Suite 435, Dallas, TX 75231, USA
    J Physiol 544:653-64. 2002
    ..We conclude that modulation of muscle sympathetic neural outflow by muscle metaboreceptors and skin nociceptors is preserved during short duration spaceflight...