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Genomes and Genes | Italo BiaggioniSummaryAffiliation: Vanderbilt University Country: USA Publications
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Publications
Vestibular influences on autonomic cardiovascular control in humansI Biaggioni
Department of Medicine, Vanderbilt University, Nashville TN 37232 2135, USA
J Vestib Res 8:35-41. 1998..Several factors may explain the apparent discordance of these results, but more research is needed before we can define the potential importance of vestibular input to cardiovascular regulation and orthostatic tolerance in humans...- Hypertension in orthostatic hypotension and autonomic dysfunctionItalo Biaggioni
Departments of Medicine and Pharmacology, Division of Clinical Pharmacology, 1500 21st Avenue South, Suite 3500, Vanderbilt University, Nashville, TN 37212, USA
Cardiol Clin 20:291-301, vii. 2002..Supine hypertension complicates the treatment of these patients but can be managed by overnight administration of antihypertensive medications... 
Sympathetic activation and nitric oxide function in early hypertensionAlfredo Gamboa
Department of Medicine, Division of Clinical Pharmacology, Vanderbilt University, Nashville, Tennessee, USA
Am J Physiol Heart Circ Physiol 302:H1438-43. 2012..If NO deficiency contributes to hypertension, it is likely to be through its modulation of the autonomic nervous system, which was excluded in this study...- Excessive nitric oxide function and blood pressure regulation in patients with autonomic failureAlfredo Gamboa
Department of Medicine, Vanderbilt University, Nashville, Tenn 37212, USA
Hypertension 51:1531-6. 2008..Potentiation of NO could be used in the treatment of supine hypertension, and its inhibition offers a novel approach to improve orthostatic hypotension... - Renal impairment of pure autonomic failureEmily M Garland
Autonomic Dysfunction Center, Vanderbilt University, Nashville, TN 37232 2195, USA
Hypertension 54:1057-61. 2009..73 m2; P=0.022) compared with patients who did not have supine hypertension. These findings may indicate that renal function is diminished in PAF in association with supine hypertension... - Clonidine for the treatment of supine hypertension and pressure natriuresis in autonomic failureCyndya Shibao
Division of Clinical Pharmacology, Department of Medicine and Pharmacology, The Autonomic Dysfunction Center, Vanderbilt University School of Medicine, Nashville, TN, USA
Hypertension 47:522-6. 2006..66; P=0.043). These results are consistent with residual sympathetic tone contributing to supine hypertension in autonomic failure, which can be targeted with clonidine to decrease BP and nocturnal natriuresis... - Autonomic contribution to blood pressure and metabolism in obesityCyndya Shibao
Division of Clinical Pharmacology and the Autonomic Dysfunction Center, Vanderbilt University School of Medicine, Nashville, TN 37212, USA
Hypertension 49:27-33. 2007..These results suggest that the sympathetic nervous system could be targeted in the treatment of obesity-associated hypertension... - Effect of A2B adenosine receptor gene ablation on proinflammatory adenosine signaling in mast cellsSergey Ryzhov
Division of Cardiovascular Medicine, Department of Medicine, Vanderbilt University, Nashville, TN 37232, USA
J Immunol 180:7212-20. 2008..Thus, our study confirmed the proinflammatory role of adenosine signaling via A(2B) receptors and the anti-inflammatory actions of A(2B) antagonists in mouse BMMCs... 
Nitric oxide and regulation of heart rate in patients with postural tachycardia syndrome and healthy subjectsAlfredo Gamboa
Division of Clinical Pharmacology, Vanderbilt University, Nashville, TN, USA
Hypertension 61:376-81. 2013..We found no evidence of a primary alteration in NO function in POTS. If NO dysfunction plays a role in POTS, it is through its interaction with the autonomic nervous system...- Norepinephrine transporter blockade with atomoxetine induces hypertension in patients with impaired autonomic functionCyndya Shibao
Department of Medicine, Division of Clinical Pharmacology, and the Autonomic Dysfunction Center, Vanderbilt University School of Medicine, Nashville, TN 37212, USA
Hypertension 50:47-53. 2007..Caution should be exercised when this medication is used in patients with milder form of autonomic impairment... - Acarbose, an alpha-glucosidase inhibitor, attenuates postprandial hypotension in autonomic failureCyndya Shibao
Department of Medicine, Division of Clinical Pharmacology and the Autonomic Dysfunction Center, Vanderbilt University School of Medicine, Nashville, TN 37212, USA
Hypertension 50:54-61. 2007..In conclusion, 100 mg of acarbose successfully improved postprandial hypotension in patients with severe autonomic failure. This effect is not explained solely by a reduction in insulin levels... - Nocturnal blood pressure dipping in the hypertension of autonomic failureLuis E Okamoto
Division of Clinical Pharmacology and Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN, USA
Hypertension 53:363-9. 2009..Dipping was not associated with increased nocturnal urinary sodium or volume excretion or less severe autonomic failure. Thus, mechanisms independent of autonomic pathways contribute to BP dipping in these patients... - Contribution of endothelial nitric oxide to blood pressure in humansAlfredo Gamboa
Department of Medicine, Vanderbilt University, Nashville, TN 37212, USA
Hypertension 49:170-7. 2007..Our results suggest that eNO is one of the most potent metabolic determinants of BP in humans, tonically restraining it by approximately 30 mm Hg... - The sympathetic nervous system in hypertension: assessment by blood pressure variability and ganglionic blockadeAndre Diedrich
Autonomic Dysfunction Center, Vanderbilt University, Nashville, TN 37232 2195, USA
J Hypertens 21:1677-86. 2003.... - Synergistic effect of norepinephrine transporter blockade and α-2 antagonism on blood pressure in autonomic failureLuis E Okamoto
Vanderbilt Autonomic Dysfunction Center, Division of Clinical Pharmacology, Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN, USA
Hypertension 59:650-6. 2012..Safety studies are required to address the clinical usefulness of this pharmacological approach... - Adenosine receptors in regulation of dendritic cell differentiation and functionSergey V Novitskiy
Division of Hematology Oncology, Vanderbilt University, Nashville, TN 37232, USA
Blood 112:1822-31. 2008..Adenosine signaling through A(2B) receptor is an important factor of aberrant DC differentiation and generation of tolerogenic, angiogenic, and proinflammatory cells... - Host A(2B) adenosine receptors promote carcinoma growthSergey Ryzhov
Division of Cardiovascular Medicine, Vanderbilt University, Nashville, TN 37232, USA
Neoplasia 10:987-95. 2008..Thus, our data suggest that tumor cells promote their growth by exploiting A(2B) adenosine receptor-dependent regulation of VEGF in host immune cells... - Diurnal variability in orthostatic tachycardia: implications for the postural tachycardia syndromeJordan A Brewster
Division of Clinical Pharmacology, Vanderbilt University School of Medicine, AA3228 Medical Center North, 1161 21st Avenue South, Nashville, TN 37232 2195, USA
Clin Sci (Lond) 122:25-31. 2012..Given the importance of orthostatic tachycardia in diagnosing POTS, this diurnal variability should be considered in the clinic as it may affect the diagnosis of POTS... - Attenuation of chronic pulmonary inflammation in A2B adenosine receptor knockout miceRinat Zaynagetdinov
Division of Cardiovascular Medicine, Vanderbilt University, Nashville, Tennessee 37232 6300, USA
Am J Respir Cell Mol Biol 42:564-71. 2010..These findings are in agreement with previous pharmacologic studies suggesting a deleterious role for A(2B) receptor signaling in chronic lung inflammation... - Portal osmopressor mechanism linked to transient receptor potential vanilloid 4 and blood pressure controlJulia McHugh
Autonomic Dysfunction Center, Departments of Medicine, Vanderbilt University, Nashville, TN 37232 2195, USA
Hypertension 55:1438-43. 2010..The same volume of physiological saline does not elicit an increase in BP, suggesting osmolality as the stimulus. The osmopressor response to water, and Trpv4 thus represent new factors now implicated in the physiology of BP regulation... - Chronic sympathetic attenuation and energy metabolism in autonomic failureCyndya Shibao
Division of Clinical Pharmacology and Autonomic Dysfunction Center, Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN 37232, USA
Hypertension 59:985-90. 2012..Our findings suggest that sympathetic tonic support of resting energy expenditure is preserved, at least in part, in pathophysiological models of chronic sympathetic attenuation... - Role of adenosine and nitric oxide on the mechanisms of action of dipyridamoleAlfredo Gamboa
Division of Clinical Pharmacology, Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN, USA
Stroke 36:2170-5. 2005..CONCLUSIONS: The effects of dipyridamole on resistance vessels are preferentially explained by potentiation of adenosine mechanisms rather than potentiation of nitric oxide or other cGMP-mediated actions... - Role of A2B adenosine receptors in regulation of paracrine functions of stem cell antigen 1-positive cardiac stromal cellsSergey Ryzhov
Division of Cardiovascular Medicine, and Department of Medicine, Vanderbilt University Medical School, Nashville, Tennessee 37232, USA
J Pharmacol Exp Ther 341:764-74. 2012..Thus, our study identified A(2B) adenosine receptors on cardiac stromal cells as potential targets for up-regulation of proangiogenic factors in the ischemic heart... - Adenosinergic regulation of the expansion and immunosuppressive activity of CD11b+Gr1+ cellsSergey Ryzhov
Division of Cardiovascular Medicine, Vanderbilt University, Nashville, TN 37232 6300, USA
J Immunol 187:6120-9. 2011..We propose that generation of adenosine by CD73 expressed at high levels on granulocytic MDSCs may promote their expansion and facilitate their immunosuppressive activity... - Altered systemic hemodynamic and baroreflex response to angiotensin II in postural tachycardia syndromeHossam I Mustafa
Division of Clinical Pharmacology, Vanderbilt University School of Medicine, Nashville, TN 37232 2195, USA
Circ Arrhythm Electrophysiol 5:173-80. 2012..In this study, we assess systemic and renal hemodynamic and functional responses to Ang II infusion in patients with POTS compared with healthy controls... - Adenosine receptor-mediated adhesion of endothelial progenitors to cardiac microvascular endothelial cellsSergey Ryzhov
Department of Medicine, Vanderbilt University, Nashville, Tenn, USA
Circ Res 102:356-63. 2008..Our results suggest a role for adenosine in vasculogenesis and its potential use to stimulate engraftment in cell-based therapies... - Propranolol decreases tachycardia and improves symptoms in the postural tachycardia syndrome: less is moreSatish R Raj
Departments of Medicine, Division of Clinical Pharmacology, Autonomic Dysfunction Center, Vanderbilt University, Nashville, Tenn 37232 2195, USA
Circulation 120:725-34. 2009..We tested the hypothesis that propranolol will attenuate the tachycardia and improve symptom burden in patients with POTS. In protocol 1, a low dose (20 mg) was compared with placebo, and the dose response was assessed in protocol 2... - Acetylcholinesterase inhibition improves tachycardia in postural tachycardia syndromeSatish R Raj
Autonomic Dysfunction Center, Division of Clinical Pharmacology, Department of Medicine, Vanderbilt University, 1161 21st Ave South, Nashville, TN 37232 2195, USA
Circulation 111:2734-40. 2005..The objective of this study was to test the hypothesis that acetylcholinesterase inhibitors will attenuate the tachycardia and improve symptom burden in patients with POTS... - Desmopressin acutely decreases tachycardia and improves symptoms in the postural tachycardia syndromeSamuel T Coffin
Autonomic Dysfunction Center, Division of Clinical Pharmacology, Department of Medicine, Vanderbilt University, Nashville, Tennessee, USA
Heart Rhythm 9:1484-90. 2012..Increasing blood volume is a promising approach to this problem... - Sodium paradoxically reduces the gastropressor response in patients with orthostatic hypotensionSatish R Raj
Autonomic Dysfunction Center, Division of Clinical Pharmacology, Department of Medicine, Vanderbilt University, Nashville, TN, USA
Hypertension 48:329-34. 2006..These data suggest a potentially important role for gastrointestinal osmolality in the activation of the sympathetic nervous system leading to cardiovascular reflexes responsible for the gastropressor response... - A simplified two-component model of blood pressure fluctuationRobert J Brychta
Autonomic Dysfunction Center, Division of Clinical Pharmacology, Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee 37232 2195, USA
Am J Physiol Heart Circ Physiol 292:H1193-203. 2007..We report a simple two-component model using neural sympathetic and mechanical respiratory inputs that can explain the majority of blood pressure fluctuation at rest and during orthostatic stress in healthy subjects... - Endothelial NO synthase polymorphisms and postural tachycardia syndromeEmily M Garland
Autonomic Dysfunction Center, Vanderbilt University, Nashville, TN 37232 2195, USA
Hypertension 46:1103-10. 2005..These results indicate that NO may influence the development of POTS and the severity of POTS symptoms... - Long-term treatment with rituximab of autoimmune autonomic ganglionopathy in a patient with lymphomaRyan Hollenbeck
MsCI, Autonomic Dysfunction Center, Division of Clinical Pharmacology, Department of Medicine, Vanderbilt University School of Medicine, AA3228 Medical Center North, 1161 21st Ave S, Nashville, TN 37232 2195, USA
Arch Neurol 68:372-5. 2011..To report on the response to therapy in a patient with autoimmune autonomic ganglionopathy with a high titer of an autoantibody directed against the α-3 subunit of the nicotinic acetylcholine receptor (nAChR) of the autonomic ganglia... - Modulation of QT interval during autonomic nervous system blockade in humansAndre Diedrich
Autonomic Dysfunction Center, Vanderbilt University, Nashville, Tenn 37232 2195, USA
Circulation 106:2238-43. 2002..We used the alternative approach of interrupting neurotransmission at the level of autonomic ganglia to determine its effect on the QT interval... - Cross-talk between G(s)- and G(q)-coupled pathways in regulation of interleukin-4 by A(2B) adenosine receptors in human mast cellsSergey Ryzhov
Divisions of Cardiovascular Medicine, Vanderbilt University, Nashville, TN 37232 6300, USA
Mol Pharmacol 70:727-35. 2006..Both forskolin and stimulation of A(2B) receptors up-regulated NFATc1 protein levels. We conclude that A(2B) receptors up-regulate IL-4 through G(q) signaling that is potentiated via cross-talk with G(s)-coupled pathways... - Water potentiates the pressor effect of ephedra alkaloidsJens Jordan
Department of Medicine and Pharmacology, Vanderbilt University, Nashville, Tenn 37212, USA
Circulation 109:1823-5. 2004..On the other hand, it could contribute to the cardiovascular complications associated with the use of ephedra alkaloids, given that baroreflex function varies widely in normal individuals and is impaired in several medical conditions... - Diagnosing postural tachycardia syndrome: comparison of tilt testing compared with standing haemodynamicsWalker B Plash
Autonomic Dysfunction Center, Vanderbilt University School of Medicine, Nashville, TN 37232 2195, USA
Clin Sci (Lond) 124:109-14. 2013..The 30 bpm ΔHR criterion is not suitable for 30 min tilt. Diagnosis of POTS should consider orthostatic intolerance criteria and not be based solely on orthostatic tachycardia regardless of test used... - Management of hypertension in the setting of autonomic failure: a pathophysiological approachCyndya Shibao
Division of Clinical Pharmacology, Department of Medicine and Pharmacology, and the Autonomic Dysfunction Center, Vanderbilt University School of Medicine, Nashville, Tenn 37212, USA
Hypertension 45:469-76. 2005..Understanding of the underlying mechanisms of disorders of the autonomic nervous system is fundamental for an effective management of these patients and provides insight into more common disorders such as essential hypertension... - PRNP M129V homozygosity in multiple system atrophy vs. Parkinson's diseaseCyndya Shibao
Autonomic Dysfunction Center, Vanderbilt University, Nashville, TN 37232, USA
Clin Auton Res 18:13-9. 2008..Considering the possibility that the prion protein contributes to the pathogenesis of MSA would require confirmation of these findings in an independent patient population... - Role of adenosine receptors in the regulation of angiogenic factors and neovascularization in hypoxiaSergey Ryzhov
Department of Medicine, Vanderbilt University, Nashville, TN 37232 6300, USA
J Pharmacol Exp Ther 320:565-72. 2007..Thus, adenosine receptors represent a potential therapeutic target for regulation of neovascularization... - Hypoxia modulates adenosine receptors in human endothelial and smooth muscle cells toward an A2B angiogenic phenotypeIgor Feoktistov
Division of Cardiovascular Medicine, Vanderbilt University, Nashville, TN 37232 6300, USA
Hypertension 44:649-54. 2004..In conclusion, hypoxia modulates the expression of adenosine receptors in human endothelial and smooth muscle cells toward an A2B"angiogenic" phenotype... - Distal sudomotor findings in postural tachycardia syndromeAmanda Catherine Peltier
Autonomic Dysfunction Center, Vanderbilt University School of Medicine, Nashville, USA
Clin Auton Res 20:93-9. 2010..Norepinephrine levels above 600 pg/ml have also been used to delineate patients with a hyperadrenergic state. This study aims to determine the relationship of sudomotor abnormalities to other aspects of dysautonomia in POTS... - Effect of A2B adenosine receptor gene ablation on adenosine-dependent regulation of proinflammatory cytokinesSergey Ryzhov
Divisions of Cardiovascular Medicine, Vanderbilt University, Nashville, Tennessee, USA
J Pharmacol Exp Ther 324:694-700. 2008.... - Comparative efficacy of yohimbine against pyridostigmine for the treatment of orthostatic hypotension in autonomic failureCyndya Shibao
Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tenn, USA
Hypertension 56:847-51. 2010..Engaging residual sympathetic tone with yohimbine is a more effective approach to improve orthostatic hypotension as compared with pyridostigmine in patients with severe orthostatic hypotension... - Angiotensin II, independent of plasma renin activity, contributes to the hypertension of autonomic failureAmy C Arnold
Division of Clinical Pharmacology, Vanderbilt University School of Medicine, Nashville, TN 37232 6602, USA
Hypertension 61:701-6. 2013..Furthermore, these studies suggest that elevations in Ang II contribute to the hypertension of autonomic failure, and provide rationale for the use of AT(1) receptor blockers for treatment of these patients... - Dysautonomia: perioperative implicationsHossam I Mustafa
Autonomic Dysfunction Center, Division of Clinical Pharmacology, Department of Medicine, Autonomic Rare Disease Clinical Research Consortium, Vanderbilt University Medical Center, Nashville, Tennessee 37232 2195, USA
Anesthesiology 116:205-15. 2012.... - Coexistent autoimmune autonomic ganglionopathy and myasthenia gravis associated with non-small-cell lung cancerAmanda C Peltier
Department of Neurology, Vanderbilt University School of Medicine, A 0118 Medical Center North, Nashville, Tennessee 37232, USA
Muscle Nerve 41:416-9. 2010.... - Water drinking as a treatment for orthostatic syndromesJohn R Shannon
Nathan Blaser Shy-Drager Research Program, Autonomic Dysfunction Center, Vanderbilt University, Nashville, Tennessee, USA
Am J Med 112:355-60. 2002..Water drinking moderately reduces orthostatic tachycardia in patients with idiopathic orthostatic intolerance. Thus, water drinking may serve as an adjunctive treatment in patients with impaired orthostatic tolerance... - Management approaches to hypertension in autonomic failureAmy C Arnold
Division of Clinical Pharmacology, Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee 37232 6602, USA
Curr Opin Nephrol Hypertens 21:481-5. 2012..This review focuses on nonpharmacologic and pharmacologic approaches to manage hypertension in these patients in the face of disabling orthostatic hypotension... - Abnormalities of angiotensin regulation in postural tachycardia syndromeHossam I Mustafa
Division of Clinical Pharmacology, Vanderbilt University School of Medicine, Nashville, Tennessee 37232 2195, USA
Heart Rhythm 8:422-8. 2011..In this study, we sought to more fully characterize the renin-angiotensin-aldosterone system (RAAS) to gain a better understanding of the pathophysiology of POTS... - Should we target the sympathetic nervous system in the treatment of obesity-associated hypertension?Italo Biaggioni
Department of Medicine, Vanderbilt University, Nashville, TN 37232, USA
Hypertension 51:168-71. 2008 - Renin-aldosterone paradox and perturbed blood volume regulation underlying postural tachycardia syndromeSatish R Raj
Division of Clinical Pharmacology, Vanderbilt University, Nashville, Tenn 37232 2195, USA
Circulation 111:1574-82. 2005..We prospectively tested the hypothesis that patients with POTS are hypovolemic compared with healthy controls and explored the role of plasma renin activity and aldosterone in the regulation of plasma volume... - Blockade of nucleoside transport is required for delivery of intraarterial adenosine into the interstitium: relevance to therapeutic preconditioning in humansAlfredo Gamboa
Department of Medicine, Vanderbilt University, Nashville, Tenn 37212, USA
Circulation 108:2631-5. 2003..04). CONCLUSIONS: Intravascular adenosine is likely ineffective in inducing myocardial preconditioning because of poor interstitial delivery. This can be overcome by blocking the nucleoside transporter with dipyridamole... - Hyperadrenergic postural tachycardia syndrome in mast cell activation disordersCyndya Shibao
Division of Clinical Pharmacology, Department of Medicine and Pharmacology, and the Autonomic Dysfunction Center, Vanderbilt University School of Medicine, Nashville, Tenn 37212, USA
Hypertension 45:385-90. 2005..These patients often present with a typical hyperadrenergic response, but beta-blockers should be used with great caution, if at all, and treatment directed against mast cell mediators may be required... - Differential role of the carboxy-terminus of the A(2B) adenosine receptor in stimulation of adenylate cyclase, phospholipase Cbeta, and interleukin-8Sergey Ryzhov
Division of Cardiovascular Medicine, Department of Medicine, Vanderbilt University, Nashville, USA
Purinergic Signal 5:289-98. 2009.... - Pharmacotherapy of autonomic failureCyndya Shibao
Department of Medicine, Division of Clinical Pharmacology and the Autonomic Dysfunction Center, Vanderbilt University School of Medicine, Nashville, TN 37212, USA
Pharmacol Ther 134:279-86. 2012..It is preferable to use short-acting pressor agents that can be taken on as needed basis in preparation for upright activities... - The sympathetic nervous system and blood volume regulation: lessons from autonomic failure patientsItalo Biaggioni
Department of Medicine, Division of Clinical Pharmacology, and Autonomic Dysfunction Center, Vanderbilt University School of Medicine, Nashville, Tennessee 37212, USA
Am J Med Sci 334:61-4. 2007..Thus, in both these conditions the feedback mechanisms involving the sympathetic nervous system and volume homeostasis are impaired... - Orthostatic hypotension-related hospitalizations in the United StatesCyndya Shibao
Department of Medicine, Division of Clinical Pharmacology, Vanderbilt University, Nashville, Tenn 37212, USA
Am J Med 120:975-80. 2007..Nevertheless, the precise burden of this condition in the US is currently unknown... - Sleep disturbances and diminished quality of life in postural tachycardia syndromeKanika Bagai
Paden Dysautonomia Center and Department of Neurology, Vanderbilt University, Nashville, TN, USA
J Clin Sleep Med 7:204-10. 2011..This study's objective was to assess the sleep quality and health-related quality of life in patients with POTS as compared with healthy control subjects... - Autonomic/metabolic interactions modulating the exercise pressor reflex: the purinergic hypothesisItalo Biaggioni
Department of Medicine, Division of Clinical Pharmacology, and the Autonomic Dysfunction Center, Vanderbilt University School of Medicine, Nashville, TN 37232-2195, USA
J Physiol 578:5-6. 2007 - Differential expression of adenosine receptors in human endothelial cells: role of A2B receptors in angiogenic factor regulationIgor Feoktistov
Division of Cardiology, Vanderbilt University, Nashville, Tenn 37232 6300, USA
Circ Res 90:531-8. 2002..A2B receptors, predominantly expressed in human microvascular cells, modulate expression of angiogenic factors via coupling to G(q), and possibly via G12/13... - Mast cell-mediated stimulation of angiogenesis: cooperative interaction between A2B and A3 adenosine receptorsIgor Feoktistov
Division of Cardiovascular Medicine, Vanderbilt University, Nashville, Tenn 37232 6300, USA
Circ Res 92:485-92. 2003..Thus, adenosine A2B and A3 receptors act in a functional cooperative fashion to promote angiogenesis by a paracrine mechanism involving the differential expression and secretion of angiogenic factors from human mast cells... - Can we diagnose, treat or even understand neurally mediated syncope?Satish R Raj
Division of Clinical Pharmacology, Department of Medicine, Vanderbilt University School of Medicine, Nashville TN 37212, USA
Clin Sci (Lond) 109:161-3. 2005..However, validation studies applied to an unselected patient population are needed before we can judge how useful this test will be in the diagnosis of NMS... - Role of adenosine A(2B) receptors in inflammationIgor Feoktistov
Department of Medicine, Vanderbilt University, Division of Cardiovascular Medicine, Nashville, Tennessee, USA
Adv Pharmacol 61:115-44. 2011.... - Adenosine-activated mast cells induce IgE synthesis by B lymphocytes: an A2B-mediated process involving Th2 cytokines IL-4 and IL-13 with implications for asthmaSergey Ryzhov
Division of Clinical Pharmacology, Department of Pharmacology, Vanderbilt University, 1500 21st Avenue South, Nashville, TN 37232, USA
J Immunol 172:7726-33. 2004.... - Clinical and translational research studios: a multidisciplinary internal support programDaniel W Byrne
Department of Biostatistics, Vanderbilt University School of Medicine, Nashville, TN 37232 2158, USA
Acad Med 87:1052-9. 2012..Investigators have indicated that their Studios have improved the quality of their science (99%; 121/122 responses), and experts have reported that the Studios have been a valuable use of their time (98%; 398/406 responses)... - Sympathetic control of the circulation in hypertension: lessons from autonomic disordersItalo Biaggioni
Department of Medicine and Pharmacology, Division of Clinical Pharmacology, Vanderbilt University, Nashville, Tennessee 37212, USA
Curr Opin Nephrol Hypertens 12:175-80. 2003..The present review summarizes the recent advances that have been made in our understanding of the role of the sympathetic nervous system in hypertension... - Clinical and molecular pharmacologic characteristics of adenosine-induced vasodilationItalo Biaggioni
Departments of Medicine and Pharmacology, Division of Clinical Pharmacology, Clinical Trials Center, Vanderbilt University, 1500 21st Avenue S, Suite 3500, Nashville, TN 37212, USA
Clin Pharmacol Ther 75:137-9. 2004 - Human muscle sympathetic nerve activity and plasma noradrenaline kinetics in spaceAndrew C Ertl
Vanderbilt University Medical Center, Nashville, TN, USA
J Physiol 538:321-9. 2002..Therefore, notwithstanding hypovolaemia, astronauts respond normally to simulated orthostatic stress and are able to maintain their arterial pressures at normal levels... - Clinical research subject recruitment: the Volunteer for Vanderbilt Research Program www.volunteer.mc.vanderbilt.eduPaul A Harris
General Clinical Research Center, Vanderbilt University, Nashville, TN 37212, USA
J Am Med Inform Assoc 12:608-13. 2005.... - Bradykinin and its metabolite bradykinin 1-5 inhibit thrombin-induced platelet aggregation in humansLaine J Murphey
Department of Medicine and Pharmacology, Vanderbilt University, Nashville, TN 37232-6602, USA
J Pharmacol Exp Ther 318:1287-92. 2006..By inhibiting thrombin-induced platelet aggregation without causing vasodilation, bradykinin 1-5 may provide a model for small molecule substrate-selective thrombin inhibitors... - Adenosine receptor, protein kinase G, and p38 mitogen-activated protein kinase-dependent up-regulation of serotonin transporters involves both transporter trafficking and activationChong-Bin Zhu
Department of Psychiatry, Vanderbilt School of Medicine, Nashville, Tennessee 37232-8548, USA
Mol Pharmacol 65:1462-74. 2004..Together, these results reveal two PKG-dependent pathways supporting rapid SERT regulation by A3 ARs, one leading to enhanced SERT surface trafficking, and a separate, p38 MAPK-dependent process augmenting SERT intrinsic activity... - Influence of microgravity on astronauts' sympathetic and vagal responses to Valsalva's manoeuvreJames F Cox
Department of Medicine and Physiology, Hunter Holmes McGuire Veterans Affairs Medical Center and Medical College of Virginia at Virginia Commonwealth University, Richmond, Virginia, USA 23249
J Physiol 538:309-20. 2002..This and earlier research suggest that exposure of healthy humans to microgravity augments arterial pressure and sympathetic responses to Valsalva straining and differentially reduces vagal, but not sympathetic baroreflex gain... - Selective norepinephrine reuptake inhibition as a human model of orthostatic intoleranceChristoph Schroeder
Clinical Research Center, Helios Klinkum Berlin, Germany
Circulation 105:347-53. 2002..Observations in patients with functional mutations of the norepinephrine transporter (NET) gene suggest that impaired norepinephrine uptake may contribute to idiopathic orthostatic intolerance... - Baroreflex buffering and susceptibility to vasoactive drugsJens Jordan
Franz Volhard Clinical Research Center and HELIOS Klinikum, Medical Faculty of the Charite, Humboldt University, Berlin, Germany
Circulation 105:1459-64. 2002..Differences in baroreflex function affect the responsiveness to vasoactive medications, particularly baroreflex buffering of blood pressure; however, the magnitude is not known... - Human muscle sympathetic neural and haemodynamic responses to tilt following spaceflightBenjamin D Levine
Institute for Exercise and Environmental Medicine, Presbyterian Hospital of Dallas and the University of Texas Southwestern Medical Center at Dallas, Dallas, TX 75231, USA
J Physiol 538:331-40. 2002..We conclude that after 16 days of spaceflight, muscle sympathetic nerve responses to upright tilt are normal... - Diagnosis and treatment of supine hypertension in autonomic failure patients with orthostatic hypotensionJens Jordan
Hypotension and Syncope Unit, Clinical Research Center, Franz Volhard Clinic, Medical Faculty of the Charit, Humboldt University, Berlin, Germany
J Clin Hypertens (Greenwich) 4:139-45. 2002..During the day, avoiding the supine position is often all that is required. Short-acting vasodilators (e.g., transdermal nitroglycerin) can be used during the night... - Four faces of baroreflex failure: hypertensive crisis, volatile hypertension, orthostatic tachycardia, and malignant vagotoniaTerry Ketch
Vanderbilt U, Nashville, TN
Circulation 105:2518-23. 2002.... - Artificial gravity: a possible countermeasure for post-flight orthostatic intoleranceSteven T Moore
Department of Neurology, Mount Sinai School of Medicine, New York, NY 10029, USA
Acta Astronaut 56:867-76. 2005..More data is necessary to evaluate this hypothesis, but if it were proven correct, in-flight short-radius centrifugation may help counteract orthostatic intolerance after space flight... - Tachycardia caused by A2A adenosine receptor agonists is mediated by direct sympathoexcitation in awake ratsArvinder K Dhalla
Department of Pharmacology, CV Therapeutics, Palo Alto, CA 94304, USA
J Pharmacol Exp Ther 316:695-702. 2006.... - Influence of an insertion variant in the 5'UTR of the endothelin-1 gene on orthostatic intoleranceRobert Winker
Division of Occupational Medicine, Medical University of Vienna, Vienna, Austria
Am J Med Sci 330:166-71. 2005..The aim of this study was therefore to ascertain whether this frequent variant of the endothelin-1 gene influences the risk for orthostatic intolerance... - Beta2-adrenoceptor genotype and function affect hemodynamic profile heterogeneity in postural tachycardia syndromeGiris Jacob
J Recanati Autonomic Dysfunction Center, Department of Internal Medicine A, Rambam Medical Center and Technion IIT, Haifa, Israel
Hypertension 47:421-7. 2006..Therefore, both decreased beta2-adrenoceptor-related vasodilation and beta2-AR polymorphisms may contribute to the hemodynamic diversity of patients with POTS... - Electrical activation of the human vestibulo-sympathetic reflexAndrei Voustianiouk
Mount Sinai School of Medicine, New York, NY, USA
Exp Brain Res 171:251-61. 2006.... - Human cerebral autoregulation before, during and after spaceflightKen Ichi Iwasaki
Institute for Exercise and Environmental Medicine, 7232 Greenville Avenue, Suite 435, Dallas, TX 75231, USA
J Physiol 579:799-810. 2007..We conclude that human cerebral autoregulation is preserved, and possibly even improved, by short-duration spaceflight... - Phenotypical evidence for a gender difference in cardiac norepinephrine transporter functionChristoph Schroeder
Franz Volhard Clinical Research Center, Haus 129, Medical Faculty of the Charité Campus Buch, Wiltbergstrasse 50, 13125 Berlin, Germany
Am J Physiol Regul Integr Comp Physiol 286:R851-6. 2004..Our observations suggest that the NET contribution to cardiac norepinephrine turnover may be decreased in women. The gender difference in NET function may not be expressed in tissues that are less NET dependent than the heart... - Tyramine-induced vasodilation mediated by dopamine contamination: a paradox resolvedGiris Jacob
Jacob Recanati Autonomic Dysfunction Center, Department of Internal Medicine C, Rambam Medical Center, Haifa, Israel
Hypertension 46:355-9. 2005..The possibility of dopamine contamination needs to be considered when interpreting previously published studies using tyramine as a pharmacological tool to assess sympathetic function, and it must be avoided in future studies... - Variations in the dopamine beta-hydroxylase gene are not associated with the autonomic disorders, pure autonomic failure, or multiple system atrophySonhae Cho
Molecular Neurobiology Laboratory, McLean Hospital, Harvard Medical School, Belmont, Massachusetts 02478, USA
Am J Med Genet A 120:234-6. 2003..In addition, no DBH mutation was found that distinguished autonomic disease patients from controls, suggesting that genetic variants of the DBH gene are not associated with the autonomic diseases OI, PAF, and MSA... - Spectrum of autonomic cardiovascular neuropathy in diabetesGiris Jacob
J. Recanati Autonomic Dysfunction Center, Rambam Medical Center, Haifa, Israel
Diabetes Care 26:2174-80. 2003..Furthermore, altered renin response can contribute to the patients' orthostatic hypotension... - Adenosine and the exercise pressor reflex: a controversy resolved?Italo Biaggioni
Clin Auton Res 13:7-9. 2003 - Neurovascular dissociation with paradoxical forearm vasodilation during systemic tyramine administrationGiris Jacob
Jacob Recanati Autonomic Dysfunction Center, Department of Internal Medicine C, Rambam Medical Center, Haifa, Israel
Circulation 107:2475-9. 2003..CONCLUSIONS: Thus, systemic tyramine infusion evokes a significant increase in peripheral norepinephrine spillover, and this, paradoxically, is associated with local vasodilatation rather than vasoconstriction... - Circadian clocks, autonomic rhythms, and blood pressure dippingItalo Biaggioni
Hypertension 52:797-8. 2008 - The A2A receptor mediates an endogenous regulatory pathway of cytokine expression in THP-1 cellsKhaled Bshesh
Division of Critical Care Medicine, Children s Hospital Medical Center, Cincinnati, Ohio 45229 3039, USA
J Leukoc Biol 72:1027-36. 2002..Thus, following immune activation with LPS, endogenous adenosine mediates a negative feedback pathway to modulate cytokine expression in THP-1 cells... - Paradoxical effect of sibutramine on autonomic cardiovascular regulationAndreas L Birkenfeld
Franz Volhard Clinical Research Center, Medical Faculty of the Charite, Humboldt University, Berlin, Germany
Circulation 106:2459-65. 2002..Norepinephrine reuptake inhibition with sibutramine conceivably could exacerbate arterial hypertension and promote cardiovascular disease... - Norepinephrine transporter function and autonomic control of metabolismMichael Boschmann
German Institute of Human Nutrition, 14558 Potsdam, Germany
J Clin Endocrinol Metab 87:5130-7. 2002..This effect cannot be explained by increased systemic or adipose tissue norepinephrine concentrations. Instead, NET inhibition may sensitize adipose tissue to beta-adrenergic stimulation... - AHA/ACCF scientific statement on the evaluation of syncope: from the American Heart Association Councils on Clinical Cardiology, Cardiovascular Nursing, Cardiovascular Disease in the Young, and Stroke, and the Quality of Care and Outcomes Research InterdiS Adam Strickberger
J Am Coll Cardiol 47:473-84. 2006 - Cardiovascular and sympathetic neural responses to handgrip and cold pressor stimuli in humans before, during and after spaceflightQi Fu
Institute for Exercise and Environmental Medicine, Presbyterian Hospital of Dallas, 7232 Greenville Avenue, Suite 435, Dallas, TX 75231, USA
J Physiol 544:653-64. 2002..We conclude that modulation of muscle sympathetic neural outflow by muscle metaboreceptors and skin nociceptors is preserved during short duration spaceflight...