G R Bernard

Summary

Affiliation: Vanderbilt University
Country: USA

Publications

  1. ncbi Safety assessment of drotrecogin alfa (activated) in the treatment of adult patients with severe sepsis
    Gordon R Bernard
    Division of Allergy, Vanderbilt University School of Medicine, Nashville, Tennessee, USA
    Crit Care 7:155-63. 2003
  2. ncbi Severe sepsis
    Gordon Bernard
    Division of Allergy, Pulmonary and Critical Care Medicine, Vanderbilt University Medical Center, Room T, 1208 Medical Center North, Nashville, TN 37232-2650, USA
    Am J Surg 184:S3-4. 2002
  3. ncbi Pulmonary artery catheterization and clinical outcomes: National Heart, Lung, and Blood Institute and Food and Drug Administration Workshop Report. Consensus Statement
    G R Bernard
    Room T 1219 Medical Center North, Vanderbilt University School of Medicine, Nashville, TN 37232, USA
    JAMA 283:2568-72. 2000
  4. ncbi Efficacy and safety of recombinant human activated protein C for severe sepsis
    G R Bernard
    Division of Allergy, Pulmonary and Critical Care Medicine, Vanderbilt University School of Medicine, Nashville, TN 37232, USA
    N Engl J Med 344:699-709. 2001
  5. ncbi Safety and dose relationship of recombinant human activated protein C for coagulopathy in severe sepsis
    G R Bernard
    Department of Medicine, Division of Allergy, Pulmonary and Critical Care Medicine, Vanderbilt University School of Medicine, Nashville, TN 37232 2650, USA
    Crit Care Med 29:2051-9. 2001
  6. ncbi Evaluation of delirium in critically ill patients: validation of the Confusion Assessment Method for the Intensive Care Unit (CAM-ICU)
    E W Ely
    Department of Internal Medicine, Divisions of General Internal Medicine and Center for Health Services Research, Vanderbilt University School of Medicine, Nashville, TN, USA
    Crit Care Med 29:1370-9. 2001
  7. ncbi Acute lung injury in patients with traumatic injuries: utility of a panel of biomarkers for diagnosis and pathogenesis
    Richard D Fremont
    Division of Allergy, Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee 37232 2650, USA
    J Trauma 68:1121-7. 2010
  8. ncbi Lower tidal volume ventilation and plasma cytokine markers of inflammation in patients with acute lung injury
    Polly E Parsons
    Division of Pulmonary and Critical Care Medicine, Department of Medicine, Fletcher Allen Health Care, University of Vermont, USA
    Crit Care Med 33:1-6; discussion 230-2. 2005
  9. ncbi Delirium as a predictor of mortality in mechanically ventilated patients in the intensive care unit
    E Wesley Ely
    Department of Medicine, Division of General Internal Medicine and Center for Health Services Research and the Veterans Affairs Tennessee Valley Geriatric Research, Education and Clinical Center, Nashville, Tenn, USA
    JAMA 291:1753-62. 2004
  10. ncbi Recovery rate and prognosis in older persons who develop acute lung injury and the acute respiratory distress syndrome
    E Wesley Ely
    Division of Allergy, Center for Health Services Research, 6th Floor, 6109 Medical Center East, Vanderbilt University Medical Center, Nashville, TN 37232-8300, USA
    Ann Intern Med 136:25-36. 2002

Detail Information

Publications78

  1. ncbi Safety assessment of drotrecogin alfa (activated) in the treatment of adult patients with severe sepsis
    Gordon R Bernard
    Division of Allergy, Vanderbilt University School of Medicine, Nashville, Tennessee, USA
    Crit Care 7:155-63. 2003
    ....
  2. ncbi Severe sepsis
    Gordon Bernard
    Division of Allergy, Pulmonary and Critical Care Medicine, Vanderbilt University Medical Center, Room T, 1208 Medical Center North, Nashville, TN 37232-2650, USA
    Am J Surg 184:S3-4. 2002
  3. ncbi Pulmonary artery catheterization and clinical outcomes: National Heart, Lung, and Blood Institute and Food and Drug Administration Workshop Report. Consensus Statement
    G R Bernard
    Room T 1219 Medical Center North, Vanderbilt University School of Medicine, Nashville, TN 37232, USA
    JAMA 283:2568-72. 2000
    ....
  4. ncbi Efficacy and safety of recombinant human activated protein C for severe sepsis
    G R Bernard
    Division of Allergy, Pulmonary and Critical Care Medicine, Vanderbilt University School of Medicine, Nashville, TN 37232, USA
    N Engl J Med 344:699-709. 2001
    ..In this phase 3 trial, we assessed whether treatment with drotrecogin alfa activated reduced the rate of death from any cause among patients with severe sepsis...
  5. ncbi Safety and dose relationship of recombinant human activated protein C for coagulopathy in severe sepsis
    G R Bernard
    Department of Medicine, Division of Allergy, Pulmonary and Critical Care Medicine, Vanderbilt University School of Medicine, Nashville, TN 37232 2650, USA
    Crit Care Med 29:2051-9. 2001
    ..To assess the safety and effect on coagulopathy of a range of doses of recombinant human activated protein C (rhAPC). To determine an effective dose and duration of rhAPC for use in future clinical trials...
  6. ncbi Evaluation of delirium in critically ill patients: validation of the Confusion Assessment Method for the Intensive Care Unit (CAM-ICU)
    E W Ely
    Department of Internal Medicine, Divisions of General Internal Medicine and Center for Health Services Research, Vanderbilt University School of Medicine, Nashville, TN, USA
    Crit Care Med 29:1370-9. 2001
    ..To develop and validate an instrument for use in the intensive care unit to accurately diagnose delirium in critically ill patients who are often nonverbal because of mechanical ventilation...
  7. ncbi Acute lung injury in patients with traumatic injuries: utility of a panel of biomarkers for diagnosis and pathogenesis
    Richard D Fremont
    Division of Allergy, Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee 37232 2650, USA
    J Trauma 68:1121-7. 2010
    ..The aims of this study were to develop a panel of plasma biomarkers to facilitate diagnosis of trauma-induced ALI and to enhance our understanding of the pathogenesis of human ALI...
  8. ncbi Lower tidal volume ventilation and plasma cytokine markers of inflammation in patients with acute lung injury
    Polly E Parsons
    Division of Pulmonary and Critical Care Medicine, Department of Medicine, Fletcher Allen Health Care, University of Vermont, USA
    Crit Care Med 33:1-6; discussion 230-2. 2005
    ..Low tidal volume ventilation is associated with a more rapid attenuation of the inflammatory response...
  9. ncbi Delirium as a predictor of mortality in mechanically ventilated patients in the intensive care unit
    E Wesley Ely
    Department of Medicine, Division of General Internal Medicine and Center for Health Services Research and the Veterans Affairs Tennessee Valley Geriatric Research, Education and Clinical Center, Nashville, Tenn, USA
    JAMA 291:1753-62. 2004
    ..CONCLUSION: Delirium was an independent predictor of higher 6-month mortality and longer hospital stay even after adjusting for relevant covariates including coma, sedatives, and analgesics in patients receiving mechanical ventilation...
  10. ncbi Recovery rate and prognosis in older persons who develop acute lung injury and the acute respiratory distress syndrome
    E Wesley Ely
    Division of Allergy, Center for Health Services Research, 6th Floor, 6109 Medical Center East, Vanderbilt University Medical Center, Nashville, TN 37232-8300, USA
    Ann Intern Med 136:25-36. 2002
    ....
  11. ncbi A replicable method for blood glucose control in critically Ill patients
    Alan H Morris
    Pulmonary Division, Department of Medicine, LDS Hospital and the University of Utah School of Medicine, Salt Lake City, UT, USA
    Crit Care Med 36:1787-95. 2008
    ..To ensure interpretability and replicability of clinical experiments, methods must be adequately explicit and should elicit the same decision from different clinicians who comply with the study protocol...
  12. ncbi Drotrecogin alfa (activated) (recombinant human activated protein C) for the treatment of severe sepsis
    Gordon R Bernard
    Department of Medicine, Division of Allergy, Pulmonary and Critical Care Medicine, Vanderbilt University School of Medicine, Nashville, TN, USA
    Crit Care Med 31:S85-93. 2003
    ..Treatment of this disorder with drotrecogin alfa (activated) directly addresses these derangements and substantially reduces morbidity and mortality rates with potential for bleeding during infusion as the only known risk...
  13. ncbi Albumin and furosemide therapy in hypoproteinemic patients with acute lung injury
    Greg S Martin
    Department of Medicine, Emory University School of Medicine, Atlanta, GA, USA
    Crit Care Med 30:2175-82. 2002
    ..Determining the effect of this simple therapy on cost, outcomes, and other patient populations requires further study...
  14. ncbi Mechanisms of late hemodynamic and airway dynamic responses to endotoxin in awake sheep
    P E Wright
    Department of Medicine, Vanderbilt University, Nashville, Tennessee
    Am Rev Respir Dis 140:672-8. 1989
    ..5 h after endotoxin...
  15. ncbi Prognostic and pathogenetic value of combining clinical and biochemical indices in patients with acute lung injury
    Lorraine B Ware
    DivisionAllergy, Pulmonary, and Critical Care Medicine, Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN 37232 2650, USA
    Chest 137:288-96. 2010
    ..We hypothesized that a combination of biologic and clinical markers would be superior to either biomarkers or clinical factors alone in predicting ALI/ARDS mortality and would provide insight into the pathogenesis of clinical ALI/ARDS...
  16. ncbi Development of a large-scale de-identified DNA biobank to enable personalized medicine
    D M Roden
    Office of Personalized Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee, USA
    Clin Pharmacol Ther 84:362-9. 2008
    ..3 and <0.1%, respectively). The rate of sample accrual is 700-900 samples/week. The advantages of this approach are the rate of sample acquisition and the diversity of phenotypes based on EMRs...
  17. ncbi Attitudes and perceptions of patients towards methods of establishing a DNA biobank
    Jill M Pulley
    Vanderbilt University Medical Center, Vanderbilt Office of Research, 2525 West End Avenue, 6th Floor, Nashville, TN 37203 8820, USA
    Cell Tissue Bank 9:55-65. 2008
    ..This study aimed to assess patient attitudes as part of the planning process for a large-scale effort to collect genetic samples for research from excess clinical blood specimens ('DNA Databank' project)...
  18. ncbi Acute lung injury and the acute respiratory distress syndrome: a clinical review
    Arthur P Wheeler
    Medical Intensive Care Unit, Vanderbilt University Medical Center, Nashville, TN 37232 2650, USA
    Lancet 369:1553-64. 2007
    ..Refinements in ventilator and fluid management supported by data from prospective randomised trials have increased the methods available to effectively manage this disorder...
  19. ncbi Mechanical ventilation in ARDS: a state-of-the-art review
    Timothy D Girard
    Center for Health Services Research, Vanderbilt University School of Medicine, Nashville, TN 37232 8300, USA
    Chest 131:921-9. 2007
    ....
  20. ncbi Comparison of the SpO2/FIO2 ratio and the PaO2/FIO2 ratio in patients with acute lung injury or ARDS
    Todd W Rice
    MSc, Division of Allergy, Pulmonary, and Critical Care Medicine, T 1218 MCN, Nashville, TN 37232 2650, USA
    Chest 132:410-7. 2007
    ..We hypothesized that the pulse oximetric saturation (Spo(2))/Fio(2) (S/F) ratio can be substituted for the P/F ratio in assessing the oxygenation criterion of ALI...
  21. ncbi Therapeutic intervention and targets for sepsis
    Todd W Rice
    Division of Allergy, Pulmonary, and Critical Care Medicine, Vanderbilt University School of Medicine, Center for Lung Research, Nashville, Tennessee 37232 2650, USA
    Annu Rev Med 56:225-48. 2005
    ..Following a review of recent advances in sepsis treatment, we briefly discuss a few of the new, promising therapeutic strategies currently being investigated...
  22. ncbi Acute respiratory distress syndrome: a historical perspective
    Gordon R Bernard
    Division of Allergy, Pulmonary and Critical Care Medicine, Vanderbilt University School of Medicine, 1161 21st Avenue South, Room T1218 MCN, Nashville, TN 37232 2650, USA
    Am J Respir Crit Care Med 172:798-806. 2005
    ....
  23. ncbi A randomized, controlled trial of furosemide with or without albumin in hypoproteinemic patients with acute lung injury
    Greg S Martin
    Division of Pulmonary, Allergy and Critical Care, Department of Medicine, Emory University School of Medicine, Atlanta, GA, USA
    Crit Care Med 33:1681-7. 2005
    ..Additional randomized clinical trials are necessary to examine mechanisms and determine the effect on important clinical outcomes, such as the duration of mechanical ventilation...
  24. ncbi Safety and efficacy of affinity-purified, anti-tumor necrosis factor-alpha, ovine fab for injection (CytoFab) in severe sepsis
    Todd W Rice
    Division of Allergy, Pulmonary, and Critical Care Medicine, Vanderbilt University School of Medicine, Nashville, TN, USA
    Crit Care Med 34:2271-81. 2006
    ..CONCLUSIONS: CytoFab is well tolerated in patients with severe sepsis, effectively reducing serum and BAL TNF-alpha and serum IL-6 concentrations and increasing the number of ventilator-free and ICU-free days at day 28...
  25. ncbi A case series of drotrecogin alfa (activated) in lung transplant recipients
    Titus L Daniels
    Division of Infectious Diseases, Department of Medicine, Vanderbilt University, Nashville, TN 37232, USA
    Transplantation 81:1739-42. 2006
    ..We report for the first time on the use of drotrecogin alfa activated in six lung transplant recipients. Clinical trials are warranted to further evaluate the use of drotrecogin alfa activated in transplant recipients...
  26. ncbi The role of the coagulation cascade in the continuum of sepsis and acute lung injury and acute respiratory distress syndrome
    Julie A Bastarache
    Division of Allergy, Pulmonary, and Critical Care Medicine, Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, USA
    Semin Respir Crit Care Med 27:365-76. 2006
    ....
  27. ncbi Pulmonary-artery versus central venous catheter to guide treatment of acute lung injury
    Arthur P Wheeler
    Vanderbilt University, Nashville, USA
    N Engl J Med 354:2213-24. 2006
    ..The balance between the benefits and the risks of pulmonary-artery catheters (PACs) has not been established...
  28. ncbi Acute lung injury and the acute respiratory distress syndrome: challenges in clinical trial design
    Todd W Rice
    Division of Allergy, Pulmonary, and Critical Care Medicine, Vanderbilt University School of Medicine, Nashville, TN 37232 2650, USA
    Clin Chest Med 27:733-54; abstract xi. 2006
    ..Delineating outcomes attributable to the lung injury will improve the power of studies to detect significant treatment effects. Future collaborative studies will be needed to investigate longer-term clinical outcomes...
  29. ncbi Lorazepam is an independent risk factor for transitioning to delirium in intensive care unit patients
    Pratik Pandharipande
    Department of Anesthesia Critical Care Medicine, Vanderbilt University Medical Center, Nashville, Tennessee 37232, USA
    Anesthesiology 104:21-6. 2006
    ..Sedative and analgesic medications relieve anxiety and pain but may contribute to patients' transitioning into delirium...
  30. ncbi Evaluation of the effectiveness of posters to provide information to patients about a DNA database and their opportunity to opt out
    Jill M Pulley
    Vanderbilt Office of Research, 3319 West End Avenue, Suite 550, Nashville, TN 37203 8820, USA
    Cell Tissue Bank 8:233-41. 2007
    ..Vanderbilt University Medical Center is implementing a DNA Databank to facilitate genomic research. This study describes the use of informational posters to communicate to patients about the Databank and their option to not participate...
  31. ncbi Risk factors for post-traumatic stress disorder symptoms following critical illness requiring mechanical ventilation: a prospective cohort study
    Timothy D Girard
    Department of Medicine, Division of Allergy, Pulmonary, and Critical Care Medicine, Vanderbilt University School of Medicine, Nashville, TN 37232 2650, USA
    Crit Care 11:R28. 2007
    ..We sought to identify factors associated with PTSD symptoms in patients following critical illness requiring mechanical ventilation...
  32. ncbi Effect of sedation with dexmedetomidine vs lorazepam on acute brain dysfunction in mechanically ventilated patients: the MENDS randomized controlled trial
    Pratik P Pandharipande
    Department of Anesthesiology Division of Critical Care, Vanderbilt University School of Medicine, Nashville, Tennessee, USA
    JAMA 298:2644-53. 2007
    ..Dexmedetomidine induces sedation via different central nervous system receptors than the benzodiazepine drugs and may lower the risk of acute brain dysfunction...
  33. ncbi Drotrecogin alfa (activated) for the treatment of severe sepsis and septic shock
    Todd W Rice
    Division of Allergy, Pulmonary, and Critical Care Medicine, Vanderbilt University School of Medicine, Center for Lung Research, Nashville, Tennessee 37232, USA
    Am J Med Sci 328:205-14. 2004
    ..Despite concern over its relatively high cost, analysis has demonstrated that recombinant human activated protein C is as cost-effective as other commonly used treatments in the intensive care unit...
  34. ncbi Monitoring sedation status over time in ICU patients: reliability and validity of the Richmond Agitation-Sedation Scale (RASS)
    E Wesley Ely
    Department of Medicine, Center for Health Services Research, Vanderbilt University School of Medicine, Tennessee Valley Veteran s Affairs Healthcare System, Geriatric Research Education and Clinical Center, Nashville 37232, USA
    JAMA 289:2983-91. 2003
    ....
  35. ncbi Delirium as a predictor of long-term cognitive impairment in survivors of critical illness
    Timothy D Girard
    Division of Allergy, Pulmonary, and Critical Care Medicine, Center for Health Services Research, Department of Medicine, Vanderbilt University School of Medicine, and Department of Medicine, Saint Thomas Hospital, Nashville, TN, USA
    Crit Care Med 38:1513-20. 2010
    ..To test the hypothesis that duration of delirium in the intensive care unit is an independent predictor of long-term cognitive impairment after critical illness requiring mechanical ventilation...
  36. ncbi Large-scale implementation of sedation and delirium monitoring in the intensive care unit: a report from two medical centers
    Brenda Truman Pun
    Department of Medicine, Division of Allergy Pulmonary Critical Care Medicine, and Center for Health Services Research, Vanderbilt University School of Medicine, Vanderbilt University School of Nursing, Nashville, TN 37232, USA
    Crit Care Med 33:1199-205. 2005
    ....
  37. ncbi Principles of human subjects protections applied in an opt-out, de-identified biobank
    Jill Pulley
    Vanderbilt Institute for Clinical and Translational Research, Vanderbilt University School of Medicine, Nashville, Tennessee, USA
    Clin Transl Sci 3:42-8. 2010
    ..Considerations of core principles and protections in the practical implementation of BioVU is the focus of this paper...
  38. ncbi Statins for acutely hospitalized patients: randomized controlled trials are long overdue
    Gordon R Bernard
    Department of Medicine, Vanderbilt University School of Medicine, Room T 1208, Medical Center North, Vanderbilt University, Nashville, TN 37232, USA
    Crit Care 14:141. 2010
    ..There is a growing body of observational literature suggesting that statins can actually reduce hospital mortality through mechanisms far beyond those that can be explained by reductions in cardiovascular events...
  39. ncbi Drotrecogin alfa (activated) administration across clinically important subgroups of patients with severe sepsis
    E Wesley Ely
    Division of Allergy, Pulmonary and Critical Care Medicine, Tennessee Valley Veteran s Affairs Geriatric Research Education and Clinical Center, Vanderbilt University School of Medicine, Nashville 37232 8300, USA
    Crit Care Med 31:12-9. 2003
    ....
  40. ncbi Long-term cognitive and psychological outcomes in the awakening and breathing controlled trial
    James C Jackson
    Department of Medicine, Division of Allergy, Pulmonary, and Critical Care Medicine, Vanderbilt University School of Medicine, Nashville, TN 37232 8300, USA
    Am J Respir Crit Care Med 182:183-91. 2010
    ..Little is known, however, of how such strategies affect long-term cognitive, psychological, and functional outcomes...
  41. ncbi Feasibility, efficacy, and safety of antipsychotics for intensive care unit delirium: the MIND randomized, placebo-controlled trial
    Timothy D Girard
    Department of Medicine, Division of Allergy, Pulmonary, and Critical Care Medicine, Vanderbilt University School of Medicine, Nashville, TN, USA
    Crit Care Med 38:428-37. 2010
    ..To demonstrate the feasibility of a placebo-controlled trial of antipsychotics for delirium in the intensive care unit and to test the hypothesis that antipsychotics would improve days alive without delirium or coma...
  42. ncbi An informatics-based tool to assist researchers in initiating research at an academic medical center: Vanderbilt Customized Action Plan
    Jill M Pulley
    Vanderbilt Institute for Clinical and Translational Research VICTR, Vanderbilt University Medical Center, Nashville, Tennessee 37203, USA
    Acad Med 85:164-8. 2010
    ..The informatics-systems-based approach of the V-CAP is scalable to other academic medical centers and may serve as a useful model to help researchers navigate the complexity of the regulatory approvals process...
  43. ncbi Drotrecogin alfa (activated) treatment of older patients with severe sepsis
    E Wesley Ely
    Division of Allergy, Center for Health Services Research, Vanderbilt University School of Medicine, Nashville, Tennessee 37232 8300, USA
    Clin Infect Dis 37:187-95. 2003
    ..97). In conclusion, older patients with severe sepsis have higher short- and long-term survival rates when treated with DAA than when treated with placebo but an increased risk of serious bleeding that is not aged related...
  44. ncbi Derivation and validation of Spo2/Fio2 ratio to impute for Pao2/Fio2 ratio in the respiratory component of the Sequential Organ Failure Assessment score
    Pratik P Pandharipande
    Department of Anesthesiology, Center for Health Services Research, Vanderbilt University School of Medicine, Nashville, TN, USA
    Crit Care Med 37:1317-21. 2009
    ....
  45. ncbi Current opinions regarding the importance, diagnosis, and management of delirium in the intensive care unit: a survey of 912 healthcare professionals
    E Wesley Ely
    Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN, USA
    Crit Care Med 32:106-12. 2004
    ..The aim of this survey was to assess the medical community's beliefs and practices regarding delirium in the intensive care unit...
  46. ncbi New additions to the intensive care armamentarium
    Todd W Rice
    Division of Allergy, Pulmonary and Critical Care Medicine, Vanderbilt University School of Medicine, Center for Lung Research, Nashville, Tennessee 37232 2650, USA
    Drugs Today (Barc) 40:157-70. 2004
    ..Unfortunately, randomized, blinded, placebo-controlled trials showing improvement in long-term outcomes such as mortality and length of stay are still lacking...
  47. ncbi Efficacy and safety of a paired sedation and ventilator weaning protocol for mechanically ventilated patients in intensive care (Awakening and Breathing Controlled trial): a randomised controlled trial
    Timothy D Girard
    Department of Medicine, Division of Allergy, Pulmonary, and Critical Care Medicine, Vanderbilt University School of Medicine, Nashville, TN 37232 8300, USA
    Lancet 371:126-34. 2008
    ..Our aim was to assess a protocol that paired spontaneous awakening trials (SATs)-ie, daily interruption of sedatives-with spontaneous breathing trials (SBTs)...
  48. ncbi Consciousness monitoring in ventilated patients: bispectral EEG monitors arousal not delirium
    E Wesley Ely
    Tennessee Valley Veteran s Affairs Healthcare System, Geriatric Research, Education and Clinical Center, Vanderbilt University School of Medicine, Nashville, TN, USA
    Intensive Care Med 30:1537-43. 2004
    ..e., arousal vs. content of consciousness) the BIS measures. This study compared BIS levels to well-validated clinical measures of arousal and the presence or absence of delirium...
  49. ncbi Extended evaluation of recombinant human activated protein C United States Trial (ENHANCE US): a single-arm, phase 3B, multicenter study of drotrecogin alfa (activated) in severe sepsis
    Gordon R Bernard
    Division of Allergy, Pulmonary, and Critical Care Medicine, Vanderbilt University School of Medicine, Nashville, TN, USA
    Chest 125:2206-16. 2004
    ..To gather additional 28-day all-cause mortality and safety data among adult patients with severe sepsis who were treated with drotrecogin alfa (activated)...
  50. ncbi A randomized, double-blind, placebo-controlled trial of TAK-242 for the treatment of severe sepsis
    Todd W Rice
    Division of Allergy, Vanderbilt University School of Medicine, Nashville, TN, USA
    Crit Care Med 38:1685-94. 2010
    ..To evaluate whether TAK-242, a small-molecule inhibitor of Toll-like receptor-4-mediated signaling, suppresses cytokine levels and improves 28-day all-cause mortality rates in patients with severe sepsis...
  51. ncbi Enteral omega-3 fatty acid, gamma-linolenic acid, and antioxidant supplementation in acute lung injury
    Todd W Rice
    Division of Allergy, Pulmonary, and Critical Care Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee, USA
    JAMA 306:1574-81. 2011
    ....
  52. ncbi Protein C concentrations in severe sepsis: an early directional change in plasma levels predicts outcome
    Andrew F Shorr
    Department of Medicine, Section of Pulmonary and Critical Care Medicine, Washington Hospital Center, Washington, DC, USA
    Crit Care 10:R92. 2006
    ..The objective of this study was to determine whether early directional changes in protein C levels correlate with outcome...
  53. ncbi Delirium and sedation in the intensive care unit: survey of behaviors and attitudes of 1384 healthcare professionals
    Rina P Patel
    School of Medicine RPP, Vanderbilt University School of Medicine, Nashville, TN, USA
    Crit Care Med 37:825-32. 2009
    ..Our objective was to assess beliefs and practices regarding ICU delirium and sedation management...
  54. ncbi Persistent generation of peptido leukotrienes in patients with the adult respiratory distress syndrome
    G R Bernard
    Medical Intensive Care Unit, School of Medicine, Vanderbilt University, Nashville, Tennessee
    Am Rev Respir Dis 144:263-7. 1991
    ..Leukotriene E4 excretion was associated with persistent abnormalities in gas exchange, pulmonary edema, and lung compliance, suggesting an important role for peptido leukotrienes in the pathophysiology of ARDS...
  55. ncbi Clinical issues and research in respiratory failure from severe acute respiratory syndrome
    Mitchell M Levy
    Department of Medicine, Brown University/Rhode Island Hospital, Providence, USA
    Am J Respir Crit Care Med 171:518-26. 2005
    ..The group recommended preparation for studies, including protocols, ethical considerations, Web-based registries, and data entry systems...
  56. ncbi Effect of bronchodilators on lung mechanics in the acute respiratory distress syndrome (ARDS)
    P E Wright
    Department of Medicine, Vanderbilt University, Nashville, Tenn
    Chest 106:1517-23. 1994
    ..We conclude that the increase in airflow resistance of ARDS is substantially reversed by aerosolized metaproterenol without affecting dead space. These data suggest that abnormalities of RL are at lest partially due to bronchospasm...
  57. ncbi Delirium in mechanically ventilated patients: validity and reliability of the confusion assessment method for the intensive care unit (CAM-ICU)
    E W Ely
    Division of Allergy Pulmonary Critical Care Medicine, Center for Health Services Research, 6th Floor Medical Center East 6109, Vanderbilt University Medical Center, Nashville, TN 37323 8300, USA
    JAMA 286:2703-10. 2001
    ..Delirium is a common problem in the intensive care unit (ICU). Accurate diagnosis is limited by the difficulty of communicating with mechanically ventilated patients and by lack of a validated delirium instrument for use in the ICU...
  58. ncbi Identifying unpredicted drug benefit through query of patient experiential knowledge: a proof of concept web-based system
    Jill Pulley
    Vanderbilt Institute for Clinical and Translational Research, Vanderbilt University School of Medicine, Nashville, Tennessee, USA
    Clin Transl Sci 3:98-103. 2010
    ..Improved data filtering and mining methods will be needed to expand this concept...
  59. ncbi Soluble intercellular adhesion molecule-1 and clinical outcomes in patients with acute lung injury
    Carolyn S Calfee
    Division of Pulmonary and Critical Care Medicine, Department of Medicine, University of California, San Francisco, 505 Parnassus Avenue, San Francisco, CA, 94143 0111, USA
    Intensive Care Med 35:248-57. 2009
    ....
  60. ncbi Effects of drotrecogin alfa (activated) on organ dysfunction in the PROWESS trial
    Jean Louis Vincent
    Department of Intensive Care, Erasme University Hospital, Free University of Brussels, Belgium
    Crit Care Med 31:834-40. 2003
    ..To assess morbidity in patients with severe sepsis managed with and without drotrecogin alfa (activated)...
  61. ncbi Drotrecogin alfa (activated) in the treatment of severe sepsis patients with multiple-organ dysfunction: data from the PROWESS trial
    Jean Francois Dhainaut
    Department of Intensive Care, Cochin Hospital AP HP, Cochin Institute, Cochin Port Royal Medical School, Paris V University, 27 rue due Faubourg Saint Jacques, 75679, Paris Cedex 14, France
    Intensive Care Med 29:894-903. 2003
    ..We report study's data on efficacy and safety in patients with multiple-organ dysfunction...
  62. ncbi Statistical evaluation of ventilator-free days as an efficacy measure in clinical trials of treatments for acute respiratory distress syndrome
    David A Schoenfeld
    Harvard Medical School, Cambridge, MA, USA
    Crit Care Med 30:1772-7. 2002
    ..This would be especially true if the treatment were also required to produce a nominal improvement in mortality...
  63. ncbi Activated protein C for severe sepsis
    E Wesley Ely
    N Engl J Med 347:1035-6. 2002
  64. ncbi Systemic host responses in severe sepsis analyzed by causative microorganism and treatment effects of drotrecogin alfa (activated)
    Steven M Opal
    Brown University School of Medicine, Providence, RI, USA
    Clin Infect Dis 37:50-8. 2003
    ..Results demonstrate that DrotAA, administered as an adjunct to standard anti-infective therapy, can improve the rate of survival for patients who develop severe sepsis regardless of causative microorganism...
  65. ncbi The Connors et al PAC Study, with expert commentary by Dr Gordon Bernard
    R Scott Watson
    Clinical Research, Investigation, and Systems Modeling of Acute Illness (CRISMA) Laboratory, University of Pittsburgh School of Medicine, PA 15261, USA
    J Crit Care 20:181-6. 2005
  66. ncbi The effect of drotrecogin alfa (activated) on long-term survival after severe sepsis
    Derek C Angus
    Department of Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
    Crit Care Med 32:2199-206. 2004
    ..Post hoc analysis suggests the effect of DrotAA varies by APACHE II score with improved long-term survival in subjects with APACHE II scores >/=25 but no benefit in those with lower scores...
  67. ncbi Sources of variability on the estimate of treatment effect in the PROWESS trial: implications for the design and conduct of future studies in severe sepsis
    William L Macias
    Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, IN, USA
    Crit Care Med 32:2385-91. 2004
    ..Diligence by coordinating centers, site investigators, study coordinators, and sponsors is necessary to ensure that the protocol is executed as designed such that a treatment benefit, if present, will be evident...
  68. ncbi Drotrecogin alfa (activated) treatment in severe sepsis from the global open-label trial ENHANCE: further evidence for survival and safety and implications for early treatment
    Jean-Louis Vincent
    Department of Intensive Care, Erasme University Hospital and University of Brussels, Brussels, Belgium
    Crit Care Med 33:2266-77. 2005
    ..4%, p = .01). CONCLUSIONS: ENHANCE provides supportive evidence for the favorable benefit/risk ratio observed in PROWESS and suggests that more effective use of drotrecogin alfa (activated) might be obtained by initiating therapy earlier...
  69. ncbi Costs associated with delirium in mechanically ventilated patients
    Eric B Milbrandt
    CRISMA Laboratory (Clinical Research, Investigation, and Systems Modeling of Acute Illness, Department of Critical Care Medicine, University of Pittsburgh, Pittsburgh, PA, USA
    Crit Care Med 32:955-62. 2004
    ..Future efforts to prevent or treat intensive care unit delirium have the potential to improve patient outcomes and reduce costs of care...
  70. ncbi Comparison of two fluid-management strategies in acute lung injury
    Herbert P Wiedemann
    Department of Pulmonary, Allergy, and Critical Care Medicine, Cleveland Clinic, 9500 Euclid Ave, Desk A 90, Cleveland, OH 44195, USA
    N Engl J Med 354:2564-75. 2006
    ..Optimal fluid management in patients with acute lung injury is unknown. Diuresis or fluid restriction may improve lung function but could jeopardize extrapulmonary-organ perfusion...
  71. ncbi Albumin influences total plasma antioxidant capacity favorably in patients with acute lung injury
    Gregory J Quinlan
    Unit of Critical Care, Imperial College School of Medicine, Royal Brompton Hospital, London, UK
    Crit Care Med 32:755-9. 2004
    ..CONCLUSIONS: In patients with acute lung injury, albumin administration favorably influences plasma thiol-dependent antioxidant status as well as levels of protein oxidative damage...
  72. ncbi Noninvasive ventilation--don't push too hard
    Jonathon Dean Truwit
    N Engl J Med 350:2512-5. 2004
  73. ncbi Findings on the portable chest radiograph correlate with fluid balance in critically ill patients
    Greg S Martin
    Division of Pulmonary and Critical Care Medicine, Emory University School of Medicine, 69 Jesse Hill Jr Drive SE, Room 2D 004, Atlanta, GA 30335, USA
    Chest 122:2087-95. 2002
    ..Chest radiographs (CXRs) quantify pulmonary edema in acute lung injury (ALI) and total blood volume in normal subjects. We hypothesized that CXRs would reflect temporal changes in fluid balance in critically ill patients...
  74. ncbi Recommendations for informed consent forms for critical care clinical trials
    Henry J Silverman
    University of Maryland School of Medicine, Baltimore, MD, USA
    Crit Care Med 33:867-82. 2005
    ..Prospective evaluation is needed to determine whether our recommendations enhance the informed consent process...
  75. ncbi Corticosteroids: the "terminator" of all untreatable serious pulmonary illness
    Gordon R Bernard
    Am J Respir Crit Care Med 168:1409-10. 2003
  76. ncbi CommLog: a communication log system for clinical trials
    Keyuan Jiang
    Department of Computer Information Systems and Information Technology, Purdue University Calumet, Hammond, IN 46321, USA
    IEEE Trans Inf Technol Biomed 7:378-83. 2003
    ..The CommLog has been operational for several industry-sponsored phase II/III clinical trails and has provided a knowledge base for the studies and repository for useful study information...
  77. ncbi A double-blind placebo-controlled study to evaluate the safety and efficacy of L-2-oxothiazolidine-4-carboxylic acid in the treatment of patients with acute respiratory distress syndrome
    Peter E Morris
    Department of Pulmonary Critical Care, Wake Forest University School of Medicine, Winston Salem, NC, USA
    Crit Care Med 36:782-8. 2008
    ..We examined the efficacy and safety of oxothiazolidine-4-carboxylic acid (OTZ), a free radical scavenger, in treating acute respiratory distress syndrome...
  78. ncbi Steroid treatment for persistent ARDS: a word of caution
    B Taylor Thompson
    Crit Care 11:425. 2007