Anthony J Baucum

Summary

Affiliation: Vanderbilt University
Country: USA

Publications

  1. pmc Differential association of postsynaptic signaling protein complexes in striatum and hippocampus
    Anthony J Baucum
    Department of Molecular Physiology and Biophysics, Vanderbilt Kennedy Center, Vanderbilt University School of Medicine, Nashville, Tennessee, USA
    J Neurochem 124:490-501. 2013
  2. pmc Age-dependent targeting of protein phosphatase 1 to Ca2+/calmodulin-dependent protein kinase II by spinophilin in mouse striatum
    Anthony J Baucum
    Department of Molecular Physiology and Biophysics, Vanderbilt Kennedy Center, Center for Molecular Neuroscience, Vanderbilt University School of Medicine, Nashville, Tennessee, United States of America
    PLoS ONE 7:e31554. 2012
  3. pmc Identification and validation of novel spinophilin-associated proteins in rodent striatum using an enhanced ex vivo shotgun proteomics approach
    Anthony J Baucum
    Department of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, Tennessee 37232 0615, USA
    Mol Cell Proteomics 9:1243-59. 2010
  4. pmc Substrate-selective and calcium-independent activation of CaMKII by α-actinin
    Nidhi Jalan-Sakrikar
    Department of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, USA
    J Biol Chem 287:15275-83. 2012
  5. pmc Loss of Thr286 phosphorylation disrupts synaptic CaMKIIα targeting, NMDAR activity and behavior in pre-adolescent mice
    Richard M Gustin
    Department of Pharmacology, Vanderbilt University School of Medicine, Nashville, TN 37232, United States
    Mol Cell Neurosci 47:286-92. 2011
  6. pmc Association of protein phosphatase 1 gamma 1 with spinophilin suppresses phosphatase activity in a Parkinson disease model
    Abigail M Brown
    Department of Molecular Physiology and Biophysics, Center for Molecular Neuroscience, Vanderbilt Kennedy Center for Research on Human Development, Vanderbilt University, Nashville, TN 37232, USA
    J Biol Chem 283:14286-94. 2008
  7. pmc Characterization of a central Ca2+/calmodulin-dependent protein kinase IIalpha/beta binding domain in densin that selectively modulates glutamate receptor subunit phosphorylation
    Yuxia Jiao
    Department of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, USA
    J Biol Chem 286:24806-18. 2011
  8. pmc Ca2+/calmodulin-dependent protein kinase II binds to and phosphorylates a specific SAP97 splice variant to disrupt association with AKAP79/150 and modulate alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid-type glutamate receptor (AMPAR) activity
    Yelyzaveta A Nikandrova
    Department of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, Tennessee 37232, USA
    J Biol Chem 285:923-34. 2010
  9. pmc GluN2B subunit deletion reveals key role in acute and chronic ethanol sensitivity of glutamate synapses in bed nucleus of the stria terminalis
    Tiffany A Wills
    Department of Molecular Physiology and Biophysics, Center for Molecular Neuroscience, Vanderbilt Brain Institute, and JF Kennedy Center for Research on Human Development, Vanderbilt University School of Medicine, Nashville, TN 37232 0615, USA
    Proc Natl Acad Sci U S A 109:E278-87. 2012
  10. pmc CaMKII regulates diacylglycerol lipase-α and striatal endocannabinoid signaling
    Brian C Shonesy
    Department of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine, Nashville, Tennessee, USA
    Nat Neurosci 16:456-63. 2013

Collaborators

Detail Information

Publications14

  1. pmc Differential association of postsynaptic signaling protein complexes in striatum and hippocampus
    Anthony J Baucum
    Department of Molecular Physiology and Biophysics, Vanderbilt Kennedy Center, Vanderbilt University School of Medicine, Nashville, Tennessee, USA
    J Neurochem 124:490-501. 2013
    ..Selective differences in the assembly of synaptic and extrasynaptic signaling complexes may contribute to differential physiological regulation of excitatory transmission in striatum and hippocampus...
  2. pmc Age-dependent targeting of protein phosphatase 1 to Ca2+/calmodulin-dependent protein kinase II by spinophilin in mouse striatum
    Anthony J Baucum
    Department of Molecular Physiology and Biophysics, Vanderbilt Kennedy Center, Center for Molecular Neuroscience, Vanderbilt University School of Medicine, Nashville, Tennessee, United States of America
    PLoS ONE 7:e31554. 2012
    ..These changes in spinophilin/CaMKII interactomes may contribute to changes in striatal dendritic spine density, morphology, and function during normal postnatal maturation and aging...
  3. pmc Identification and validation of novel spinophilin-associated proteins in rodent striatum using an enhanced ex vivo shotgun proteomics approach
    Anthony J Baucum
    Department of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, Tennessee 37232 0615, USA
    Mol Cell Proteomics 9:1243-59. 2010
    ....
  4. pmc Substrate-selective and calcium-independent activation of CaMKII by α-actinin
    Nidhi Jalan-Sakrikar
    Department of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, USA
    J Biol Chem 287:15275-83. 2012
    ..These data show that Ca(2+)-independent binding of α-actinin to CaMKII differentially modulates the phosphorylation of physiological targets that play key roles in long-term synaptic plasticity...
  5. pmc Loss of Thr286 phosphorylation disrupts synaptic CaMKIIα targeting, NMDAR activity and behavior in pre-adolescent mice
    Richard M Gustin
    Department of Pharmacology, Vanderbilt University School of Medicine, Nashville, TN 37232, United States
    Mol Cell Neurosci 47:286-92. 2011
    ..Thus, disruption of CaMKII synaptic targeting caused by elimination of Thr286 autophosphorylation leads to synaptic and behavioral deficits during pre-adolescence...
  6. pmc Association of protein phosphatase 1 gamma 1 with spinophilin suppresses phosphatase activity in a Parkinson disease model
    Abigail M Brown
    Department of Molecular Physiology and Biophysics, Center for Molecular Neuroscience, Vanderbilt Kennedy Center for Research on Human Development, Vanderbilt University, Nashville, TN 37232, USA
    J Biol Chem 283:14286-94. 2008
    ....
  7. pmc Characterization of a central Ca2+/calmodulin-dependent protein kinase IIalpha/beta binding domain in densin that selectively modulates glutamate receptor subunit phosphorylation
    Yuxia Jiao
    Department of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, USA
    J Biol Chem 286:24806-18. 2011
    ..Thus, densin can target multiple CaMKII isoforms to differentially modulate phosphorylation of physiologically relevant downstream targets...
  8. pmc Ca2+/calmodulin-dependent protein kinase II binds to and phosphorylates a specific SAP97 splice variant to disrupt association with AKAP79/150 and modulate alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid-type glutamate receptor (AMPAR) activity
    Yelyzaveta A Nikandrova
    Department of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, Tennessee 37232, USA
    J Biol Chem 285:923-34. 2010
    ....
  9. pmc GluN2B subunit deletion reveals key role in acute and chronic ethanol sensitivity of glutamate synapses in bed nucleus of the stria terminalis
    Tiffany A Wills
    Department of Molecular Physiology and Biophysics, Center for Molecular Neuroscience, Vanderbilt Brain Institute, and JF Kennedy Center for Research on Human Development, Vanderbilt University School of Medicine, Nashville, TN 37232 0615, USA
    Proc Natl Acad Sci U S A 109:E278-87. 2012
    ..These findings demonstrate that GluN2B is a key point of regulation for ethanol's actions and suggest a unique role of extrasynaptic GluN2B-containing receptors in facilitating LTP...
  10. pmc CaMKII regulates diacylglycerol lipase-α and striatal endocannabinoid signaling
    Brian C Shonesy
    Department of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine, Nashville, Tennessee, USA
    Nat Neurosci 16:456-63. 2013
    ..These findings provide mechanistic insights into the molecular regulation of striatal endocannabinoid signaling with implications for physiological control of motor function...
  11. pmc Selective targeting of the gamma1 isoform of protein phosphatase 1 to F-actin in intact cells requires multiple domains in spinophilin and neurabin
    Leigh C Carmody
    Department of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine, Nashville, Tennessee, USA
    FASEB J 22:1660-71. 2008
    ..Thus, selective targeting of PP1gamma1 to F-actin by neurabins in intact cells requires both the canonical PP1-binding motif and an auxiliary PP1gamma1-selectivity determinant...
  12. pmc Differential Localization of G Protein βγ Subunits
    Katherine M Betke
    Department of Pharmacology, Mass Spectrometry Research Center, Department of Molecular Physiology and Biophysics, and Department of Biochemistry, Vanderbilt University Medical Center, Nashville, Tennessee 37232 6600, United States
    Biochemistry 53:2329-43. 2014
    ..Such differences are a prerequisite for understanding roles of individual subunits in regulating specific signaling pathways throughout the central nervous system. ..
  13. pmc Alcohol exposure alters NMDAR function in the bed nucleus of the stria terminalis
    Thomas L Kash
    Department of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine, Nashville, TN, USA
    Neuropsychopharmacology 34:2420-9. 2009
    ....
  14. pmc Localization of myocyte enhancer factor 2 in the rodent forebrain: regionally-specific cytoplasmic expression of MEF2A
    M Diana Neely
    Department of Psychiatry, Vanderbilt University Medical Center, Nashville, TN 37212, USA
    Brain Res 1274:55-65. 2009
    ..The extranuclear localization of MEF2A suggests novel roles for MEF2A in specific neuronal populations...