Julie A Bastarache

Summary

Affiliation: Vanderbilt University
Country: USA

Publications

  1. pmc Markers of inflammation and coagulation may be modulated by enteral feeding strategy
    Julie A Bastarache
    Division of Allergy, Pulmonary, and Critical Care Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee 37232 2650, USA
    JPEN J Parenter Enteral Nutr 36:732-40. 2012
  2. pmc Low levels of tissue factor lead to alveolar haemorrhage, potentiating murine acute lung injury and oxidative stress
    Julie A Bastarache
    Division of Allergy, Pulmonary, and Critical Care Medicine, Vanderbilt University School of Medicine, Nashville, TN 37232 2650, USA
    Thorax 67:1032-9. 2012
  3. pmc Postoperative estradiol levels associate with development of primary graft dysfunction in lung transplantation patients
    Julie A Bastarache
    Division of Allergy, Pulmonary and Critical Care, Vanderbilt University School of Medicine, Nashville, TN 37232 2650, USA
    Gend Med 9:154-65. 2012
  4. pmc Alveolar fluid clearance is faster in women with acute lung injury compared to men
    Julie A Bastarache
    Division of Allergy, Pulmonary and Critical Care Medicine, Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN 37232 2650, USA
    J Crit Care 26:249-56. 2011
  5. pmc Accuracy and reproducibility of a multiplex immunoassay platform: a validation study
    Julie A Bastarache
    Division of Allergy, Pulmonary and Critical Care Medicine, Department of Medicine, Vanderbilt University School of Medicine, United States
    J Immunol Methods 367:33-9. 2011
  6. pmc Procoagulant alveolar microparticles in the lungs of patients with acute respiratory distress syndrome
    Julie A Bastarache
    Vanderbilt Univ School of Medicine, Nashville, TN 37232 2650, USA
    Am J Physiol Lung Cell Mol Physiol 297:L1035-41. 2009
  7. pmc Development of animal models for the acute respiratory distress syndrome
    Julie A Bastarache
    Department of Medicine, Division of Allergy, Vanderbilt University School of Medicine, Nashville, TN 37232, USA
    Dis Model Mech 2:218-23. 2009
  8. pmc Interferon-γ and tumor necrosis factor-α act synergistically to up-regulate tissue factor in alveolar epithelial cells
    Julie A Bastarache
    Division of Allergy, Pulmonary and Critical Care Medicine, Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee, USA
    Exp Lung Res 37:509-17. 2011
  9. pmc Intra-alveolar tissue factor pathway inhibitor is not sufficient to block tissue factor procoagulant activity
    Julie A Bastarache
    Division of Allergy, Pulmonary, and Critical Care Medicine, Vanderbilt Univ School of Medicine, T 1218 Medical Center North, Nashville, TN 37232 2650, USA
    Am J Physiol Lung Cell Mol Physiol 294:L874-81. 2008
  10. pmc The alveolar epithelium can initiate the extrinsic coagulation cascade through expression of tissue factor
    Julie A Bastarache
    Division of Allergy, Pulmonary and Critical Care Medicine, Vanderbilt University School of Medicine, T1218 Medical Center North, Nashville, Tennessee 37232 2650, USA
    Thorax 62:608-16. 2007

Detail Information

Publications20

  1. pmc Markers of inflammation and coagulation may be modulated by enteral feeding strategy
    Julie A Bastarache
    Division of Allergy, Pulmonary, and Critical Care Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee 37232 2650, USA
    JPEN J Parenter Enteral Nutr 36:732-40. 2012
    ..Although enteral nutrition (EN) is provided to most mechanically ventilated patients, the effect of specific feeding strategies on circulating markers of coagulation and inflammation is unknown...
  2. pmc Low levels of tissue factor lead to alveolar haemorrhage, potentiating murine acute lung injury and oxidative stress
    Julie A Bastarache
    Division of Allergy, Pulmonary, and Critical Care Medicine, Vanderbilt University School of Medicine, Nashville, TN 37232 2650, USA
    Thorax 67:1032-9. 2012
    ..We used mice with complete knockout of mouse TF and low levels (∼1%) of human TF (LTF mice) to test the hypothesis that global TF deficiency attenuates lung inflammation in direct lung injury...
  3. pmc Postoperative estradiol levels associate with development of primary graft dysfunction in lung transplantation patients
    Julie A Bastarache
    Division of Allergy, Pulmonary and Critical Care, Vanderbilt University School of Medicine, Nashville, TN 37232 2650, USA
    Gend Med 9:154-65. 2012
    ..Both female gender and estradiol modulate the body's response to injury and can influence the rate of alveolar fluid clearance...
  4. pmc Alveolar fluid clearance is faster in women with acute lung injury compared to men
    Julie A Bastarache
    Division of Allergy, Pulmonary and Critical Care Medicine, Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN 37232 2650, USA
    J Crit Care 26:249-56. 2011
    ..Few studies have directly addressed the association of sex and alveolar fluid clearance (AFC), a process that is critical to ALI resolution...
  5. pmc Accuracy and reproducibility of a multiplex immunoassay platform: a validation study
    Julie A Bastarache
    Division of Allergy, Pulmonary and Critical Care Medicine, Department of Medicine, Vanderbilt University School of Medicine, United States
    J Immunol Methods 367:33-9. 2011
    ..We sought to validate a specific multiplex cytokine immunoassay (Human 9-plex cytokine array on the Searchlight® platform by Thermoscientific) prior to use in a large clinical study...
  6. pmc Procoagulant alveolar microparticles in the lungs of patients with acute respiratory distress syndrome
    Julie A Bastarache
    Vanderbilt Univ School of Medicine, Nashville, TN 37232 2650, USA
    Am J Physiol Lung Cell Mol Physiol 297:L1035-41. 2009
    ..These findings suggest that alveolar epithelial-derived MPs are one potential source of TF procoagulant activity in the air space in ARDS and that epithelial MP formation and release may represent a unique therapeutic target in ARDS...
  7. pmc Development of animal models for the acute respiratory distress syndrome
    Julie A Bastarache
    Department of Medicine, Division of Allergy, Vanderbilt University School of Medicine, Nashville, TN 37232, USA
    Dis Model Mech 2:218-23. 2009
    ..Hopefully, as new technologies and approaches emerge, barriers to scientific progress in ARDS will be overcome...
  8. pmc Interferon-γ and tumor necrosis factor-α act synergistically to up-regulate tissue factor in alveolar epithelial cells
    Julie A Bastarache
    Division of Allergy, Pulmonary and Critical Care Medicine, Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee, USA
    Exp Lung Res 37:509-17. 2011
    ..These findings have important implications for regulation of fibrin formation in the lung in the setting of acute inflammation...
  9. pmc Intra-alveolar tissue factor pathway inhibitor is not sufficient to block tissue factor procoagulant activity
    Julie A Bastarache
    Division of Allergy, Pulmonary, and Critical Care Medicine, Vanderbilt Univ School of Medicine, T 1218 Medical Center North, Nashville, TN 37232 2650, USA
    Am J Physiol Lung Cell Mol Physiol 294:L874-81. 2008
    ..Levels of intra-alveolar TFPI in ARDS are not sufficient to block intra-alveolar TF procoagulant activity due to truncation and inactivation of intra-alveolar TFPI...
  10. pmc The alveolar epithelium can initiate the extrinsic coagulation cascade through expression of tissue factor
    Julie A Bastarache
    Division of Allergy, Pulmonary and Critical Care Medicine, Vanderbilt University School of Medicine, T1218 Medical Center North, Nashville, Tennessee 37232 2650, USA
    Thorax 62:608-16. 2007
    ..A study was undertaken to test the hypothesis that the alveolar epithelium can initiate intra-alveolar coagulation by expressing active tissue factor (TF)...
  11. ncbi request reprint The role of the coagulation cascade in the continuum of sepsis and acute lung injury and acute respiratory distress syndrome
    Julie A Bastarache
    Division of Allergy, Pulmonary, and Critical Care Medicine, Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, USA
    Semin Respir Crit Care Med 27:365-76. 2006
    ....
  12. pmc Novel role of the human alveolar epithelium in regulating intra-alveolar coagulation
    Ling Wang
    Division of Allergy, Pulmonary, and Critical Care Medicine, Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee, USA
    Am J Respir Cell Mol Biol 36:497-503. 2007
    ..Local fibrin deposition may be a fundamental mechanism for the lung to localize and confine injury, thus limiting the risk of dissemination of injury or infection to the systemic circulation...
  13. ncbi request reprint The coagulation cascade in sepsis
    Ling Wang
    Division of Allergy, Pulmonary and Critical Care Medicine, Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN, USA
    Curr Pharm Des 14:1860-9. 2008
    ..This review summarizes recent basic and clinical findings with regard to the role of the coagulation cascade in sepsis and explores potential therapeutic targets in the coagulation and fibrinolytic pathways in the management of sepsis...
  14. pmc Association between cell-free hemoglobin, acetaminophen, and mortality in patients with sepsis: an observational study
    David R Janz
    Department of Medicine, Division of Allergy, Pulmonary, and Critical Care Medicine, Vanderbilt University School of Medicine, Nashville, TN, USA
    Crit Care Med 41:784-90. 2013
    ..To determine the association of circulating cell-free hemoglobin with poor clinical outcomes in patients with sepsis and to characterize the potential protective effects of acetaminophen, an inhibitor of hemoprotein-mediated oxidation...
  15. pmc Mechanical Stretch Inhibits Lipopolysaccharide-induced Keratinocyte-derived Chemokine and Tissue Factor Expression While Increasing Procoagulant Activity in Murine Lung Epithelial Cells
    Sara C Sebag
    From the Division of Allergy, Pulmonary, and Critical Care Medicine, Department of Medicine, and
    J Biol Chem 288:7875-84. 2013
    ..Ultimately, loss of LPS responsiveness in the epithelium induced by MS could result in increased susceptibility of the lung to bacterial infections in the setting of mechanical ventilation...
  16. ncbi request reprint Therapeutic modulation of coagulation and fibrinolysis in acute lung injury and the acute respiratory distress syndrome
    Sara C Sebag
    Department of Allergy, Pulmonary and Critical Care Medicine, Vanderbilt University Medical Center, T1218 MCN, 1161 21st Avenue S Nashville, TN 37232 2650, USA
    Curr Pharm Biotechnol 12:1481-96. 2011
    ..Modulation of coagulation and fibrinolysis has complex effects on both hemostasis and inflammatory pathways and further studies are needed to develop new treatment strategies for patients with ALI/ARDS...
  17. ncbi request reprint Coagulation and fibrinolysis in human acute lung injury--new therapeutic targets?
    Lorraine B Ware
    Division of Allergy, Pulmonary, and Critical Care, Department of Medicine Vanderbilt University School of Medicine, Nashville, TN 37232 2650, USA
    Keio J Med 54:142-9. 2005
    ..Modulation of fibrin deposition in the lung through targeting activation and modulation of coagulation as well as fibrinolysis may be an important therapeutic target in clinical ALI/ARDS that deserves further exploration...
  18. pmc The severity of shock is associated with impaired rates of net alveolar fluid clearance in clinical acute lung injury
    Yosaf F Zeyed
    Division of Allergy, Pulmonary and Critical Care Medicine, Department of Medicine, Microbiology and Immunology, Vanderbilt University School of Medicine, Nashville, Tennessee, USA
    Am J Physiol Lung Cell Mol Physiol 303:L550-5. 2012
    ....
  19. ncbi request reprint Computed tomography and the idiopathic form of proliferative fibrosing mediastinitis
    John A Worrell
    Department of Radiology and Radiological Sciences S1319 MCN, Vanderbilt University School of Medicine, 1161 21st Avenue South, Nashville, TN 37232 3675, USA
    J Thorac Imaging 22:235-40. 2007
    ..Mimics may include the precalcific form of postinflammatory mediastinal fibrosis, mediastinal granuloma, malignancy (esp. lymphoma), sarcoidosis, and Castleman disease...
  20. pmc Acute lung injury edema fluid decreases net fluid transport across human alveolar epithelial type II cells
    Jae W Lee
    Department of Anesthesiology, University of California, San Francisco, CA 94143, USA
    J Biol Chem 282:24109-19. 2007
    ....