M Aschner

Summary

Affiliation: Vanderbilt University
Country: USA

Publications

  1. pmc SMF-1, SMF-2 and SMF-3 DMT1 orthologues regulate and are regulated differentially by manganese levels in C. elegans
    Catherine Au
    Department of Pediatrics, Vanderbilt University, Nashville, Tennessee, USA
    PLoS ONE 4:e7792. 2009
  2. pmc Revelations from the Nematode Caenorhabditis elegans on the Complex Interplay of Metal Toxicological Mechanisms
    Ebany J Martinez-Finley
    Division of Pediatric Clinical Pharmacology and Toxicology, Vanderbilt University Medical Center, Nashville, USA
    J Toxicol 2011:895236. 2011
  3. pmc Manganese as a potential confounder of serum prolactin
    Michael Aschner
    Environ Health Perspect 114:A458; author reply A458. 2006
  4. pmc Metal-induced neurodegeneration in C. elegans
    Pan Chen
    Department of Pediatrics, Vanderbilt University Medical Center Nashville, TN, USA
    Front Aging Neurosci 5:18. 2013
  5. pmc Genome-Wide Analyses of Metal Responsive Genes in Caenorhabditis elegans
    Samuel Caito
    Division of Clinical Pharmacology and Pediatric Toxicology, Department of Pediatrics, Vanderbilt University Medical Center Nashville, TN, USA
    Front Genet 3:52. 2012
  6. pmc An interview with Lucio G. Costa and Michael Aschner, section editors for toxicology
    Lucio G Costa
    Department of Environmental and Occupational Health Sciences University of Washington, 4225 Roosevelt 100, Seattle, WA 98105, USA
    BMC Pharmacol Toxicol 13:16. 2012
  7. pmc Role of astrocytes in manganese mediated neurotoxicity
    Marta Sidoryk-Węgrzynowicz
    Department of Pediatrics, Vanderbilt University Medical Center, Nashville, TN 23233, USA
    BMC Pharmacol Toxicol 14:23. 2013
  8. pmc Mechanism of Mn(II)-mediated dysregulation of glutamine-glutamate cycle: focus on glutamate turnover
    Marta Sidoryk-Węgrzynowicz
    Department of Pediatrics Vanderbilt University Medical Center, Nashville, TN 37232, USA
    J Neurochem 122:856-67. 2012
  9. doi request reprint Cellular transport and homeostasis of essential and nonessential metals
    Ebany J Martinez-Finley
    Department of Pediatrics, and The Kennedy Center for Research on Human Development, Vanderbilt University Medical Center, Nashville, TN, USA
    Metallomics 4:593-605. 2012
  10. doi request reprint Volume measurements in cultured primary astrocytes
    Michael Aschner
    Department of Pediatrics, Vanderbilt University School of Medicine, Nashville, TN, USA
    Methods Mol Biol 758:391-402. 2011

Research Grants

  1. MECHANISMS OF METHYLMERCURY INDUCED NEURONAL TOXICITY
    Michael Aschner; Fiscal Year: 1999
  2. MECHANISMS OF METHYLMERCURY INDUCED NEURONAL TOXICITY
    Michael Aschner; Fiscal Year: 2004
  3. BBB Transport of MMT Metabolites
    Michael Aschner; Fiscal Year: 2004
  4. MECHANISMS OF METHYLMERCURY INDUCED NEURONAL TOXICITY
    Michael Aschner; Fiscal Year: 2006
  5. Mechanisms of Manganese Neurotoxicity
    Michael Aschner; Fiscal Year: 2007
  6. MECHANISMS OF METHYLMERCURY INDUCED NEURONAL TOXICITY
    Michael Aschner; Fiscal Year: 2007
  7. Mechanisms of Manganese Neurotoxicity
    Michael Aschner; Fiscal Year: 2009
  8. Mechanisms of Manganese Neurotoxicity
    Michael Aschner; Fiscal Year: 2010
  9. MECHANISMS OF METHYLMERCURY INDUCED NEURONAL TOXICITY
    Michael Aschner; Fiscal Year: 2005
  10. BBB Transport of MMT Metabolites
    Michael Aschner; Fiscal Year: 2005

Collaborators

Detail Information

Publications127 found, 100 shown here

  1. pmc SMF-1, SMF-2 and SMF-3 DMT1 orthologues regulate and are regulated differentially by manganese levels in C. elegans
    Catherine Au
    Department of Pediatrics, Vanderbilt University, Nashville, Tennessee, USA
    PLoS ONE 4:e7792. 2009
    ..In sum, we unraveled a complex interplay of transcriptional and post-translational regulations of 3 DMT1-like transporters in two adjacent tissues, which regulate metal-content in C. elegans...
  2. pmc Revelations from the Nematode Caenorhabditis elegans on the Complex Interplay of Metal Toxicological Mechanisms
    Ebany J Martinez-Finley
    Division of Pediatric Clinical Pharmacology and Toxicology, Vanderbilt University Medical Center, Nashville, USA
    J Toxicol 2011:895236. 2011
    ..elegans model system for investigation and analysis...
  3. pmc Manganese as a potential confounder of serum prolactin
    Michael Aschner
    Environ Health Perspect 114:A458; author reply A458. 2006
  4. pmc Metal-induced neurodegeneration in C. elegans
    Pan Chen
    Department of Pediatrics, Vanderbilt University Medical Center Nashville, TN, USA
    Front Aging Neurosci 5:18. 2013
    ..This review discusses methods to assess degeneration as well as outlines techniques for genetic manipulation and presents a comprehensive survey of the existing literature on metal-induced degeneration studies in the worm...
  5. pmc Genome-Wide Analyses of Metal Responsive Genes in Caenorhabditis elegans
    Samuel Caito
    Division of Clinical Pharmacology and Pediatric Toxicology, Department of Pediatrics, Vanderbilt University Medical Center Nashville, TN, USA
    Front Genet 3:52. 2012
    ..Recent work focusing on neurodegeneration in Parkinson's disease will be discussed as an example of the usefulness of genetic screens in C. elegans and the novel findings that can be produced...
  6. pmc An interview with Lucio G. Costa and Michael Aschner, section editors for toxicology
    Lucio G Costa
    Department of Environmental and Occupational Health Sciences University of Washington, 4225 Roosevelt 100, Seattle, WA 98105, USA
    BMC Pharmacol Toxicol 13:16. 2012
    ..elegans, tissue cultures and rodents) to understand the acute toxicity of manganese deposition in the brains of human neonates.In this interview we find out a little more about the key issues in the field of toxicology research...
  7. pmc Role of astrocytes in manganese mediated neurotoxicity
    Marta Sidoryk-Węgrzynowicz
    Department of Pediatrics, Vanderbilt University Medical Center, Nashville, TN 23233, USA
    BMC Pharmacol Toxicol 14:23. 2013
    ..In this review, we discuss recent advances in support of the important roles for astrocytes in normal as well as neuropathological conditions primarily those caused by exposure to Mn...
  8. pmc Mechanism of Mn(II)-mediated dysregulation of glutamine-glutamate cycle: focus on glutamate turnover
    Marta Sidoryk-Węgrzynowicz
    Department of Pediatrics Vanderbilt University Medical Center, Nashville, TN 37232, USA
    J Neurochem 122:856-67. 2012
    ..Taken together, these findings demonstrate that PKCδ signaling is involved in the Mn(II)-induced deregulation of Glu turnover in astrocytes...
  9. doi request reprint Cellular transport and homeostasis of essential and nonessential metals
    Ebany J Martinez-Finley
    Department of Pediatrics, and The Kennedy Center for Research on Human Development, Vanderbilt University Medical Center, Nashville, TN, USA
    Metallomics 4:593-605. 2012
    ..Much work has been done to advance our understanding of how these metals are transported across plasma and organelle membranes. This review provides an overview of essential and nonessential metal transport and homeostatic processes...
  10. doi request reprint Volume measurements in cultured primary astrocytes
    Michael Aschner
    Department of Pediatrics, Vanderbilt University School of Medicine, Nashville, TN, USA
    Methods Mol Biol 758:391-402. 2011
    ..This review will briefly detail these methods and provide insight into molecular mechanisms associated with cell swelling and the ensuing regulatory decrease (RVD)...
  11. doi request reprint Toxicology of alkylmercury compounds
    Michael Aschner
    Vanderbilt University School of Medicine, Department of Pediatrics, Pharmacology, and The Kennedy Center for Research on Human Development, Nashville, TN 37232, USA
    Met Ions Life Sci 7:403-34. 2010
    ..Mechanisms that trigger these effects are discussed in detail...
  12. ncbi request reprint Involvement of glutamate and reactive oxygen species in methylmercury neurotoxicity
    M Aschner
    Departments of Pediatrics and Pharmacology, Vanderbilt University Medical Center, B3307 Medical Center North, Nashville, TN 37232, USA
    Braz J Med Biol Res 40:285-91. 2007
    ....
  13. doi request reprint Chapter 8 - Nanoparticles: Transport across the olfactory epithelium and application to the assessment of brain function in health and disease
    Michael Aschner
    Department of Pediatrics, Pharmacology and The Kennedy Center for Research on Human Development, Vanderbilt University School of Medicine, Nashville, TN, USA
    Prog Brain Res 180:141-52. 2009
    ....
  14. doi request reprint Toxicity studies on depleted uranium in primary rat cortical neurons and in Caenorhabditis elegans: what have we learned?
    Michael Aschner
    Department of Pediatrics, Vanderbilt University Medical Center, Nashville, Tennessee, USA
    J Toxicol Environ Health B Crit Rev 12:525-39. 2009
    ..In addition, recent studies also demonstrate that only one of the two forms, metallothionein-1, is important in the accumulation of uranium in worms...
  15. ncbi request reprint Metallothioneins: mercury species-specific induction and their potential role in attenuating neurotoxicity
    Michael Aschner
    Department of Pediatrics, B 3307 Medical Center North, Vanderbilt University School of Medicine, Nashville, TN 37232 2495, USA
    Exp Biol Med (Maywood) 231:1468-73. 2006
    ..This manuscript represents a survey on the ability of MTs to modulate mercury neurotoxicity, a neurotoxin that has been implied to play an etiologic role in Minamata disease, erethism, and autism, just to name a few...
  16. ncbi request reprint The Manganese Health Research Program (MHRP): status report and future research needs and directions
    M Aschner
    Departments of Pediatrics and Pharmacology, Vanderbilt University School of Medicine, B 3307 Medical Center North, Nashville, TN 37232 2495, USA
    Neurotoxicology 27:733-6. 2006
    ..This summary provides background on the MHRP, identifies the speakers and topics discussed at the symposium, and identifies research needs and anticipated progress in understanding Mn health- and disease-related issues...
  17. ncbi request reprint Effects of acrylamide on primary neonatal rat astrocyte functions
    Michael Aschner
    Department of Pediatrics and Pharmacology, B 3307 Medical Center North, Vanderbilt University Medical Center, 1162 21st Avenue South, Nashville, Tennessee 37232 2495, USA
    Ann N Y Acad Sci 1053:444-54. 2005
    ..Taken together, these studies suggest that acrylamide promotes astrocytic cell proliferation in the CNS even though DNA synthesis did not appear stimulated...
  18. doi request reprint Manganese and its role in Parkinson's disease: from transport to neuropathology
    Michael Aschner
    Departments of Pediatrics and Pharmacology and the Kennedy Center for Research on Human Development, Vanderbilt University Medical Center, 2215 B Garland Avenue, 11425 MRB IV, Nashville, TN, 37232 0414, USA
    Neuromolecular Med 11:252-66. 2009
    ..For additional reading on several topics inherent to this review as well as others, the reader may wish to consult Aschner and Dorman (Toxicological Review 25:147-154, 2007) and Bowman et al. (Metals and neurodegeneration, 2009)...
  19. ncbi request reprint Are neuropathological conditions relevant to ethylmercury exposure?
    Michael Aschner
    Department of Pediatrics, Vanderbilt University Medical Center, Nashville, TN 37232, USA
    Neurotox Res 18:59-68. 2010
    ..However, one cannot rule out the possibility that the individual gene profile and/or gene-environment interactions may play a role in modulating the response to acquired risk by modifying the individual susceptibility...
  20. ncbi request reprint Methylmercury: recent advances in the understanding of its neurotoxicity
    Michael Aschner
    Department of Pediatrics and the Kennedy Center, Vanderbilt University Medical Center, Nashville, Tennessee 37232 2495, USA
    Ther Drug Monit 27:278-83. 2005
  21. ncbi request reprint The role of MT in neurological disorders
    Michael Aschner
    Department of Pediatrics, Vanderbilt University Medical Center, Nashville, TN 37232 2495, USA
    J Alzheimers Dis 8:139-45; discussion 209-15. 2005
    ....
  22. ncbi request reprint Neurotoxicology: principles and considerations of in vitro assessment
    Michael Aschner
    Department of Physiology and Pharmacology, Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, NC 27157 1083, USA
    Altern Lab Anim 32:323-7. 2004
    ..In addition, in vitro models and their utility in the assessment of neurotoxicological outcome are discussed, with reference to both their advantages and disadvantages...
  23. pmc Manganese: recent advances in understanding its transport and neurotoxicity
    Michael Aschner
    Department of Pediatrics, and The Kennedy Center for Research on Human Development, Vanderbilt University, School of Medicine, Nashville, TN 37232 2495, USA
    Toxicol Appl Pharmacol 221:131-47. 2007
    ..Finally, we discuss potential therapeutic modalities for treating Mn intoxication in humans...
  24. pmc Gene-environment interactions: neurodegeneration in non-mammals and mammals
    Michael Aschner
    Department of Pediatrics, Vanderbilt University Medical Center, Nashville, TN, USA
    Neurotoxicology 31:582-8. 2010
    ....
  25. ncbi request reprint Methylmercury has a selective effect on mitochondria in cultured astrocytes in the presence of [U-(13)C]glutamate
    J W Allen
    Department of Physiology and Pharmacology, Wake Forest University School of Medicine, Medical Center Blvd, Winston-Salem, NC 27157-1083, USA
    Brain Res 908:149-54. 2001
    ..The decreased lactate production from glutamate might be detrimental to surrounding cells since lactate has been shown to be an important substrate for neurons...
  26. ncbi request reprint The uptake of cysteine in cultured primary astrocytes and neurons
    G Shanker
    Department of Physiology and Pharmacology, Wake Forest University School of Medicine, Medical Center Blvd, 27157-1083, Winston-Salem, NC, USA
    Brain Res 902:156-63. 2001
    ....
  27. ncbi request reprint Methylmercury inhibits cysteine uptake in cultured primary astrocytes, but not in neurons
    G Shanker
    Department of Physiology and Pharmacology, Wake Forest University School of Medicine, Medical Center Blvd, Winston-Salem, NC 27157-1083, USA
    Brain Res 914:159-65. 2001
    ..These results suggest that the inhibition of cysteine uptake by MeHg in astrocytes occurs through specific inhibition of both the X(AG(-)) as well as the ASC transport system...
  28. ncbi request reprint Metallothionein induction in fetal rat brain and neonatal primary astrocyte cultures by in utero exposure to elemental mercury vapor (Hg0)
    M Aschner
    Department of Physiology and Pharmacology, Bowman Gray School of Medicine of Wake Forest University, Winston Salem, NC 27157 1083, USA
    Brain Res 778:222-32. 1997
    ..It is concluded that induction of MT by fetal/neonatal astrocytes represents an attempt by these glial cells to protect against Hg cytotoxicity in maintaining cerebral homeostasis...
  29. ncbi request reprint Induction of astrocyte metallothioneins (MTs) by zinc confers resistance against the acute cytotoxic effects of methylmercury on cell swelling, Na+ uptake, and K+ release
    M Aschner
    Department of Physiology and Pharmacology, Wake Forest University School of Medicine, Winston Salem, NC, USA
    Brain Res 813:254-61. 1998
    ..Taken together, the data suggest that astrocytic MT induction offers effective cellular adaptation to MeHg cytotoxicity...
  30. ncbi request reprint Methylmercury-induced astrocytic swelling is associated with activation of the Na+/H+ antiporter, and is fully reversed by amiloride
    M Aschner
    Departments of Physiology and Pharmacology, Wake Forest University School of Medicine, Winston Salem, NC, USA
    Brain Res 799:207-14. 1998
    ..Accordingly, increased cellular permeability to Na+ via the Na+/H+ antiporter is invoked as the primary mechanism of MeHg-induced astrocytic swelling...
  31. ncbi request reprint Methylmercury-mediated inhibition of 3H-D-aspartate transport in cultured astrocytes is reversed by the antioxidant catalase
    J W Allen
    Department of Physiology and Pharmacology, Wake Forest University School of Medicine, Medical Center Boulevard, Winston-Salem, NC 27157-1083, USA
    Brain Res 902:92-100. 2001
    ..This study suggests that methylmercury-induced overproduction of H2O2 is a mechanism for inhibition of glutamate transport and transporter expression in cultured astrocytes...
  32. ncbi request reprint Methylmercury inhibits the in vitro uptake of the glutathione precursor, cystine, in astrocytes, but not in neurons
    J W Allen
    Department of Physiology and Pharmacology, Wake Forest University, School of Medicine Medical Center Blvd, Winston-Salem, NC 27157-1083, USA
    Brain Res 894:131-40. 2001
    ..Inhibition of cystine uptake in astrocytes by methylmercury appears to be due to actions on the System X(AG)- transporter...
  33. ncbi request reprint Induction of metallothionein-I (MT-I) mRNA in primary astrocyte cultures is mediated by hypotonicity and not ethanol (EtOH) per se
    M Aschner
    Department of Physiology and Pharmacology, Bowman Gray School of Medicine, Wake Forest University, Winston Salem, NC 27157 1083, USA
    Brain Res 770:289-93. 1997
    ....
  34. ncbi request reprint Methylmercury-induced inhibition of regulatory volume decrease in astrocytes: characterization of osmoregulator efflux and its reversal by amiloride
    M Aschner
    Department of Physiology and Pharmacology, Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, NC 27157 1083, USA
    Brain Res 811:133-42. 1998
    ....
  35. pmc Methylmercury induces oxidative injury, alterations in permeability and glutamine transport in cultured astrocytes
    Zhaobao Yin
    Department of Pediatrics, Vanderbilt University Medical Center, TN, USA
    Brain Res 1131:1-10. 2007
    ..Ultimately, MeHg initiates multiple additive or synergistic disruptive mechanisms that lead to cellular dysfunction and cell death...
  36. ncbi request reprint Astrocytes in methylmercury, ammonia, methionine sulfoximine and alcohol-induced neurotoxicity
    M Aschner
    Department of Physiology and Pharmacology, Wake Forest University School of Medicine, Winston Salem, NC 27157 1083, USA
    Neurotoxicology 21:573-9. 2000
    ..In addition, the potential role of astrocytic proteins, the metallothioneins, in attenuating the neurotoxicity of methylmercury is discussed...
  37. ncbi request reprint Aspartate and glutamate transport in acutely and chronically ethanol exposed neonatal rat primary astrocyte cultures
    M Aschner
    Department of Physiology and Pharmacology, Wake Forest University School of Medicine, Winston Salem, NC 27157 1083, USA
    Neurotoxicology 22:601-5. 2001
    ..In the course of these studies, we have investigated the effects of acute and chronic exposure to EtOH on cell volume, as well as uptake and release of amino acids in neonatal rat primary astrocyte cultures...
  38. ncbi request reprint Neuron-astrocyte interactions: implications for cellular energetics and antioxidant levels
    M Aschner
    Department of Physiology and Pharmacology, and Interdisciplinary Program in Neuroscience, Wake Forest University School of Medicine of Wake Forest University, Winston Salem, NC 27157 1083, USA
    Neurotoxicology 21:1101-7. 2000
    ..Testing the developmental effects of compounds on this interaction is warranted and likely to establish the mechanisms by which it is compromised in a variety of disease states...
  39. ncbi request reprint The in vitro uptake of glutamate in GLAST and GLT-1 transfected mutant CHO-K1 cells is inhibited by manganese
    Lysette Mutkus
    Department of Physiology and Pharmacology, Wake Forest University School of Medicine, Winston Salem, NC, USA
    Biol Trace Elem Res 107:221-30. 2005
    ..05) of glutamate uptake compared with transfected control in the absence of Mn treatment. These studies suggest that Mn accumulation in the CNS might contribute to dysregulation of glutamate homeostasis...
  40. pmc Mitochondrial-dependent manganese neurotoxicity in rat primary astrocyte cultures
    Zhaoobao Yin
    Department of Pediatrics, Vanderbilt University Medical Center, TN, USA
    Brain Res 1203:1-11. 2008
    ..These results suggest that activations of astrocytic caspase-3 and ERK are involved in Mn-induced neurotoxicity via mitochondrial-dependent pathways...
  41. ncbi request reprint Free radical formation in cerebral cortical astrocytes in culture induced by methylmercury
    Gouri Shanker
    Department of Physiology and Pharmacology, Wake Forest University School of Medicine, Winston Salem, NC, USA
    Brain Res Mol Brain Res 128:48-57. 2004
    ..Taken together, these studies illustrate that MeHg induces the generation of astrocyte-derived ROS and support a role for astrocytic ROS in MeHg-associated neurotoxic damage...
  42. pmc Ferroportin is a manganese-responsive protein that decreases manganese cytotoxicity and accumulation
    Zhaobao Yin
    Departments of Pediatrics and Pharmacology, and Kennedy Center for Research on Human Development, Vanderbilt University Medical Center, Nashville, TN 37232, USA
    J Neurochem 112:1190-8. 2010
    ..Collectively, these results indicate that (i) Mn exposure promotes Fpn protein expression, (ii) Fpn expression reduces net Mn accumulation, and (iii) reduces cytotoxicity associated with exposure to this metal...
  43. pmc Manganese toxicity in the central nervous system: the glutamine/glutamate-γ-aminobutyric acid cycle
    M Sidoryk-Węgrzynowicz
    Department of Pediatrics, Vanderbilt University Medical Center, Nashville, TN, USA
    J Intern Med 273:466-77. 2013
    ..Here we discuss the common mechanisms underlying Mn-induced neurotoxicity and their relationship to CNS pathology and GGC impairment...
  44. pmc NADPH oxidases and reactive oxygen species at different stages of chronic hypoxia-induced pulmonary hypertension in newborn piglets
    Kathleen E Dennis
    Dept of Pediatrics, Vanderbilt Univ Medical Center, 2215 B Garland Ave, Nashville, TN 37232 0656, USA
    Am J Physiol Lung Cell Mol Physiol 297:L596-607. 2009
    ....
  45. ncbi request reprint Methylmercury alters glutamate transport in astrocytes
    M Aschner
    Department of Physiology and Pharmacology, Wake Forest University School of Medicine, Winston Salem, NC 27157 1083, USA
    Neurochem Int 37:199-206. 2000
    ..This manuscript details the role of astrocytes in mediating MeHg-induced excitotoxicity, and elaborates on the protective role afforded by metallothioneins (MTs) in attenuating MeHg cytotoxicity...
  46. ncbi request reprint Astrocytic swelling, phospholipase A2, glutathione and glutamate: interactions in methylmercury-induced neurotoxicity
    M Aschner
    Department of Physiology and Pharmacology, and Interdisciplinary Program in Neuroscience, Wake Forest University School of Medicine of Wake Forest University, Winston Salem 27157 1083, USA
    Cell Mol Biol (Noisy-le-grand) 46:843-54. 2000
    ..In addition, the effect of MeHg on glutathione (GSH) homeostasis will be discussed, with particular emphasis on its effects on cystine and cysteine uptake, precursors of GSH synthesis...
  47. ncbi request reprint Identification and characterization of uptake systems for cystine and cysteine in cultured astrocytes and neurons: evidence for methylmercury-targeted disruption of astrocyte transport
    G Shanker
    Department of Physiology and Pharmacology, Wake Forest University School of Medicine, Medical Center Boulevard, Winston-Salem, NC 27157-1083, USA
    J Neurosci Res 66:998-1002. 2001
    ..The review summarizes recent observations on transport systems for cysteine and cystine, precursors of GSH, in primary cultures of astrocytes and neurons, and their sensitivity to MeHg treatment...
  48. ncbi request reprint Ethanol-induced swelling in neonatal rat primary astrocyte cultures
    M Aschner
    Department of Physiology and Pharmacology, Wake Forest University School of Medicine, Medical Center Blvd, Winston Salem, NC 27157 1083, USA
    Brain Res 900:219-26. 2001
    ..Furthermore, the changes associated with EtOH are osmotic in nature, and they are not reversed by anion cotransport blockers...
  49. pmc Pharmacologic suppression of oxidative damage and dendritic degeneration following kainic acid-induced excitotoxicity in mouse cerebrum
    Snjezana Zaja-Milatovic
    Vanderbilt University Medical Center, Vanderbilt University, Nashville, TN 37232, United States
    Neurotoxicology 29:621-7. 2008
    ....
  50. ncbi request reprint Glutamate/aspartate transporter (GLAST), taurine transporter and metallothionein mRNA levels are differentially altered in astrocytes exposed to manganese chloride, manganese phosphate or manganese sulfate
    Keith M Erikson
    Department of Physiology and Pharmacology, School of Medicine, Wake Forest University, Winston Salem 27157 1083, USA
    Neurotoxicology 23:281-8. 2002
    ....
  51. pmc Manganese disrupts astrocyte glutamine transporter expression and function
    Marta Sidoryk-Węgrzynowicz
    Department of Pediatrics, Vanderbilt University Medical Center, Nashville, Tennessee 37232, USA
    J Neurochem 110:822-30. 2009
    ..Consequently, deregulation of glutamate homeostasis and its diminished availability to neurons may lead to impairment in glutamatergic neurotransmission, a phenomenon characteristic of Mn-induced neurotoxicity...
  52. pmc Protection of DFP-induced oxidative damage and neurodegeneration by antioxidants and NMDA receptor antagonist
    Snjezana Zaja-Milatovic
    Vanderbilt University School of Medicine, Department of Pediatrics Pediatric Toxicology, Nashville, TN 37232 0414, USA
    Toxicol Appl Pharmacol 240:124-31. 2009
    ....
  53. ncbi request reprint Modulatory effect of glutathione status and antioxidants on methylmercury-induced free radical formation in primary cultures of cerebral astrocytes
    Gouri Shanker
    Department of Physiology and Pharmacology, Wake Forest University School of Medicine, Winston Salem, NC 27109, USA
    Brain Res Mol Brain Res 137:11-22. 2005
    ..Taken together, these studies point to the important protective effect of adequate intracellular GSH content as well as antioxidants against MeHg-triggered oxidative stress in primary astrocyte cultures...
  54. ncbi request reprint Astrocyte modulation of neurotoxic injury
    Michael Aschner
    Department of Physiology and Pharmacology, Wake Forest University School of Medicine, Winston Salem, NC 27157 1083, USA
    Brain Pathol 12:475-81. 2002
    ....
  55. pmc Estrogen and tamoxifen protect against Mn-induced toxicity in rat cortical primary cultures of neurons and astrocytes
    Eun Sook Y Lee
    Department of Neurology, School of Medicine, Meharry Medical College, Nashville, Tennessee 37208, USA
    Toxicol Sci 110:156-67. 2009
    ..Taken together, the results suggest that both E2 and TX offer effective therapeutic means for neuroprotection against Mn-induced toxicity...
  56. ncbi request reprint Manganese induces oxidative impairment in cultured rat astrocytes
    Dejan Milatovic
    Department of Pediatrics, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, USA
    Toxicol Sci 98:198-205. 2007
    ..Our results demonstrate that induction of oxidative stress, associated mitochondrial dysfunction, and alterations in GLN/glutamate cycling in astrocytes represent key mechanisms by which Mn exerts its neurotoxicity...
  57. pmc Manganese exposure is cytotoxic and alters dopaminergic and GABAergic neurons within the basal ganglia
    Gregg D Stanwood
    Vanderbilt Kennedy Center for Research on Human Development, Vanderbilt University, Nashville, Tennessee 37620, USA
    J Neurochem 110:378-89. 2009
    ..These studies suggest that acute manganese exposure induces cytoskeletal dysfunction prior to degeneration and that chronic manganese exposure results in neurochemical dysfunction with overlapping features to PD...
  58. ncbi request reprint Manganese uptake and distribution in the central nervous system (CNS)
    M Aschner
    Department of Physiology and Pharmacology, Wake Forest University School of Medicine of Wake Forest University, Winston Salem, NC, USA
    Neurotoxicology 20:173-80. 1999
    ....
  59. pmc Manganese: brain transport and emerging research needs
    M Aschner
    Department of Physiology and Pharmacology, and Interdisciplinary Program in Neuroscience, Wake Forest University School of Medicine, Winston Salem, North Carolina, USA
    Environ Health Perspect 108:429-32. 2000
    ..g., iron-deficient) to Mn exposure, and addresses future research needs for Mn...
  60. ncbi request reprint Astrocyte metallothioneins (MTs) and their neuroprotective role
    M Aschner
    Department of Physiology and Pharmacology, Bowman Gray School of Medicine of Wake Forest University, Winston Salem, North Carolina 27157 1083, USA
    Ann N Y Acad Sci 825:334-47. 1997
    ..Future studies on the expression and regulation of MT genes are likely to culminate in novel strategies for manipulating intracellular MT levels, providing insight to their role in both health and disease...
  61. pmc Altered expression of genes involved in inflammation and apoptosis in frontal cortex in major depression
    R C Shelton
    Department of Psychiatry, Vanderbilt University School of Medicine, Nashville, TN 37212, USA
    Mol Psychiatry 16:751-62. 2011
    ..The results of this study indicate that post-mortem brain tissue samples from BA10, a region that is involved in reward-related behavior, show evidence of local inflammatory, apoptotic, and oxidative stress in MDD...
  62. ncbi request reprint Neurotoxic potential of depleted uranium effects in primary cortical neuron cultures and in Caenorhabditis elegans
    George C T Jiang
    Department of Physiology and Pharmacology, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157 1083, USA
    Toxicol Sci 99:553-65. 2007
    ..These findings should alleviate the some of public concerns regarding DU as an etiologic agent of neurodegenerative conditions associated with GWS...
  63. ncbi request reprint Anticholinesterase toxicity and oxidative stress
    Dejan Milatovic
    Department of Pediatrics, Medical School, Vanderbilt University, Nashville, TN, USA
    ScientificWorldJournal 6:295-310. 2006
    ..This review describes the mechanisms involved in anticholinesterase-induced oxidative/nitrosative injury in target organs of OPs/CMs, and protection by various agents...
  64. pmc Methylmercury toxicity and Nrf2-dependent detoxification in astrocytes
    Ling Wang
    Vanderbilt Eye Institute, Vanderbilt University Medical Center, Nashville, TN 37232, USA
    Toxicol Sci 107:135-43. 2009
    ..Modulation of Nrf2 by pharmacological modalities should afford a treatment to attenuate MeHg-induced neurotoxicity...
  65. ncbi request reprint Iron deficient and manganese supplemented diets alter metals and transporters in the developing rat brain
    Stephanie J Garcia
    Department of Physiology and Pharmacology, Wake Forest University Health Sciences, Winston Salem, North Carolina 27157, USA
    Toxicol Sci 95:205-14. 2007
    ..The results of this study confirm that there is homeostatic relationship among several essential metals in the brain and not simply between Fe and Mn...
  66. ncbi request reprint Effects of manganese (Mn) on the developing rat brain: oxidative-stress related endpoints
    Sarah Weber
    Department of Physiology and Pharmacology, Bowman Gray School of Medicine of Wake Forest University, Winston Salem, NC 27157 1083, USA
    Neurotoxicology 23:169-75. 2002
    ..05) total cerebrocortical GSH without accompanying changes in any of the other measured parameters. Therefore, it is unlikely that high dose Mn exposure is associated with oxidative stress in this experimental paradigm...
  67. ncbi request reprint Methylmercury alters the in vitro uptake of glutamate in GLAST- and GLT-1-transfected mutant CHO-K1 cells
    Lysette Mutkus
    Department of Physiology and Pharmacology, Wake Forest University School of Medicine, Winston Salem, NC 27157 1083, USA
    Biol Trace Elem Res 107:231-45. 2005
    ..01) increased following exposure to 5 and 10 microM MeHg. These studies suggest that MeHg contributes to the dysregulation of glutamate homeostasis and that its effects are distinct for GLAST and GLT-1...
  68. ncbi request reprint Airborne manganese exposure differentially affects end points of oxidative stress in an age- and sex-dependent manner
    Keith M Erikson
    Department of Physiology and Pharmacology and Interdisciplinary Program in Neuroscience, Wake Forest University School of Medicine, Winston Salem, NC, USA
    Biol Trace Elem Res 100:49-62. 2004
    ..1-mg/m3 manganese phosphate exposure. These results demonstrate that age and sex are variables that must be considered when assessing the neurotoxicity of manganese...
  69. pmc Altered manganese homeostasis and manganese toxicity in a Huntington's disease striatal cell model are not explained by defects in the iron transport system
    B Blairanne Williams
    Neuroscience Graduate Program, Vanderbilt University Medical Center, Nashville, Tennessee 37232 8552, USA
    Toxicol Sci 117:169-79. 2010
    ..Therefore, although Fe transporters contribute to Mn uptake and toxicity in the striatal cell lines, functional alterations in this pathway are insufficient to explain the strong Mn resistance phenotype of this HD cell model...
  70. ncbi request reprint In vitro uptake of glutamate in GLAST- and GLT-1-transfected mutant CHO-K1 cells is inhibited by the ethylmercury-containing preservative thimerosal
    Lysette Mutkus
    Department of Physiology and Pharmacology, Wake Forest University School of Medicine, Winston Salem, NC 27157 1083, USA
    Biol Trace Elem Res 105:71-86. 2005
    ..These studies suggest that thimerosal accumulation in the central nervous system might contribute to dysregulation of glutamate homeostasis...
  71. pmc Oxidative damage and neurodegeneration in manganese-induced neurotoxicity
    Dejan Milatovic
    Vanderbilt University Medical Center, Department of Pediatrics Pediatric Toxicology, 2215 B Garland Avenue, 11415 MRB IV, Nashville, TN 37232 0414, USA
    Toxicol Appl Pharmacol 240:219-25. 2009
    ..These findings suggest that oxidative stress, mitochondrial dysfunction and neuroinflammation are underlying mechanisms in Mn-induced neurodegeneration...
  72. ncbi request reprint The acute effects of acrylamide on astrocyte functions
    Michael Aschner
    Department of Physiology and Pharmacology and Interdisciplinary Program in Neuroscience, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157, USA
    Ann N Y Acad Sci 993:296-304; discussion 345-9. 2003
    ..0 mM) mRNA expression levels. All other measurements were insignificant in comparison with controls, suggesting that astrocytic function is minimally compromised even at exceedingly high levels of acute acrylamide exposure...
  73. pmc Characterization of the effects of methylmercury on Caenorhabditis elegans
    Kirsten J Helmcke
    Pharmacology Department, Vanderbilt University Medical Center, Nashville, TN 37232 0414, USA
    Toxicol Appl Pharmacol 240:265-72. 2009
    ..We propose, therefore, that C. elegans should be a useful model for discovering intrinsic mechanisms that confer resistance to MeHgCl exposure...
  74. ncbi request reprint Glial cells in neurotoxicity development
    M Aschner
    Department of Physiology and Pharmacology, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157, USA
    Annu Rev Pharmacol Toxicol 39:151-73. 1999
    ....
  75. ncbi request reprint Interactions between pesticides and glia: an unexplored experimental field
    M Aschner
    Department of Physiology and Pharmacology, Wake Forest University School of Medicine, Winston Salem, NC 27157 1083, USA
    Neurotoxicology 21:175-80. 2000
    ..This review will focus on astrocytic cholinergic receptors, choline uptake and metabolism, and address the potential importance of astrocytes in organophosphorous insecticide mediated neurotoxicity...
  76. ncbi request reprint The neuropathogenesis of mercury toxicity
    M Aschner
    Department of Physiology and Pharmacology, Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, NC 27157 1083, USA
    Mol Psychiatry 7:S40-1. 2002
  77. ncbi request reprint Transendothelial permeability of chlorpyrifos in RBE4 monolayers is modulated by astrocyte-conditioned medium
    J Yang
    Department of Physiology and Pharmacology, Wake Forest University, School of Medicine, Winston-Salem, NC 27157, USA
    Brain Res Mol Brain Res 97:43-50. 2001
    ..This work demonstrates that with additional refinements the RBE4 monolayers might serve as a useful in vitro model for the study of BBB permeability and modulation by astrocyte-derived soluble factors...
  78. pmc Comparison of alterations in amino acids content in cultured astrocytes or neurons exposed to methylmercury separately or in co-culture
    Zhaobao Yin
    Department of Pediatrics, and The Kennedy Center for Research on Human Development, Vanderbilt University Medical Center, Nashville, TN 37232, USA
    Neurochem Int 55:136-42. 2009
    ..Delineating the mechanisms underlying the mutual neuroprotective effects of astrocytes and neurons in co-culture to MeHg-induced amino acid imbalance requires further investigation...
  79. ncbi request reprint Manganese dosimetry: species differences and implications for neurotoxicity
    Michael Aschner
    Vanderbilt University, Nashville, Tennessee, USA
    Crit Rev Toxicol 35:1-32. 2005
    ..g., pre-parkinsonian state, aging), may have altered manganese metabolism and could be at greater risk for manganese toxicity...
  80. ncbi request reprint The importance of glutamate, glycine, and gamma-aminobutyric acid transport and regulation in manganese, mercury and lead neurotoxicity
    Vanessa A Fitsanakis
    Department of Pediatrics, B 3307 Medical Center North, Vanderbilt University School of Medicine, Nashville, TN 37232 2495, USA
    Toxicol Appl Pharmacol 204:343-54. 2005
    ..Additionally, the review will address the hypothesis that aberrant homeostasis of any of these amino acids, or a combination of the three, plays a role in the neurotoxicity of Mn, Hg, or Pb...
  81. ncbi request reprint Methylmercury-induced reactive oxygen species formation in neonatal cerebral astrocytic cultures is attenuated by antioxidants
    Gouri Shanker
    Department of Physiology and Pharmacology, Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, NC 27157 1083, USA
    Brain Res Mol Brain Res 110:85-91. 2003
    ..Combined, these studies invoke ROS as potent mediators of MeHg cytotoxicity and support the hypothesis that excessive ROS generation, at least in part, plays an important role in MeHg-induced neurotoxicity...
  82. ncbi request reprint Manganese transport by rat brain endothelial (RBE4) cell-based transwell model in the presence of astrocyte conditioned media
    Vanessa A Fitsanakis
    Department of Pediatrics, Vanderbilt University Medical Center, Nashville, TN 37232 2495, USA
    J Neurosci Res 81:235-43. 2005
    ....
  83. ncbi request reprint Manganese causes differential regulation of glutamate transporter (GLAST) taurine transporter and metallothionein in cultured rat astrocytes
    Keith Erikson
    Department of Physiology and Pharmacology, Wake Forest University School of Medicine, Winston Salem, NC 27157 1083, USA
    Neurotoxicology 23:595-602. 2002
    ..MT mRNA decreased in these Mn exposed astrocytes possibly due to altered metal metabolism, although this was not examined. These data show that glutamate and taurine transport in Mn exposed astrocytes are temporally different...
  84. ncbi request reprint The functional significance of brain metallothioneins
    M Aschner
    Department of Physiology and Pharmacology, Bowman Gray School of Medicine, Winston Salem, North Carolina, USA
    FASEB J 10:1129-36. 1996
    ..Aschner, M. The functional significance of brain metallothioneins...
  85. doi request reprint Caenorhabditis elegans metallothioneins protect against toxicity induced by depleted uranium
    George C T Jiang
    Department of Pediatrics, Vanderbilt University Medical Center, Nashville, Tennessee 37232, USA
    Toxicol Sci 111:345-54. 2009
    ..elegans. These findings suggest that these highly homologous proteins may have subtle functional differences and indicate that MTs mediate the response to DU...
  86. ncbi request reprint Manganese neurotoxicity
    Allison W Dobson
    Department of Physiology and Pharmacology, and Interdisciplinary Program in Neuroscience, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157 1083, USA
    Ann N Y Acad Sci 1012:115-28. 2004
    ..Additionally, evidence for the role of oxidative stress in the progression of manganism is reviewed here...
  87. ncbi request reprint Manganese (Mn) and iron (Fe): interdependency of transport and regulation
    Vanessa A Fitsanakis
    Department of Biology, King College, Bristol, TN, USA
    Neurotox Res 18:124-31. 2010
    ..Finally, this review will provide information about various transport proteins currently under investigation in the research community related to Fe and Mn regulation and transport...
  88. pmc Hormetic effect of methylmercury on Caenorhabditis elegans
    Kirsten J Helmcke
    Pharmacology Department and Center in Molecular Toxicology, Vanderbilt University, Nashville, TN 37232, USA
    Toxicol Appl Pharmacol 248:156-64. 2010
    ..Our results implicate GSH, HSPs, and MTs in protecting C. elegans from MeHg toxicity and show a potential role of gst-4 in MeHg-induced hormesis...
  89. ncbi request reprint Characteristics of manganese (Mn) transport in rat brain endothelial (RBE4) cells, an in vitro model of the blood-brain barrier
    Vanessa A Fitsanakis
    Department of Pediatrics, B 3307 Medical Center North, Vanderbilt University School of Medicine, Nashville, TN 37232 2495, USA
    Neurotoxicology 27:60-70. 2006
    ..These data reinforce observations that transport of Mn across the BBB occurs in part through active transport process...
  90. pmc Chronic exposure to manganese alters brain responses to amphetamine: a pharmacological magnetic resonance imaging study
    Jason M Williams
    Department of Radiology and Radiological Sciences, Vanderbilt University Medical Center, Nashville, Tennessee 37232, USA
    Toxicol Sci 114:310-22. 2010
    ..These results demonstrate the utility of AMPH-evoked phMRI as readout of the DAergic signaling in vivo and confirm the vulnerability of DAergic systems to Mn...
  91. ncbi request reprint The transport of manganese across the blood-brain barrier
    Michael Aschner
    Department of Physiology and Pharmacology, Wake Forest University, School of Medicine, Winston Salem, NC 27157 1083, USA
    Neurotoxicology 27:311-4. 2006
    ..Specifically, putative carriers for manganese into and out of the brain will be discussed...
  92. ncbi request reprint Developmental aspects of blood-brain barrier (BBB) and rat brain endothelial (RBE4) cells as in vitro model for studies on chlorpyrifos transport
    Jian Yang
    Department of Physiology and Pharmacology, School of Medicine, Wake Forest University, Winston Salem, NC 27157, USA
    Neurotoxicology 24:741-5. 2003
    ....
  93. doi request reprint Utility of Caenorhabditis elegans in high throughput neurotoxicological research
    Kirsten J Helmcke
    Pharmacology Department, Vanderbilt University Medical Center, Nashville, TN, USA
    Neurotoxicol Teratol 32:62-7. 2010
    ....
  94. ncbi request reprint The effects of manganese on glutamate, dopamine and gamma-aminobutyric acid regulation
    Vanessa A Fitsanakis
    Department of Pediatrics, Vanderbilt University Medical Center, Nashville, TN 37232, USA
    Neurochem Int 48:426-33. 2006
    ..Finally, we suggest that current research focus on the interdependence of these basal ganglial neurochemicals, with a greater emphasis on the GABAergic and glutamatergic systems...
  95. ncbi request reprint Open issues from the 15th International Conference on Manganese
    Michael Aschner
    Department of Physiology and Pharmacology, Wake Forest University, School of Medicine, Winston Salem, NC 27157 1083, USA
    Neurotoxicology 23:123-5. 2002
  96. ncbi request reprint Methylmercury enhances arachidonic acid release and cytosolic phospholipase A2 expression in primary cultures of neonatal astrocytes
    Gouri Shanker
    Department of Physiology and Pharmacology, and Interdisciplinary Program in Neuroscience, Wake Forest University School of Medicine, Medical Center Blvd, Winston Salem, NC 27157 1083, USA
    Brain Res Mol Brain Res 106:1-11. 2002
    ..These results invoke cPLA(2) as a putative target for MeHg toxicity, and support the notion that cPLA(2)-stimulated hydrolysis and release of AA play a critical role in MeHg-induced neurotoxicity...
  97. ncbi request reprint The consequences of methylmercury exposure on interactive functions between astrocytes and neurons
    Jeffrey W Allen
    Interdisciplinary Program in Neuroscience, Department of Physiology and Pharmacology, Wake Forest University School of Medicine, Winston Salem, NC 27157 1083, USA
    Neurotoxicology 23:755-9. 2002
    ..These effects likely increase neuronal vulnerability to MeHg-induced oxidative stress, and excess N-methyl D-aspartate (NMDA) receptor activation leading to neuronal demise...
  98. pmc Prenatal exposure to benzo(a)pyrene impairs later-life cortical neuronal function
    Monique M McCallister
    Department of Neurobiology and Neurotoxicology, Center for Molecular and Behavioral Neuroscience, Meharry Medical College, Nashville, TN 37208, USA
    Neurotoxicology 29:846-54. 2008
    ....
  99. ncbi request reprint A manganese-enhanced diet alters brain metals and transporters in the developing rat
    Stephanie J Garcia
    Department of Physiology and Pharmacology, Wake Forest University Health Sciences, Winston Salem, North Carolina 27157, USA
    Toxicol Sci 92:516-25. 2006
    ....
  100. ncbi request reprint Oxidative stress is induced in the rat brain following repeated inhalation exposure to manganese sulfate
    Allison W Dobson
    Department of Physiology, Wake Forest University School of Medicine, Winston Salem, NC, USA
    Biol Trace Elem Res 93:113-26. 2003
    ....

Research Grants23

  1. MECHANISMS OF METHYLMERCURY INDUCED NEURONAL TOXICITY
    Michael Aschner; Fiscal Year: 1999
    ....
  2. MECHANISMS OF METHYLMERCURY INDUCED NEURONAL TOXICITY
    Michael Aschner; Fiscal Year: 2004
    ..Additionally, studies on altered post-translational modification of Hsp90 client proteins might offer new mechanistic insight into other neurodegenerative disorders, and therefore they have broad biological implications ..
  3. BBB Transport of MMT Metabolites
    Michael Aschner; Fiscal Year: 2004
    ..3+). (2) The identification of populations (Fe-deficient) susceptible and at heightened risk to Mn toxicity. (3) Delineation of the potential mechanisms of Mn-induced neurotoxicity vis-a-vis its accumulation in the CNS. ..
  4. MECHANISMS OF METHYLMERCURY INDUCED NEURONAL TOXICITY
    Michael Aschner; Fiscal Year: 2006
    ..Additionally, studies on altered post-translational modification of Hsp90 client proteins might offer new mechanistic insight into other neurodegenerative disorders, and therefore they have broad biological implications ..
  5. Mechanisms of Manganese Neurotoxicity
    Michael Aschner; Fiscal Year: 2007
    ..Understanding the relationship between genetic vulnerability and Mn exposure will provide critical insights into the mechanisms of Mn-induced toxicity and the development of novel therapeutic neuroprotective strategies. ..
  6. MECHANISMS OF METHYLMERCURY INDUCED NEURONAL TOXICITY
    Michael Aschner; Fiscal Year: 2007
    ..Additionally, studies on altered post-translational modification of Hsp90 client proteins might offer new mechanistic insight into other neurodegenerative disorders, and therefore they have broad biological implications ..
  7. Mechanisms of Manganese Neurotoxicity
    Michael Aschner; Fiscal Year: 2009
    ..Understanding the relationship between genetic vulnerability and Mn exposure will provide critical insights into the mechanisms of Mn-induced toxicity and the development of novel therapeutic neuroprotective strategies. ..
  8. Mechanisms of Manganese Neurotoxicity
    Michael Aschner; Fiscal Year: 2010
    ..Understanding the relationship between genetic vulnerability and Mn exposure will provide critical insights into the mechanisms of Mn-induced toxicity and the development of novel therapeutic neuroprotective strategies. ..
  9. MECHANISMS OF METHYLMERCURY INDUCED NEURONAL TOXICITY
    Michael Aschner; Fiscal Year: 2005
    ..Additionally, studies on altered post-translational modification of Hsp90 client proteins might offer new mechanistic insight into other neurodegenerative disorders, and therefore they have broad biological implications ..
  10. BBB Transport of MMT Metabolites
    Michael Aschner; Fiscal Year: 2005
    ..3+). (2) The identification of populations (Fe-deficient) susceptible and at heightened risk to Mn toxicity. (3) Delineation of the potential mechanisms of Mn-induced neurotoxicity vis-a-vis its accumulation in the CNS. ..
  11. MECHANISMS OF METHYLMERCURY INDUCED NEURONAL TOXICITY
    Michael Aschner; Fiscal Year: 2004
    ..Additionally, studies on altered post-translational modification of Hsp90 client proteins might offer new mechanistic insight into other neurodegenerative disorders, and therefore they have broad biological implications ..
  12. MECHANISMS OF METHYLMERCURY INDUCED NEURONAL TOXICITY
    Michael Aschner; Fiscal Year: 2000
    ..Our approach will encompass a broad array of methods, including molecular biology, electrophysiology, radiolabel trans-membrane fluxes, and electrical impedance measurements of cell volume. ..
  13. BBB Transport of MMT Metabolites
    Michael Aschner; Fiscal Year: 2001
    ..3+). (2) The identification of populations (Fe-deficient) susceptible and at heightened risk to Mn toxicity. (3) Delineation of the potential mechanisms of Mn-induced neurotoxicity vis-a-vis its accumulation in the CNS. ..
  14. MECHANISMS OF METHYLMERCURY INDUCED NEURONAL TOXICITY
    Michael Aschner; Fiscal Year: 2000
    ..Our approach will encompass a broad array of methods, including molecular biology, electrophysiology, radiolabel trans-membrane fluxes, and electrical impedance measurements of cell volume. ..
  15. MECHANISMS OF METHYLMERCURY INDUCED NEURONAL TOXICITY
    Michael Aschner; Fiscal Year: 2001
    ..Our approach will encompass a broad array of methods, including molecular biology, electrophysiology, radiolabel trans-membrane fluxes, and electrical impedance measurements of cell volume. ..
  16. MECHANISMS OF METHYLMERCURY INDUCED NEURONAL TOXICITY
    Michael Aschner; Fiscal Year: 2002
    ..Our approach will encompass a broad array of methods, including molecular biology, electrophysiology, radiolabel trans-membrane fluxes, and electrical impedance measurements of cell volume. ..
  17. BBB Transport of MMT Metabolites
    Michael Aschner; Fiscal Year: 2002
    ..3+). (2) The identification of populations (Fe-deficient) susceptible and at heightened risk to Mn toxicity. (3) Delineation of the potential mechanisms of Mn-induced neurotoxicity vis-a-vis its accumulation in the CNS. ..
  18. MECHANISMS OF METHYLMERCURY INDUCED NEURONAL TOXICITY
    Michael Aschner; Fiscal Year: 2003
    ..Our approach will encompass a broad array of methods, including molecular biology, electrophysiology, radiolabel trans-membrane fluxes, and electrical impedance measurements of cell volume. ..
  19. BBB Transport of MMT Metabolites
    Michael Aschner; Fiscal Year: 2003
    ..3+). (2) The identification of populations (Fe-deficient) susceptible and at heightened risk to Mn toxicity. (3) Delineation of the potential mechanisms of Mn-induced neurotoxicity vis-a-vis its accumulation in the CNS. ..
  20. 9th International Neurotoxicology Assoc (INA9) Meeting
    Michael Aschner; Fiscal Year: 2003
    ....
  21. MECHANISMS OF METHYLMERCURY INDUCED NEURONAL TOXICITY
    Michael Aschner; Fiscal Year: 2010
    ..Results from studies in the worm on the sensitivity of distinct populations of brain cells to this ubiquitous environmental pollutant will also offer new targets for therapeutic interventions. ..