Michael Weinreich

Summary

Affiliation: Van Andel Research Institute
Country: USA

Publications

  1. pmc High-resolution analysis of four efficient yeast replication origins reveals new insights into the ORC and putative MCM binding elements
    FuJung Chang
    Laboratory of Chromosome Replication, Van Andel Research Institute, 333 Bostwick Ave NE Grand Rapids, MI 49503, USA
    Nucleic Acids Res 39:6523-35. 2011
  2. pmc Cdc7p-Dbf4p regulates mitotic exit by inhibiting Polo kinase
    Charles T Miller
    Graduate Program in Cell and Molecular Biology, Michigan State University, East Lansing, MI, USA
    PLoS Genet 5:e1000498. 2009
  3. ncbi request reprint The activities of eukaryotic replication origins in chromatin
    Michael Weinreich
    Laboratory of Chromosome Replication, Van Andel Research Institute, 333 Bostwick Ave NE, Grand Rapids, MI 49503, USA
    Biochim Biophys Acta 1677:142-57. 2004
  4. doi request reprint An ARS element inhibits DNA replication through a SIR2-dependent mechanism
    Amber Crampton
    Laboratory of Chromosome Replication, Van Andel Research Institute, Grand Rapids, MI 49503, USA
    Mol Cell 30:156-66. 2008
  5. pmc A Dbf4p BRCA1 C-terminal-like domain required for the response to replication fork arrest in budding yeast
    Carrie Gabrielse
    Laboratory of Chromosome Replication, Van Andel Research Institute, Grand Rapids, Michigan 49503, USA
    Genetics 173:541-55. 2006
  6. pmc Dbf4 regulates the Cdc5 Polo-like kinase through a distinct non-canonical binding interaction
    Ying Chou Chen
    Van Andel Research Institute, Grand Rapids, Michigan 49503, USA
    J Biol Chem 285:41244-54. 2010
  7. pmc DNA replication checkpoint signaling depends on a Rad53-Dbf4 N-terminal interaction in Saccharomyces cerevisiae
    Ying Chou Chen
    Laboratory of Genome Integrity and Tumorigenesis, Van Andel Research Institute, Grand Rapids, MI 49503, USA
    Genetics 194:389-401. 2013
  8. pmc Budding yeast Dbf4 sequences required for Cdc7 kinase activation and identification of a functional relationship between the Dbf4 and Rev1 BRCT domains
    Victoria Harkins
    Laboratory of Chromosome Replication, Van Andel Research Institute, Grand Rapids, Michigan 49503, USA
    Genetics 183:1269-82. 2009
  9. pmc Analysis of chromosome III replicators reveals an unusual structure for the ARS318 silencer origin and a conserved WTW sequence within the origin recognition complex binding site
    FuJung Chang
    Laboratory of Chromosome Replication, Van Andel Research Institute, Grand Rapids, MI 49503, USA
    Mol Cell Biol 28:5071-81. 2008
  10. pmc The NAD(+)-dependent Sir2p histone deacetylase is a negative regulator of chromosomal DNA replication
    Donald L Pappas
    Laboratory of Chromosome Replication, Van Andel Research Institute, Grand Rapids, Michigan 49503, USA
    Genes Dev 18:769-81. 2004

Collaborators

  • Catherine A Fox
  • Conrad A Nieduszynski
  • Han Mo Koo
  • Min Han Tan
  • Chun Zhang
  • Philip Zegerman
  • Ying Chou Chen
  • FuJung Chang
  • Carrie Gabrielse
  • Charles T Miller
  • Donald L Pappas
  • Jeremy Miller
  • Victoria Harkins
  • Dorine Bonte
  • Amber Crampton
  • Kristopher H McConnell
  • Melissa E Bose
  • Jessica Kenworthy
  • Christine Hänni
  • Caitlin D May
  • Timothy Hoggard
  • Louise Haste
  • Carol S Newlon
  • Kyle Furge
  • Ryan L Frisch
  • James F Theis
  • Hongyu Liu
  • Karl Dykema
  • Charlotta Lindvall
  • Aaron DeWard
  • Kelly A Gardner-Aukema
  • Ulrika Muller
  • James L Keck
  • Ryan Frisch

Detail Information

Publications13

  1. pmc High-resolution analysis of four efficient yeast replication origins reveals new insights into the ORC and putative MCM binding elements
    FuJung Chang
    Laboratory of Chromosome Replication, Van Andel Research Institute, 333 Bostwick Ave NE Grand Rapids, MI 49503, USA
    Nucleic Acids Res 39:6523-35. 2011
    ....
  2. pmc Cdc7p-Dbf4p regulates mitotic exit by inhibiting Polo kinase
    Charles T Miller
    Graduate Program in Cell and Molecular Biology, Michigan State University, East Lansing, MI, USA
    PLoS Genet 5:e1000498. 2009
    ..Therefore, Cdc7p-Dbf4p prevents inappropriate exit from mitosis by inhibiting Polo kinase and functions in the spindle position checkpoint...
  3. ncbi request reprint The activities of eukaryotic replication origins in chromatin
    Michael Weinreich
    Laboratory of Chromosome Replication, Van Andel Research Institute, 333 Bostwick Ave NE, Grand Rapids, MI 49503, USA
    Biochim Biophys Acta 1677:142-57. 2004
    ..These roles are not linked obligatorily to replication origin activity per se, but instead exploit multi-subunit replication proteins with the potential to form context-dependent protein-protein interactions...
  4. doi request reprint An ARS element inhibits DNA replication through a SIR2-dependent mechanism
    Amber Crampton
    Laboratory of Chromosome Replication, Van Andel Research Institute, Grand Rapids, MI 49503, USA
    Mol Cell 30:156-66. 2008
    ..These data suggest that Sir2p and I(S) elements inhibit origin activity by promoting an unfavorable chromatin structure for pre-RC assembly...
  5. pmc A Dbf4p BRCA1 C-terminal-like domain required for the response to replication fork arrest in budding yeast
    Carrie Gabrielse
    Laboratory of Chromosome Replication, Van Andel Research Institute, Grand Rapids, Michigan 49503, USA
    Genetics 173:541-55. 2006
    ..Rad53p likely directly phosphorylated Dbf4p in response to RF arrest and Dbf4p was required for Rad53p abundance. Rad53p and Dbf4p therefore cooperated to coordinate a robust cellular response to RF arrest...
  6. pmc Dbf4 regulates the Cdc5 Polo-like kinase through a distinct non-canonical binding interaction
    Ying Chou Chen
    Van Andel Research Institute, Grand Rapids, Michigan 49503, USA
    J Biol Chem 285:41244-54. 2010
    ..This study, therefore, details the molecular nature of a new type of PBD binding and reveals that Cdc5 targeting to phosphorylated substrates likely regulates spindle dynamics...
  7. pmc DNA replication checkpoint signaling depends on a Rad53-Dbf4 N-terminal interaction in Saccharomyces cerevisiae
    Ying Chou Chen
    Laboratory of Genome Integrity and Tumorigenesis, Van Andel Research Institute, Grand Rapids, MI 49503, USA
    Genetics 194:389-401. 2013
    ..This indicated that Rad53 must stably bind to Dbf4 to regulate its activity...
  8. pmc Budding yeast Dbf4 sequences required for Cdc7 kinase activation and identification of a functional relationship between the Dbf4 and Rev1 BRCT domains
    Victoria Harkins
    Laboratory of Chromosome Replication, Van Andel Research Institute, Grand Rapids, Michigan 49503, USA
    Genetics 183:1269-82. 2009
    ..Our data also suggest that the Dbf4 and Rev1 BRCT domains interact with a common protein or structure, although the precise function of both domains and their binding partners remains elusive...
  9. pmc Analysis of chromosome III replicators reveals an unusual structure for the ARS318 silencer origin and a conserved WTW sequence within the origin recognition complex binding site
    FuJung Chang
    Laboratory of Chromosome Replication, Van Andel Research Institute, Grand Rapids, MI 49503, USA
    Mol Cell Biol 28:5071-81. 2008
    ..This analysis revealed a highly conserved WTW motif 17 to 19 bp from the ACS that is functionally important and is apparent in the 228 phylogenetically conserved ARS elements among the six sensu stricto Saccharomyces species...
  10. pmc The NAD(+)-dependent Sir2p histone deacetylase is a negative regulator of chromosomal DNA replication
    Donald L Pappas
    Laboratory of Chromosome Replication, Van Andel Research Institute, Grand Rapids, Michigan 49503, USA
    Genes Dev 18:769-81. 2004
    ....
  11. pmc Cdc7-Dbf4 kinase overexpression in multiple cancers and tumor cell lines is correlated with p53 inactivation
    Dorine Bonte
    Laboratories of Chromosome Replication, Van Andel Research Institute, Grand Rapids, MI 49503, USA
    Neoplasia 10:920-31. 2008
    ..6 x 10(-9) and 1.8 x 10(-10), respectively) and in the cancer cell lines we studied. Therefore, increased Cdc7-Dbf4 abundance may be a common occurrence in human malignancies...
  12. ncbi request reprint Parafibromin inhibits cancer cell growth and causes G1 phase arrest
    Chun Zhang
    Laboratory of Cancer Genetics, Van Andel Research Institute, Grand Rapids, MI 49503, USA
    Biochem Biophys Res Commun 350:17-24. 2006
    ..These findings suggest that parafibromin has a critical role in cell growth, and mutations in HRPT2 can directly inhibit this role...
  13. pmc The origin recognition complex and Sir4 protein recruit Sir1p to yeast silent chromatin through independent interactions requiring a common Sir1p domain
    Melissa E Bose
    Department of Biomolecular Chemistry, 587 MSC, University of Wisconsin Medical School, 1300 University Avenue, Madison, WI 43706 1532, USA
    Mol Cell Biol 24:774-86. 2004
    ....