Bin T Teh

Summary

Affiliation: Van Andel Research Institute
Country: USA

Publications

  1. pmc Exome sequencing identifies frequent mutation of the SWI/SNF complex gene PBRM1 in renal carcinoma
    Ignacio Varela
    Cancer Genome Project, Wellcome Trust Sanger Institute, Hinxton CB10 1SA, UK
    Nature 469:539-42. 2011
  2. pmc Systematic sequencing of renal carcinoma reveals inactivation of histone modifying genes
    Gillian L Dalgliesh
    Cancer Genome Project, Wellcome Trust Sanger Institute, Hinxton CB10 1SA, UK
    Nature 463:360-3. 2010
  3. pmc Deficiency of FLCN in mouse kidney led to development of polycystic kidneys and renal neoplasia
    Jindong Chen
    Laboratory of Cancer Genetics, Van Andel Research Institute, Grand Rapids, Michigan, USA
    PLoS ONE 3:e3581. 2008
  4. pmc First somatic mutation of E2F1 in a critical DNA binding residue discovered in well-differentiated papillary mesothelioma of the peritoneum
    Willie Yu
    NCCS VARI Translational Research Laboratory, National Cancer Centre Singapore, 11 Hospital Drive, 169610, Singapore
    Genome Biol 12:R96. 2011
  5. pmc Transient bilateral abducens neuropathy with post-tetanic facilitation and acute hypokalemia associated with oxaliplatin: a case report
    Min Han Tan
    Department of Medical Oncology, National Cancer Centre, 11 Hospital Drive, Singapore 169610, Republic of Singapore
    J Med Case Reports 4:36. 2010
  6. pmc Genomic expression and single-nucleotide polymorphism profiling discriminates chromophobe renal cell carcinoma and oncocytoma
    Min Han Tan
    Laboratory of Cancer Genetics, Van Andel Research Institute, 333 Bostwick Avenue NE, Grand Rapids, MI 49503, USA
    BMC Cancer 10:196. 2010
  7. ncbi Human gene mutations. Gene symbol: HRPT2. Disease: Hyperparathyroidism Jaw-tumor syndrome
    B T Teh
    Laboratory of Cancer Genetics, Van Andel Research Institute, 333 Bostwick NE, Grand Rapids, MI 49503, USA
    Hum Genet 114:223. 2004
  8. ncbi Human gene mutations. Gene symbol: HRPT2. Disease: Hyperparathyroidism Jaw-tumor syndrome
    B T Teh
    Laboratory of Cancer Genetics, Van Andel Research Institute, 333 Bostwick NE, Grand Rapids, MI 49503, USA
    Hum Genet 114:221. 2004
  9. ncbi Human gene mutations. Gene symbol: HRPT2. Disease: Hyperparathyroidism Jaw-tumor syndrome
    B T Teh
    Laboratory of Cancer Genetics, Van Andel Research Institute, 333 Bostwick NE, Grand Rapids, MI 49503, USA
    Hum Genet 114:222. 2004
  10. ncbi Human gene mutations. Gene symbol: HRPT2. Disease: Hyperparathyroidism Jaw-tumor syndrome
    B T Teh
    Laboratory of Cancer Genetics, Van Andel Research Institute, 333 Bostwick NE, Grand Rapids, MI 49503, USA
    Hum Genet 114:222. 2004

Detail Information

Publications66

  1. pmc Exome sequencing identifies frequent mutation of the SWI/SNF complex gene PBRM1 in renal carcinoma
    Ignacio Varela
    Cancer Genome Project, Wellcome Trust Sanger Institute, Hinxton CB10 1SA, UK
    Nature 469:539-42. 2011
    ..4) as a second major ccRCC cancer gene, with truncating mutations in 41% (92/227) of cases. These data further elucidate the somatic genetic architecture of ccRCC and emphasize the marked contribution of aberrant chromatin biology...
  2. pmc Systematic sequencing of renal carcinoma reveals inactivation of histone modifying genes
    Gillian L Dalgliesh
    Cancer Genome Project, Wellcome Trust Sanger Institute, Hinxton CB10 1SA, UK
    Nature 463:360-3. 2010
    ..These results indicate that substantial genetic heterogeneity exists in a cancer type dominated by mutations in a single gene, and that systematic screens will be key to fully determining the somatic genetic architecture of cancer...
  3. pmc Deficiency of FLCN in mouse kidney led to development of polycystic kidneys and renal neoplasia
    Jindong Chen
    Laboratory of Cancer Genetics, Van Andel Research Institute, Grand Rapids, Michigan, USA
    PLoS ONE 3:e3581. 2008
    ....
  4. pmc First somatic mutation of E2F1 in a critical DNA binding residue discovered in well-differentiated papillary mesothelioma of the peritoneum
    Willie Yu
    NCCS VARI Translational Research Laboratory, National Cancer Centre Singapore, 11 Hospital Drive, 169610, Singapore
    Genome Biol 12:R96. 2011
    ..In this study, we perform the first exome sequencing of WDPMP...
  5. pmc Transient bilateral abducens neuropathy with post-tetanic facilitation and acute hypokalemia associated with oxaliplatin: a case report
    Min Han Tan
    Department of Medical Oncology, National Cancer Centre, 11 Hospital Drive, Singapore 169610, Republic of Singapore
    J Med Case Reports 4:36. 2010
    ..To the best of our knowledge, we report the first case of a patient demonstrating post-tetanic facilitation in the setting of transient bilateral abducens neuropathy and hypokalemia, after being infused with oxaliplatin...
  6. pmc Genomic expression and single-nucleotide polymorphism profiling discriminates chromophobe renal cell carcinoma and oncocytoma
    Min Han Tan
    Laboratory of Cancer Genetics, Van Andel Research Institute, 333 Bostwick Avenue NE, Grand Rapids, MI 49503, USA
    BMC Cancer 10:196. 2010
    ..Previous studies have been relatively limited in terms of examining the differences between oncocytoma and chromophobe RCC...
  7. ncbi Human gene mutations. Gene symbol: HRPT2. Disease: Hyperparathyroidism Jaw-tumor syndrome
    B T Teh
    Laboratory of Cancer Genetics, Van Andel Research Institute, 333 Bostwick NE, Grand Rapids, MI 49503, USA
    Hum Genet 114:223. 2004
  8. ncbi Human gene mutations. Gene symbol: HRPT2. Disease: Hyperparathyroidism Jaw-tumor syndrome
    B T Teh
    Laboratory of Cancer Genetics, Van Andel Research Institute, 333 Bostwick NE, Grand Rapids, MI 49503, USA
    Hum Genet 114:221. 2004
  9. ncbi Human gene mutations. Gene symbol: HRPT2. Disease: Hyperparathyroidism Jaw-tumor syndrome
    B T Teh
    Laboratory of Cancer Genetics, Van Andel Research Institute, 333 Bostwick NE, Grand Rapids, MI 49503, USA
    Hum Genet 114:222. 2004
  10. ncbi Human gene mutations. Gene symbol: HRPT2. Disease: Hyperparathyroidism Jaw-tumor syndrome
    B T Teh
    Laboratory of Cancer Genetics, Van Andel Research Institute, 333 Bostwick NE, Grand Rapids, MI 49503, USA
    Hum Genet 114:222. 2004
  11. ncbi Human gene mutations. Gene symbol: HRPT2. Disease: Hyperparathyroidism Jaw-tumor syndrome
    B T Teh
    Laboratory of Cancer Genetics, Van Andel Research Institute, 333 Bostwick NE, Grand Rapids, MI 49503, USA
    Hum Genet 114:223. 2004
  12. ncbi Human gene mutations. Gene symbol: HRPT2. Disease: Hyperparathyroidism Jaw-tumor syndrome
    B T Teh
    Laboratory of Cancer Genetics, Van Andel Research Institute, 333 Bostwick NE, Grand Rapids, MI 49503, USA
    Hum Genet 114:223. 2004
  13. ncbi Human gene mutations. Gene symbol: HRPT2. Disease: Hyperparathyroidism Jaw-tumor syndrome
    B T Teh
    Laboratory of Cancer Genetics, Van Andel Research Institute, 333 Bostwick NE, Grand Rapids, MI 49503, USA
    Hum Genet 114:224. 2004
  14. ncbi Multiple endocrine neoplasia
    B T Teh
    Laboratory of Cancer Genetics, Van Andel Research Institute, Grand Rapids, MI 49503, USA
    J Intern Med 253:588-9. 2003
  15. ncbi A tribute to George F. Vande Woude, a man of character: 2006 Scientific Symposium Winning the War against Cancer: from Genomics to Bedside and Back
    Bin T Teh
    Van Andel Research Institute, Grand Rapids, Michigan 49503, USA
    Cancer Res 67:2394-5. 2007
  16. ncbi Tumor suppressor genes (TSG)
    B T Teh
    Department of Molecular Medicine, Karolinska Hospital, Stockholm, Sweden
    Anticancer Res 19:4715-28. 1999
    ..This review is to give a summary of the history, new concepts and recent advancements in the field of TSG in the hope that some of these concepts and works can be evaluated, expanded or even challenged...
  17. ncbi MicroRNA profiling of human kidney cancer subtypes
    David Petillo
    Laboratory of Cancer Genetics, Van Andel Research Institute, Grand Rapids, MI 49503, USA
    Int J Oncol 35:109-14. 2009
    ....
  18. doi Combined gene expression profiling and RNAi screening in clear cell renal cell carcinoma identify PLK1 and other therapeutic kinase targets
    Yan Ding
    Van Andel Research Institute, Grand Rapids, MI, USA
    Cancer Res 71:5225-34. 2011
    ..Taken together, these findings highlight PLK1 as a rational therapeutic target for ccRCC...
  19. doi The tumor suppressor parafibromin is required for posttranscriptional processing of histone mRNA
    Leslie J Farber
    Laboratory of Cancer Genetics, Van Andel Research Institute, Grand Rapids, Michigan 49503, USA
    Mol Carcinog 49:215-23. 2010
    ..These results indicate that parafibromin regulates the 3' processing of histone RNA, an essential component of the cell cycle...
  20. ncbi Robust classification of renal cell carcinoma based on gene expression data and predicted cytogenetic profiles
    Kyle A Furge
    Bioinformatics Special Program, Van Andel Research Institute, Grand Rapids, Michigan 49503, USA
    Cancer Res 64:4117-21. 2004
    ..Taken together, these data demonstrate that it is possible to construct a robust classification model for RCC using both transcriptional and cytogenetic features derived from a gene expression profile...
  21. pmc Chromosomal amplification of leucine-rich repeat kinase-2 (LRRK2) is required for oncogenic MET signaling in papillary renal and thyroid carcinomas
    Brendan D Looyenga
    Laboratory of Systems Biology, Van Andel Research Institute, Grand Rapids, MI 49503, USA
    Proc Natl Acad Sci U S A 108:1439-44. 2011
    ..Loss of these critical mitogenic pathways induces cell cycle arrest and cell death due to loss of ATP production, indicating that MET and LRRK2 cooperate to promote efficient tumor cell growth and survival in these cancers...
  22. doi A comparison study reveals important features of agreement and disagreement between summarized DNA and RNA data obtained from renal cell carcinoma
    Zhong Fa Zhang
    Laboratory of Cancer Genetics, Van Andel Research Institute, 333 Bostwick Avenue NE, Grand Rapids, MI 49503, USA
    Mutat Res 657:77-83. 2008
    ..The usefulness of the combined data set for identifying regions of mutated genes is also discussed...
  23. ncbi Gene expression of parathyroid tumors: molecular subclassification and identification of the potential malignant phenotype
    Carola J Haven
    Laboratory of Cancer Genetics and Bioinformatics Special Program, Van Andel Research Institute, Grand Rapids, Michigan, USA
    Cancer Res 64:7405-11. 2004
    ..These findings provide insights into the molecular pathways involved in parathyroid tumorigenesis and will contribute to a better understanding, diagnosis, and treatment of parathyroid tumors...
  24. pmc The E2F3-Oncomir-1 axis is activated in Wilms' tumor
    Eric J Kort
    Laboratory of Molecular Epidemiology, Van Andel Research Institute, Grand Rapids, MI 49503, USA
    Cancer Res 68:4034-8. 2008
    ..Our study also shows the utility of integrated genomics combining gene signature analysis with miRNA expression profiling to identify protein-miRNA interactions that are perturbed in disease states...
  25. pmc Signatures of mutation and selection in the cancer genome
    Graham R Bignell
    Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1SA, UK
    Nature 463:893-8. 2010
    ..The extensive copy number, genotyping, sequence and expression data available for this large series of publicly available cancer cell lines renders them informative reagents for future studies of cancer biology and drug discovery...
  26. pmc Germline and de novo mutations in the HRPT2 tumour suppressor gene in familial isolated hyperparathyroidism (FIHP)
    A Villablanca
    Department of Molecular Medicine, Karolinska Hospital, Stockholm, Sweden
    J Med Genet 41:e32. 2004
  27. pmc HRPT2 mutations are associated with malignancy in sporadic parathyroid tumours
    V M Howell
    Laboratory of Cancer Genetics, Van Andel Research Institute, 333 Bostwick NE, Grand Rapids, Michigan 49503, USA
    J Med Genet 40:657-63. 2003
    ..Hyperparathyroidism is a common endocrinopathy characterised by the formation of parathyroid tumours. In this study, we determine the role of the recently identified gene, HRPT2, in parathyroid tumorigenesis...
  28. pmc Birt-Hogg-Dubé renal tumors are genetically distinct from other renal neoplasias and are associated with up-regulation of mitochondrial gene expression
    Jeff A Klomp
    Laboratory of Computational Biology, Van Andel Research Institute, Grand Rapids, MI, USA
    BMC Med Genomics 3:59. 2010
    ..However, most sporadic tumors lack FLCN mutations and the extent to which the BHDS-derived renal tumors share genetic defects associated with the sporadic tumors has not been well studied...
  29. pmc Comparative gene expression profiling analysis of urothelial carcinoma of the renal pelvis and bladder
    Zhongfa Zhang
    Van Andel Research Institute, Grand Rapids, MI 49503, USA
    BMC Med Genomics 3:58. 2010
    ..Because differences may facilitate different screening and treatment modalities, we sought to examine the relationship between urothelial carcinoma of the renal pelvis (rUC) and urothelial carcinoma of the bladder (bUC)...
  30. ncbi Kinase targets in renal-cell carcinomas: reassessing the old and discovering the new
    Kyle A Furge
    Laboratory of Computational Biology, Van Andel Research Institute, Grand Rapids, MI, USA
    Lancet Oncol 11:571-8. 2010
    ..In this review, we discuss the use of molecularly-targeted kinase inhibitors in the treatment of renal-cell carcinoma and identify the next generation of kinase inhibitors that show promise for treatment...
  31. doi Genome-wide scan identifies novel modifier loci of acromegalic phenotypes for isolated familial somatotropinoma
    S K Khoo
    Laboratory of Cancer Genetics, Van Andel Research Institute, Grand Rapids, Michigan 49503, USA
    Endocr Relat Cancer 16:1057-63. 2009
    ..Identification of modifier loci may provide further insight into the disease mechanism and explain the clinical variability observed in its patients...
  32. ncbi Cancer: biology and therapeutics--a tribute to George Vande Woude
    N S Duesbery
    Laboratory of Cancer and Developmental Cell Biology, Van Andel Research Institute, 333 Boostwick Avenue N E, Grand Rapids, MI 49503, USA
    Oncogene 26:1258-9. 2007
  33. ncbi Histone acetylation/deacetylation and cancer: an "open" and "shut" case?
    S G Gray
    Van Andel Research Institute, Grand Rapids, MI 49503, USA
    Curr Mol Med 1:401-29. 2001
    ..This article describes some of the current knowledge about histone acetyltransferases and histone deacetylases, and how their multitudinal roles in cellular events may have important roles in tumorigensis...
  34. ncbi Hyperparathyroidism-jaw tumour syndrome
    J D Chen
    Laboratory of Cancer Genetics, Van Andel Research Institute, Grand Rapids, MI 49503, USA
    J Intern Med 253:634-42. 2003
    ..In this article, we review the clinico-pathological features and genetic basis of this syndrome with the hope that it will create awareness and interest in this disease amongst clinicians and basic scientists...
  35. ncbi Spectral karyotyping of sarcomas and fibroblasts derived from Ink4a/Arf-deficient mice reveals chromosomal instability in vitro
    Scott A Robertson
    Laboratory of Cell Signaling and Carcinogenesis, Van Andel Research Institute, Grand Rapids, MI 49503, USA
    Int J Oncol 26:629-34. 2005
    ..Therefore, interpretation of cytogenetic data from cell lines derived from Ink4a/Arf deficient tumors should be done on early passage cells...
  36. ncbi Nuclear imaging of Met-expressing human and canine cancer xenografts with radiolabeled monoclonal antibodies (MetSeek)
    Rick V Hay
    Van Andel Research Institute, Grand Rapids, Michigan 49503, USA
    Clin Cancer Res 11:7064s-7069s. 2005
    ..In this study, we compared two antibodies, Met5 and Met3, for nuclear imaging of human and canine Met-expressing tumor xenografts in nude mice...
  37. ncbi Gene expression profiling of renal cell carcinoma and its implications in diagnosis, prognosis, and therapeutics
    Masayuki Takahashi
    Laboratory of Cancer Genetics, Van Andel Research Institute, Grand Rapids, Michigan 49503, USA
    Adv Cancer Res 89:157-81. 2003
    ..Finally, this chapter discusses what additional studies should be performed to help uncover the molecular mechanisms of RCC and to bring this new knowledge into use in the clinical arena...
  38. ncbi Genetic and expression profiles of squamous cell carcinoma of the head and neck correlate with cisplatin sensitivity and resistance in cell lines and patients
    Jan Akervall
    Department of Otolaryngology, Head and Neck Surgery, University of Michigan, Ann Arbor, Michigan, USA
    Clin Cancer Res 10:8204-13. 2004
    ..The aim of the present study was to examine genetic changes and gene expression profiles that might correlate with sensitivity to cisplatin [3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay] in 10 SCCHN cell lines...
  39. ncbi Differential loss of heterozygosity in familial, sporadic, and uremic hyperparathyroidism
    F Farnebo
    Department of Molecular Medicine, Karolinska Hospital, Stockholm, Sweden
    Hum Genet 99:342-9. 1997
    ..We therefore conclude that the tumorigenesis of familial, sporadic, and uremic hyperparathyroidism involves different genetic triggers in a non-progressive pattern...
  40. ncbi Familial isolated hyperparathyroidism maps to the hyperparathyroidism-jaw tumor locus in 1q21-q32 in a subset of families
    B T Teh
    Department of Molecular Medicine, Karolinska Hospital, Stockholm, Sweden
    J Clin Endocrinol Metab 83:2114-20. 1998
    ..Taken together, the results suggest that some of the FIHP are a variant of HPT-JT and that the gene involved is a tumor suppressor gene...
  41. ncbi Linkage analysis of candidate regions in Swedish nonsyndromic cleft lip with or without cleft palate families
    F K Wong
    Department of Orthodontics, Institute of Odontology, Karolinska Institute, Stockholm, Sweden
    Cleft Palate Craniofac J 37:357-62. 2000
    ..To analyze linkage of five candidate regions for nonsyndromic cleft lip with or without palate (CLP) on chromosome 2p13, 4q, 6p23, and 19q13; in addition chromosome 1q32, the locus for van der Woude syndrome, on Swedish CLP families...
  42. ncbi HRPT2, a tumor suppressor gene for hyperparathyroidism-jaw tumor syndrome
    P F Wang
    Laboratory of Cancer Genetics, Van Andel Research Institute, 333 Bostwick Avenue NE, Grand Rapids, MI 49503, USA
    Horm Metab Res 37:380-3. 2005
    ..Here, we will review recent advances in genetic and protein studies on parafibromin, and examine its biological functions...
  43. ncbi Birt-Hogg-Dubé syndrome: mapping of a novel hereditary neoplasia gene to chromosome 17p12-q11.2
    S K Khoo
    Laboratory of Cancer Genetics, Van Andel Research Institute, Grand Rapids, MI 49503, USA
    Oncogene 20:5239-42. 2001
    ..This information will facilitate the identification of the BHD gene, leading to the understanding of its underlying molecular etiology...
  44. ncbi Genotyping of adrenocortical tumors: very frequent deletions of the MEN1 locus in 11q13 and of a 1-centimorgan region in 2p16
    M Kjellman
    Department of Surgery, Karolinska Hospital, Stockholm, Sweden
    J Clin Endocrinol Metab 84:730-5. 1999
    ..LOH in 11q13 also occurred frequently in the carcinomas, but was not associated with a MEN1 mutation, suggesting the involvement of a different tumor suppressor gene on this chromosome...
  45. ncbi Renal neoplasia in the hyperparathyroidism-jaw tumor syndrome
    M H Tan
    Laboratory of Cancer Genetics, Van Andel Research Institute, Grand Rapids, MI 49503, USA
    Curr Mol Med 4:895-7. 2004
    ..We review current knowledge of the renal manifestations of the HPT-JT syndrome, and examine recent advances in understanding the biological function of parafibromin...
  46. pmc Clinical and genetic studies of Birt-Hogg-Dubé syndrome
    S K Khoo
    Laboratory of Cancer Genetics, Van Andel Research Institute, Grand Rapids, MI 49503, USA
    J Med Genet 39:906-12. 2002
    ....
  47. pmc Familial adult renal neoplasia
    M Takahashi
    Laboratory of Cancer Genetics, Van Andel Research Institute, Grand Rapids, MI 49503, USA
    J Med Genet 39:1-5. 2002
    ..We review recent advances in this field and discuss a genetic approach to managing familial cases of renal tumours occasionally encountered by cancer geneticists and urologists...
  48. ncbi Microarray profiling of the effects of histone deacetylase inhibitors on gene expression in cancer cell lines
    S G Gray
    Laboratory for Cancer Genetics, Van Andel Research Institute, Grand Rapids, MI 49503, USA
    Int J Oncol 24:773-95. 2004
    ..Our results show that the patterns of alterations which emerge are similar for each cell type...
  49. ncbi The phospholipase C beta 3 gene located in the MEN1 region shows loss of expression in endocrine tumours
    G Weber
    Department of Clinical Genetics, Karolinska Hospital, Stockholm, Sweden
    Hum Mol Genet 3:1775-81. 1994
    ..Sequence characterization showed that this gene encodes for the phospholipase C beta 3, a key enzyme in signal transduction...
  50. ncbi Modulation of splicing events in histone deacetylase 3 by various extracellular and signal transduction pathways
    S G Gray
    Van Andel Research Institute, Laboratory for Cancer Research, 333 Bostwick NE, Grand Rapids, MI 49503, USA
    Gene Expr 11:13-21. 2003
    ..These results indicate that differential pathways in mouse and human may control the regulation of HDAC3, and that splice variants may play important roles in responding to exogenous stimuli that act via signal transduction pathways...
  51. ncbi Identification of deregulated oncogenic pathways in renal cell carcinoma: an integrated oncogenomic approach based on gene expression profiling
    K A Furge
    Laboratory of Computational Biology, Van Andel Research Institute, 333 Bostwick Avenue N E, Grand Rapids, MI 49503, USA
    Oncogene 26:1346-50. 2007
    ....
  52. ncbi Overexpression of glutathione s-transferase alpha in clear cell renal cell carcinoma
    Shang Tian Chuang
    Department of Pathology, Northwestern University, Feinberg School of Medicine, Chicago, IL 60611, USA
    Am J Clin Pathol 123:421-9. 2005
    ..62). Other renal tumor types did not exhibit significant GST-alpha immunoreactivity, confirming mRNA results. Through cDNA microarrays and immunohistochemical analysis, we demonstrated GST-alpha as a biomarker for clear cell RCCs...
  53. ncbi From tissue phenotype to proteotype: sensitive protein identification in microdissected tumor tissue
    Zhengping Zhuang
    Surgical Neurology Branch, NINDS NIH, Bethesda, MD 20892, USA
    Int J Oncol 28:103-10. 2006
    ..This new combination of techniques allows not only for sensitive identification of specific protein patterns that correspond to a histological tumor phenotype, but also for identification of specific disease-associated protein targets...
  54. ncbi Gene expression profiling of renal cell carcinoma and clinical implications
    Craig G Rogers
    Brady Urological Institute, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Urology 65:231-7. 2005
  55. ncbi Elucidation of the molecular signatures of renal cell carcinoma by gene expression profiling
    Masayuki Takahashi
    Department of Urology, Institute of Health Biosciences, The University of Tokushima Graduate School, Japan
    J Med Invest 53:9-19. 2006
    ..Although various clinical parameters are being refined for diagnosis and prognosis, these data obtained by microarray studies will undoubtedly contribute to both and eventually impacts the treatment of RCC...
  56. ncbi Expression of kidney-specific cadherin in chromophobe renal cell carcinoma and renal oncocytoma
    Brian P Adley
    Department of Pathology, Northwestern University, Feinberg School of Medicine, Chicago, IL 60611, USA
    Am J Clin Pathol 126:79-85. 2006
    ..Ksp-cad was present in chromophobe RCCs and oncocytomas at mRNA and protein levels, providing strong evidence that Ksp-cad immunohistochemical analysis cannot be used in differentiating these tumors...
  57. ncbi Diagnostic value of cytokeratin 7 and parvalbumin in differentiating chromophobe renal cell carcinoma from renal oncocytoma
    Brian P Adley
    Department of Pathology, Northwestern University, Feinberg School of Medicine, Chicago, Illinois 60611, USA
    Anal Quant Cytol Histol 28:228-36. 2006
    ..To investigate the diagnostic value of cytokeratin 7 (CK7) and parvalbumin at mRNA and protein levels...
  58. ncbi Expression of RON Proto-oncogene in Renal Oncocytoma and Chromophobe Renal Cell Carcinoma
    Kurt T Patton
    Department of Pathology, Northwestern University, Feinberg School of Medicine, 251 East Huron Street, Chicago, IL 60611, USA
    Am J Surg Pathol 28:1045-50. 2004
    ..Our study indicates that Ron immunostaining cannot be used to distinguish oncocytoma from chromophobe renal cell carcinoma...
  59. ncbi HRPT2 and parathyroid cancer
    Deborah J Marsh
    Kolling Institute of Medical Research, Royal North Shore Hospital, Sydney, NSW, Australia
    Lancet Oncol 5:78. 2004
  60. doi Renal translocation carcinomas: clinicopathologic, immunohistochemical, and gene expression profiling analysis of 31 cases with a review of the literature
    Philippe Camparo
    HIA Val de Grace, Van Andel Research Institute, Paris, France
    Am J Surg Pathol 32:656-70. 2008
    ..Our results suggest that these differentially expressed genes may serve as novel diagnostic or prognostic markers...
  61. doi Familial hyperparathyroidism: surgical outcome after 30 years of follow-up in three families with germline HRPT2 mutations
    Marta S Sarquis
    Department of Medicine, Surgery, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil
    Surgery 143:630-40. 2008
    ..Our objective was to study the gene sequence and expression of HRPT2 and clinical outcome regarding recurrence or persistence rates in three Brazilian kindreds with familial hyperparathyroidism after up to 30 years of follow-up...
  62. ncbi Coexpression of erythropoietin and erythropoietin receptor in von Hippel-Lindau disease-associated renal cysts and renal cell carcinoma
    Youn Soo Lee
    Surgical Neurology Branch, National Institute of Neurological Disorders and Stroke, National Cancer Institute NIH, 10 Center Drive, Bethesda, MD 20892, USA
    Clin Cancer Res 11:1059-64. 2005
    ..Such arrest may lead to autocrine stimulation, cell proliferation, and renal tumor development, similar to tumorigenesis of VHL disease-associated hemangioblastomas...
  63. ncbi Renal papillary adenoma--a putative precursor of papillary renal cell carcinoma
    Kim L Wang
    Department of Pathology, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA
    Hum Pathol 38:239-46. 2007
    ..In contrast, adenomas associated with APKD exhibit distinct morphological and immunohistochemical features and, therefore, may have an entirely different pathogenesis...
  64. pmc VHL promotes E2 box-dependent E-cadherin transcription by HIF-mediated regulation of SIP1 and snail
    Andrew J Evans
    Department of Laboratory Medicine and Pathobiology, Faculty of Medicine, University of Toronto, 1 King s College Circle, Toronto, Ontario M5S 1A8, Canada
    Mol Cell Biol 27:157-69. 2007
    ..These findings reveal a critical HIF-dependent molecular pathway connecting VHL, an established "gatekeeper" of the renal epithelium, with a major epithelial tumor suppressor, E-cadherin...
  65. ncbi Human kidney injury molecule-1 (hKIM-1): a useful immunohistochemical marker for diagnosing renal cell carcinoma and ovarian clear cell carcinoma
    Fan Lin
    Department of Laboratory Medicine, Geisinger Medical Center, 100 N Academy Avenue, Danville, PA 17822, USA
    Am J Surg Pathol 31:371-81. 2007
    ....
  66. pmc Independent genetic events associated with the development of multiple parathyroid tumors in patients with primary hyperparathyroidism
    Trisha Dwight
    Cancer Genetics Unit, Royal North Shore Hospital, Sydney, Australia
    Am J Pathol 161:1299-306. 2002
    ....