Chao Nan Qian

Summary

Affiliation: Van Andel Research Institute
Country: USA

Publications

  1. doi request reprint International collaborations preparing for a cancer "moon shot": a summary of the Sino-US Symposium on Head and Neck Cancer
    Wei Wei Xiao
    State Key Laboratory of Oncology in South China Department of Radiation Oncology, Sun Yat sen University Cancer Center, Guangzhou, Guangdong 510060, P R China
    Chin J Cancer 31:121-5. 2012
  2. ncbi request reprint Preparing the "soil": the primary tumor induces vasculature reorganization in the sentinel lymph node before the arrival of metastatic cancer cells
    Chao Nan Qian
    Laboratory of Cancer Genetics, Van Andel Research Institute, Grand Rapids, Michigan 49503, USA
    Cancer Res 66:10365-76. 2006
  3. ncbi request reprint Prospects for vasculature reorganization in sentinel lymph nodes
    Chao Nan Qian
    Laboratory of Cancer Genetics, Van Andel Research Institute, Grand Rapids, Michigan 49503, USA
    Cell Cycle 6:514-7. 2007
  4. pmc Activation of the PI3K/AKT pathway induces urothelial carcinoma of the renal pelvis: identification in human tumors and confirmation in animal models
    Chao Nan Qian
    Laboratories of Cancer Genetics, Van Andel Research Institute, Grand Rapids, Michigan 49503, USA
    Cancer Res 69:8256-64. 2009
  5. doi request reprint Sunitinib acts primarily on tumor endothelium rather than tumor cells to inhibit the growth of renal cell carcinoma
    Dan Huang
    Laboratory of Cancer Genetics, Van Andel Research Institute, Grand Rapids, Michigan 49503, USA
    Cancer Res 70:1053-62. 2010
  6. pmc Interleukin-8 mediates resistance to antiangiogenic agent sunitinib in renal cell carcinoma
    Dan Huang
    Laboratory of Cancer Genetics, Laboratory of Computational Biology, Van Andel Research Institute, Grand Rapids, Michigan 49503, USA
    Cancer Res 70:1063-71. 2010
  7. doi request reprint Prospective validation of the prognostic value of elevated serum vascular endothelial growth factor in patients with nasopharyngeal carcinoma: more distant metastases and shorter overall survival after treatment
    Xing Lv
    Department of Nasopharyngeal Carcinoma, Sun Yat sen University Cancer Center, Guangzhou, People s Republic of China 510060
    Head Neck 33:780-5. 2011
  8. ncbi request reprint Molecular subclassification of kidney tumors and the discovery of new diagnostic markers
    Masayuki Takahashi
    Laboratory of Cancer Genetics, Van Andel Research Institute, 333 Bostwick NE, Grand Rapids, MI 49503, USA
    Oncogene 22:6810-8. 2003
  9. ncbi request reprint Cystic renal neoplasia following conditional inactivation of apc in mouse renal tubular epithelium
    Chao Nan Qian
    Laboratories of Cancer Genetics and Cell Signaling and Carcinogenesis, Van Andel Research Institute, Grand Rapids, Michigan 49508, USA
    J Biol Chem 280:3938-45. 2005
  10. ncbi request reprint Two distinct types of blood vessels in clear cell renal cell carcinoma have contrasting prognostic implications
    Xin Yao
    Laboratory of Cancer Genetics, Van Andel Research Institute, Grand Rapids, Michigan 49503, USA
    Clin Cancer Res 13:161-9. 2007

Collaborators

Detail Information

Publications35

  1. doi request reprint International collaborations preparing for a cancer "moon shot": a summary of the Sino-US Symposium on Head and Neck Cancer
    Wei Wei Xiao
    State Key Laboratory of Oncology in South China Department of Radiation Oncology, Sun Yat sen University Cancer Center, Guangzhou, Guangdong 510060, P R China
    Chin J Cancer 31:121-5. 2012
    ..International exchanges of experience and in-depth cooperation are definitely needed to improve our capability of caring for cancer patients. In this article, we provide highlights of the presentations...
  2. ncbi request reprint Preparing the "soil": the primary tumor induces vasculature reorganization in the sentinel lymph node before the arrival of metastatic cancer cells
    Chao Nan Qian
    Laboratory of Cancer Genetics, Van Andel Research Institute, Grand Rapids, Michigan 49503, USA
    Cancer Res 66:10365-76. 2006
    ..e., vasculature reorganization in the SLN) can be initiated by a primary tumor before and independent of the physical presence of metastatic cancer cells...
  3. ncbi request reprint Prospects for vasculature reorganization in sentinel lymph nodes
    Chao Nan Qian
    Laboratory of Cancer Genetics, Van Andel Research Institute, Grand Rapids, Michigan 49503, USA
    Cell Cycle 6:514-7. 2007
    ..Further study of this pathological process may help to explain some clinical phenomena, and should aid in developing novel therapeutics and prevention strategies against cancer metastasis...
  4. pmc Activation of the PI3K/AKT pathway induces urothelial carcinoma of the renal pelvis: identification in human tumors and confirmation in animal models
    Chao Nan Qian
    Laboratories of Cancer Genetics, Van Andel Research Institute, Grand Rapids, Michigan 49503, USA
    Cancer Res 69:8256-64. 2009
    ..g., mTOR inhibitor) may serve as effective therapeutic agents...
  5. doi request reprint Sunitinib acts primarily on tumor endothelium rather than tumor cells to inhibit the growth of renal cell carcinoma
    Dan Huang
    Laboratory of Cancer Genetics, Van Andel Research Institute, Grand Rapids, Michigan 49503, USA
    Cancer Res 70:1053-62. 2010
    ..Our findings indicate that sunitinib inhibits ccRCC growth primarily through an antiangiogenic mechanism and not through direct targeting of ccRCC tumor cells...
  6. pmc Interleukin-8 mediates resistance to antiangiogenic agent sunitinib in renal cell carcinoma
    Dan Huang
    Laboratory of Cancer Genetics, Laboratory of Computational Biology, Van Andel Research Institute, Grand Rapids, Michigan 49503, USA
    Cancer Res 70:1063-71. 2010
    ..Our results reveal IL-8 as an important contributor to sunitinib resistance in ccRCC and a candidate therapeutic target to reverse acquired or intrinsic resistance to sunitinib in this malignancy...
  7. doi request reprint Prospective validation of the prognostic value of elevated serum vascular endothelial growth factor in patients with nasopharyngeal carcinoma: more distant metastases and shorter overall survival after treatment
    Xing Lv
    Department of Nasopharyngeal Carcinoma, Sun Yat sen University Cancer Center, Guangzhou, People s Republic of China 510060
    Head Neck 33:780-5. 2011
    ..The purpose of this prospective study was to investigate the prognostic value of serum vascular endothelial growth factor (sVEGF) in patients with nasopharyngeal carcinoma (NPC)...
  8. ncbi request reprint Molecular subclassification of kidney tumors and the discovery of new diagnostic markers
    Masayuki Takahashi
    Laboratory of Cancer Genetics, Van Andel Research Institute, 333 Bostwick NE, Grand Rapids, MI 49503, USA
    Oncogene 22:6810-8. 2003
    ..We have also identified in these subtypes differentially expressed genes that could have important diagnostic and therapeutic implications...
  9. ncbi request reprint Cystic renal neoplasia following conditional inactivation of apc in mouse renal tubular epithelium
    Chao Nan Qian
    Laboratories of Cancer Genetics and Cell Signaling and Carcinogenesis, Van Andel Research Institute, Grand Rapids, Michigan 49508, USA
    J Biol Chem 280:3938-45. 2005
    ..Our results confirm an important role for proper regulation of Wnt/beta-catenin signaling in renal development and provide evidence that dysregulation of the pathway can initiate tumorigenesis in the kidney...
  10. ncbi request reprint Two distinct types of blood vessels in clear cell renal cell carcinoma have contrasting prognostic implications
    Xin Yao
    Laboratory of Cancer Genetics, Van Andel Research Institute, Grand Rapids, Michigan 49503, USA
    Clin Cancer Res 13:161-9. 2007
    ..In this study, we aimed to evaluate the association of different categories of blood vessels with the patients' outcomes...
  11. pmc Distribution, characterization, and induction of CD8+ regulatory T cells and IL-17-producing CD8+ T cells in nasopharyngeal carcinoma
    Jiang Li
    State Key Laboratory of Oncology in South China, Sun Yat sen University Cancer Center, Guangzhou, China
    J Transl Med 9:189. 2011
    ..Their role in the antitumor response remains largely unknown. In the present study, we aimed to investigate the distribution, characterization, and generation of CD8+ Tcregs and Tc17 cells in NPC patients...
  12. ncbi request reprint Met protein expression level correlates with survival in patients with late-stage nasopharyngeal carcinoma
    Chao Nan Qian
    Laboratories of Cancer Genetics, Van Andel Research Institute, Grand Rapids, Michigan 49503, USA
    Cancer Res 62:589-96. 2002
    ....
  13. pmc Epstein-Barr virus-encoded LMP2A induces an epithelial-mesenchymal transition and increases the number of side population stem-like cancer cells in nasopharyngeal carcinoma
    Qing Li Kong
    State Key Laboratory of Oncology in South China, Sun Yat sen University Cancer Center, Guangzhou, People s Republic of China
    PLoS Pathog 6:e1000940. 2010
    ..Taken together, our data indicate that LMP2A induces EMT and stem-like cell self-renewal in NPC, suggesting a novel mechanism by which Epstein-Barr virus induces the initiation, metastasis and recurrence of NPC...
  14. doi request reprint Inhibition of MAPK kinase signaling pathways suppressed renal cell carcinoma growth and angiogenesis in vivo
    Dan Huang
    Laboratory of Cancer Genetics, Van Andel Research Institute, Grand Rapids, Michigan 49503, USA
    Cancer Res 68:81-8. 2008
    ..LeTx also showed direct inhibition of proliferation of endothelial cells in vitro. Our results suggest that suppression of one or more MAPK signaling pathways may inhibit RCC growth through the disruption of tumor vasculature...
  15. ncbi request reprint Identifying cancer-related genes in nasopharyngeal carcinoma cell lines using DNA and mRNA expression profiling analyses
    Xiang Guo
    Laboratory of Cancer Genetics, Van Andel Research Institute, Grand Rapids, MI 49503, USA
    Int J Oncol 21:1197-204. 2002
    ..Taken together, the combination of copy number and gene expression profiling using cDNA microarrays provides an improved strategy for gene discovery in human cancer...
  16. pmc Deficiency of FLCN in mouse kidney led to development of polycystic kidneys and renal neoplasia
    Jindong Chen
    Laboratory of Cancer Genetics, Van Andel Research Institute, Grand Rapids, Michigan, USA
    PLoS ONE 3:e3581. 2008
    ....
  17. ncbi request reprint Effect of sildenafil citrate on an orthotopic prostate cancer growth and metastasis model
    Chao Nan Qian
    Laboratory of Cancer Genetics, Van Andel Research Institute, Grand Rapids, MI, USA
    J Urol 170:994-7. 2003
    ..We characterized the effects of sildenafil citrate on the growth and metastasis of human prostate cancer cells in nude mice...
  18. doi request reprint Serglycin is a theranostic target in nasopharyngeal carcinoma that promotes metastasis
    Xin Jian Li
    State Key Laboratory of Oncology in South China, Departments of Pathology and Nasopharyngeal Carcinoma, Sun Yat sen University Cancer Center, Guangzhou, Guangdong, China
    Cancer Res 71:3162-72. 2011
    ....
  19. doi request reprint Complexity of tumor vasculature in clear cell renal cell carcinoma
    Chao Nan Qian
    The State Key Laboratory of Oncology in South China, Sun Yat sen University Cancer Center, Guangzhou, P R China
    Cancer 115:2282-9. 2009
    ....
  20. ncbi request reprint Inactivation of Apc in the mouse prostate causes prostate carcinoma
    Katia J Bruxvoort
    Laboratory of Cell Signaling and Carcinogenesis, Van Andel Research Institute, Grand Rapids, Michigan 49503 2518, USA
    Cancer Res 67:2490-6. 2007
    ....
  21. ncbi request reprint Detection of nasopharyngeal carcinoma using surface-enhanced laser desorption and ionization mass spectrometry profiles of the serum proteome
    Su Mei Cao
    State Key Laboratory of Oncology in South China, Guangzhou, Guangdong 510060, P R China
    Chin J Cancer 29:721-8. 2010
    ..This study was to investigate potential and consistent biomarkers for NPC, particularly for early detection of NPC...
  22. ncbi request reprint Nuclear imaging of Met-expressing human and canine cancer xenografts with radiolabeled monoclonal antibodies (MetSeek)
    Rick V Hay
    Van Andel Research Institute, Grand Rapids, Michigan 49503, USA
    Clin Cancer Res 11:7064s-7069s. 2005
    ..In this study, we compared two antibodies, Met5 and Met3, for nuclear imaging of human and canine Met-expressing tumor xenografts in nude mice...
  23. doi request reprint Pericyte coverage of differentiated vessels inside tumor vasculature is an independent unfavorable prognostic factor for patients with clear cell renal cell carcinoma
    Yun Cao
    State Key Laboratory of Oncology in South China, Sun Yat sen University Cancer Center, Guangdong, China
    Cancer 119:313-24. 2013
    ..The objective of this study was to evaluate the effect of pericyte coverage (PC) of differentiated tumor microvessels on the prognosis of patients with clear cell renal cell carcinoma (CCRCC)...
  24. pmc Different subsets of tumor infiltrating lymphocytes correlate with NPC progression in different ways
    Yi Lan Zhang
    State Key Laboratory of Oncology in Southern China, Sun Yat sen University Cancer Center, Guangzhou, PR China
    Mol Cancer 9:4. 2010
    ....
  25. pmc DNA methylation is associated with transcription of Snail and Slug genes
    Ying Chen
    Department of Obstetrics, Gynecology and Reproductive Biology, Michigan State University, Grand Rapids, MI, USA
    Biochem Biophys Res Commun 430:1083-90. 2013
    ..In summary, based on these results, DNA methylation is one of the molecular mechanisms regulating Snail and Slug genes during EMT/MET process...
  26. doi request reprint Outsmarting cancer: an international brainstorm in Guangzhou
    Chao Nan Qian
    Laboratory of Cancer and Developmental Cell Biology, Van Andel Research Institute, Grand Rapids, MI 49503, USA
    Chin J Cancer 30:505-7. 2011
    ..Many of the presenters have published or will publish reviews and research articles in the Chinese Journal of Cancer, which has become an important international forum in disseminating exciting cancer research progress...
  27. doi request reprint Predictive value of intratumoral microvascular density in patients with advanced non-small cell lung cancer receiving chemotherapy plus bevacizumab
    Yuan Yuan Zhao
    State Key Laboratory of Oncology in South China, Sun Yat sen University Cancer Center, Guangzhou, People s Republic of China
    J Thorac Oncol 7:71-5. 2012
    ..Our study was designed to investigate the predictive value of intratumoral microvascular density (MVD) in patients with NSCLC treated with bevacizumab...
  28. doi request reprint Serglycin in human cancers
    Xin Jian Li
    State Key Laboratory of Oncology in South China, Sun Yat sen University Cancer Center, Guangzhou, Guangdong 510060, P R China qianchn sysucc org cn
    Chin J Cancer 30:585-9. 2011
    ..Further investigations are warranted to elucidate serglycin signaling mechanisms with the goal of targeting them to prevent cancer cell metastasis...
  29. ncbi request reprint The prevalence and prevention of nasopharyngeal carcinoma in China
    Su Mei Cao
    State Key Laboratory of Oncology in South China and Department of Epidemiology, Clinical Trial Study Center, Sun Yat sen University Cancer Center, Guangzhou, Guangdong 510060, PR China
    Chin J Cancer 30:114-9. 2011
    ..Conduction of prospective randomized controlled screening trials in southern China can be expected to maximize the cost-effectiveness of early NPC detection screening...
  30. doi request reprint Endoscopic nasopharyngectomy for locally recurrent nasopharyngeal carcinoma
    Ming Yuan Chen
    State Key Laboratory of Oncology in South China, Sun Yat sen University Cancer Center, Guangzhou, China
    Laryngoscope 119:516-22. 2009
    ..This report introduces an innovative, minimally invasive, oncological, endoscopic nasopharyngectomy...
  31. doi request reprint Antibodies against Epstein-Barr virus gp78 antigen: a novel marker for serological diagnosis of nasopharyngeal carcinoma detected by xMAP technology
    Ai Di Gu
    State Key Laboratory of Oncology in Southern China, Department of Experimental Research, Cancer Center, Sun Yat Sen University, Guangzhou, PR China
    J Gen Virol 89:1152-8. 2008
    ..Thus, simultaneous detection of these EBV serological markers could improve the predictive values of NPC using xMAP technology...
  32. doi request reprint Downregulation of BMI-1 enhances 5-fluorouracil-induced apoptosis in nasopharyngeal carcinoma cells
    Li Qin
    Department of Pharmacology, School of Pharmaceutical Science, Central South University, Changsha 410078, China
    Biochem Biophys Res Commun 371:531-5. 2008
    ..Taken together, BMI-1 depletion enhanced the chemosensitivity of NPC cells by inducing apoptosis; which is associated with inhibition of the PI3K/AKT pathway...
  33. ncbi request reprint Distinct serumal proteomic patterns between ascending and descending types of loco-regionally advanced nasopharyngeal carcinoma assessed by surface enhanced laser desorption ionization and artificial neural network analyses
    Xiang Guo
    Department of Nasopharyngeal Carcinoma, Cancer Center, Sun Yat Sen University, Guangzhou 510060, China
    Chin Med J (Engl) 118:1912-7. 2005
  34. ncbi request reprint Genetic and expression profiles of squamous cell carcinoma of the head and neck correlate with cisplatin sensitivity and resistance in cell lines and patients
    Jan Akervall
    Department of Otolaryngology, Head and Neck Surgery, University of Michigan, Ann Arbor, Michigan, USA
    Clin Cancer Res 10:8204-13. 2004
    ..The aim of the present study was to examine genetic changes and gene expression profiles that might correlate with sensitivity to cisplatin [3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay] in 10 SCCHN cell lines...
  35. ncbi request reprint Characterization of a new SNP c767A/T (Arg222Trp) in the candidate TSG FUS2 on human chromosome 3p21.3: prevalence in Asian populations and analysis of association with nasopharyngeal cancer
    Fuh Mei Duh
    Basic Research Program, SAIC Frederick, Inc, NCI Frederick, Frederick, MD 21702, USA
    Mol Cell Probes 18:39-44. 2004
    ..Our analysis, albeit limited, suggests no likely association between NPC and the FUS2 gene polymorphism. Further large-scale case-control studies are necessary and warranted to prove the strength of this contention...