Brendan D Looyenga

Summary

Affiliation: Van Andel Research Institute
Country: USA

Publications

  1. pmc Cytokine receptor-like factor 1 (CRLF1) protects against 6-hydroxydopamine toxicity independent of the gp130/JAK signaling pathway
    Brendan D Looyenga
    Laboratory of Systems Biology, Van Andel Research Institute, Grand Rapids, Michigan, USA
    PLoS ONE 8:e66548. 2013
  2. pmc STAT3 is activated by JAK2 independent of key oncogenic driver mutations in non-small cell lung carcinoma
    Brendan D Looyenga
    Systems Biology, Van Andel Research Institute, Grand Rapids, Michigan, United States of America
    PLoS ONE 7:e30820. 2012
  3. doi request reprint Combined gene expression profiling and RNAi screening in clear cell renal cell carcinoma identify PLK1 and other therapeutic kinase targets
    Yan Ding
    Van Andel Research Institute, Grand Rapids, MI, USA
    Cancer Res 71:5225-34. 2011
  4. pmc Chromosomal amplification of leucine-rich repeat kinase-2 (LRRK2) is required for oncogenic MET signaling in papillary renal and thyroid carcinomas
    Brendan D Looyenga
    Laboratory of Systems Biology, Van Andel Research Institute, Grand Rapids, MI 49503, USA
    Proc Natl Acad Sci U S A 108:1439-44. 2011
  5. pmc Tailoring tyrosine kinase inhibitors to fit the lung cancer genome
    Brendan D Looyenga
    Van Andel Research Institute, Systems Biology, Grand Rapids, MI, USA
    Transl Oncol 4:59-70. 2011
  6. pmc Identification of PTPsigma as an autophagic phosphatase
    Katie R Martin
    Laboratory of Systems Biology, Van Andel Research Institute, Grand Rapids, MI 49503, USA
    J Cell Sci 124:812-9. 2011
  7. pmc A mitochondrial RNAi screen defines cellular bioenergetic determinants and identifies an adenylate kinase as a key regulator of ATP levels
    Nathan J Lanning
    Laboratory of Systems Biology, Van Andel Research Institute, Grand Rapids, MI 49503, USA
    Cell Rep 7:907-17. 2014
  8. pmc Inhibin-A antagonizes TGFbeta2 signaling by down-regulating cell surface expression of the TGFbeta coreceptor betaglycan
    Brendan D Looyenga
    Van Andel Research Institute, Grand Rapids, Michigan 49503, USA
    Mol Endocrinol 24:608-20. 2010
  9. pmc Characterization of differential protein tethering at the plasma membrane in response to epidermal growth factor signaling
    Brendan D Looyenga
    Laboratory of Systems Biology, Van Andel Research Institute, Grand Rapids, Michigan 49503, United States
    J Proteome Res 11:3101-11. 2012

Collaborators

Detail Information

Publications9

  1. pmc Cytokine receptor-like factor 1 (CRLF1) protects against 6-hydroxydopamine toxicity independent of the gp130/JAK signaling pathway
    Brendan D Looyenga
    Laboratory of Systems Biology, Van Andel Research Institute, Grand Rapids, Michigan, USA
    PLoS ONE 8:e66548. 2013
    ..These data provide an additional role for CRLF1 that could potentially explain its broad expression pattern and effects on cells lacking expression of this receptor. ..
  2. pmc STAT3 is activated by JAK2 independent of key oncogenic driver mutations in non-small cell lung carcinoma
    Brendan D Looyenga
    Systems Biology, Van Andel Research Institute, Grand Rapids, Michigan, United States of America
    PLoS ONE 7:e30820. 2012
    ....
  3. doi request reprint Combined gene expression profiling and RNAi screening in clear cell renal cell carcinoma identify PLK1 and other therapeutic kinase targets
    Yan Ding
    Van Andel Research Institute, Grand Rapids, MI, USA
    Cancer Res 71:5225-34. 2011
    ..Taken together, these findings highlight PLK1 as a rational therapeutic target for ccRCC...
  4. pmc Chromosomal amplification of leucine-rich repeat kinase-2 (LRRK2) is required for oncogenic MET signaling in papillary renal and thyroid carcinomas
    Brendan D Looyenga
    Laboratory of Systems Biology, Van Andel Research Institute, Grand Rapids, MI 49503, USA
    Proc Natl Acad Sci U S A 108:1439-44. 2011
    ..Loss of these critical mitogenic pathways induces cell cycle arrest and cell death due to loss of ATP production, indicating that MET and LRRK2 cooperate to promote efficient tumor cell growth and survival in these cancers...
  5. pmc Tailoring tyrosine kinase inhibitors to fit the lung cancer genome
    Brendan D Looyenga
    Van Andel Research Institute, Systems Biology, Grand Rapids, MI, USA
    Transl Oncol 4:59-70. 2011
    ....
  6. pmc Identification of PTPsigma as an autophagic phosphatase
    Katie R Martin
    Laboratory of Systems Biology, Van Andel Research Institute, Grand Rapids, MI 49503, USA
    J Cell Sci 124:812-9. 2011
    ..Mechanistic knowledge of this process is crucial for understanding and targeting therapies for several human diseases, including cancer and Alzheimer's disease, in which abnormal autophagy might be pathological...
  7. pmc A mitochondrial RNAi screen defines cellular bioenergetic determinants and identifies an adenylate kinase as a key regulator of ATP levels
    Nathan J Lanning
    Laboratory of Systems Biology, Van Andel Research Institute, Grand Rapids, MI 49503, USA
    Cell Rep 7:907-17. 2014
    ..This study maps the bioenergetic landscape of >1,000 mitochondrial proteins in the context of varied metabolic substrates and begins to link key metabolic genes with clinical outcome. ..
  8. pmc Inhibin-A antagonizes TGFbeta2 signaling by down-regulating cell surface expression of the TGFbeta coreceptor betaglycan
    Brendan D Looyenga
    Van Andel Research Institute, Grand Rapids, Michigan 49503, USA
    Mol Endocrinol 24:608-20. 2010
    ..These data indicate that inhibin can specifically antagonize TGFbeta2 signaling in cellular contexts where surface expression of betaglycan is limiting and provide a novel mechanism for activin-independent phenotypes in Inha-/- mice...
  9. pmc Characterization of differential protein tethering at the plasma membrane in response to epidermal growth factor signaling
    Brendan D Looyenga
    Laboratory of Systems Biology, Van Andel Research Institute, Grand Rapids, Michigan 49503, United States
    J Proteome Res 11:3101-11. 2012
    ..This finding parallels previous indications that PTPRS is involved in the desensitization of EGFR and provides a potential mechanism to coordinate localization of these two membrane proteins in the same compartment upon EGFR activation. ..