Donald F Smee

Summary

Affiliation: Utah State University
Country: USA

Publications

  1. pmc Effects of nasal or pulmonary delivered treatments with an adenovirus vectored interferon (mDEF201) on respiratory and systemic infections in mice caused by cowpox and vaccinia viruses
    Donald F Smee
    Department of Animal, Dairy and Veterinary Sciences, Institute for Antiviral Research, Utah State University, Logan, Utah, United States of America
    PLoS ONE 8:e68685. 2013
  2. pmc Exacerbation of influenza virus infections in mice by intranasal treatments and implications for evaluation of antiviral drugs
    Donald F Smee
    Department of Animal, Dairy and Veterinary Sciences, Utah State University, Logan, UT, USA
    Antimicrob Agents Chemother 56:6328-33. 2012
  3. pmc Treatment of oseltamivir-resistant influenza A (H1N1) virus infections in mice with antiviral agents
    Donald F Smee
    Institute for Antiviral Research, Utah State University, Logan, UT 84322, USA
    Antiviral Res 96:13-20. 2012
  4. doi request reprint D282, a non-nucleoside inhibitor of influenza virus infection that interferes with de novo pyrimidine biosynthesis
    Donald F Smee
    Institute for Antiviral Research, Utah State University, Logan, UT, USA
    Antivir Chem Chemother 22:263-72. 2012
  5. pmc Intracellular metabolism of favipiravir (T-705) in uninfected and influenza A (H5N1) virus-infected cells
    Donald F Smee
    Department of Animal, Dairy and Veterinary Sciences, Institute for Antiviral Research, Utah State University, Logan, UT, USA
    J Antimicrob Chemother 64:741-6. 2009
  6. pmc Effects of the combination of favipiravir (T-705) and oseltamivir on influenza A virus infections in mice
    Donald F Smee
    Department of Animal, Dairy, and Veterinary Sciences, 5600 Old Main Hill, Utah State University, Logan, UT 84322 5600, USA
    Antimicrob Agents Chemother 54:126-33. 2010
  7. doi request reprint Lack of efficacy of aurintricarboxylic acid and ethacrynic acid against vaccinia virus respiratory infections in mice
    Donald F Smee
    Institute for Antiviral Research, Department of Animal, Dairy and Veterinary Sciences, Utah State University, Logan, UT, USA
    Antivir Chem Chemother 20:201-5. 2010
  8. pmc Combinations of oseltamivir and peramivir for the treatment of influenza A (H1N1) virus infections in cell culture and in mice
    Donald F Smee
    Institute for Antiviral Research, Department of Animal, Dairy and Veterinary Sciences, Utah State University, 5600 Old Main Hill, Logan, UT 84322 5600, United States
    Antiviral Res 88:38-44. 2010
  9. doi request reprint Topical treatment of cutaneous vaccinia virus infections in immunosuppressed hairless mice with selected antiviral substances
    Donald F Smee
    Institute for Antiviral Research, Department of Animal, Dairy and Veterinary Sciences, Utah State University, Logan, UT, USA
    Antivir Chem Chemother 21:201-8. 2011
  10. pmc Therapy and long-term prophylaxis of vaccinia virus respiratory infections in mice with an adenovirus-vectored interferon alpha (mDEF201)
    Donald F Smee
    Institute for Antiviral Research, Department of Animal, Dairy and Veterinary Sciences, Utah State University, Logan, Utah, United States of America
    PLoS ONE 6:e26330. 2011

Collaborators

Detail Information

Publications66

  1. pmc Effects of nasal or pulmonary delivered treatments with an adenovirus vectored interferon (mDEF201) on respiratory and systemic infections in mice caused by cowpox and vaccinia viruses
    Donald F Smee
    Department of Animal, Dairy and Veterinary Sciences, Institute for Antiviral Research, Utah State University, Logan, Utah, United States of America
    PLoS ONE 8:e68685. 2013
    ..Thus, mDEF201 was able to treat different vaccinia and cowpox virus infections using both nasal sinus and pulmonary treatment regimens, supporting its development for humans. ..
  2. pmc Exacerbation of influenza virus infections in mice by intranasal treatments and implications for evaluation of antiviral drugs
    Donald F Smee
    Department of Animal, Dairy and Veterinary Sciences, Utah State University, Logan, UT, USA
    Antimicrob Agents Chemother 56:6328-33. 2012
    ..In addition, the intranasal treatments were shown to facilitate virus replication and promote lung pathology...
  3. pmc Treatment of oseltamivir-resistant influenza A (H1N1) virus infections in mice with antiviral agents
    Donald F Smee
    Institute for Antiviral Research, Utah State University, Logan, UT 84322, USA
    Antiviral Res 96:13-20. 2012
    ..These infection models will be useful to study newly discovered anti-influenza virus agents and to evaluate compounds in combination...
  4. doi request reprint D282, a non-nucleoside inhibitor of influenza virus infection that interferes with de novo pyrimidine biosynthesis
    Donald F Smee
    Institute for Antiviral Research, Utah State University, Logan, UT, USA
    Antivir Chem Chemother 22:263-72. 2012
    ..The discovery of novel influenza virus inhibitors remains an important priority in light of the emergence of drug-resistant viruses. Toward this end, a library of over 6,000 compounds was tested for antiviral activity...
  5. pmc Intracellular metabolism of favipiravir (T-705) in uninfected and influenza A (H5N1) virus-infected cells
    Donald F Smee
    Department of Animal, Dairy and Veterinary Sciences, Institute for Antiviral Research, Utah State University, Logan, UT, USA
    J Antimicrob Chemother 64:741-6. 2009
    ..Effects of treatment on intracellular guanosine triphosphate (GTP) pools and influenza virus-inhibitory activity were also assessed...
  6. pmc Effects of the combination of favipiravir (T-705) and oseltamivir on influenza A virus infections in mice
    Donald F Smee
    Department of Animal, Dairy, and Veterinary Sciences, 5600 Old Main Hill, Utah State University, Logan, UT 84322 5600, USA
    Antimicrob Agents Chemother 54:126-33. 2010
    ..Thus, synergistic responses were achieved with low doses of T-705 combined with oseltamivir. These compounds may be viable candidates for combination treatment of human influenza infections...
  7. doi request reprint Lack of efficacy of aurintricarboxylic acid and ethacrynic acid against vaccinia virus respiratory infections in mice
    Donald F Smee
    Institute for Antiviral Research, Department of Animal, Dairy and Veterinary Sciences, Utah State University, Logan, UT, USA
    Antivir Chem Chemother 20:201-5. 2010
    ..The purpose of this work was to determine if these inhibitors would effectively treat vaccinia virus infections in mice, which has not previously been studied...
  8. pmc Combinations of oseltamivir and peramivir for the treatment of influenza A (H1N1) virus infections in cell culture and in mice
    Donald F Smee
    Institute for Antiviral Research, Department of Animal, Dairy and Veterinary Sciences, Utah State University, 5600 Old Main Hill, Logan, UT 84322 5600, United States
    Antiviral Res 88:38-44. 2010
    ..The data demonstrate that combinations of oseltamivir and peramivir perform better than suboptimal doses of each compound alone to treat influenza infections in mice. Treatment with these two compounds should be considered as an option...
  9. doi request reprint Topical treatment of cutaneous vaccinia virus infections in immunosuppressed hairless mice with selected antiviral substances
    Donald F Smee
    Institute for Antiviral Research, Department of Animal, Dairy and Veterinary Sciences, Utah State University, Logan, UT, USA
    Antivir Chem Chemother 21:201-8. 2011
    ..We used an immunosuppressed hairless mouse model to study the effects of 10 antiviral agents on progressive vaccinia infections...
  10. pmc Therapy and long-term prophylaxis of vaccinia virus respiratory infections in mice with an adenovirus-vectored interferon alpha (mDEF201)
    Donald F Smee
    Institute for Antiviral Research, Department of Animal, Dairy and Veterinary Sciences, Utah State University, Logan, Utah, United States of America
    PLoS ONE 6:e26330. 2011
    ..These results demonstrate the long-acting prophylactic and treatment capacity of mDEF201 to combat vaccinia virus infections...
  11. doi request reprint Effects of TheraMax on influenza virus infections in cell culture and in mice
    Donald F Smee
    Institute for Antiviral Research, Department of Animal, Dairy and Veterinary Sciences, Utah State University, Logan, UT, USA
    Antivir Chem Chemother 21:231-7. 2011
    ..They are thought to act by blocking virus adsorption to cells. TheraMax(®) is a proprietary medication administered by nasal spray that contains both green tea and elderberry extracts that was evaluated for antiviral activity...
  12. pmc Effects of double combinations of amantadine, oseltamivir, and ribavirin on influenza A (H5N1) virus infections in cell culture and in mice
    Donald F Smee
    Institute for Antiviral Research, Department of Animal, Dairy, and Veterinary Sciences, 5600 Old Main Hill, Utah State University, Logan, UT 84322 5600, USA
    Antimicrob Agents Chemother 53:2120-8. 2009
    ..Results indicate a lack of benefit of amantadine in combinations against amantadine-resistant virus, but positive benefits in combinations against amantadine-sensitive virus...
  13. pmc Efficacy of favipiravir (T-705) and T-1106 pyrazine derivatives in phlebovirus disease models
    Brian B Gowen
    Institute for Antiviral Research and Department of Animal, Dairy, and Veterinary Sciences, Utah State University, Logan, UT 84322 5600, USA
    Antiviral Res 86:121-7. 2010
    ....
  14. ncbi request reprint Topical cidofovir is more effective than is parenteral therapy for treatment of progressive vaccinia in immunocompromised mice
    Donald F Smee
    Department of Animal, Dairy, and Veterinary Sciences, Institute for Antiviral Research, Utah State University, 5600 University Boulevard, Logan, UT 84322 5600, USA
    J Infect Dis 190:1132-9. 2004
    ..We developed a new mouse model for studying the effects of antiviral agents on progressive vaccinia virus infections...
  15. ncbi request reprint Combinatorial ribavirin and interferon alfacon-1 therapy of acute arenaviral disease in hamsters
    Brian B Gowen
    Institute for Antiviral Research, Utah State University, Logan, UT, USA
    Antivir Chem Chemother 17:175-83. 2006
    ..Further, combination therapy reduces the effective dosage of ribavirin, which would serve to limit its toxicity...
  16. doi request reprint Induction of interferon-gamma-inducible protein 10 by SARS-CoV infection, interferon alfacon 1 and interferon inducer in human bronchial epithelial Calu-3 cells and BALB/c mice
    Yohichi Kumaki
    Institute for Antiviral Research, Department of Animal, Dairy and Veterinary Sciences, Utah State University, Logan, UT, USA
    Antivir Chem Chemother 20:169-77. 2010
    ..We previously reported that interferon (IFN) alfacon-1 was more active against SARS-CoV infection in human bronchial epithelial Calu-3 cells than in African green monkey kidney epithelial cells on day 3 post-infection...
  17. pmc Efficacy of 2'-C-methylcytidine against yellow fever virus in cell culture and in a hamster model
    Justin G Julander
    Institute for Antiviral Research, Utah State University, Logan, UT, USA
    Antiviral Res 86:261-7. 2010
    ..Broadly active antiviral compounds, such as 2'-C-MeC, represent potential for the development of compounds active against related viruses for the treatment of YFV...
  18. pmc Treatment of late stage disease in a model of arenaviral hemorrhagic fever: T-705 efficacy and reduced toxicity suggests an alternative to ribavirin
    Brian B Gowen
    Institute for Antiviral Research, Logan, UT, USA
    PLoS ONE 3:e3725. 2008
    ..Our findings support further pre-clinical development of T-705 for the treatment of severe arenaviral infections...
  19. pmc Efficacy of orally administered T-705 on lethal avian influenza A (H5N1) virus infections in mice
    Robert W Sidwell
    Institute for Antiviral Research, Utah State University, 5600 Old Main Hill, Logan, UT 84322 5600, USA
    Antimicrob Agents Chemother 51:845-51. 2007
    ..These data indicate that T-705 may be useful for the treatment of avian influenza virus infections...
  20. ncbi request reprint Effects of four antiviral substances on lethal vaccinia virus (IHD strain) respiratory infections in mice
    Donald F Smee
    Department of Animal, Dairy and Veterinary Sciences, Institute for Antiviral Research, Utah State University, Logan, UT 84322 5600, USA
    Int J Antimicrob Agents 23:430-7. 2004
    ..These data indicate the utility of parenteral cidofovir, oral HDP-CDV and oral HOE961 in treating severe respiratory infections caused by this virus...
  21. ncbi request reprint Treatment of lethal cowpox virus respiratory infections in mice with 2-amino-7-[(1,3-dihydroxy-2-propoxy)methyl]purine and its orally active diacetate ester prodrug
    Donald F Smee
    Department of Animal, Dairy and Veterinary Sciences, Institute for Antiviral Research, Utah State University, 84322 5600, Logan, UT 84322 5600, USA
    Antiviral Res 54:113-20. 2002
    ..Since, HOE961 was orally active, it may have advantages over the other parenterally administered compounds for treating orthopoxvirus infections...
  22. pmc Differential pathogenesis of cowpox virus intranasal infections in mice induced by low and high inoculum volumes and effects of cidofovir treatment
    Donald F Smee
    Institute for Antiviral Research, Department of Animal, Dairy and Veterinary Sciences, Utah State University, Logan, UT 84322, USA
    Int J Antimicrob Agents 31:352-9. 2008
    ..Cidofovir effectively treated both infections and slowed viral replication sufficiently to subdue the exaggerated release of pro-inflammatory mediators...
  23. pmc Efficacy of N-methanocarbathymidine in treating mice infected intranasally with the IHD and WR strains of vaccinia virus
    Donald F Smee
    Institute for Antiviral Research, Department of Animal, Dairy and Veterinary Sciences, Utah State University, Logan, UT 84322 5600, USA
    Antiviral Res 76:124-9. 2007
    ..p. cidofovir (100 mg/(kg day)). Significant reductions in tissue virus titers occurred with both treatment regimens. (N)-MCT could be further pursued for its potential to treat orthopoxvirus infections in humans...
  24. pmc Effect of T-705 treatment on western equine encephalitis in a mouse model
    Justin G Julander
    Institute for Antiviral Research, Utah State University, Logan, 84322 5600, United States
    Antiviral Res 82:169-71. 2009
    ..Treatment with T-705 improved morbidity and mortality of WEEV-infected mice, further illustrating the broad-spectrum activity of T-705 in the treatment of RNA viruses...
  25. pmc Correlation between breakdown of the blood-brain barrier and disease outcome of viral encephalitis in mice
    Aaron L Olsen
    Institute for Antiviral Research, Department of Animal, Dairy, and Veterinary Sciences, Utah State University, 5600 Old Main Hill, Logan, UT 84322 5600, USA
    Antiviral Res 75:104-12. 2007
    ..In general, it was found that evaluation of BBB permeability was a more sensitive indicator of disease outcome and the antiviral efficacy Ampligen than either weight change or brain viral titers...
  26. ncbi request reprint Cell line dependency for antiviral activity and in vivo efficacy of N-methanocarbathymidine against orthopoxvirus infections in mice
    Donald F Smee
    Institute for Antiviral Research, Department of Animal, Dairy and Veterinary Sciences, Utah State University, Logan, UT 84322 5600, USA
    Antiviral Res 73:69-77. 2007
    ..Cidofovir (100mg/kg/day) protected animals from death in all three infections...
  27. pmc Efficacy of orally administered T-705 pyrazine analog on lethal West Nile virus infection in rodents
    John D Morrey
    Institute for Antiviral Research, Utah State University, 4700 Old Main Hill, UT 84322 4700, USA
    Antiviral Res 80:377-9. 2008
    ..c. challenge of mice. Treatment could be delayed out to 2 days after viral challenge to still achieve efficacy in mice. Further development of this compound should be considered for treatment of WNV...
  28. ncbi request reprint Characterization and treatment of cidofovir-resistant vaccinia (WR strain) virus infections in cell culture and in mice
    Donald F Smee
    Institute for Antiviral Research, Department of Animal, Dairy and Veterinary Sciences, Utah State University, Logan, UT, USA
    Antivir Chem Chemother 16:203-11. 2005
    ..Cidofovir, HDP-cidofovir and arabinofuranosyladenine treatments reduced lung virus titres <fourfold, and snout virus titres > or = eight-fold. The animal model appears to have limited utility in drug efficacy testing...
  29. pmc Inhibition of severe acute respiratory syndrome coronavirus replication in a lethal SARS-CoV BALB/c mouse model by stinging nettle lectin, Urtica dioica agglutinin
    Yohichi Kumaki
    Institute for Antiviral Research, Department of Animal, Dairy and Veterinary Science, 5600 Old Main Hill, Utah State University, Logan, UT 84322, USA
    Antiviral Res 90:22-32. 2011
    ..These data support the conclusion that UDA might bind to N-acetylglucosamine-like residues present on the glycosylated envelope glycoproteins, thereby preventing virus attachment to cells...
  30. ncbi request reprint Effect of interferon-alpha and interferon-inducers on West Nile virus in mouse and hamster animal models
    John D Morrey
    Institute for Antiviral Research, Department of Animal, Dairy and Veterinary Sciences, Utah State University, Logan, UT, USA
    Antivir Chem Chemother 15:101-9. 2004
    ....
  31. ncbi request reprint Activities of oseltamivir and ribavirin used alone and in combination against infections in mice with recent isolates of influenza A (H1N1) and B viruses
    Donald F Smee
    Institute for Antiviral Research, Department of Animal, Dairy and Veterinary Sciences, Utah State University, Logan, Utah 84321 5600, USA
    Antivir Chem Chemother 17:185-92. 2006
    ..These activities differed from published results with older, more established virus strains as oseltamivir was less effective and ribavirin was more active than previously reported...
  32. pmc Recombinant Eimeria protozoan protein elicits resistance to acute phlebovirus infection in mice but not hamsters
    Brian B Gowen
    Institute for Antiviral Research, Utah State University, Logan, 84322, USA
    Antimicrob Agents Chemother 50:2023-9. 2006
    ..Further investigation into the immunostimulatory capacity of rEA in other mammalian systems is necessary...
  33. ncbi request reprint Comparative effects of cidofovir and cyclic HPMPC on lethal cowpox and vaccinia virus respiratory infections in mice
    Donald F Smee
    Department of Animal, Dairy and Veterinary Sciences, Institute for Antiviral Research, Utah State University, Logan, Utah 84322 5600, USA
    Chemotherapy 49:126-31. 2003
    ..Thus, it was deemed important to directly compare the activities of cidofovir and cyclic HPMPC against poxvirus infections in mouse models...
  34. pmc In vitro and in vivo efficacy of fluorodeoxycytidine analogs against highly pathogenic avian influenza H5N1, seasonal, and pandemic H1N1 virus infections
    Yohichi Kumaki
    Institute for Antiviral Research, Department of Animal, Dairy and Veterinary Science, 5600 Old Main Hill, Logan, Utah State University, Logan, UT 84322, USA
    Antiviral Res 92:329-40. 2011
    ..05). Given the demonstrated in vitro and in vivo inhibition of avian influenza virus replication, 2'FdC may qualify as a lead compound for the development of agents treating influenza virus infections...
  35. pmc Effective oral favipiravir (T-705) therapy initiated after the onset of clinical disease in a model of arenavirus hemorrhagic Fever
    Michelle Mendenhall
    Department of Animal, Dairy, and Veterinary Sciences, Utah State University, Logan, Utah, United States of America
    PLoS Negl Trop Dis 5:e1342. 2011
    ..At present, ribavirin is the only antiviral drug indicated for use in treatment of these diseases, but because of its limited efficacy in advanced cases of disease and its toxicity, safer and more effective antivirals are needed...
  36. pmc Interferon alfacon 1 inhibits SARS-CoV infection in human bronchial epithelial Calu-3 cells
    Yohichi Kumaki
    Institute for Antiviral Research, Department of Animal, Dairy and Veterinary Science, Utah State University, 5600 Old Main Hill, Logan, UT 84322 5600, USA
    Biochem Biophys Res Commun 371:110-3. 2008
    ..The data might provide an important insight into the mechanism of pathogenesis of SARS-CoV allowing further development of antiviral therapies for treating SARS infections...
  37. pmc Treatment of Venezuelan equine encephalitis virus infection with (-)-carbodine
    Justin G Julander
    Institute for Antiviral Research, Department of Animal, Dairy, and Veterinary Sciences, Utah State University, 5600 Old Main Hill, Logan, UT 84322 5600, United States
    Antiviral Res 80:309-15. 2008
    ..It is remarkable that (-)-carbodine is effective when initiated after the establishment of brain infection...
  38. pmc Interferon alfacon-1 protects hamsters from lethal pichinde virus infection
    Brian B Gowen
    Institute for Antiviral Research, 5600 Old Main Hill, Utah State University, Logan, UT 84322, USA
    Antimicrob Agents Chemother 49:2378-86. 2005
    ..These data are the first report demonstrating efficacious treatment of acute arenaviral disease with alpha interferon therapy, and further study is warranted...
  39. ncbi request reprint Treatment of mannan-enhanced influenza B virus infections in mice with oseltamivir, ribavirin and viramidine
    Donald F Smee
    Institute for Antiviral Research, Department of Animal, Dairy and Veterinary Sciences, Utah State University, Logan, UT, USA
    Antivir Chem Chemother 15:261-8. 2004
    ..The overall results demonstrate that mannan can be used to enhance certain non-lethal influenza virus infections sufficiently to allow antiviral studies...
  40. ncbi request reprint Protective immunity against acute phleboviral infection elicited through immunostimulatory cationic liposome-DNA complexes
    Brian B Gowen
    Institute for Antiviral Research, Utah State University, Logan, UT 84322, United States
    Antiviral Res 69:165-72. 2006
    ..Taken together, our findings indicate that non-specific immunotherapy with CLDC appears to be an effective treatment for blocking PTV-induced disease and suggests that further exploration in other viral disease models may be warranted...
  41. pmc Combinations of favipiravir and peramivir for the treatment of pandemic influenza A/California/04/2009 (H1N1) virus infections in mice
    E Bart Tarbet
    Institute for Antiviral Research, Department of Animal, Dairy and Veterinary Sciences, Utah State University, Logan, United States
    Antiviral Res 94:103-10. 2012
    ..25 and 0.5 mg/kg/d. These data demonstrate that combinations of favipiravir and peramivir perform better than suboptimal doses of each compound alone for the treatment of influenza virus infections in mice...
  42. ncbi request reprint Antiviral activities and phosphorylation of 5-halo-2'-deoxyuridines and N-methanocarbathymidine in cells infected with vaccinia virus
    Donald F Smee
    Institute for Antiviral Research, Department of Animal, Dairy and Veterinary Sciences, Utah State University, Logan, Utah, USA
    Antivir Chem Chemother 19:15-24. 2008
    ..The antipoxviral activities and phosphorylation of N-methanocarbathymidine ([N]-MCT) and four 5-halo-2'-deoxyuridines, namely 5-fluoro-(FdU), 5-chloro-(CldU), 5-bromo-(BrdU), and 5-iodo-(IdU) derivatives, were explored...
  43. ncbi request reprint Effects of cidofovir treatment on cytokine induction in murine models of cowpox and vaccinia virus infection
    Corinna W Knorr
    Department of Animal, Dairy and Veterinary Sciences, Utah State University, Logan, Utah 84322 5600, USA
    Antiviral Res 72:125-33. 2006
    ..Characterization of cytokine responses has implications for understanding the immune responses and pathogeneses of viral infections in these mouse models...
  44. ncbi request reprint Error-prone replication of West Nile virus caused by ribavirin
    Craig W Day
    Institute for Antiviral Research, Department of Animal, Dairy, and Veterinary Sciences, 4700 Old Main Hill, Utah State University, Logan, UT 84322 4700, USA
    Antiviral Res 67:38-45. 2005
    ..These data support the hypothesis that error catastrophe is one of the modes of action for ribavirin against WNV...
  45. pmc Treatment of influenza A (H1N1) virus infections in mice and ferrets with cyanovirin-N
    Donald F Smee
    Institute for Antiviral Research, Utah State University, Logan, UT, USA
    Antiviral Res 80:266-71. 2008
    ..CV-N has the potential for prophylaxis and early initiation of treatment of influenza virus infections...
  46. pmc Maporal virus as a surrogate for pathogenic New World hantaviruses and its inhibition by favipiravir
    Kristin K Buys
    Institute for Antiviral Research and Department of Animal, Dairy, and Veterinary Sciences, Utah State University, Logan, UT, USA
    Antivir Chem Chemother 21:193-200. 2011
    ..Dobrava virus causes HFRS in Europe. Maporal virus (MPRLV), recently isolated from western Venezuela, is phylogenetically similar to Andes virus, the principal cause of HCPS in Argentina...
  47. pmc T-705 (favipiravir) inhibition of arenavirus replication in cell culture
    Michelle Mendenhall
    Institute for Antiviral Research and Department of Animal, Dairy, and Veterinary Sciences, Utah State University, Logan, UT 84322 5600, USA
    Antimicrob Agents Chemother 55:782-7. 2011
    ..Our findings indicate that T-705 acts to inhibit arenavirus replication/transcription and may directly target the viral RNA-dependent RNA polymerase...
  48. pmc A new mouse-adapted strain of SARS-CoV as a lethal model for evaluating antiviral agents in vitro and in vivo
    Craig W Day
    Institute for Antiviral Research, Utah State University, UMC 5600, Logan, UT 84322 5600, USA
    Virology 395:210-22. 2009
    ..Ribavirin, UDA, and Ampligen decreased IL-6 expression. Strain v2163 provided a valuable model for anti-SARS research...
  49. pmc Activity of T-705 in a hamster model of yellow fever virus infection in comparison with that of a chemically related compound, T-1106
    Justin G Julander
    Institute for Antiviral Research, Utah State University, Logan, Utah 84322 5600, USA
    Antimicrob Agents Chemother 53:202-9. 2009
    ....
  50. pmc C3H/HeN mouse model for the evaluation of antiviral agents for the treatment of Venezuelan equine encephalitis virus infection
    Justin G Julander
    Institute for Antiviral Research, Department of Animal, Dairy, and Veterinary Sciences, Utah State University, 5600 Old Main Hill, Logan, UT 84322 5600, United States
    Antiviral Res 78:230-41. 2008
    ..Thus, infection of C3H/HeN mice with TC-83 VEEV may serve as a suitable model for the evaluation of antiviral compounds for the treatment of this viral disease...
  51. ncbi request reprint Combination treatment of influenza A virus infections in cell culture and in mice with the cyclopentane neuraminidase inhibitor RWJ-270201 and ribavirin
    Donald F Smee
    Institute for Antiviral Research, Department of Animal, Dairy and Veterinary Sciences, Utah State University, Logan, Utah 84322 5600, USA
    Chemotherapy 48:88-93. 2002
    ..Treatment of influenza infections in the clinical setting may benefit by these two agents in combination...
  52. pmc Characterization of wild-type and cidofovir-resistant strains of camelpox, cowpox, monkeypox, and vaccinia viruses
    Donald F Smee
    Institute for Antiviral Research, Utah State University, Logan, Utah 84322 5600, USA
    Antimicrob Agents Chemother 46:1329-35. 2002
    ..Studies will need to be conducted with cidofovir-resistant monkeypox virus in monkeys to further support these hypotheses...
  53. pmc Evaluation of imiquimod for topical treatment of vaccinia virus cutaneous infections in immunosuppressed hairless mice
    E Bart Tarbet
    Institute for Antiviral Research and Department of Animal, Dairy, and Veterinary Sciences, Utah State University, Logan, Utah 84322 5600, United States
    Antiviral Res 90:126-33. 2011
    ..These results demonstrate the protective effects of topically administered imiquimod against a disseminated vaccinia virus infection in this mouse model...
  54. ncbi request reprint Inhibition of severe acute respiratory syndrome-associated coronavirus (SARSCoV) by calpain inhibitors and beta-D-N4-hydroxycytidine
    Dale L Barnard
    Institute for Antiviral Research, Utah State University, Logan, UT, USA
    Antivir Chem Chemother 15:15-22. 2004
    ..These compounds or analogues warrant further evaluation as potential therapies for treating SARS or could be used as lead compounds for discovery of more potent SARSCoV inhibitors...
  55. ncbi request reprint A review of compounds exhibiting anti-orthopoxvirus activity in animal models
    Donald F Smee
    Department of Animal, Dairy and Veterinary Sciences, Institute for Antiviral Research, Utah State University, Logan, UT 84322 5600, USA
    Antiviral Res 57:41-52. 2003
    ....
  56. doi request reprint Use of plethysmography in assessing the efficacy of antivirals in a mouse model of pandemic influenza A virus
    Justin G Julander
    Institute for Antiviral Research, Department of Animal, Dairy and Veterinary Sciences, Utah State University, 4700 Old Main Hill, Logan, UT 84322 5600, United States
    Antiviral Res 92:228-36. 2011
    ..Moreover, a combination of these two drugs further improved these parameters. Plethysmography provides a sensitive evaluation of lung function in IAV-infected mice in response to antiviral therapy...
  57. ncbi request reprint Identification of active antiviral compounds against a New York isolate of West Nile virus
    John D Morrey
    Department of Animal, Dairy, and Veterinary Sciences, Institute for Antiviral Research, Utah State University, Logan, UT 84322 4700, USA
    Antiviral Res 55:107-16. 2002
    ....
  58. ncbi request reprint Coumarins and pyranocoumarins, potential novel pharmacophores for inhibition of measles virus replication
    Dale L Barnard
    Institute for Antiviral Research, Utah State University, Logan, USA
    Antivir Chem Chemother 13:39-59. 2002
    ..This and related compounds may be valuable leads in the development of a potent and selective class of MV inhibitors that could be used in future in the clinic...
  59. pmc A recombinant, infectious human parainfluenza virus type 3 expressing the enhanced green fluorescent protein for use in high-throughput antiviral assays
    Jason P Roth
    Institute for Antiviral Research, Department of Animal, Dairy and Veterinary Sciences, Utah State University, Logan, UT 84322 5600, USA
    Antiviral Res 82:12-21. 2009
    ..Thus, the use of an EGFP-based antiviral assay for testing potential antiviral compounds against HPIV-3 in a high-throughput format may be justified...
  60. ncbi request reprint Comparison of colorimetric, fluorometric, and visual methods for determining anti-influenza (H1N1 and H3N2) virus activities and toxicities of compounds
    Donald F Smee
    Department of Animal, Dairy and Veterinary Sciences, Institute for Antiviral Research, Utah State University, Logan, UT 84322 5600, USA
    J Virol Methods 106:71-9. 2002
    ..These methods should also be applicable to evaluating antiviral effects against other lytic virus infections...
  61. doi request reprint Methods for evaluation of antiviral efficacy against influenza virus infections in animal models
    Donald F Smee
    Department of Animal, Dairy, and Veterinary Sciences, Institute for Antiviral Research, Utah State University, Logan, UT, USA
    Methods Mol Biol 1030:407-25. 2013
    ..Thus, for each animal model there is a certain set of disease parameters that can be measured. Here we describe methods for assessing the efficacy of anti-influenza virus compounds in each of these animal species. ..
  62. ncbi request reprint Progress in the discovery of compounds inhibiting orthopoxviruses in animal models
    Donald F Smee
    Institute for Antiviral Research, Department of Animal, Dairy and Veterinary Sciences, Utah State University, Logan, UT 84322, USA
    Antivir Chem Chemother 19:115-24. 2008
    ..Another compound with high activity but requiring parenteral administration is HPMPO-DAPy. Further development of these compounds is warranted...
  63. ncbi request reprint Anti-cowpox virus activities of certain adenosine analogs, arabinofuranosyl nucleosides, and 2'-fluoro-arabinofuranosyl nucleosides
    Donald F Smee
    Institute for Antiviral Research, Department of Animal, Dairy, and Veterinary Sciences, Utah State University, Logan, Utah 84322 5600, USA
    Nucleosides Nucleotides Nucleic Acids 23:375-83. 2004
    ..None of the other compounds, including IDU, prevented death nor delayed the time to death. Cidofovir had the best potential for treating orthopoxvirus infections of those tested...
  64. ncbi request reprint Peramivir (BCX-1812, RWJ-270201): potential new therapy for influenza
    Robert W Sidwell
    Institute for Antiviral Research, Utah State University, Logan, UT 84322 5600, USA
    Expert Opin Investig Drugs 11:859-69. 2002
    ..In clinical trials with patients experimentally infected with influenza A or B viruses, oral treatment with peramivir significantly reduced nasal wash virus titres with no adverse effects. Phase III clinical trials are underway...
  65. ncbi request reprint Viruses of the Bunya- and Togaviridae families: potential as bioterrorism agents and means of control
    Robert W Sidwell
    Institute for Antiviral Research, Utah State University, Logan, UT 94322 5600, USA
    Antiviral Res 57:101-11. 2003
    ..Against infections induced by viruses in the Togaviridae family, interferon-alpha would appear to currently be the most useful for therapy...
  66. ncbi request reprint Influenza A (H1N1) virus resistance to cyanovirin-N arises naturally during adaptation to mice and by passage in cell culture in the presence of the inhibitor
    Donald F Smee
    Institute for Antiviral Research, Utah State University, Logan, UT, USA
    Antivir Chem Chemother 18:317-27. 2007
    ..The mutations reported here causing resistance to CVN are consistent with its known mode of action...