Brian B Gowen

Summary

Affiliation: Utah State University
Country: USA

Publications

  1. pmc Interferon alfacon-1 protects hamsters from lethal pichinde virus infection
    Brian B Gowen
    Institute for Antiviral Research, 5600 Old Main Hill, Utah State University, Logan, UT 84322, USA
    Antimicrob Agents Chemother 49:2378-86. 2005
  2. pmc Immunoprophylaxis of Punta Toro virus (Phlebovirus, Bunyaviridae) infection in hamsters with recombinant Eimeria profilin-like antigen
    Brian B Gowen
    Institute for Antiviral Research and Department of Animal, Dairy, and Veterinary Sciences, Utah State University, Logan, Utah, USA
    Int Immunopharmacol 8:1089-94. 2008
  3. ncbi request reprint Animal models of highly pathogenic RNA viral infections: hemorrhagic fever viruses
    Brian B Gowen
    Institute for Antiviral Research and Department of Animal, Dairy, and Veterinary Sciences, Utah State University, Logan, UT 84322 5600, USA
    Antiviral Res 78:79-90. 2008
  4. pmc Prophylaxis with cationic liposome-DNA complexes protects hamsters from phleboviral disease: importance of liposomal delivery and CpG motifs
    Brian B Gowen
    Institute for Antiviral Research and Department of Animal, Dairy, and Veterinary Sciences, Utah State University, Logan, UT, USA
    Antiviral Res 81:37-46. 2009
  5. pmc In vitro and in vivo activities of T-705 against arenavirus and bunyavirus infections
    Brian B Gowen
    Institute for Antiviral Research, Utah State University, Logan, UT 84322, USA
    Antimicrob Agents Chemother 51:3168-76. 2007
  6. ncbi request reprint TLR3 is essential for the induction of protective immunity against Punta Toro Virus infection by the double-stranded RNA (dsRNA), poly(I:C12U), but not Poly(I:C): differential recognition of synthetic dsRNA molecules
    Brian B Gowen
    Institute for Antiviral Research, Utah State University, Logan, Utah 84341, USA
    J Immunol 178:5200-8. 2007
  7. ncbi request reprint Combinatorial ribavirin and interferon alfacon-1 therapy of acute arenaviral disease in hamsters
    Brian B Gowen
    Institute for Antiviral Research, Utah State University, Logan, UT, USA
    Antivir Chem Chemother 17:175-83. 2006
  8. pmc Recombinant Eimeria protozoan protein elicits resistance to acute phlebovirus infection in mice but not hamsters
    Brian B Gowen
    Institute for Antiviral Research, Utah State University, Logan, 84322, USA
    Antimicrob Agents Chemother 50:2023-9. 2006
  9. ncbi request reprint Protective immunity against acute phleboviral infection elicited through immunostimulatory cationic liposome-DNA complexes
    Brian B Gowen
    Institute for Antiviral Research, Utah State University, Logan, UT 84322, United States
    Antiviral Res 69:165-72. 2006
  10. pmc Prophylactic and therapeutic intervention of Punta Toro virus (Phlebovirus, Bunyaviridae) infection in hamsters with interferon alfacon-1
    Brian B Gowen
    Institute for Antiviral Research and Department of Animal, Dairy, and Veterinary Sciences, Utah State University, 5600 Old Main Hill, Logan, UT 84322 5600, USA
    Antiviral Res 77:215-24. 2008

Collaborators

Detail Information

Publications32

  1. pmc Interferon alfacon-1 protects hamsters from lethal pichinde virus infection
    Brian B Gowen
    Institute for Antiviral Research, 5600 Old Main Hill, Utah State University, Logan, UT 84322, USA
    Antimicrob Agents Chemother 49:2378-86. 2005
    ..These data are the first report demonstrating efficacious treatment of acute arenaviral disease with alpha interferon therapy, and further study is warranted...
  2. pmc Immunoprophylaxis of Punta Toro virus (Phlebovirus, Bunyaviridae) infection in hamsters with recombinant Eimeria profilin-like antigen
    Brian B Gowen
    Institute for Antiviral Research and Department of Animal, Dairy, and Veterinary Sciences, Utah State University, Logan, Utah, USA
    Int Immunopharmacol 8:1089-94. 2008
    ....
  3. ncbi request reprint Animal models of highly pathogenic RNA viral infections: hemorrhagic fever viruses
    Brian B Gowen
    Institute for Antiviral Research and Department of Animal, Dairy, and Veterinary Sciences, Utah State University, Logan, UT 84322 5600, USA
    Antiviral Res 78:79-90. 2008
    ..Such models are sufficient for testing of drugs that directly block viral replication, but may be inadequate for evaluating therapies that depend for their success on the activation or inhibition of host responses...
  4. pmc Prophylaxis with cationic liposome-DNA complexes protects hamsters from phleboviral disease: importance of liposomal delivery and CpG motifs
    Brian B Gowen
    Institute for Antiviral Research and Department of Animal, Dairy, and Veterinary Sciences, Utah State University, Logan, UT, USA
    Antiviral Res 81:37-46. 2009
    ..The results suggest a broad T(H)1 response elicited by liposomal delivery of a diverse sequence containing CpG and non-CpG elements may be a more effective antiviral treatment than other nucleic acid based immunotherapeutics...
  5. pmc In vitro and in vivo activities of T-705 against arenavirus and bunyavirus infections
    Brian B Gowen
    Institute for Antiviral Research, Utah State University, Logan, UT 84322, USA
    Antimicrob Agents Chemother 51:3168-76. 2007
    ..Our results suggest that T-705 may be a viable alternative for the treatment of life-threatening bunyaviral and arenaviral infections...
  6. ncbi request reprint TLR3 is essential for the induction of protective immunity against Punta Toro Virus infection by the double-stranded RNA (dsRNA), poly(I:C12U), but not Poly(I:C): differential recognition of synthetic dsRNA molecules
    Brian B Gowen
    Institute for Antiviral Research, Utah State University, Logan, Utah 84341, USA
    J Immunol 178:5200-8. 2007
    ..We conclude that TLR3 is essential to the induction of antiviral activity elicited by poly(I:C(12)U), which does not appear to be recognized by the cytosolic sensor of poly(I:C), melanoma differentiation-associated gene-5...
  7. ncbi request reprint Combinatorial ribavirin and interferon alfacon-1 therapy of acute arenaviral disease in hamsters
    Brian B Gowen
    Institute for Antiviral Research, Utah State University, Logan, UT, USA
    Antivir Chem Chemother 17:175-83. 2006
    ..Further, combination therapy reduces the effective dosage of ribavirin, which would serve to limit its toxicity...
  8. pmc Recombinant Eimeria protozoan protein elicits resistance to acute phlebovirus infection in mice but not hamsters
    Brian B Gowen
    Institute for Antiviral Research, Utah State University, Logan, 84322, USA
    Antimicrob Agents Chemother 50:2023-9. 2006
    ..Further investigation into the immunostimulatory capacity of rEA in other mammalian systems is necessary...
  9. ncbi request reprint Protective immunity against acute phleboviral infection elicited through immunostimulatory cationic liposome-DNA complexes
    Brian B Gowen
    Institute for Antiviral Research, Utah State University, Logan, UT 84322, United States
    Antiviral Res 69:165-72. 2006
    ..Taken together, our findings indicate that non-specific immunotherapy with CLDC appears to be an effective treatment for blocking PTV-induced disease and suggests that further exploration in other viral disease models may be warranted...
  10. pmc Prophylactic and therapeutic intervention of Punta Toro virus (Phlebovirus, Bunyaviridae) infection in hamsters with interferon alfacon-1
    Brian B Gowen
    Institute for Antiviral Research and Department of Animal, Dairy, and Veterinary Sciences, Utah State University, 5600 Old Main Hill, Logan, UT 84322 5600, USA
    Antiviral Res 77:215-24. 2008
    ..These studies suggest that IFN alfacon-1 may be an effective treatment for early intervention following infection with RVFV...
  11. pmc Treatment of late stage disease in a model of arenaviral hemorrhagic fever: T-705 efficacy and reduced toxicity suggests an alternative to ribavirin
    Brian B Gowen
    Institute for Antiviral Research, Logan, UT, USA
    PLoS ONE 3:e3725. 2008
    ..Our findings support further pre-clinical development of T-705 for the treatment of severe arenaviral infections...
  12. pmc Efficacy of favipiravir (T-705) and T-1106 pyrazine derivatives in phlebovirus disease models
    Brian B Gowen
    Institute for Antiviral Research and Department of Animal, Dairy, and Veterinary Sciences, Utah State University, Logan, UT 84322 5600, USA
    Antiviral Res 86:121-7. 2010
    ....
  13. pmc Extended protection against phlebovirus infection conferred by recombinant adenovirus expressing consensus interferon (DEF201)
    Brian B Gowen
    Institute for Antiviral Research and Department of Animal, Dairy, and Veterinary Sciences, Utah State University, Logan, Utah, USA
    Antimicrob Agents Chemother 56:4168-74. 2012
    ..The prolonged antiphlebovirus prophylactic effect, low production costs, and ease of administration make DEF201 a promising agent for intervention during natural disease outbreaks and for countering possible bioterrorist acts...
  14. pmc Effective oral favipiravir (T-705) therapy initiated after the onset of clinical disease in a model of arenavirus hemorrhagic Fever
    Michelle Mendenhall
    Department of Animal, Dairy, and Veterinary Sciences, Utah State University, Logan, Utah, United States of America
    PLoS Negl Trop Dis 5:e1342. 2011
    ..At present, ribavirin is the only antiviral drug indicated for use in treatment of these diseases, but because of its limited efficacy in advanced cases of disease and its toxicity, safer and more effective antivirals are needed...
  15. ncbi request reprint TLR3 deletion limits mortality and disease severity due to Phlebovirus infection
    Brian B Gowen
    Institute for Antiviral Research, Department of Animal, Dairy, and Veterinary Sciences, Utah State University, 5600 Old Main, Logan, UT 84322, USA
    J Immunol 177:6301-7. 2006
    ....
  16. pmc Maporal virus as a surrogate for pathogenic New World hantaviruses and its inhibition by favipiravir
    Kristin K Buys
    Institute for Antiviral Research and Department of Animal, Dairy, and Veterinary Sciences, Utah State University, Logan, UT, USA
    Antivir Chem Chemother 21:193-200. 2011
    ..Dobrava virus causes HFRS in Europe. Maporal virus (MPRLV), recently isolated from western Venezuela, is phylogenetically similar to Andes virus, the principal cause of HCPS in Argentina...
  17. pmc T-705 (favipiravir) inhibition of arenavirus replication in cell culture
    Michelle Mendenhall
    Institute for Antiviral Research and Department of Animal, Dairy, and Veterinary Sciences, Utah State University, Logan, UT 84322 5600, USA
    Antimicrob Agents Chemother 55:782-7. 2011
    ..Our findings indicate that T-705 acts to inhibit arenavirus replication/transcription and may directly target the viral RNA-dependent RNA polymerase...
  18. pmc Punta Toro virus (Bunyaviridae, Phlebovirus) infection in mice: strain differences in pathogenesis and host interferon response
    Michelle Mendenhall
    Institute for Antiviral Research, Utah State University, Logan, UT 84322 5600, USA
    Virology 395:143-51. 2009
    ..Also, a number of genes specific to IFN response pathways were upregulated in PTV-B-infected macrophages. Our findings provide new insights into the type I IFN response during PTV infection in the mouse model of phleboviral disease...
  19. pmc Differential pathogenesis of cowpox virus intranasal infections in mice induced by low and high inoculum volumes and effects of cidofovir treatment
    Donald F Smee
    Institute for Antiviral Research, Department of Animal, Dairy and Veterinary Sciences, Utah State University, Logan, UT 84322, USA
    Int J Antimicrob Agents 31:352-9. 2008
    ..Cidofovir effectively treated both infections and slowed viral replication sufficiently to subdue the exaggerated release of pro-inflammatory mediators...
  20. pmc Assessing changes in vascular permeability in a hamster model of viral hemorrhagic fever
    Brian B Gowen
    Institute for Antiviral Research and Department of Animal, Dairy, and Veterinary Sciences, Utah State University, Logan, Utah, USA
    Virol J 7:240. 2010
    ..Although rodent models have been used to evaluate treatments for increased vascular permeability (VP) in bacterial sepsis, such studies have not been performed for VHF...
  21. ncbi request reprint Single-dose intranasal treatment with DEF201 (adenovirus vectored consensus interferon) prevents lethal disease due to Rift Valley fever virus challenge
    Brian B Gowen
    Department of Animal, Dairy and Veterinary Sciences, Utah State University, Logan, UT 84322, USA
    Viruses 6:1410-23. 2014
    ..Our findings suggest that DEF201 may be a useful countermeasure against RVFV infection and further demonstrates its broad-spectrum capacity to stimulate single dose protective immunity. ..
  22. pmc Vascular leak ensues a vigorous proinflammatory cytokine response to Tacaribe arenavirus infection in AG129 mice
    Eric J Sefing
    Department of Animal, Dairy, and Veterinary Sciences, Utah State University, Logan, Utah, USA
    Virol J 10:221. 2013
    ..AG129 type I and II interferon receptor knockout mice have been shown to be susceptible to TCRV infection, but the pathogenic mechanisms contributing to the lethal disease are unclear...
  23. pmc Activity of a phenolic dibenzylsulfide against New World arenavirus infections
    Brian B Gowen
    Department of Animal, Dairy, and Veterinary Sciences, Utah State University, Logan, UT, USA
    Antivir Chem Chemother 23:151-9. 2014
    ....
  24. ncbi request reprint Favipiravir (T-705) protects against peracute Rift Valley fever virus infection and reduces delayed-onset neurologic disease observed with ribavirin treatment
    Dionna Scharton
    Department of Animal, Dairy, and Veterinary Sciences, Utah State University, Logan, UT, USA Institute for Antiviral Research, Utah State University, Logan, UT, USA
    Antiviral Res 104:84-92. 2014
    ..Our findings demonstrate significant post-RVFV exposure efficacy with favipiravir against both peracute disease and delayed-onset neuroinvasion, and suggest added benefit when combined with ribavirin. ..
  25. pmc Post-exposure vaccination with MP-12 lacking NSs protects mice against lethal Rift Valley fever virus challenge
    Brian B Gowen
    Department of Animal, Dairy, and Veterinary Sciences, Utah State University, Logan, UT, USA
    Antiviral Res 98:135-43. 2013
    ..Our findings suggest that post-exposure vaccination with MP-12 lacking NSs may be developed as a novel post-exposure treatment to prevent RVF...
  26. pmc Progress in the experimental therapy of severe arenaviral infections
    Brian B Gowen
    Institute for Antiviral Research and Department of Animal, Dairy and Veterinary Sciences, Utah State University, Logan, UT, USA
    Future Microbiol 6:1429-41. 2011
    ..In this paper, we review current developments in the experimental therapy of severe arenaviral infections, focusing on drugs that have been tested in animal models, and provide a perspective on future research...
  27. pmc Use of recombinant adenovirus vectored consensus IFN-α to avert severe arenavirus infection
    Brian B Gowen
    Institute for Antiviral Research and Department of Animal, Dairy, and Veterinary Sciences, Utah State University, Logan, Utah, United States of America
    PLoS ONE 6:e26072. 2011
    ..The DEF201 technology has the potential to address all of these issues and may serve as a broad-spectrum antiviral to enhance host defense against a number of viral pathogens...
  28. pmc Favipiravir (T-705) inhibits junín virus infection and reduces mortality in a Guinea pig model of argentine hemorrhagic Fever
    Brian B Gowen
    Department of Animal, Dairy, and Veterinary Sciences, Utah State University, Logan, Utah, United States of America Institute for Antiviral Research, Utah State University, Logan, Utah, United States of America School of Veterinary Medicine, Utah State University, Logan, Utah, United States of America
    PLoS Negl Trop Dis 7:e2614. 2013
    ..We have previously reported on the in vitro activity of favipiravir against several strains of JUNV and other pathogenic New World arenaviruses...
  29. doi request reprint Potent in vitro activity of the albumin fusion type 1 interferons (albumin-interferon-alpha and albumin-interferon-beta) against RNA viral agents of bioterrorism and the severe acute respiratory syndrome (SARS) virus
    G Mani Subramanian
    Human Genome Sciences, Inc, Rockville, MD 20850, USA
    Chemotherapy 54:176-80. 2008
    ..The type 1 interferons (INF-alpha and INF-beta) are potent antiviral agents. Albumin-INF-alpha and albumin-INF-beta are novel recombinant proteins consisting of IFN-alpha or IFN-beta genetically fused to human albumin...
  30. ncbi request reprint Animal models of highly pathogenic RNA viral infections: encephalitis viruses
    Michael R Holbrook
    Department of Pathology, 301 University Boulevard, University of Texas Medical Branch, Galveston, TX 77555 0609, United States
    Antiviral Res 78:69-78. 2008
    ..In this review we provide a brief summary of the current status of animal models used to study highly pathogenic encephalitic RNA viruses for the development of antiviral therapeutics and vaccines...
  31. ncbi request reprint Novel 3-sulphonamido-quinazolin-4(3H)-one derivatives: microwave-assisted synthesis and evaluation of antiviral activities against respiratory and biodefense viruses
    Periyasamy Selvam
    Arulmigu Kalasalingam College of Pharmacy, Krishnankoil 626190, India
    Antivir Chem Chemother 18:301-5. 2007
    ..Compound 5 was also moderately active against VEE and Tacaribe viruses. The methodology described in this report is applicable for rapid synthesis of many compounds with potential antiviral properties...
  32. pmc Full-exon resequencing reveals toll-like receptor variants contribute to human susceptibility to tuberculosis disease
    Xin Ma
    Center for Human Bacterial Pathogenesis, Department of Pathology, Baylor College of Medicine, Houston, Texas, United States of America
    PLoS ONE 2:e1318. 2007
    ..Extensive full-exon resequencing was critical for revealing new information about the role of TLRs in human-pathogen interactions and the genetic basis of innate immune function...