Dale L Barnard

Summary

Affiliation: Utah State University
Country: USA

Publications

  1. pmc A new mouse-adapted strain of SARS-CoV as a lethal model for evaluating antiviral agents in vitro and in vivo
    Craig W Day
    Institute for Antiviral Research, Utah State University, UMC 5600, Logan, UT 84322 5600, USA
    Virology 395:210-22. 2009
  2. pmc Animal models for the study of influenza pathogenesis and therapy
    Dale L Barnard
    Institute for Antiviral Research, Utah State University, Logan, UT 84322 5600, USA
    Antiviral Res 82:A110-22. 2009
  3. pmc Is the anti-psychotic, 10-(3-(dimethylamino)propyl)phenothiazine (promazine), a potential drug with which to treat SARS infections? Lack of efficacy of promazine on SARS-CoV replication in a mouse model
    Dale L Barnard
    Institute for Antiviral Research, Utah State University, 5600 Old Main Hill, Logan, UT 84322 5600, USA
    Antiviral Res 79:105-13. 2008
  4. ncbi Enhancement of the infectivity of SARS-CoV in BALB/c mice by IMP dehydrogenase inhibitors, including ribavirin
    Dale L Barnard
    Institute for Antiviral Research, Utah State University, Logan, 84322 5600, USA
    Antiviral Res 71:53-63. 2006
  5. ncbi Evaluation of immunomodulators, interferons and known in vitro SARS-coV inhibitors for inhibition of SARS-coV replication in BALB/c mice
    Dale L Barnard
    Institute for Antiviral Research, Utah State University, Logan, UT, USA
    Antivir Chem Chemother 17:275-84. 2006
  6. doi Induction of interferon-gamma-inducible protein 10 by SARS-CoV infection, interferon alfacon 1 and interferon inducer in human bronchial epithelial Calu-3 cells and BALB/c mice
    Yohichi Kumaki
    Institute for Antiviral Research, Department of Animal, Dairy and Veterinary Sciences, Utah State University, Logan, UT, USA
    Antivir Chem Chemother 20:169-77. 2010
  7. pmc Inhibition of severe acute respiratory syndrome coronavirus replication in a lethal SARS-CoV BALB/c mouse model by stinging nettle lectin, Urtica dioica agglutinin
    Yohichi Kumaki
    Institute for Antiviral Research, Department of Animal, Dairy and Veterinary Science, 5600 Old Main Hill, Utah State University, Logan, UT 84322, USA
    Antiviral Res 90:22-32. 2011
  8. ncbi Effect of oral gavage treatment with ZnAL42 and other metallo-ion formulations on influenza A H5N1 and H1N1 virus infections in mice
    Dale L Barnard
    Institute for Antiviral Research, Utah State University, Logan, UT, USA
    Antivir Chem Chemother 18:125-32. 2007
  9. pmc Efficacy of orally administered T-705 on lethal avian influenza A (H5N1) virus infections in mice
    Robert W Sidwell
    Institute for Antiviral Research, Utah State University, 5600 Old Main Hill, Logan, UT 84322 5600, USA
    Antimicrob Agents Chemother 51:845-51. 2007
  10. pmc Single-dose intranasal administration with mDEF201 (adenovirus vectored mouse interferon-alpha) confers protection from mortality in a lethal SARS-CoV BALB/c mouse model
    Yohichi Kumaki
    Institute for Antiviral Research, Department of Animal, Dairy and Veterinary Science, 5600 Old Main Hill, Logan, Utah State University, Logan, UT 84322, USA
    Antiviral Res 89:75-82. 2011

Collaborators

Detail Information

Publications35

  1. pmc A new mouse-adapted strain of SARS-CoV as a lethal model for evaluating antiviral agents in vitro and in vivo
    Craig W Day
    Institute for Antiviral Research, Utah State University, UMC 5600, Logan, UT 84322 5600, USA
    Virology 395:210-22. 2009
    ..Ribavirin, UDA, and Ampligen decreased IL-6 expression. Strain v2163 provided a valuable model for anti-SARS research...
  2. pmc Animal models for the study of influenza pathogenesis and therapy
    Dale L Barnard
    Institute for Antiviral Research, Utah State University, Logan, UT 84322 5600, USA
    Antiviral Res 82:A110-22. 2009
    ..This review describes models currently in use for elucidating influenza pathogenesis and evaluating new therapeutic agents...
  3. pmc Is the anti-psychotic, 10-(3-(dimethylamino)propyl)phenothiazine (promazine), a potential drug with which to treat SARS infections? Lack of efficacy of promazine on SARS-CoV replication in a mouse model
    Dale L Barnard
    Institute for Antiviral Research, Utah State University, 5600 Old Main Hill, Logan, UT 84322 5600, USA
    Antiviral Res 79:105-13. 2008
    ..Thus, promazine did not affect SARS-CoV replication in vitro or in vivo, nor were any other phenothiazines efficacious in reducing virus replication. Therefore, treating SARS infections with compounds like promazine is not warranted...
  4. ncbi Enhancement of the infectivity of SARS-CoV in BALB/c mice by IMP dehydrogenase inhibitors, including ribavirin
    Dale L Barnard
    Institute for Antiviral Research, Utah State University, Logan, 84322 5600, USA
    Antiviral Res 71:53-63. 2006
    ..Our data do not support the use of ribavirin or other IMP dehydrogenase inhibitors for treating SARS infections in humans...
  5. ncbi Evaluation of immunomodulators, interferons and known in vitro SARS-coV inhibitors for inhibition of SARS-coV replication in BALB/c mice
    Dale L Barnard
    Institute for Antiviral Research, Utah State University, Logan, UT, USA
    Antivir Chem Chemother 17:275-84. 2006
    ..In summary, the data suggest that induction of IFN by mismatched dsRNA or actual treatment with exogenous IFN-alpha can inhibit SARS-CoV replication in the lungs of mice...
  6. doi Induction of interferon-gamma-inducible protein 10 by SARS-CoV infection, interferon alfacon 1 and interferon inducer in human bronchial epithelial Calu-3 cells and BALB/c mice
    Yohichi Kumaki
    Institute for Antiviral Research, Department of Animal, Dairy and Veterinary Sciences, Utah State University, Logan, UT, USA
    Antivir Chem Chemother 20:169-77. 2010
    ..We previously reported that interferon (IFN) alfacon-1 was more active against SARS-CoV infection in human bronchial epithelial Calu-3 cells than in African green monkey kidney epithelial cells on day 3 post-infection...
  7. pmc Inhibition of severe acute respiratory syndrome coronavirus replication in a lethal SARS-CoV BALB/c mouse model by stinging nettle lectin, Urtica dioica agglutinin
    Yohichi Kumaki
    Institute for Antiviral Research, Department of Animal, Dairy and Veterinary Science, 5600 Old Main Hill, Utah State University, Logan, UT 84322, USA
    Antiviral Res 90:22-32. 2011
    ..These data support the conclusion that UDA might bind to N-acetylglucosamine-like residues present on the glycosylated envelope glycoproteins, thereby preventing virus attachment to cells...
  8. ncbi Effect of oral gavage treatment with ZnAL42 and other metallo-ion formulations on influenza A H5N1 and H1N1 virus infections in mice
    Dale L Barnard
    Institute for Antiviral Research, Utah State University, Logan, UT, USA
    Antivir Chem Chemother 18:125-32. 2007
    ..The data suggest that the prophylactic use of ZnAL42 is effective against avian influenza H5N1 or H1N1 virus infection in mice and should be further explored as an option for treating human influenza virus infections...
  9. pmc Efficacy of orally administered T-705 on lethal avian influenza A (H5N1) virus infections in mice
    Robert W Sidwell
    Institute for Antiviral Research, Utah State University, 5600 Old Main Hill, Logan, UT 84322 5600, USA
    Antimicrob Agents Chemother 51:845-51. 2007
    ..These data indicate that T-705 may be useful for the treatment of avian influenza virus infections...
  10. pmc Single-dose intranasal administration with mDEF201 (adenovirus vectored mouse interferon-alpha) confers protection from mortality in a lethal SARS-CoV BALB/c mouse model
    Yohichi Kumaki
    Institute for Antiviral Research, Department of Animal, Dairy and Veterinary Science, 5600 Old Main Hill, Logan, Utah State University, Logan, UT 84322, USA
    Antiviral Res 89:75-82. 2011
    ..001). The data suggest that mDEF201 is a new class of antiviral agent further development as treatment for SARS-CoV infections...
  11. pmc Interferon alfacon 1 inhibits SARS-CoV infection in human bronchial epithelial Calu-3 cells
    Yohichi Kumaki
    Institute for Antiviral Research, Department of Animal, Dairy and Veterinary Science, Utah State University, 5600 Old Main Hill, Logan, UT 84322 5600, USA
    Biochem Biophys Res Commun 371:110-3. 2008
    ..The data might provide an important insight into the mechanism of pathogenesis of SARS-CoV allowing further development of antiviral therapies for treating SARS infections...
  12. pmc In vitro and in vivo efficacy of fluorodeoxycytidine analogs against highly pathogenic avian influenza H5N1, seasonal, and pandemic H1N1 virus infections
    Yohichi Kumaki
    Institute for Antiviral Research, Department of Animal, Dairy and Veterinary Science, 5600 Old Main Hill, Logan, Utah State University, Logan, UT 84322, USA
    Antiviral Res 92:329-40. 2011
    ..05). Given the demonstrated in vitro and in vivo inhibition of avian influenza virus replication, 2'FdC may qualify as a lead compound for the development of agents treating influenza virus infections...
  13. ncbi Inhibition of severe acute respiratory syndrome-associated coronavirus (SARSCoV) by calpain inhibitors and beta-D-N4-hydroxycytidine
    Dale L Barnard
    Institute for Antiviral Research, Utah State University, Logan, UT, USA
    Antivir Chem Chemother 15:15-22. 2004
    ..These compounds or analogues warrant further evaluation as potential therapies for treating SARS or could be used as lead compounds for discovery of more potent SARSCoV inhibitors...
  14. pmc Human parainfluenza virus type 3 (HPIV-3): construction and rescue of an infectious, recombinant virus expressing the enhanced green fluorescent protein (EGFP)
    Jason P Roth
    Institute for Antiviral Research, Department of Animal, Dairy, and Veterinary Sciences, Utah State University, Logan, Utah, USA
    Curr Protoc Microbiol . 2010
    ..Ultimately, cells infected with the rHPIV3-EGFP virus will emit green fluorescence that can be photographed and quantitated...
  15. doi Use of plethysmography in assessing the efficacy of antivirals in a mouse model of pandemic influenza A virus
    Justin G Julander
    Institute for Antiviral Research, Department of Animal, Dairy and Veterinary Sciences, Utah State University, 4700 Old Main Hill, Logan, UT 84322 5600, United States
    Antiviral Res 92:228-36. 2011
    ..Moreover, a combination of these two drugs further improved these parameters. Plethysmography provides a sensitive evaluation of lung function in IAV-infected mice in response to antiviral therapy...
  16. pmc A recombinant, infectious human parainfluenza virus type 3 expressing the enhanced green fluorescent protein for use in high-throughput antiviral assays
    Jason P Roth
    Institute for Antiviral Research, Department of Animal, Dairy and Veterinary Sciences, Utah State University, Logan, UT 84322 5600, USA
    Antiviral Res 82:12-21. 2009
    ..Thus, the use of an EGFP-based antiviral assay for testing potential antiviral compounds against HPIV-3 in a high-throughput format may be justified...
  17. doi Methods for evaluation of antiviral efficacy against influenza virus infections in animal models
    Donald F Smee
    Department of Animal, Dairy, and Veterinary Sciences, Institute for Antiviral Research, Utah State University, Logan, UT, USA
    Methods Mol Biol 1030:407-25. 2013
    ..Thus, for each animal model there is a certain set of disease parameters that can be measured. Here we describe methods for assessing the efficacy of anti-influenza virus compounds in each of these animal species. ..
  18. ncbi Antiviral activities and phosphorylation of 5-halo-2'-deoxyuridines and N-methanocarbathymidine in cells infected with vaccinia virus
    Donald F Smee
    Institute for Antiviral Research, Department of Animal, Dairy and Veterinary Sciences, Utah State University, Logan, Utah, USA
    Antivir Chem Chemother 19:15-24. 2008
    ..The antipoxviral activities and phosphorylation of N-methanocarbathymidine ([N]-MCT) and four 5-halo-2'-deoxyuridines, namely 5-fluoro-(FdU), 5-chloro-(CldU), 5-bromo-(BrdU), and 5-iodo-(IdU) derivatives, were explored...
  19. pmc Interferon alfacon-1 protects hamsters from lethal pichinde virus infection
    Brian B Gowen
    Institute for Antiviral Research, 5600 Old Main Hill, Utah State University, Logan, UT 84322, USA
    Antimicrob Agents Chemother 49:2378-86. 2005
    ..These data are the first report demonstrating efficacious treatment of acute arenaviral disease with alpha interferon therapy, and further study is warranted...
  20. ncbi In vitro activity of favipiravir and neuraminidase inhibitor combinations against oseltamivir-sensitive and oseltamivir-resistant pandemic influenza A (H1N1) virus
    E Bart Tarbet
    Institute for Antiviral Research, Utah State University, Logan, UT, 84322, USA
    Arch Virol 159:1279-91. 2014
    ..Although the clinical relevance of these drug combinations remains to be evaluated, results obtained from this study support the use of combination therapy with favipiravir and NAIs for treatment of human influenza virus infections...
  21. doi Deletion of the D domain of the human parainfluenza virus type 3 (HPIV3) PD protein results in decreased viral RNA synthesis and beta interferon (IFN-β) expression
    Jason P Roth
    Department of Animal, Dairy, and Veterinary Sciences, Institute for Antiviral Research, Utah State University, 5600 Old Main Hill, Logan, UT 84322 5600, USA
    Virus Genes 47:10-9. 2013
    ..These data suggest that the D domain of the PD protein may play a luxury role in HPIV3 RNA synthesis and may also be involved in disrupting the expression of beta interferon. ..
  22. ncbi Coumarins and pyranocoumarins, potential novel pharmacophores for inhibition of measles virus replication
    Dale L Barnard
    Institute for Antiviral Research, Utah State University, Logan, USA
    Antivir Chem Chemother 13:39-59. 2002
    ..This and related compounds may be valuable leads in the development of a potent and selective class of MV inhibitors that could be used in future in the clinic...
  23. ncbi Comparison of colorimetric, fluorometric, and visual methods for determining anti-influenza (H1N1 and H3N2) virus activities and toxicities of compounds
    Donald F Smee
    Department of Animal, Dairy and Veterinary Sciences, Institute for Antiviral Research, Utah State University, Logan, UT 84322 5600, USA
    J Virol Methods 106:71-9. 2002
    ..These methods should also be applicable to evaluating antiviral effects against other lytic virus infections...
  24. ncbi Interferon-alpha. Amarillo Biosciences
    Dale L Barnard
    Utah State University, Institute for Antiviral Research, Logan 84322 5600, USA
    Curr Opin Investig Drugs 3:693-7. 2002
    ..The product is registered in Ghana for the treatment of HBV infection. In October 2001, Amarillo licensed rights to its low-dose oral IFNalpha to Atrix Laboratories for the Orphan indications of oral papillomavirus and Behçet's disease...
  25. ncbi Inhibitors of measles virus
    Dale L Barnard
    Institute for Antiviral Research, Dept ADVS, Utah State University, Logan, UT, USA
    Antivir Chem Chemother 15:111-9. 2004
    ..Thus, further research is needed to develop more potent and less toxic drugs that could be used for treating MV infections to supplement the existing MV vaccine campaigns...
  26. ncbi American Society for Virology-23rd annual meeting. Vaccines and antiviral agents 10-14 July 2004, Montreal Canada
    Dale L Barnard
    Utah State University, Institute of Antiviral Research, Department ADVS, 5600 Old Main Hill, Logan, UT 84322 5600, USA
    IDrugs 7:822-4. 2004
  27. ncbi Respiratory syncytial virus infections: recent prospects for control
    Robert W Sidwell
    Institute for Antiviral Research, Utah State University, 5600 Old Main Hill, Logan, UT 84322 5600, United States
    Antiviral Res 71:379-90. 2006
    ..In this review, updates on the status of the approved anti-RSV antibodies, ribavirin, and recent results of studies with potential new anti-RSV compounds are summarized and discussed...
  28. ncbi Current status of anti-picornavirus therapies
    Dale L Barnard
    Institute for Antiviral Research, Utah State University, 5600 Old Main Hill, Logan, Utah, 84322 5600, USA
    Curr Pharm Des 12:1379-90. 2006
    ..Thus, these results strongly emphasize the need for the development of potent and nontoxic compounds for the treatment of picornavirus infections...
  29. ncbi in vitro inhibition of the measles virus by novel ring-expanded ('fat') nucleoside analogues containing the imidazo[4,5-e]diazepine ring system
    Ning Zhang
    Laboratory for Drug Design and Synthesis, Department of Chemistry and Biochemistry, University of Maryland, Baltimore County 21250, USA
    Bioorg Med Chem Lett 12:3391-4. 2002
    ..Both compounds showed higher anti-MV activity than the control drug ribavirin...
  30. ncbi An orally bioavailable oxime ether capsid binder with potent activity against human rhinovirus
    Keith G Watson
    Biota Chemistry Laboratory, School of Chemistry, Monash University, PO Box 23 Victoria, Australia 3800
    J Med Chem 46:3181-4. 2003
    ..Compound 14 illustrates that an oxime ether group can act as a metabolically stable bioisostere for an ester functionality...
  31. doi Potent in vitro activity of the albumin fusion type 1 interferons (albumin-interferon-alpha and albumin-interferon-beta) against RNA viral agents of bioterrorism and the severe acute respiratory syndrome (SARS) virus
    G Mani Subramanian
    Human Genome Sciences, Inc, Rockville, MD 20850, USA
    Chemotherapy 54:176-80. 2008
    ..The type 1 interferons (INF-alpha and INF-beta) are potent antiviral agents. Albumin-INF-alpha and albumin-INF-beta are novel recombinant proteins consisting of IFN-alpha or IFN-beta genetically fused to human albumin...
  32. ncbi Antiviral activity of nucleoside analogues against SARS-coronavirus (SARS-coV)
    Chung K Chu
    The University of Georgia, College of Pharmacy, Athens, GA, USA
    Antivir Chem Chemother 17:285-9. 2006
    ..Herein we describe the antiviral activity of several classes of nucleoside analogues evaluated against SARS-CoV in Vero 76 cells, some of which exhibited moderate activity...
  33. pmc Neutralizing viruses in suspensions by copper oxide-based filters
    Gadi Borkow
    Ruth Ben Ari Institute of Clinical Immunology, Kaplan Medical Center, Rehovot 76100, Israel
    Antimicrob Agents Chemother 51:2605-7. 2007
    ..Enveloped, nonenveloped, RNA, and DNA viruses were affected, suggesting the possibility of using copper oxide-containing devices to deactivate a wide spectrum of infectious viruses found in filterable suspensions...
  34. ncbi Novel 3-sulphonamido-quinazolin-4(3H)-one derivatives: microwave-assisted synthesis and evaluation of antiviral activities against respiratory and biodefense viruses
    Periyasamy Selvam
    Arulmigu Kalasalingam College of Pharmacy, Krishnankoil 626190, India
    Antivir Chem Chemother 18:301-5. 2007
    ..Compound 5 was also moderately active against VEE and Tacaribe viruses. The methodology described in this report is applicable for rapid synthesis of many compounds with potential antiviral properties...
  35. ncbi Intranasal Protollin-formulated recombinant SARS S-protein elicits respiratory and serum neutralizing antibodies and protection in mice
    Mary C Hu
    GlaxoSmithKline Biologicals North America of Washington, 19204 North Creek Parkway, Bothell, WA 98011, USA
    Vaccine 25:6334-40. 2007
    ..Following live virus challenge of aged mice, no virus was detected in the lungs of intranasally immunized mice, in contrast to intramuscularly immunized mice whose lung virus titers were comparable to those observed in control mice...