Vickie S Wilson

Summary

Affiliation: U.S. Environmental Protection Agency
Country: USA

Publications

  1. doi request reprint Utilizing toxicogenomic data to understand chemical mechanism of action in risk assessment
    Vickie S Wilson
    National Health and Environmental Effects Research Laboratory, Office of Research and Development, U S Environmental Protection Agency, Research Triangle Park, NC 27711, USA Electronic address
    Toxicol Appl Pharmacol 271:299-308. 2013
  2. ncbi request reprint A novel cell line, MDA-kb2, that stably expresses an androgen- and glucocorticoid-responsive reporter for the detection of hormone receptor agonists and antagonists
    Vickie S Wilson
    U S Environmental Protection Agency, Office of Research and Development, National Health and Environmental Effects Research Laboratory, Reproductive Toxicology Division, MD 72, Research Triangle Park, North Carolina 27711, USA
    Toxicol Sci 66:69-81. 2002
  3. doi request reprint The herbicide linuron reduces testosterone production from the fetal rat testis during both in utero and in vitro exposures
    Vickie S Wilson
    U S Environmental Protection Agency, Office of Research and Development, NHEERL, Research Triangle Park, NC, USA
    Toxicol Lett 186:73-7. 2009
  4. doi request reprint Diverse mechanisms of anti-androgen action: impact on male rat reproductive tract development
    Vickie S Wilson
    US Environmental Protection Agency, Office of Research and Development, National Health and Environmental Effects Laboratory, Reproductive Toxicology Division, Research Triangle Park, NC 27711, USA
    Int J Androl 31:178-87. 2008
  5. ncbi request reprint Competitive binding comparison of endocrine-disrupting compounds to recombinant androgen receptor from fathead minnow, rainbow trout, and human
    Vickie S Wilson
    U S Environmental Protection Agency, ORD, NHEERL, Reproductive Toxicology Division, MD 72, Research Triangle Park, NC 27711, USA
    Environ Toxicol Chem 26:1793-802. 2007
  6. ncbi request reprint Cloning and in vitro expression and characterization of the androgen receptor and isolation of estrogen receptor alpha from the fathead Minnow (Pimephales promelas)
    Vickie S Wilson
    US Environmental Protection Agency, ORD, NHEERL, Reproductive Toxicology Division, North Carolina 27711, USA
    Environ Sci Technol 38:6314-21. 2004
  7. ncbi request reprint Development and characterization of a cell line that stably expresses an estrogen-responsive luciferase reporter for the detection of estrogen receptor agonist and antagonists
    Vickie S Wilson
    US Environmental Protection Agency, ORD, NHEERL, Reproductive Toxicology Division, Research Triangle Park, NC 27711, USA
    Toxicol Sci 81:69-77. 2004
  8. ncbi request reprint Phthalate ester-induced gubernacular lesions are associated with reduced insl3 gene expression in the fetal rat testis
    Vickie S Wilson
    Reproductive Toxicology Division, United States Environmental Protection Agency, NHEERL, ORD, MD 72, Research Triangle Park, NC 27711, USA
    Toxicol Lett 146:207-15. 2004
  9. ncbi request reprint In vitro and in vivo effects of 17beta-trenbolone: a feedlot effluent contaminant
    Vickie S Wilson
    US Environmental Protection Agency, Office of Research and Development, National Health and Environmental Effects Research Laboratory, Reproductive Toxicology Division, MD 72, Research Triangle Park, North Carolina 27711, USA
    Toxicol Sci 70:202-11. 2002
  10. ncbi request reprint Cumulative effects of in utero administration of mixtures of "antiandrogens" on male rat reproductive development
    Cynthia V Rider
    MD 72, Endocrinology Branch, Reproductive Toxicology Division, NHEERL, ORD, U S Environmental Protection Agency, RTP, North Carolina 27713, USA
    Toxicol Pathol 37:100-13. 2009

Collaborators

Detail Information

Publications36

  1. doi request reprint Utilizing toxicogenomic data to understand chemical mechanism of action in risk assessment
    Vickie S Wilson
    National Health and Environmental Effects Research Laboratory, Office of Research and Development, U S Environmental Protection Agency, Research Triangle Park, NC 27711, USA Electronic address
    Toxicol Appl Pharmacol 271:299-308. 2013
    ....
  2. ncbi request reprint A novel cell line, MDA-kb2, that stably expresses an androgen- and glucocorticoid-responsive reporter for the detection of hormone receptor agonists and antagonists
    Vickie S Wilson
    U S Environmental Protection Agency, Office of Research and Development, National Health and Environmental Effects Research Laboratory, Reproductive Toxicology Division, MD 72, Research Triangle Park, North Carolina 27711, USA
    Toxicol Sci 66:69-81. 2002
    ..In summary, we have developed a cell line that can be used to screen chemicals, not just for AR- but for GR-mediated activities as well...
  3. doi request reprint The herbicide linuron reduces testosterone production from the fetal rat testis during both in utero and in vitro exposures
    Vickie S Wilson
    U S Environmental Protection Agency, Office of Research and Development, NHEERL, Research Triangle Park, NC, USA
    Toxicol Lett 186:73-7. 2009
    ..These results indicate the malformations induced by linuron and phthalate esters in male offspring are similar because both reduce fetal T levels during the critical period of sex differentiation but suggest that the mechanisms differ...
  4. doi request reprint Diverse mechanisms of anti-androgen action: impact on male rat reproductive tract development
    Vickie S Wilson
    US Environmental Protection Agency, Office of Research and Development, National Health and Environmental Effects Laboratory, Reproductive Toxicology Division, Research Triangle Park, NC 27711, USA
    Int J Androl 31:178-87. 2008
    ..Furthermore, the effects of mixtures of these compounds are just beginning to be explored...
  5. ncbi request reprint Competitive binding comparison of endocrine-disrupting compounds to recombinant androgen receptor from fathead minnow, rainbow trout, and human
    Vickie S Wilson
    U S Environmental Protection Agency, ORD, NHEERL, Reproductive Toxicology Division, MD 72, Research Triangle Park, NC 27711, USA
    Environ Toxicol Chem 26:1793-802. 2007
    ..Studies such as these will facilitate the identification of EDCs that may differentially affect specific species and aid in the development and support of future risk assessment protocols...
  6. ncbi request reprint Cloning and in vitro expression and characterization of the androgen receptor and isolation of estrogen receptor alpha from the fathead Minnow (Pimephales promelas)
    Vickie S Wilson
    US Environmental Protection Agency, ORD, NHEERL, Reproductive Toxicology Division, North Carolina 27711, USA
    Environ Sci Technol 38:6314-21. 2004
    ..Future plans include comparison of binding affinities of the fhAR to those of the human AR, also expressed in COS cells, using a range of EDCs...
  7. ncbi request reprint Development and characterization of a cell line that stably expresses an estrogen-responsive luciferase reporter for the detection of estrogen receptor agonist and antagonists
    Vickie S Wilson
    US Environmental Protection Agency, ORD, NHEERL, Reproductive Toxicology Division, Research Triangle Park, NC 27711, USA
    Toxicol Sci 81:69-77. 2004
    ..In addition, herein we also provide key protocol recommendations necessary to identify and eliminate common problems encountered in in vitro screening for estrogenicity...
  8. ncbi request reprint Phthalate ester-induced gubernacular lesions are associated with reduced insl3 gene expression in the fetal rat testis
    Vickie S Wilson
    Reproductive Toxicology Division, United States Environmental Protection Agency, NHEERL, ORD, MD 72, Research Triangle Park, NC 27711, USA
    Toxicol Lett 146:207-15. 2004
    ..These results provide the first demonstration of PE-induced alteration of insl3 mRNA in the fetal male rat testis...
  9. ncbi request reprint In vitro and in vivo effects of 17beta-trenbolone: a feedlot effluent contaminant
    Vickie S Wilson
    US Environmental Protection Agency, Office of Research and Development, National Health and Environmental Effects Research Laboratory, Reproductive Toxicology Division, MD 72, Research Triangle Park, North Carolina 27711, USA
    Toxicol Sci 70:202-11. 2002
    ..In summary, TB is a potent environmental androgen both in vitro and in vivo and, in contrast to other reports, can induce developmental abnormalities in the fetus...
  10. ncbi request reprint Cumulative effects of in utero administration of mixtures of "antiandrogens" on male rat reproductive development
    Cynthia V Rider
    MD 72, Endocrinology Branch, Reproductive Toxicology Division, NHEERL, ORD, U S Environmental Protection Agency, RTP, North Carolina 27713, USA
    Toxicol Pathol 37:100-13. 2009
    ..In this study, the complex mixture behaved in a dose-additive manner. Our results indicate that compounds that act by disparate mechanisms of toxicity display cumulative, dose-additive effects when present in combination...
  11. doi request reprint Dose-response assessment of fetal testosterone production and gene expression levels in rat testes following in utero exposure to diethylhexyl phthalate, diisobutyl phthalate, diisoheptyl phthalate, and diisononyl phthalate
    Bethany R Hannas
    Toxicology Assessment Division, Reproductive Toxicology Branch, U S Environmental Protection Agency, National Health and Environmental Effects Research Laboratory, Research Triangle Park, North Carolina 27711, USA
    Toxicol Sci 123:206-16. 2011
    ....
  12. ncbi request reprint Effects of two fungicides with multiple modes of action on reproductive endocrine function in the fathead minnow (Pimephales promelas)
    Gerald T Ankley
    U S Environmental Protection Agency, ORD, NHEERL, Mid Continent Ecology Division, Duluth, Minnesota 55804, USA
    Toxicol Sci 86:300-8. 2005
    ..These studies contribute to a better mechanistic understanding of the extrapolation of effects of endocrine-disrupting chemicals across vertebrate classes...
  13. ncbi request reprint Gestational and lactational exposure to ethinyl estradiol, but not bisphenol A, decreases androgen-dependent reproductive organ weights and epididymal sperm abundance in the male long evans hooded rat
    Kembra L Howdeshell
    US Environmental Protection Agency, Office of Research and Development, National Health and Environmental Effects Research Laboratory, Reproductive Toxicology Division, Research Triangle Park, North Carolina 27711, USA
    Toxicol Sci 102:371-82. 2008
    ..05-1.5 mug/kg/day did not significantly affect any male endpoint in the current study. These results demonstrate that developmental exposure to oral micromolar doses of EE can permanently disrupt the reproductive tract of the male rat...
  14. doi request reprint A mixture of five phthalate esters inhibits fetal testicular testosterone production in the sprague-dawley rat in a cumulative, dose-additive manner
    Kembra L Howdeshell
    Reproductive Toxicology Division, NHEERL, ORD, United States Environmental Protection Agency USEPA, Research Triangle Park, North Carolina 27711, USA
    Toxicol Sci 105:153-65. 2008
    ..These data demonstrate that individual phthalates with a similar mechanism of action can elicit cumulative, dose additive effects on fetal testosterone production and pregnancy when administered as a mixture...
  15. doi request reprint Use of genomic data in risk assessment case study: II. Evaluation of the dibutyl phthalate toxicogenomic data set
    Susan Y Euling
    National Center for Environmental Assessment, U S Environmental Protection Agency, Washington, DC, USA Electronic address
    Toxicol Appl Pharmacol 271:349-62. 2013
    ..Furthermore, this study demonstrated an approach for evaluating toxicogenomic data in human health risk assessment that could be applied to future chemicals. ..
  16. pmc Genomic biomarkers of phthalate-induced male reproductive developmental toxicity: a targeted RT-PCR array approach for defining relative potency
    Bethany R Hannas
    Reproductive Toxicology Branch, Toxicology Assessment Division, National Health and Environmental Effects Research Laboratory, Office of Research and Development, U S Environmental Protection Agency, Research Triangle Park, North Carolina 27711, USA
    Toxicol Sci 125:544-57. 2012
    ..Finally, the observed mixture interaction was adequately modeled by the dose-addition model for most of the affected genes. Together, these data advance our understanding of the collective reproductive toxicity of the PE compounds...
  17. ncbi request reprint Identification of estrogenic compounds emitted from the combustion of computer printed circuit boards in electronic waste
    Clyde V Owens
    National Risk Management Research LaboratoryReproductive Toxicology Division, Office of Research and Development, U S Environmental Protection Agency, Research Triangle Park, North Carolina 27711, USA
    Environ Sci Technol 41:8506-11. 2007
    ..However, it was about 1000-fold less potent than ethynyl estradiol...
  18. ncbi request reprint Differential expression of the phthalate syndrome in male Sprague-Dawley and Wistar rats after in utero DEHP exposure
    Vickie S Wilson
    U S Environmental Protection Agency, ORD, NHEERL, Reproductive Toxicology Division, MD 72, Research Triangle Park, NC 27711, USA
    Toxicol Lett 170:177-84. 2007
    ....
  19. ncbi request reprint Adverse effects of environmental antiandrogens and androgens on reproductive development in mammals
    L Earl Gray
    MD 72, Endocrinology Branch, Reproductive Toxicology Division, NHEERL, ORD, US Environmental Protection Agency, RTP, NC 27771, USA
    Int J Androl 29:96-104; discussion 105-8. 2006
    ....
  20. ncbi request reprint Detection of androgenic activity in emissions from diesel fuel and biomass combustion
    Clyde V Owens
    US Environmental Protection Agency, Office of Research and Development, Research Triangle Park, North Carolina 27711, USA
    Environ Toxicol Chem 25:2123-31. 2006
    ..The present study demonstrates that in vitro bioassays can serve as sensitive bioanalytical tools to aid in characterization of complex environmental mixtures...
  21. ncbi request reprint Late gestational exposure to the fungicide prochloraz delays the onset of parturition and causes reproductive malformations in male but not female rat offspring
    Nigel C Noriega
    Endocrinology Branch, MD 72, RTD, NHEERL, ORD, US Environmental Protection Agency, Research Triangle Park, North Carolina 27711, USA
    Biol Reprod 72:1324-35. 2005
    ..Despite severe malformations in males, no malformations were noted in females. Together, these results indicate that PZ alters sexual differentiation in an antiandrogenic manner...
  22. ncbi request reprint Effects of the androgenic growth promoter 17-beta-trenbolone on fecundity and reproductive endocrinology of the fathead minnow
    Gerald T Ankley
    U S Environmental Protection Agency, National Health and Environmental Effects Research Laboratory, Mid Continent Ecology Division, 6201 Congdon Boulevard, Duluth, Minnesota 55804, USA
    Environ Toxicol Chem 22:1350-60. 2003
    ..Given the widespread use of trenbolone acetate as a growth promoter, and relative stability of its metabolites in animal wastes, further studies are warranted to assess potential ecological risk...
  23. ncbi request reprint Gene expression analysis in the ventral prostate of rats exposed to vinclozolin or procymidone
    Mitchell B Rosen
    United States Environmental Protection Agency, Office of Research and Development, National Health and Environmental Effects Research Laboratory, Reproductive Toxicology Division, MD72, Research Triangle Park, NC 27711, USA
    Reprod Toxicol 19:367-79. 2005
    ..These results support the hypothesis that procymidone and vinclozolin share a common mechanism or mode of action, a critical step in a cumulative risk assessment...
  24. pmc Dipentyl phthalate dosing during sexual differentiation disrupts fetal testis function and postnatal development of the male Sprague-Dawley rat with greater relative potency than other phthalates
    Bethany R Hannas
    National Research Council Fellowship Program, National Health and Environmental Effects Laboratory, Office of Research and Development, U S Environmental Protection Agency, Research Triangle Park, North Carolina 27711, USA
    Toxicol Sci 120:184-93. 2011
    ....
  25. ncbi request reprint Mechanisms of action of phthalate esters, individually and in combination, to induce abnormal reproductive development in male laboratory rats
    Kembra L Howdeshell
    Reproductive Toxicology Division, National Health and Environmental Effects Laboratory, Office of Research and Development, United States Environmental Protection Agency, Research Triangle Park, NC 27711, USA
    Environ Res 108:168-76. 2008
    ..Since phthalate ester metabolites are detected in maternal and fetal body fluids, and androgen-signaling and insl3 are highly conserved among mammals, phthalates may potentially affect human reproductive development...
  26. pmc Identification of metabolites of trenbolone acetate in androgenic runoff from a beef feedlot
    Elizabeth J Durhan
    Mid Continent Ecology Division, National Health and Environmental Effects Laboratory, U S Environmental Protection Agency, Duluth, Minnesota 55804, USA
    Environ Health Perspect 114:65-8. 2006
    ..Further work is needed to ascertain the degree to which synthetic androgens such as trenbolone contribute to androgenic activity of feedlot discharges...
  27. ncbi request reprint DNA arrays to monitor gene expression in rat blood and uterus following 17beta-estradiol exposure: biomonitoring environmental effects using surrogate tissues
    John C Rockett
    Reproductive Toxicology Division, National Health and Environmental Effects Research Laboratory, Office of Research and Development, U S Environmental Protection Agency, Research Triangle Park, North Carolina 27711, USA
    Toxicol Sci 69:49-59. 2002
    ....
  28. doi request reprint Modelling defined mixtures of environmental oestrogens found in domestic animal and sewage treatment effluents using an in vitro oestrogen-mediated transcriptional activation assay (T47D-KBluc)
    Dieldrich S Bermudez
    Department of Molecular Biomedical Sciences, North Carolina State University, Raleigh, NC, USA
    Int J Androl 35:397-406. 2012
    ..Results show that the observed data did not vary consistently from either the CA or EEQ predictions for any mixture. Therefore, either the CA or EEQ model should be useful predictors for modelling oestrogen mixtures...
  29. doi request reprint A mixture of seven antiandrogens induces reproductive malformations in rats
    Cynthia V Rider
    Department of Molecular Biomedical Sciences, North Carolina State University, Raleigh, NC, USA
    Int J Androl 31:249-62. 2008
    ....
  30. doi request reprint Characterization of the androgen-sensitive MDA-kb2 cell line for assessing complex environmental mixtures
    Lindsey S Blake
    Integrated Biosciences, University of Minnesota, Duluth, 1035 University Dr, Duluth, Minnesota 55812, USA
    Environ Toxicol Chem 29:1367-76. 2010
    ....
  31. ncbi request reprint Sensitivity of fetal rat testicular steroidogenesis to maternal prochloraz exposure and the underlying mechanism of inhibition
    Chad R Blystone
    Department of Environmental and Molecular Toxicology, NC State University, Raleigh, NC 27695, USA
    Toxicol Sci 97:512-9. 2007
    ..These results demonstrate that PCZ lowers testicular testosterone synthesis by inhibiting CYP17 activity which likely contributes to the induced malformations in androgen-dependent tissues of male offspring...
  32. ncbi request reprint Prochloraz inhibits testosterone production at dosages below those that affect androgen-dependent organ weights or the onset of puberty in the male Sprague Dawley rat
    Chad R Blystone
    Department of Environmental and Molecular Toxicology, North Carolina State University, Raleigh, North Carolina 27695, USA
    Toxicol Sci 97:65-74. 2007
    ....
  33. ncbi request reprint Cumulative effects of dibutyl phthalate and diethylhexyl phthalate on male rat reproductive tract development: altered fetal steroid hormones and genes
    Kembra L Howdeshell
    North Carolina State University, Department of Molecular Biomedical Sciences, Raleigh, North Carolina 27606, USA
    Toxicol Sci 99:190-202. 2007
    ....
  34. pmc Fifteen years after "Wingspread"--environmental endocrine disrupters and human and wildlife health: where we are today and where we need to go
    Andrew K Hotchkiss
    USEPA NCSU Cooperative Training agreement CT826512010, Raleigh, North Carolina 27695, USA
    Toxicol Sci 105:235-59. 2008
    ....
  35. ncbi request reprint Iprodione delays male rat pubertal development, reduces serum testosterone levels, and decreases ex vivo testicular testosterone production
    Chad R Blystone
    Department of Molecular Biomedical Sciences, North Carolina State University, Raleigh, NC 27695, USA
    Toxicol Lett 174:74-81. 2007
    ....
  36. pmc The biocide tributyltin reduces the accumulation of testosterone as fatty acid esters in the mud snail (Ilyanassa obsoleta)
    Meredith P Gooding
    Department of Environmental and Molecular Toxicology, North Carolina State University, Raleigh, North Carolina 27695, USA
    Environ Health Perspect 111:426-30. 2003
    ..The target of TBT may be a co-contributor to the testosterone fatty esterification process or a factor in the enhanced hydrolysis of the testosterone-fatty acid pool...