Rong Lin Wang

Summary

Affiliation: U.S. Environmental Protection Agency
Country: USA

Publications

  1. pmc Discovery and validation of gene classifiers for endocrine-disrupting chemicals in zebrafish (danio rerio)
    Rong Lin Wang
    USEPA, Ecological Exposure Research Division, National Exposure Research Laboratory, 26 W Martin Luther King Dr, Cincinnati, OH 45268, USA
    BMC Genomics 13:358. 2012
  2. ncbi request reprint DNA microarray application in ecotoxicology: experimental design, microarray scanning, and factors affecting transcriptional profiles in a small fish species
    Rong Lin Wang
    Ecological Exposure Research Division, National Exposure Research Laboratory, US Environmental Protection Agency, Cincinnati, Ohio 45268, USA
    Environ Toxicol Chem 27:652-63. 2008
  3. ncbi request reprint DNA microarray-based ecotoxicological biomarker discovery in a small fish model species
    Rong Lin Wang
    Ecological Exposure Research Division, National Exposure Research Lab, US Environmental Protection Agency, Cincinnati, Ohio 45268, USA
    Environ Toxicol Chem 27:664-75. 2008
  4. ncbi request reprint A transcriptomics-based biological framework for studying mechanisms of endocrine disruption in small fish species
    Rong Lin Wang
    USEPA, Ecological Exposure Research Division, National Exposure Research Laboratory, 26 W Martin Luther King Dr, Cincinnati, OH 45268, USA
    Aquat Toxicol 98:230-44. 2010
  5. ncbi request reprint Transcriptional regulatory dynamics of the hypothalamic-pituitary-gonadal axis and its peripheral pathways as impacted by the 3-beta HSD inhibitor trilostane in zebrafish (Danio rerio)
    Rong Lin Wang
    USEPA, Ecological Exposure Research Division, National Exposure Research Laboratory, 26 W Martin Luther King Dr Cincinnati, OH 45268, USA
    Ecotoxicol Environ Saf 74:1461-70. 2011
  6. doi request reprint Gene expression profiling of the androgen receptor antagonists flutamide and vinclozolin in zebrafish (Danio rerio) gonads
    Dalma Martinovic-Weigelt
    US Environmental Protection Agency, Office of Research and Development, National Health and Environmental Effects Research Laboratory, Mid Continent Ecology Division, 6201 Congdon Blvd, Duluth, MN 55804, USA
    Aquat Toxicol 101:447-58. 2011
  7. ncbi request reprint Altered gene expression in the brain and ovaries of zebrafish (Danio rerio) exposed to the aromatase inhibitor fadrozole: microarray analysis and hypothesis generation
    L Villeneuve
    U S Environmental Protection Agency, Office of Research and Development, National Health and Environmental Effects Research Laboratory, Mid Continent Ecology Division, 6201 Congdon Boulevard, Duluth, Minnesosta 55804, USA
    Environ Toxicol Chem 28:1767-82. 2009
  8. doi request reprint Endocrine disrupting chemicals in fish: developing exposure indicators and predictive models of effects based on mechanism of action
    Gerald T Ankley
    USEPA, National Health and Environmental Effects Research Lab, Duluth, MN, USA
    Aquat Toxicol 92:168-78. 2009
  9. pmc Global transcription profiling reveals differential responses to chronic nitrogen stress and putative nitrogen regulatory components in Arabidopsis
    Yong Mei Bi
    Department of Molecular and Cellular Biology, University of Guelph, Guelph, Ontario, N1G 2W1, Canada
    BMC Genomics 8:281. 2007

Detail Information

Publications9

  1. pmc Discovery and validation of gene classifiers for endocrine-disrupting chemicals in zebrafish (danio rerio)
    Rong Lin Wang
    USEPA, Ecological Exposure Research Division, National Exposure Research Laboratory, 26 W Martin Luther King Dr, Cincinnati, OH 45268, USA
    BMC Genomics 13:358. 2012
    ..Candidate classifiers were evaluated by gene set enrichment analysis (GSEA) on both the original training data and a dedicated validation dataset...
  2. ncbi request reprint DNA microarray application in ecotoxicology: experimental design, microarray scanning, and factors affecting transcriptional profiles in a small fish species
    Rong Lin Wang
    Ecological Exposure Research Division, National Exposure Research Laboratory, US Environmental Protection Agency, Cincinnati, Ohio 45268, USA
    Environ Toxicol Chem 27:652-63. 2008
    ..These findings will help to improve applications of microarrays in future ecotoxicological studies...
  3. ncbi request reprint DNA microarray-based ecotoxicological biomarker discovery in a small fish model species
    Rong Lin Wang
    Ecological Exposure Research Division, National Exposure Research Lab, US Environmental Protection Agency, Cincinnati, Ohio 45268, USA
    Environ Toxicol Chem 27:664-75. 2008
    ..These gene classifiers could serve as potential biomarkers of exposure to specific classes of endocrine disruptors...
  4. ncbi request reprint A transcriptomics-based biological framework for studying mechanisms of endocrine disruption in small fish species
    Rong Lin Wang
    USEPA, Ecological Exposure Research Division, National Exposure Research Laboratory, 26 W Martin Luther King Dr, Cincinnati, OH 45268, USA
    Aquat Toxicol 98:230-44. 2010
    ..These candidate networks/pathways have a variety of profound impacts on such cellular functions as stress response, cell cycle, and apoptosis...
  5. ncbi request reprint Transcriptional regulatory dynamics of the hypothalamic-pituitary-gonadal axis and its peripheral pathways as impacted by the 3-beta HSD inhibitor trilostane in zebrafish (Danio rerio)
    Rong Lin Wang
    USEPA, Ecological Exposure Research Division, National Exposure Research Laboratory, 26 W Martin Luther King Dr Cincinnati, OH 45268, USA
    Ecotoxicol Environ Saf 74:1461-70. 2011
    ..Its impact on corticosteroid synthesis could also have contributed to some system wide transcriptional changes in zebrafish observed in this study...
  6. doi request reprint Gene expression profiling of the androgen receptor antagonists flutamide and vinclozolin in zebrafish (Danio rerio) gonads
    Dalma Martinovic-Weigelt
    US Environmental Protection Agency, Office of Research and Development, National Health and Environmental Effects Research Laboratory, Mid Continent Ecology Division, 6201 Congdon Blvd, Duluth, MN 55804, USA
    Aquat Toxicol 101:447-58. 2011
    ..This information should prove useful to elucidating specific mechanisms of reproductive effects of anti-androgens in fish, as well as developing biomarkers for this important class of endocrine-active chemicals...
  7. ncbi request reprint Altered gene expression in the brain and ovaries of zebrafish (Danio rerio) exposed to the aromatase inhibitor fadrozole: microarray analysis and hypothesis generation
    L Villeneuve
    U S Environmental Protection Agency, Office of Research and Development, National Health and Environmental Effects Research Laboratory, Mid Continent Ecology Division, 6201 Congdon Boulevard, Duluth, Minnesosta 55804, USA
    Environ Toxicol Chem 28:1767-82. 2009
    ..These hypotheses and others derived from the microarray results provide a foundation for future studies aimed at understanding responses of the HPG axis to EACs and other chemical stressors...
  8. doi request reprint Endocrine disrupting chemicals in fish: developing exposure indicators and predictive models of effects based on mechanism of action
    Gerald T Ankley
    USEPA, National Health and Environmental Effects Research Lab, Duluth, MN, USA
    Aquat Toxicol 92:168-78. 2009
    ..Although our project is focused specifically on EDCs in fish, we believe that the basic conceptual approach has utility for systematically assessing exposure and effects of chemicals with other MOA across a variety of biological systems...
  9. pmc Global transcription profiling reveals differential responses to chronic nitrogen stress and putative nitrogen regulatory components in Arabidopsis
    Yong Mei Bi
    Department of Molecular and Cellular Biology, University of Guelph, Guelph, Ontario, N1G 2W1, Canada
    BMC Genomics 8:281. 2007
    ..No studies have yet delineated these responses at the transcriptional level when plants are grown under chronic N stress and the understanding of regulatory elements involved in N response is very limited...