Timothy J Wade

Summary

Affiliation: U.S. Environmental Protection Agency
Country: USA

Publications

  1. ncbi request reprint Comment on "Derivation of numerical values for the World Health Organization guidelines for recreational waters"
    Larry J Wymer
    U S Environmental Protection Agency, National Exposure Research Laboratory, 26 West M L King Drive, Cincinnati, OH 45268, USA
    Water Res 39:2774-7. 2005
  2. pmc Rapidly measured indicators of recreational water quality are predictive of swimming-associated gastrointestinal illness
    Timothy J Wade
    National Health and Environmental Effects Research Laboratory, Human Studies Division, U S Environmental Protection Agency, Research Triangle Park, North Carolina 27711, USA
    Environ Health Perspect 114:24-8. 2006
  3. ncbi request reprint Assessing waterborne risks: an introduction
    Gunther F Craun
    Gunther F Craun and Associates, 101 West Frederick Street, Suite 207, Staunton, VA 24401, USA
    J Water Health 4:3-18. 2006
  4. doi request reprint High sensitivity of children to swimming-associated gastrointestinal illness: results using a rapid assay of recreational water quality
    Timothy J Wade
    US Environmental Protection Agency, National Health and Environmental Effects Research Laboratory, Chapel Hill, NC 27711, USA
    Epidemiology 19:375-83. 2008
  5. pmc Do U.S. Environmental Protection Agency water quality guidelines for recreational waters prevent gastrointestinal illness? A systematic review and meta-analysis
    Timothy J Wade
    Epidemiology and Biomarkers Branch, U S Environmental Protection Agency, Research Triangle Park, North Carolina, USA
    Environ Health Perspect 111:1102-9. 2003
  6. ncbi request reprint Drinking water source and human Toxoplasma gondii infection in the United States: a cross-sectional analysis of NHANES data
    Whitney S Krueger
    Environmental Public Health Division, Office of Research and Development, US Environmental Protection Agency, 104 Mason Farm Road, Chapel Hill, North Carolina, USA
    BMC Public Health 14:711. 2014
  7. pmc The incidence and health burden of earaches attributable to recreational swimming in natural waters: a prospective cohort study
    Timothy J Wade
    Office of Research and Development, United States Environmental Protection Agency, Chapel Hill, NC, USA
    Environ Health 12:67. 2013
  8. pmc Rapidly measured indicators of recreational water quality and swimming-associated illness at marine beaches: a prospective cohort study
    Timothy J Wade
    United States Environmental Protection Agency, National Health and Environmental Effects Research Laboratory, Research Triangle Park, North Carolina, USA
    Environ Health 9:66. 2010
  9. pmc Increased mortality associated with well-water arsenic exposure in Inner Mongolia, China
    Timothy J Wade
    US Environmental Protection Agency, National Health and Environmental Effects Research Laboratory, Chapel Hill, North Carolina, USA
    Int J Environ Res Public Health 6:1107-23. 2009
  10. pmc Elevated human telomerase reverse transcriptase gene expression in blood cells associated with chronic arsenic exposure in Inner Mongolia, China
    Jinyao Mo
    Center for Environmental Medicine, Asthma and Lung Biology, University of North Carolina Chapel Hill, Chapel Hill, North Carolina, USA
    Environ Health Perspect 117:354-60. 2009

Detail Information

Publications25

  1. ncbi request reprint Comment on "Derivation of numerical values for the World Health Organization guidelines for recreational waters"
    Larry J Wymer
    U S Environmental Protection Agency, National Exposure Research Laboratory, 26 West M L King Drive, Cincinnati, OH 45268, USA
    Water Res 39:2774-7. 2005
    ....
  2. pmc Rapidly measured indicators of recreational water quality are predictive of swimming-associated gastrointestinal illness
    Timothy J Wade
    National Health and Environmental Effects Research Laboratory, Human Studies Division, U S Environmental Protection Agency, Research Triangle Park, North Carolina 27711, USA
    Environ Health Perspect 114:24-8. 2006
    ..The association between Enterococcus and illness strengthened as time spent swimming in the water increased. This is the first study to show that water quality measured by rapid methods can predict swimming-associated health effects...
  3. ncbi request reprint Assessing waterborne risks: an introduction
    Gunther F Craun
    Gunther F Craun and Associates, 101 West Frederick Street, Suite 207, Staunton, VA 24401, USA
    J Water Health 4:3-18. 2006
    ..For example, one author's definition of attributable risk may be quite different from another author's in terms of the population to which the risk may apply and how it should be interpreted...
  4. doi request reprint High sensitivity of children to swimming-associated gastrointestinal illness: results using a rapid assay of recreational water quality
    Timothy J Wade
    US Environmental Protection Agency, National Health and Environmental Effects Research Laboratory, Chapel Hill, NC 27711, USA
    Epidemiology 19:375-83. 2008
    ..We evaluated the quantitative polymerase chain reaction (QPCR) as a faster method to assess recreational water quality and predict swimming-associated illnesses...
  5. pmc Do U.S. Environmental Protection Agency water quality guidelines for recreational waters prevent gastrointestinal illness? A systematic review and meta-analysis
    Timothy J Wade
    Epidemiology and Biomarkers Branch, U S Environmental Protection Agency, Research Triangle Park, North Carolina, USA
    Environ Health Perspect 111:1102-9. 2003
    ..Future studies should focus on the ability of new, more rapid and specific microbial methods to predict health effects, and estimating the risks of recreational water exposure among susceptible persons...
  6. ncbi request reprint Drinking water source and human Toxoplasma gondii infection in the United States: a cross-sectional analysis of NHANES data
    Whitney S Krueger
    Environmental Public Health Division, Office of Research and Development, US Environmental Protection Agency, 104 Mason Farm Road, Chapel Hill, North Carolina, USA
    BMC Public Health 14:711. 2014
    ..We sought to examine National Health and Nutrition Examination Survey (NHANES) data for risk factors associated with T. gondii seroprevalence...
  7. pmc The incidence and health burden of earaches attributable to recreational swimming in natural waters: a prospective cohort study
    Timothy J Wade
    Office of Research and Development, United States Environmental Protection Agency, Chapel Hill, NC, USA
    Environ Health 12:67. 2013
    ..In this study, we estimated the excess risk and health burden of earaches due to swimming in natural fresh and marine waters using results from a survey of over 50,000 beachgoers at nine beaches across the United States...
  8. pmc Rapidly measured indicators of recreational water quality and swimming-associated illness at marine beaches: a prospective cohort study
    Timothy J Wade
    United States Environmental Protection Agency, National Health and Environmental Effects Research Laboratory, Research Triangle Park, North Carolina, USA
    Environ Health 9:66. 2010
    ..In this paper, we report on results from three marine beach sites...
  9. pmc Increased mortality associated with well-water arsenic exposure in Inner Mongolia, China
    Timothy J Wade
    US Environmental Protection Agency, National Health and Environmental Effects Research Laboratory, Chapel Hill, North Carolina, USA
    Int J Environ Res Public Health 6:1107-23. 2009
    ..This is the first study to document increased arsenic-associated mortality in the Bayingnormen region of Inner Mongolia...
  10. pmc Elevated human telomerase reverse transcriptase gene expression in blood cells associated with chronic arsenic exposure in Inner Mongolia, China
    Jinyao Mo
    Center for Environmental Medicine, Asthma and Lung Biology, University of North Carolina Chapel Hill, Chapel Hill, North Carolina, USA
    Environ Health Perspect 117:354-60. 2009
    ..Arsenic exposure is associated with human cancer. Telomerase-containing human telomerase reverse transcriptase (hTERT) can extend telomeres of chromosomes, delay senescence, and promote cell proliferation leading to tumorigenesis...
  11. pmc Fecal indicators in sand, sand contact, and risk of enteric illness among beachgoers
    Christopher D Heaney
    Department of Epidemiology, University of North Carolina at Chapel Hill, NC, USA
    Epidemiology 23:95-106. 2012
    ..Beach sand can harbor fecal indicator organisms and pathogens, but enteric illness risk associated with sand contact remains unclear...
  12. doi request reprint Modeling Enterococcus densities measured by quantitative polymerase chain reaction and membrane filtration using environmental conditions at four Great Lakes beaches
    Justin W Telech
    National Health and Environmental Effects Research Laboratory, Human Studies Division, US Environmental Protection Agency, MD 58C, Research Triangle Park, NC 27711, USA
    Water Res 43:4947-55. 2009
    ..Results also show that models for both methods did not perform well at predicting occurrences in which water quality levels exceeded a threshold...
  13. ncbi request reprint Elevated ERCC1 gene expression in blood cells associated with exposure to arsenic from drinking water in Inner Mongolia
    Jinyao Mo
    Center for Environmental Medicine, Asthma and Lung Biology, University of North Carolina, Chapel Hill, North Carolina, USA
    Anticancer Res 29:3253-9. 2009
    ..Chronic arsenic exposure has been associated with human cancer. The objective of this study was to investigate the effects of arsenic exposure on a DNA nucleotide excision repair gene, ERCC1, expression in human blood cells...
  14. doi request reprint Dramatic improvements in beach water quality following gull removal
    Reagan R Converse
    US Environmental Protection Agency, Chapel Hill, North Carolina 27514, United States
    Environ Sci Technol 46:10206-13. 2012
    ..005). This study demonstrates that gull removal can be a highly successful beach remedial action to improve microbial water quality...
  15. ncbi request reprint Did a severe flood in the Midwest cause an increase in the incidence of gastrointestinal symptoms?
    Timothy J Wade
    Human Studies Division, National Health and Environmental Effects Research Laboratory, Epidemiology and Biomarkers Branch, Environmental Protection Agency, Chapel Hill, NC, USA
    Am J Epidemiol 159:398-405. 2004
    ..These findings suggest that severe climatic events can result in an increase in the endemic incidence of gastrointestinal symptoms in the United States...
  16. pmc Equivalency of risk for a modified health endpoint: a case from recreational water epidemiology studies
    Larry J Wymer
    United States Environmental Protection Agency, National Exposure Research Laboratory, 26 W, Martin Luther King Drive, Cincinnati, OH 45268, USA
    BMC Public Health 13:459. 2013
    ..NGI differed from the previous definition of "highly credible gastrointestinal illness" (HCGI) upon which the USEPA's 1986 bathing water criteria had been based, primarily by excluding fever as a prerequisite...
  17. doi request reprint Contact with beach sand among beachgoers and risk of illness
    Christopher D Heaney
    Department of Epidemiology, University of North Carolina, Chapel Hill, NC 27599 7435, USA
    Am J Epidemiol 170:164-72. 2009
    ..Sand contact activities were associated with enteric illness at beach sites. Variation in beach-specific results suggests that site-specific factors may be important in the risk of illness following sand exposure...
  18. pmc Altered gene expression by low-dose arsenic exposure in humans and cultured cardiomyocytes: assessment by real-time PCR arrays
    Jinyao Mo
    Center for Environmental Medicine, Asthma and Lung Biology, University of North Carolina, Chapel Hill, NC 27599, USA
    Int J Environ Res Public Health 8:2090-108. 2011
    ....
  19. ncbi request reprint A randomized, controlled trial of in-home drinking water intervention to reduce gastrointestinal illness
    John M Colford
    Centers for Occupational and Environmental Health and Family and Community Health, University of California, Berkeley, School of Public Health, Berkeley, CA, USA
    Am J Epidemiol 161:472-82. 2005
    ..active) for the entire trial was 0.98 (95% confidence interval: 0.86, 1.10). No reduction in gastrointestinal illness was detected after in-home use of a device designed to be highly effective in removing microorganisms from water...
  20. ncbi request reprint Water quality indicators and the risk of illness at beaches with nonpoint sources of fecal contamination
    John M Colford
    University of California Berkeley, School of Public Health, Division of Epidemiology, Berkeley, CA 94720 7360, USA
    Epidemiology 18:27-35. 2007
    ..Few studies have addressed the utility of indicator bacteria where nonpoint sources are the dominant fecal input. Extrapolating current water-quality thresholds to such locations is uncertain...
  21. pmc Inferences drawn from a risk assessment compared directly with a randomized trial of a home drinking water intervention
    Joseph N S Eisenberg
    Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, Michigan 48104, USA
    Environ Health Perspect 114:1199-204. 2006
    ..Key words: drinking water, gastrointestinal, intervention trial, microbial risk assessment, waterborne pathogens...
  22. ncbi request reprint A pilot randomized, controlled trial of an in-home drinking water intervention among HIV + persons
    John M Colford
    University of California, Berkeley, School of Public Health, Divisions of Epidemiology and Environmental Health Sciences, 140 Warren Hall 7360, Berkeley, CA 94720, USA
    J Water Health 3:173-84. 2005
    ..The magnitude of the point estimate of the risk, its consistency with recently published observational data, and its relevance for drinking water choices by immunocompromised individuals support the need for larger trials...
  23. ncbi request reprint Arsenic speciation analysis in human saliva
    Chungang Yuan
    Analytical and Environmental Toxicology, Department of Laboratory Medicine and Pathology, University of Alberta, Edmonton, Alberta, Canada
    Clin Chem 54:163-71. 2008
    ..Determination of arsenic species in saliva is potentially useful for biomonitoring of human exposure and studying arsenic metabolism. Arsenic speciation in saliva has not been reported previously...
  24. ncbi request reprint A review of household drinking water intervention trials and an approach to the estimation of endemic waterborne gastroenteritis in the United States
    John M Colford
    Division of Epidemiology, School of Public Health, University of California, Berkeley, 140 Warren Hall, MC 7360, Berkeley, CA 94720, USA
    J Water Health 4:71-88. 2006
    ..Using this approach we estimate there to be 4.26-11.69 million cases of AGI annually attributable to public drinking water systems in the United States. We believe this preliminary estimate should be updated as new data become available...
  25. pmc Participant blinding and gastrointestinal illness in a randomized, controlled trial of an in-home drinking water intervention
    John M Colford
    School of Public Health, University of California Berkeley, 140 Warren Hall 7360, Berkeley, CA 94720, USA
    Emerg Infect Dis 8:29-36. 2002
    ..75, 2.33) and the attributable risk was 0.24 (95% CI -0.33, 0.57). These data confirm that participants can be successfully blinded to treatment group assignment during a randomized trial of an in-home drinking water intervention...