Nisha S Sipes

Summary

Affiliation: U.S. Environmental Protection Agency
Country: USA

Publications

  1. pmc Profiling 976 ToxCast chemicals across 331 enzymatic and receptor signaling assays
    Nisha S Sipes
    National Center for Computational Toxicology, Office of Research and Development, U S Environmental Protection Agency, Research Triangle Park, North Carolina 27711, USA
    Chem Res Toxicol 26:878-95. 2013
  2. doi request reprint Predictive models of prenatal developmental toxicity from ToxCast high-throughput screening data
    Nisha S Sipes
    National Center for Computational Toxicology, Office of Research and Development, U S Environmental Protection Agency, Research Triangle Park, North Carolina 27711, USA
    Toxicol Sci 124:109-27. 2011
  3. doi request reprint Zebrafish: as an integrative model for twenty-first century toxicity testing
    Nisha S Sipes
    National Center for Computational Toxicology, U S Environmental Protection Agency, Research Triangle Park, North Carolina, USA
    Birth Defects Res C Embryo Today 93:256-67. 2011
  4. pmc Environmental impact on vascular development predicted by high-throughput screening
    Nicole C Kleinstreuer
    National Center for Computational Toxiciology, Office of Research and Development, U S Environmental Protection Agency, Research Triangle Park, North Carolina, USA
    Environ Health Perspect 119:1596-603. 2011
  5. doi request reprint Activity profiles of 309 ToxCastâ„¢ chemicals evaluated across 292 biochemical targets
    Thomas B Knudsen
    National Center for Computational Toxicology B205 01, Office of Research and Development, U S Environmental Protection Agency, Research Triangle Park, NC 27711, USA
    Toxicology 282:1-15. 2011
  6. pmc Evaluation of 309 environmental chemicals using a mouse embryonic stem cell adherent cell differentiation and cytotoxicity assay
    Kelly J Chandler
    National Health and Environmental Effects Research Laboratory, Office of Research and Development, U S Environmental Protection Agency, Research Triangle Park, North Carolina, United States of America
    PLoS ONE 6:e18540. 2011

Detail Information

Publications6

  1. pmc Profiling 976 ToxCast chemicals across 331 enzymatic and receptor signaling assays
    Nisha S Sipes
    National Center for Computational Toxicology, Office of Research and Development, U S Environmental Protection Agency, Research Triangle Park, North Carolina 27711, USA
    Chem Res Toxicol 26:878-95. 2013
    ..Results from this large inventory of chemical-biological interactions can inform read-across methods as well as link potential targets to molecular initiating events in adverse outcome pathways for diverse toxicities...
  2. doi request reprint Predictive models of prenatal developmental toxicity from ToxCast high-throughput screening data
    Nisha S Sipes
    National Center for Computational Toxicology, Office of Research and Development, U S Environmental Protection Agency, Research Triangle Park, North Carolina 27711, USA
    Toxicol Sci 124:109-27. 2011
    ..This work indicates the utility of HTS assays for developing pathway-level models predictive of developmental toxicity...
  3. doi request reprint Zebrafish: as an integrative model for twenty-first century toxicity testing
    Nisha S Sipes
    National Center for Computational Toxicology, U S Environmental Protection Agency, Research Triangle Park, North Carolina, USA
    Birth Defects Res C Embryo Today 93:256-67. 2011
    ..Cross-species comparisons implied a common basis for biological pathways associated with neuronal defects, extracellular matrix remodeling, and mitotic arrest...
  4. pmc Environmental impact on vascular development predicted by high-throughput screening
    Nicole C Kleinstreuer
    National Center for Computational Toxiciology, Office of Research and Development, U S Environmental Protection Agency, Research Triangle Park, North Carolina, USA
    Environ Health Perspect 119:1596-603. 2011
    ....
  5. doi request reprint Activity profiles of 309 ToxCastâ„¢ chemicals evaluated across 292 biochemical targets
    Thomas B Knudsen
    National Center for Computational Toxicology B205 01, Office of Research and Development, U S Environmental Protection Agency, Research Triangle Park, NC 27711, USA
    Toxicology 282:1-15. 2011
    ..The primary dataset, summary data and details on quality control checks are available for download at http://www.epa.gov/ncct/toxcast/...
  6. pmc Evaluation of 309 environmental chemicals using a mouse embryonic stem cell adherent cell differentiation and cytotoxicity assay
    Kelly J Chandler
    National Health and Environmental Effects Research Laboratory, Office of Research and Development, U S Environmental Protection Agency, Research Triangle Park, North Carolina, United States of America
    PLoS ONE 6:e18540. 2011
    ..Taken together, these results provide an initial characterization of metabolic and regulatory pathways by which some environmental chemicals may act to disrupt ES cell growth and differentiation...