Research Topics

Steven O Simmons

Summary

Affiliation: U.S. Environmental Protection Agency
Country: USA

Publications

  1. Paul Friedman K, Watt E, Hornung M, Hedge J, Judson R, Crofton K, et al. Tiered High-Throughput Screening Approach to Identify Thyroperoxidase Inhibitors Within the ToxCast Phase I and II Chemical Libraries. Toxicol Sci. 2016;151:160-80 pubmed publisher
    ..This effort represents the most extensive TPO inhibition screening campaign to date and illustrates a tiered screening approach that focuses resources, maximizes assay throughput, and reduces animal use. ..
  2. request reprint
    Simmons S. Fireflies in the coalmine: luciferase technologies in next-generation toxicity testing. Comb Chem High Throughput Screen. 2011;14:688-702 pubmed
  3. DeGroot D, Swank A, Thomas R, Strynar M, Lee M, Carmichael P, et al. mRNA transfection retrofits cell-based assays with xenobiotic metabolism. J Pharmacol Toxicol Methods. 2018;92:77-94 pubmed publisher
    ..Overall, transfection of CYP-encoding mRNAs is an effective and portable solution for retrofitting existing cell-based HTS assays with metabolic competence. ..
  4. Lavrich K, Corteselli E, Wages P, Bromberg P, Simmons S, Gibbs Flournoy E, et al. Investigating mitochondrial dysfunction in human lung cells exposed to redox-active PM components. Toxicol Appl Pharmacol. 2018;342:99-107 pubmed publisher
    ..This study also highlights the methodological utility and challenges in the use of extracellular flux analysis to elucidate the mechanisms of action of redox-active electrophiles present in ambient air. ..