John M Rogers

Summary

Affiliation: U.S. Environmental Protection Agency
Country: USA

Publications

  1. ncbi request reprint Embryonic and fetal programming of physiological disorders in adulthood
    Christopher Lau
    Reproductive Toxicology Division, National Health and Environmental Effects Research Laboratory, Office of Research and Development, U S Environmental Protection Agency, Research Triangle Park, North Carolina 27711, USA
    Birth Defects Res C Embryo Today 72:300-12. 2004
  2. ncbi request reprint Screening for developmental toxicity of tobacco smoke constituents
    John M Rogers
    Reproductive Toxicology Division, National Health and Environmental Effects Research Laboratory, Office of Research and Development, United States Environmental Protection Agency, Research Triangle Park, North Carolina 27711, USA
    Toxicol Sci 75:227-8. 2003
  3. ncbi request reprint Chemically induced supernumerary lumbar ribs in CD-1 mice: size distribution and dose response
    John M Rogers
    Developmental Biology Branch, National Health and Environmental Effects Research Laboratory, Office of Research and Development, United States Environmental Protection Agency, Research Triangle Park, North Carolina 27711, USA
    Birth Defects Res B Dev Reprod Toxicol 71:17-25. 2004
  4. ncbi request reprint Evaluation and interpretation of maternal toxicity in Segment II studies: issues, some answers, and data needs
    John M Rogers
    National Health and Environmental Effects Research Laboratory, Office of Research and Development, MD 67, U S Environmental Protection Agency, Research Triangle Park, NC 27711, USA
    Toxicol Appl Pharmacol 207:367-74. 2005
  5. ncbi request reprint Casting a broad network: fishing for mechanisms of retinoid teratogenicity
    John M Rogers
    Reproductive Toxicology Division, National Health and Environmental Effects Research Laboratory, Office of Research and Development, United States Environmental Protection Agency, Research Triangle Park, North Carolina 27711, USA
    Toxicol Sci 94:1-2. 2006
  6. ncbi request reprint Methanol exposure during gastrulation causes holoprosencephaly, facial dysgenesis, and cervical vertebral malformations in C57BL/6J mice
    John M Rogers
    Reproductive Toxicology Division, National Health and Environmental Effects Research Laboratory, Office of Research and Development, United States Environmental Protection Agency, Research Triangle Park, North Carolina 27711, USA
    Birth Defects Res B Dev Reprod Toxicol 71:80-8. 2004
  7. doi request reprint Tobacco and pregnancy: overview of exposures and effects
    John M Rogers
    Developmental Biology Branch, Reproductive Toxicology Division, United States Environmental Protection Agency, Research Triangle Park, North Carolina 27711, USA
    Birth Defects Res C Embryo Today 84:1-15. 2008
  8. doi request reprint Tobacco and pregnancy
    John M Rogers
    Developmental Biology Branch MD 67, Reproductive Toxicology Division, National Health and Environmental Effect Research Laboratory, United States Environmental Protection Agency, Research Triangle Park, NC 27711, United States
    Reprod Toxicol 28:152-60. 2009
  9. ncbi request reprint Exposure to perfluorooctane sulfonate during pregnancy in rat and mouse. I: maternal and prenatal evaluations
    Julie R Thibodeaux
    Reproductive Toxicology Division, National Health and Environmental Effects Research Laboratory, Office of Research and Development, U S Environmental Protection Agency, Research Triangle Park, North Carolina 27711, USA
    Toxicol Sci 74:369-81. 2003
  10. ncbi request reprint Effects of perfluorooctanoic acid exposure during pregnancy in the mouse
    Christopher Lau
    Reproductive Toxicology Division, National Health and Environmental Effects Research Laboratory, U S Environmental Protection Agency, Research Triangle Park, North Carolina 27711, USA
    Toxicol Sci 90:510-8. 2006

Detail Information

Publications31

  1. ncbi request reprint Embryonic and fetal programming of physiological disorders in adulthood
    Christopher Lau
    Reproductive Toxicology Division, National Health and Environmental Effects Research Laboratory, Office of Research and Development, U S Environmental Protection Agency, Research Triangle Park, North Carolina 27711, USA
    Birth Defects Res C Embryo Today 72:300-12. 2004
    ..This article provides an overview of the Barker hypothesis, its supporting evidence, the current advances in understanding the biological mechanisms underlying this phenomenon, and its implications for developmental toxicology...
  2. ncbi request reprint Screening for developmental toxicity of tobacco smoke constituents
    John M Rogers
    Reproductive Toxicology Division, National Health and Environmental Effects Research Laboratory, Office of Research and Development, United States Environmental Protection Agency, Research Triangle Park, North Carolina 27711, USA
    Toxicol Sci 75:227-8. 2003
  3. ncbi request reprint Chemically induced supernumerary lumbar ribs in CD-1 mice: size distribution and dose response
    John M Rogers
    Developmental Biology Branch, National Health and Environmental Effects Research Laboratory, Office of Research and Development, United States Environmental Protection Agency, Research Triangle Park, North Carolina 27711, USA
    Birth Defects Res B Dev Reprod Toxicol 71:17-25. 2004
    ..These data support the idea that extra and rudimentary SNR may reflect separate developmental phenomena, and should be considered and reported separately in developmental toxicity studies for risk assessment...
  4. ncbi request reprint Evaluation and interpretation of maternal toxicity in Segment II studies: issues, some answers, and data needs
    John M Rogers
    National Health and Environmental Effects Research Laboratory, Office of Research and Development, MD 67, U S Environmental Protection Agency, Research Triangle Park, NC 27711, USA
    Toxicol Appl Pharmacol 207:367-74. 2005
    ....
  5. ncbi request reprint Casting a broad network: fishing for mechanisms of retinoid teratogenicity
    John M Rogers
    Reproductive Toxicology Division, National Health and Environmental Effects Research Laboratory, Office of Research and Development, United States Environmental Protection Agency, Research Triangle Park, North Carolina 27711, USA
    Toxicol Sci 94:1-2. 2006
  6. ncbi request reprint Methanol exposure during gastrulation causes holoprosencephaly, facial dysgenesis, and cervical vertebral malformations in C57BL/6J mice
    John M Rogers
    Reproductive Toxicology Division, National Health and Environmental Effects Research Laboratory, Office of Research and Development, United States Environmental Protection Agency, Research Triangle Park, North Carolina 27711, USA
    Birth Defects Res B Dev Reprod Toxicol 71:80-8. 2004
    ..C57BL/6J fetuses exhibit the holoprosencephaly spectrum of malformations after maternal exposure to ethanol during gastrulation, but the sensitivity of C57BL/6J mice to methanol-induced teratogenesis has not been previously described...
  7. doi request reprint Tobacco and pregnancy: overview of exposures and effects
    John M Rogers
    Developmental Biology Branch, Reproductive Toxicology Division, United States Environmental Protection Agency, Research Triangle Park, North Carolina 27711, USA
    Birth Defects Res C Embryo Today 84:1-15. 2008
    ..It is hoped that this review and those to follow in this issue will serve to keep a focus on the critical and continuing problem of tobacco use impacting human development...
  8. doi request reprint Tobacco and pregnancy
    John M Rogers
    Developmental Biology Branch MD 67, Reproductive Toxicology Division, National Health and Environmental Effect Research Laboratory, United States Environmental Protection Agency, Research Triangle Park, NC 27711, United States
    Reprod Toxicol 28:152-60. 2009
    ..Effects in surviving offspring are probably life-long, and are still being elucidated. It is hoped that this review will serve to keep a focus on the critical and continuing problem of tobacco use impacting human development...
  9. ncbi request reprint Exposure to perfluorooctane sulfonate during pregnancy in rat and mouse. I: maternal and prenatal evaluations
    Julie R Thibodeaux
    Reproductive Toxicology Division, National Health and Environmental Effects Research Laboratory, Office of Research and Development, U S Environmental Protection Agency, Research Triangle Park, North Carolina 27711, USA
    Toxicol Sci 74:369-81. 2003
    ..Our results demonstrate both maternal and developmental toxicity of PFOS in the rat and mouse...
  10. ncbi request reprint Effects of perfluorooctanoic acid exposure during pregnancy in the mouse
    Christopher Lau
    Reproductive Toxicology Division, National Health and Environmental Effects Research Laboratory, U S Environmental Protection Agency, Research Triangle Park, North Carolina 27711, USA
    Toxicol Sci 90:510-8. 2006
    ..These data indicate maternal and developmental toxicity of PFOA in the mouse, leading to early pregnancy loss, compromised postnatal survival, delays in general growth and development, and sex-specific alterations in pubertal maturation...
  11. ncbi request reprint Developmental toxicity of methanol: Pathogenesis in CD-1 and C57BL/6J mice exposed in whole embryo culture
    Sigmund J Degitz
    United States Environmental Protection Agency, Research Triangle Park, North Carolina, USA
    Birth Defects Res A Clin Mol Teratol 70:179-84. 2004
    ..We evaluated methanol-induced pathogenesis in CD-1 and C57BL/6J embryos exposed during gastrulation in whole embryo culture...
  12. ncbi request reprint Altered axial skeletal development
    Rochelle W Tyl
    Center for Life Sciences and Toxicology, Research Triangle Institute, Research Triangle Park, North Carolina 27709 2194, USA
    Birth Defects Res B Dev Reprod Toxicol 80:451-72. 2007
    ..Tables of the spontaneous incidence of axial anomalies in both humans and animals are provided...
  13. doi request reprint Altered health outcomes in adult offspring of Sprague Dawley and Wistar rats undernourished during early or late pregnancy
    Robert G Ellis-Hutchings
    Toxicology Assessment Division, National Health and Environmental Effects Research Laboratory, Office of Research and Development, United States Environmental Protection Agency, Research Triangle Park, North Carolina, USA
    Birth Defects Res B Dev Reprod Toxicol 89:396-407. 2010
    ..Birth weight in humans has been inversely associated with adult disease risk. Results of animal studies have varied depending on species, strain, and treatment...
  14. ncbi request reprint Prenatal window of susceptibility to perfluorooctane sulfonate-induced neonatal mortality in the Sprague-Dawley rat
    Rayetta C Grasty
    Reproductive Toxicology Division, National Health and Environmental Effects Research Laboratory, Office of Research and Development, US Environmental Protection Agency, Research Triangle Park, North Carolina 27711, USA
    Birth Defects Res B Dev Reprod Toxicol 68:465-71. 2003
    ..We conclude that exposure to PFOS late in gestation is sufficient to induce 100% pup mortality and that inhibition of lung maturation may be involved...
  15. doi request reprint Elevated blood pressure in offspring of rats exposed to diverse chemicals during pregnancy
    John M Rogers
    Toxicity Assessment Division, National Health and Environmental Effects Research Laboratory, Office of Research and Development, United States Environmental Protection Agency, Research Triangle Park, North Carolina 27711
    Toxicol Sci 137:436-46. 2014
    ..Elevated offspring BP was induced by maternal exposure to toxicants. Because all treatments affected maternal gestational weight gain, maternal stress may be a common underlying factor in these observations. ..
  16. doi request reprint Fetal programming of adult disease: implications for prenatal care
    Christopher Lau
    Toxicity Assessment Division, National Health and Environmental Effects Research Laboratory, Office of Research and Development, U S Environmental Protection Agency, Research Triangle Park, North Carolina, USA
    Obstet Gynecol 117:978-85. 2011
    ....
  17. ncbi request reprint Supernumerary ribs in developmental toxicity bioassays and in human populations: incidence and biological significance
    Neil Chernoff
    US Environmental Protection Agency, National Health and Environmental Effects Research Laboratory, Reproductive Toxicology Division, Research Triangle Park, North Carolina 27711, USA
    J Toxicol Environ Health B Crit Rev 7:437-49. 2004
    ....
  18. ncbi request reprint The developmental toxicity of perfluoroalkyl acids and their derivatives
    Christopher Lau
    Reproductive Toxicology Division, National Health and Environmental Effects Research Laboratory, Office of Research and Development, U S Environmental Protection Agency, Research Triangle Park, NC 27711, USA
    Toxicol Appl Pharmacol 198:231-41. 2004
    ..Based on current understanding of the developmental effects of PFOS and PFOA in rodents, several avenues of research are suggested that would further support the risk assessment of these perfluorinated organic chemicals...
  19. ncbi request reprint Pathogenesis of methanol-induced craniofacial defects in C57BL/6J mice
    Sigmund J Degitz
    United States Environmental Protection Agency, Research Triangle Park, North Carolina, USA
    Birth Defects Res A Clin Mol Teratol 70:172-8. 2004
    ..We describe dysmorphogenesis, cell death, cell cycle assessment, and effects on development of cranial ganglia and nerves observed following administration of methanol to pregnant C57BL/6J mice on gestation day (GD) 7...
  20. doi request reprint Fetal programming and environmental exposures: implications for prenatal care and preterm birth
    Thaddeus T Schug
    National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA
    Ann N Y Acad Sci 1276:37-46. 2012
    ..Speakers went on to discuss many other factors that affect prenatal development, from genetics to parental diet, revealing the extraordinary sensitivity of the developing fetus...
  21. doi request reprint Hypoxia and the Edema Syndrome: elucidation of a mechanism of teratogenesis
    Neil Chernoff
    Toxicity Assessment Division, National Health and Environmental Effects Research Laboratory, Office of Research and Development, United States Environmental Protection Agency, Research Triangle Park, North Carolina, USA
    Birth Defects Res B Dev Reprod Toxicol 89:300-3. 2010
    ..Vascular disruption is also associated with a number of birth defects in humans, including limb and digit reduction defects and urogenital defects...
  22. ncbi request reprint Exposure to perfluorooctane sulfonate during pregnancy in rat and mouse. II: postnatal evaluation
    Christopher Lau
    Reproductive Toxicology Division, National Health and Environmental Effects Research Laboratory, Office of Research and Development, U S Environmental Protection Agency, Research Triangle Park, North Carolina 27711, USA
    Toxicol Sci 74:382-92. 2003
    ..These results indicate that in utero exposure to PFOS severely compromised postnatal survival of neonatal rats and mice, and caused delays in growth and development that were accompanied by hypothyroxinemia in the surviving rat pups...
  23. ncbi request reprint Zinc influences the in vitro development of peri-implantation mouse embryos
    Lynn A Hanna
    Department of Nutrition, University of California, Davis, California 95616, USA
    Birth Defects Res A Clin Mol Teratol 67:414-20. 2003
    ..We investigated the influence of zinc (Zn) deficiency on embryonic development at the time of embryo implantation...
  24. ncbi request reprint Effects of gestational exposure to ethane dimethanesulfonate in CD-1 mice: microtia and preliminary hearing tests
    Dana K Tarka-Leeds
    Curriculum in Toxicology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA
    Birth Defects Res B Dev Reprod Toxicol 68:383-90. 2003
    ..We report microtia in CD-1 mice after gestational exposure to ethane dimethanesulfonate (EDS), an alkylating agent and adult rat Leydig cell toxicant...
  25. ncbi request reprint The embryolethality of lipopolysaccharide in CD-1 and metallothionein I-II null mice: lack of a role for induced zinc deficiency or metallothionein induction
    Tyra M Leazer
    Curriculum in Toxicology, University of North Carolina, Chapel Hill, North Carolina 27599, USA
    Toxicol Sci 73:442-7. 2003
    ..In conclusion, while LPS can induce maternal hepatic MT and Zn redistribution in CD-1 mice, this does not appear to be a key mechanism leading to LPS embryotoxicity...
  26. ncbi request reprint Evaluation of physiologically based models of pregnancy and lactation for their application in children's health risk assessments
    Richard A Corley
    Battelle, Pacific Northwest Division, Richland, WA 99352, USA
    Crit Rev Toxicol 33:137-211. 2003
    ....
  27. ncbi request reprint Dose-dependent transitions in mechanisms of toxicity
    William Slikker
    US FDA National Center for Toxicological Research, Jefferson, AR 72079, USA
    Toxicol Appl Pharmacol 201:203-25. 2004
    ..This paper addresses the issues discussed at both workshops, and presents the consensus conclusions drawn by expert participants...
  28. ncbi request reprint The plausibility of micronutrient deficiencies being a significant contributing factor to the occurrence of pregnancy complications
    Carl L Keen
    Department of Nutrition and Internal Medicine, University of California, Davis, CA 95616, USA
    J Nutr 133:1597S-1605S. 2003
    ..An implication of the above is that the frequency and severity of pregnancy complications may be reduced through an improvement in the micronutrient status of the mother...
  29. ncbi request reprint Gestational exposure to ethane dimethanesulfonate permanently alters reproductive competence in the CD-1 mouse
    Dana K Tarka-Leeds
    Curriculum in Toxicology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599 7270, USA
    Biol Reprod 69:959-67. 2003
    ..Thus, although adult mouse LCs are insensitive to EDS, EDS appears to have direct action on fetal LCs, resulting in abnormal testis development...
  30. ncbi request reprint NTP-CERHR expert panel report on the reproductive and developmental toxicity of hydroxyurea
    Erica L Liebelt
    University of Alabama, Birmingham, AL, USA
    Birth Defects Res B Dev Reprod Toxicol 80:259-366. 2007
  31. ncbi request reprint Role of the maternal acute phase response and tumor necrosis factor alpha in the developmental toxicity of lipopolysaccharide in the CD-1 mouse
    Tyra M Leazer
    Curriculum in Toxicology, University of North Carolina at Chapel Hill, USA
    Reprod Toxicol 16:173-9. 2002
    ..Direct LPS exposure in whole embryo culture was nontoxic. These data support a maternally mediated mechanism of LPS embryolethality, and suggest that TNF-alpha may be an important mediator of this developmental toxicity...