D C Rice

Summary

Affiliation: U.S. Environmental Protection Agency
Country: USA

Publications

  1. pmc Evaluation of the U.S. EPA/OSWER preliminary remediation goal for perchlorate in groundwater: focus on exposure to nursing infants
    Gary L Ginsberg
    Connecticut Department of Public Health, Hartford, Connecticut 06134, USA
    Environ Health Perspect 115:361-9. 2007
  2. ncbi request reprint Effects of exposure to 3,3',4,4',5-pentachlorobiphenyl (PCB 126) throughout gestation and lactation on behavior (concurrent random interval-random interval and progressive ratio performance) in rats
    D C Rice
    Toxicology Research Division, Bureau of Chemical Safety, Ottawa, Ontario, Canada
    Neurotoxicol Teratol 21:679-87. 1999
  3. ncbi request reprint Comparison of visual function at adulthood and during aging in monkeys exposed to lead or methylmercury
    D C Rice
    Toxicology Research Division, Bureau of Chemical Safety, Food Directorate, Health Protection Branch, Health Canada
    Neurotoxicology 20:767-84. 1999
  4. pmc Parallels between attention deficit hyperactivity disorder and behavioral deficits produced by neurotoxic exposure in monkeys
    D C Rice
    U S Environmental Protection Agency, Office of Research and Development, National Center for Environmental Assessment, Washington, D C, USA
    Environ Health Perspect 108:405-8. 2000
  5. ncbi request reprint Methods and rationale for derivation of a reference dose for methylmercury by the U.S. EPA
    Deborah C Rice
    National Center for Environmental Assessment, Office of Research and Development, U S Environmental Protection Agency, Washington, DC 20460, USA
    Risk Anal 23:107-15. 2003
  6. ncbi request reprint Low-frequency hearing loss following perinatal exposure to 3,3',4,4',5-pentachlorobiphenyl (PCB 126) in rats
    K M Crofton
    Neurotoxicology Division, National Health and Environmental Effects Research Laboratory, U S Environmental Protection Agency, Research Triangle Park, NC 27711, USA
    Neurotoxicol Teratol 21:299-301. 1999
  7. ncbi request reprint Lack of effect of 3,3'4,4',5-pentachlorobiphenyl (PCB 126) throughout gestation and lactation on multiple fixed interval-fixed ratio and DRL performance in rats
    D C Rice
    Toxicology Research Division, Bureau of Chemical Safety and Bureau of Biostatistics and Computer Applications, Health Protection Branch, Health Canada, Ottawa, Ontario
    Neurotoxicol Teratol 20:645-50. 1998
  8. ncbi request reprint Effects of postnatal exposure of monkeys to a PCB mixture on spatial discrimination reversal and DRL performance
    D C Rice
    Toxicology Research Division, Bureau of Chemical Safety, Health Canada, Ottawa, Ontario
    Neurotoxicol Teratol 20:391-400. 1998
  9. ncbi request reprint Effect of postnatal exposure to a PCB mixture in monkeys on multiple fixed interval-fixed ratio performance
    D C Rice
    Toxicology Research Division, Health Canada, Ottawa, Ontario, Canada
    Neurotoxicol Teratol 19:429-34. 1997
  10. pmc Lessons for neurotoxicology from selected model compounds: SGOMSEC joint report
    D C Rice
    Banting Research Centre, Ottawa, Ontario, Canada
    Environ Health Perspect 104:205-15. 1996

Collaborators

Detail Information

Publications28

  1. pmc Evaluation of the U.S. EPA/OSWER preliminary remediation goal for perchlorate in groundwater: focus on exposure to nursing infants
    Gary L Ginsberg
    Connecticut Department of Public Health, Hartford, Connecticut 06134, USA
    Environ Health Perspect 115:361-9. 2007
    ..This does not account for the greater exposure that is possible in nursing infants or for the relative source contribution (RSC), a factor normally used to lower the PRG due to nonwater exposures...
  2. ncbi request reprint Effects of exposure to 3,3',4,4',5-pentachlorobiphenyl (PCB 126) throughout gestation and lactation on behavior (concurrent random interval-random interval and progressive ratio performance) in rats
    D C Rice
    Toxicology Research Division, Bureau of Chemical Safety, Ottawa, Ontario, Canada
    Neurotoxicol Teratol 21:679-87. 1999
    ..These data extend previous findings concerning the pattern of behavioral effects as a consequence of gestational and lactational exposure to a dioxin-like PCB congener...
  3. ncbi request reprint Comparison of visual function at adulthood and during aging in monkeys exposed to lead or methylmercury
    D C Rice
    Toxicology Research Division, Bureau of Chemical Safety, Food Directorate, Health Protection Branch, Health Canada
    Neurotoxicology 20:767-84. 1999
    ..These results extend previous findings of evidence for delayed neurotoxicity in the somatosensory and auditory systems of these methylmercury-exposed groups...
  4. pmc Parallels between attention deficit hyperactivity disorder and behavioral deficits produced by neurotoxic exposure in monkeys
    D C Rice
    U S Environmental Protection Agency, Office of Research and Development, National Center for Environmental Assessment, Washington, D C, USA
    Environ Health Perspect 108:405-8. 2000
    ..Whereas the etiology of ADHD is multifactorial, the possibility that neurotoxic agents in the environment contribute to the incidence of ADHD warrants attention...
  5. ncbi request reprint Methods and rationale for derivation of a reference dose for methylmercury by the U.S. EPA
    Deborah C Rice
    National Center for Environmental Assessment, Office of Research and Development, U S Environmental Protection Agency, Washington, DC 20460, USA
    Risk Anal 23:107-15. 2003
    ..Other areas that EPA identified as significant areas requiring further attention are cardiovascular consequences of methylmercury exposure and delayed neurotoxicity during aging as a result of previous developmental or adult exposure...
  6. ncbi request reprint Low-frequency hearing loss following perinatal exposure to 3,3',4,4',5-pentachlorobiphenyl (PCB 126) in rats
    K M Crofton
    Neurotoxicology Division, National Health and Environmental Effects Research Laboratory, U S Environmental Protection Agency, Research Triangle Park, NC 27711, USA
    Neurotoxicol Teratol 21:299-301. 1999
    ..These results are important in that the data implicate, at least partially, the coplanar PCBs in the developmental ototoxicity induced by Aroclor 1254...
  7. ncbi request reprint Lack of effect of 3,3'4,4',5-pentachlorobiphenyl (PCB 126) throughout gestation and lactation on multiple fixed interval-fixed ratio and DRL performance in rats
    D C Rice
    Toxicology Research Division, Bureau of Chemical Safety and Bureau of Biostatistics and Computer Applications, Health Protection Branch, Health Canada, Ottawa, Ontario
    Neurotoxicol Teratol 20:645-50. 1998
    ..These data provide further evidence for absence of behavioral toxicity as a result of gestational and lactational exposure to a dioxin-like PCB congener...
  8. ncbi request reprint Effects of postnatal exposure of monkeys to a PCB mixture on spatial discrimination reversal and DRL performance
    D C Rice
    Toxicology Research Division, Bureau of Chemical Safety, Health Canada, Ottawa, Ontario
    Neurotoxicol Teratol 20:391-400. 1998
    ....
  9. ncbi request reprint Effect of postnatal exposure to a PCB mixture in monkeys on multiple fixed interval-fixed ratio performance
    D C Rice
    Toxicology Research Division, Health Canada, Ottawa, Ontario, Canada
    Neurotoxicol Teratol 19:429-34. 1997
    ....
  10. pmc Lessons for neurotoxicology from selected model compounds: SGOMSEC joint report
    D C Rice
    Banting Research Centre, Ottawa, Ontario, Canada
    Environ Health Perspect 104:205-15. 1996
    ..It is unlikely that the use of advanced behavioral methodology would alleviate the apparent lack of sensitivity of the rodent model for many agents...
  11. ncbi request reprint Lack of effect of methylmercury exposure from birth to adulthood on information processing speed in the monkey
    D C Rice
    Toxicology Research Division, Health Canada, Ottawa, Ontario, Canada
    Neurotoxicol Teratol 20:275-83. 1998
    ..There were no differences between groups on any aspect of the experiment. These data provide further evidence for absence of cognitive impairment in monkeys exposed developmentally to methylmercury...
  12. ncbi request reprint Effects of postnatal exposure of monkeys to a PCB mixture on concurrent random interval-random interval and progressive ratio performance
    D C Rice
    Toxicology Research Division, Bureau of Chemical Safety, Food Directorate Health Protection Branch, Health Canada, Ottawa, Ontario
    Neurotoxicol Teratol 21:47-58. 1999
    ..These results extend previous studies in these monkeys on the characterization of PCB-induced behavioral deficits...
  13. ncbi request reprint Effect of exposure to 3,3',4,4',5-pentachlorobiphenyl (PCB 126) throughout gestation and lactation on development and spatial delayed alternation performance in rats
    D C Rice
    Toxicology Research Division, Bureau of Chemical Safety, Food Directorate, Health Protection Branch, Health Canada, Ottawa, Ontario
    Neurotoxicol Teratol 21:59-69. 1999
    ..These data provide further evidence for the lack of neurotoxicity of dioxin-like PCB congeners. However, assessment of performance on additional behavioral indices is required before definitive conclusions may be drawn...
  14. pmc Behavioral effects of lead: commonalities between experimental and epidemiologic data
    D C Rice
    Bureau of Chemical Safety, Food Directorate, Health Canada, Ottawa, Ontario, Canada
    Environ Health Perspect 104:337-51. 1996
    ..However, careful behavioral analysis was required from researchers in both fields for such understanding to emerge...
  15. ncbi request reprint Sperm chromatin structure is altered in cynomolgus monkeys with environmentally relevant blood lead levels
    W G Foster
    Environmental Health Directorate, Department of Health, Ottawa, Ontario, Canada
    Toxicol Ind Health 12:723-35. 1996
    ..We conclude that chronic lead exposure alters sperm chromatin structure at blood lead levels relevant to the human population and in the absence of effects on endocrine function and traditional measures of semen quality...
  16. pmc Neurotoxicity of lead, methylmercury, and PCBs in relation to the Great Lakes
    D C Rice
    Bureau of Chemical Safety, Food Directorate, Health Canada, Ottawa, Ontario
    Environ Health Perspect 103:71-87. 1995
    ..However, the fact that the present human body burden is in a range at which functional deficits are probable suggests that efforts should be made to eliminate point sources of lead contamination in the Great Lakes basin...
  17. ncbi request reprint Behavioral and electrophysiological estimates of visual thresholds in awake rats treated with 3,3',4,4',5-pentachlorobiphenyl (PCB 126)
    A M Geller
    Neurotoxicology Division, US EPA, Research Triangle Park, NC 27711, USA
    Neurotoxicol Teratol 22:521-31. 2000
    ..Developmental exposure to PCB 126 had no significant effect on absolute threshold or peak amplitudes and latencies...
  18. ncbi request reprint Behavioral assessments of learning and attention in rats exposed perinatally to 3,3',4,4',5-pentachlorobiphenyl (PCB 126)
    P J Bushnell
    Neurotoxicology Division, United States Environmental Protection Agency, Research Triangle Park, NC 27711, USA
    Neurotoxicol Teratol 21:381-92. 1999
    ..Taken together, these data provide little support for the possibility that perinatal exposure to PCB 126 causes deficits in attention, but suggest that PCB 126 may alter GABA-mediated pathways in the CNS during development...
  19. ncbi request reprint Age-related increase in auditory impairment in monkeys exposed in utero plus postnatally to methylmercury
    D C Rice
    Toxicology Research Division, Health Protection Branch, Health Canada, Ottawa, Canada
    Toxicol Sci 44:191-6. 1998
    ..This study also provides evidence for development or acceleration of impairment of auditory function during aging as a consequence of developmental methylmercury exposure...
  20. ncbi request reprint Issues in developmental neurotoxicology: interpretation and implications of the data
    D C Rice
    Toxicology Research Division, Bureau of Chemical Safety, Health Protection Branch, Health Canada
    Can J Public Health 89:S31-6, S34-40. 1998
    ..Such changes in the functional abilities of a significant proportion of a population have potentially serious consequences for society as well as for affected individuals...
  21. ncbi request reprint Identification of functional domains affected by developmental exposure to methylmercury: Faroe islands and related studies
    D C Rice
    National Center for Environmental Assessment, US EPA, Washington, DC 20460, USA
    Neurotoxicology 21:1039-44. 2000
    ..However, the results of the cross-sectional studies must be interpreted with caution, due to limited statistical power as well as a lack of opportunity to correlate effects to in utero exposure...
  22. ncbi request reprint Chronic lead exposure effects in the cynomolgus monkey (Macaca fascicularis) testis
    W G Foster
    Reproductive Toxicology Section, Health Canada, Ottawa, Ontario, Canada
    Ultrastruct Pathol 22:63-71. 1998
    ..Results of this study on the primate, following extrapolation to humans, could influence further refining of the impact of environmental lead contamination concentrations vis-à-vis the health of children, adults, and aged human beings...
  23. ncbi request reprint The US EPA reference dose for methylmercury: sources of uncertainty
    Deborah C Rice
    National Center for Environmental Assessment Office of Research and Development, US Environmental Protection Agency, Washington, DC 20460, USA
    Environ Res 95:406-13. 2004
    ..In addition, it may be argued that derivation of a RfD for methylmercury is inappropriate, given that there does not appear to be a threshold for adverse neuropsychological effects based on available data...
  24. ncbi request reprint Blood lead concentration and delayed puberty in girls
    Sherry G Selevan
    National Center for Environmental Assessment, Office of Research and Development, Environmental Protection Agency, Washington, DC 20460, USA
    N Engl J Med 348:1527-36. 2003
    ..Environmental lead exposure has been linked to alterations in growth and endocrine function. It is not known whether such exposure affects pubertal development...
  25. ncbi request reprint Prenatal methylmercury exposure affects spatial vision in adult monkeys
    Thomas M Burbacher
    Department of Environmental and Occupational Health Sciences, Box 357234, University of Washington, Seattle, WA 98195, USA
    Toxicol Appl Pharmacol 208:21-8. 2005
    ..The results from this study demonstrate that chronic in utero MeHg exposure, at subclinical levels, is associated with permanent adverse effects on spatial vision in adult monkeys...
  26. pmc Effects of PCB exposure on neuropsychological function in children
    Susan L Schantz
    Department of Veterinary Biosciences, College of Veterinary Medicine, University of Illinois at Urbana Champaign, Urbana, Illinois 61802, USA
    Environ Health Perspect 111:357-576. 2003
    ..More complete information on the health effects of various congeners or congener classes would allow more informed scientific and risk assessment decisions...
  27. ncbi request reprint Maternal seafood consumption and children's development
    Alan H Stern
    Lancet 370:217-8; author reply 218. 2007
  28. pmc Alzheimer's disease (AD)-like pathology in aged monkeys after infantile exposure to environmental metal lead (Pb): evidence for a developmental origin and environmental link for AD
    Jinfang Wu
    Department of Biomedical and Pharmaceutical Sciences, University of Rhode Island, Kingston, Rhode Island 02881, USA
    J Neurosci 28:3-9. 2008
    ..These data suggest that AD pathogenesis is influenced by early life exposures and argue for both an environmental trigger and a developmental origin of AD...