Research Topics
| R Julian PrestonSummaryAffiliation: U.S. Environmental Protection Agency Country: USA Publications
| Collaborators
|
Detail Information
Publications
Quantitation of molecular endpoints for the dose-response component of cancer risk assessmentR Julian Preston
Environmental Carcinogenesis Division, US Environmental Protection Agency, Research Triangle Park, North Carolina 27711, USA
Toxicol Pathol 30:112-6. 2002..This hypothesis can be addressed through whole cell molecular assessment using microarrays and quantitative PCR together with the emerging proteomic approaches. This is the world of the new computational cell biology...- Cancer risk assessment for 1,3-butadiene: data integration opportunitiesR Julian Preston
National Health and Environmental Effects Research Laboratory, U S Environmental Protection Agency, Research Triangle Park, NC 27711, USA
Chem Biol Interact 166:150-5. 2007..Truly informative predictors of tumor responses should be able to provide estimates of human tumor frequencies at low, environmental exposures to 1,3-butadiene... - Epigenetic processes and cancer risk assessmentR Julian Preston
National Health and Environmental Effects Research Laboratory, U S Environmental Protection Agency, Research Triangle Park, NC 27711, USA
Mutat Res 616:7-10. 2007..These concepts are described and discussed... - Bystander effects, genomic instability, adaptive response, and cancer risk assessment for radiation and chemical exposuresR Julian Preston
Environmental Carcinogenesis Division, National Health and Environmental Effects Research Laboratory, U S Environmental Protection Agency, Research Triangle Park, NC 27711, USA
Toxicol Appl Pharmacol 207:550-6. 2005..In addition, it is not known how widespread they are as regards inducing agents. Thus, their impact on low dose cancer risk remains to be established... - Radiation biology: concepts for radiation protectionR Julian Preston
Environmental Carcinogenesis Division, NHEERL, U S Environmental Protection Agency, Research Triangle Park, NC 27711, USA
Health Phys 88:545-56. 2005..Thus, radiation biology research has always had a focus on how best to protect human health from radiation exposures and will continue to do so... - Extrapolations are the Achilles heel of risk assessmentR J Preston
Environmental Carcinogenesis Division, US Environmental Protection Agency, Research Triangle Park, NC 27711, USA
Mutat Res 589:153-7. 2005..The reduction in reliance on default options and safety factors in the risk assessment process is a real possibility... - Mechanistic data and cancer risk assessment: the need for quantitative molecular endpointsR Julian Preston
Environmental Carcinogenesis Division, National Health and Environmental Effects Research Laboratory, U S Environmental Protection Agency, Research Triangle Park, North Carolina 27711, USA
Environ Mol Mutagen 45:214-21. 2005..e., DNA, RNA, and protein) will be the most productive for biomarker development. The rapid progress that is being made will make this tool kit even more applicable for the cancer risk assessment process... - Children as a sensitive subpopulation for the risk assessment processR Julian Preston
Environmental Carcinogenesis Division, National Health and Environmental Effects Research Laboratory, U S Environmental Protection Agency, Research Triangle Park, NC 27711, USA
Toxicol Appl Pharmacol 199:132-41. 2004..Clearly, this is an interim position that is dependent on more pertinent data being collected. A significant component of this is to conduct cancer bioassays that include early-life exposures... - Radiation biology: concepts for radiation protectionR Julian Preston
Environmental Carcinogenesis Division, NHEERL, U S Environmental Protection Agency, Research Triangle Park, NC 27711, USA
Health Phys 87:3-14. 2004..Thus, radiation biology research has always had a focus on how best to protect human health from radiation exposures and will continue to do so... - Update on linear non-threshold dose-response model and implications for diagnostic radiology proceduresR Julian Preston
National Health and Environmental Effects Research Laboratory, US Environmental Protection Agency, Research Triangle Park, NC 27711, USA
Health Phys 95:541-6. 2008..The major conclusion is that potential radiation risks need to be considered along with the pros and cons of the detection limits of the procedure and the impact of false positives... - The LNT model is the best we can do--todayR Julian Preston
Environmental Carcinogenesis Division, National Health and Environmental Effects Research Laboratory, US Environmental Protection Agency MD B143 06, Research Triangle Park, NC 27711, USA
J Radiol Prot 23:263-8. 2003..Additional data pertinent to addressing the shape of the tumour dose-response relationship at low doses are needed... - 26th Lauriston S. Taylor Lecture: developing mechanistic data for incorporation into cancer and genetic risk assessments: old problems and new approachesR Julian Preston
Environmental Carcinogenesis Division, U S Environmental Protection Agency, NHEERL, Research Triangle Park, NC 27711, USA
Health Phys 85:4-12. 2003..The attention is still on the role of genetic alterations in cancer and hereditary effects and the mechanism of their formation--it is the approaches to address these that are changing... - Molecular epidemiology: potential impacts on the assessment of public healthR Julian Preston
Environmental Carcinogenesis Division, National Health and Environmental Effects Research Laboratory, US Environmental Protection Agency, Research Triangle Park, NC 27711, USA
Mutat Res 543:121-4. 2003..Jim Neel would have loved to have entered into this discussion; he would have enhanced it in is own inimitable way... - DNA-reactive carcinogens: mode of action and human cancer hazardR Julian Preston
US Environmental Protection Agency, Research Triangle Park, North Carolina 27711, USA
Crit Rev Toxicol 35:673-83. 2005..In contrast, the HRF predicted that the human carcinogenic potential of dichloromethane was at best less likely than in rodents; this conclusion was supported by the available epidemiological data... - Creating context for the use of DNA adduct data in cancer risk assessment: I. Data organizationAnnie M Jarabek
National Health and Environmental Effects Research Laboratory, on detail from National Center for Environmental Assessment, US Environmental Protection Agency, Research Triangle Park, North Carolina, USA
Crit Rev Toxicol 39:659-78. 2009..DNA adducts are considered biomarkers of exposure, whereas gene mutations and chromosomal alterations are often biomarkers of early biological effects and also can be bioindicators of the carcinogenic process... - Toxicoproteomics and its application to human health risk assessmentYue Ge
Environmental Carcinogenesis Division, National Health and Environmental Effects Research Laboratory, US Environmental Protection Agency, Research Triangle Park, NC, USA
Proteomics Clin Appl 1:1613-24. 2007..The discussion includes a focus on challenges and future directions... - The effect of arsenicals on ultraviolet-radiation-induced growth arrest and related signaling events in human keratinocytesAnuradha Mudipalli
Environmental Carcinogenesis Division, National Health and Environmental Effects Research Laboratory, ORD, US EPA, Research Triangle Park, NC 27711, USA
Int J Oncol 27:769-78. 2005..Taken together, the data suggest that both UV exposure and methylation status of the arsenicals dictate the participation of key cell cycle proteins and related signaling events in arsenical-induced cell proliferation... - Overview: Using mode of action and life stage information to evaluate the human relevance of animal toxicity dataJennifer Seed
US Environmental Protection Agency, Washington, DC, USA
Crit Rev Toxicol 35:664-72. 2005.... - Childhood acute lymphocytic leukemia and perspectives on risk assessment of early-life stage exposuresAndrea S Kim
National Center for Environmental Assessment, Office of Research and Development, U S Environmental Protection Agency, 1200 Pennsylvania Avenue MC 8623D, Washington, DC 20460, USA
Mutat Res 613:138-60. 2006.... - Systems biology and mode of action based risk assessmentStephen W Edwards
National Health and Environmental Effects Research Laboratory, U S Environmental Protection Agency, Research Triangle Park, North Carolina 27711, USA
Toxicol Sci 106:312-8. 2008..To realize the full potential of these approaches, larger integrated projects which include all these individual components are necessary... - Impact of life stage and duration of exposure on arsenic-induced proliferative lesions and neoplasia in C3H miceGene J Ahlborn
United States Environmental Protection Agency, Office of Research and Development, National Health and Environmental Effects Research Laboratory, Research Triangle Park, NC, USA
Toxicology 262:106-13. 2009..The paradoxical nature of these effects may be related to altered lipid metabolism, the effective dose in each target organ, and/or the shorter one-year observational period... - Reciprocal translocations in somatic and germ cells of mice chronically exposed by inhalation to ethylene oxide: implications for risk assessmentE Maria Donner
The Hamner Institutes for Health Sciences, Research Triangle Park, NC 27709, USA
Mutagenesis 25:49-55. 2010.... - 4-Aminobiphenyl and DNA reactivity: case study within the context of the 2006 IPCS Human Relevance Framework for Analysis of a cancer mode of action for humansSamuel M Cohen
Department of Pathology and Microbiology and Eppley Institute for Cancer Research, University of Nebraska Medical Center, Omaha, Nebraska, USA
Crit Rev Toxicol 36:803-19. 2006..The IPCA Human Relevance Framework is useful in evaluating DNA-reactive carcinogens... - Proceedings of a workshop on DNA adducts: biological significance and applications to risk assessment Washington, DC, April 13-14, 2004Miriam Sander
Page One Editorial Services, Durham, NC 27707, USA
Toxicol Appl Pharmacol 208:1-20. 2005.... - Cancer risks attributable to low doses of ionizing radiation: assessing what we really knowDavid J Brenner
Center for Radiological Research, Columbia University, 630 West 168th Street, New York, NY 10032, USA
Proc Natl Acad Sci U S A 100:13761-6. 2003..This linearity assumption is not necessarily the most conservative approach, and it is likely that it will result in an underestimate of some radiation-induced cancer risks and an overestimate of others... - Molecular and cellular biology of moderate-dose (1-10 Gy) radiation and potential mechanisms of radiation protection: report of a workshop at Bethesda, Maryland, December 17-18, 2001C Norman Coleman
Radiation Oncology Sciences Program, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland 20892, USA
Radiat Res 159:812-34. 2003..Communicate knowledge of the effects of radiation exposure to the general public and to investigators, policy makers and agencies involved in response to nuclear accidents/events and protection/treatment of the general public... - Comments on 'Cytogenetic effects in children treated with methylphenidate' by El-Zein et alR Julian Preston
Cancer Lett 230:292-4. 2005