R Julian Preston

Summary

Affiliation: U.S. Environmental Protection Agency
Country: USA

Publications

  1. doi request reprint Uncertainties in estimating health risks associated with exposure to ionising radiation
    R Julian Preston
    National Health and Environmental Effects Research Laboratory, US Environmental Protection Agency, Research Triangle Park, NC 27711, USA
    J Radiol Prot 33:573-88. 2013
  2. doi request reprint DNA reactivity as a mode of action and its relevance to cancer risk assessment
    R Julian Preston
    National Health and Environmental Effects Research Laboratory, US Environmental Protection Agency, Research Triangle Park, North Carolina 27711, USA
    Toxicol Pathol 41:322-5. 2013
  3. doi request reprint Update on linear non-threshold dose-response model and implications for diagnostic radiology procedures
    R Julian Preston
    National Health and Environmental Effects Research Laboratory, US Environmental Protection Agency, Research Triangle Park, NC 27711, USA
    Health Phys 95:541-6. 2008
  4. ncbi request reprint Epigenetic processes and cancer risk assessment
    R Julian Preston
    National Health and Environmental Effects Research Laboratory, U S Environmental Protection Agency, Research Triangle Park, NC 27711, USA
    Mutat Res 616:7-10. 2007
  5. ncbi request reprint Cancer risk assessment for 1,3-butadiene: data integration opportunities
    R Julian Preston
    National Health and Environmental Effects Research Laboratory, U S Environmental Protection Agency, Research Triangle Park, NC 27711, USA
    Chem Biol Interact 166:150-5. 2007
  6. ncbi request reprint DNA-reactive carcinogens: mode of action and human cancer hazard
    R Julian Preston
    US Environmental Protection Agency, Research Triangle Park, North Carolina 27711, USA
    Crit Rev Toxicol 35:673-83. 2005
  7. ncbi request reprint Quantitation of molecular endpoints for the dose-response component of cancer risk assessment
    R Julian Preston
    Environmental Carcinogenesis Division, US Environmental Protection Agency, Research Triangle Park, North Carolina 27711, USA
    Toxicol Pathol 30:112-6. 2002
  8. ncbi request reprint Bystander effects, genomic instability, adaptive response, and cancer risk assessment for radiation and chemical exposures
    R Julian Preston
    Environmental Carcinogenesis Division, National Health and Environmental Effects Research Laboratory, U S Environmental Protection Agency, Research Triangle Park, NC 27711, USA
    Toxicol Appl Pharmacol 207:550-6. 2005
  9. ncbi request reprint Radiation biology: concepts for radiation protection
    R Julian Preston
    Environmental Carcinogenesis Division, NHEERL, U S Environmental Protection Agency, Research Triangle Park, NC 27711, USA
    Health Phys 88:545-56. 2005
  10. ncbi request reprint Extrapolations are the Achilles heel of risk assessment
    R J Preston
    Environmental Carcinogenesis Division, US Environmental Protection Agency, Research Triangle Park, NC 27711, USA
    Mutat Res 589:153-7. 2005

Collaborators

Detail Information

Publications29

  1. doi request reprint Uncertainties in estimating health risks associated with exposure to ionising radiation
    R Julian Preston
    National Health and Environmental Effects Research Laboratory, US Environmental Protection Agency, Research Triangle Park, NC 27711, USA
    J Radiol Prot 33:573-88. 2013
    ....
  2. doi request reprint DNA reactivity as a mode of action and its relevance to cancer risk assessment
    R Julian Preston
    National Health and Environmental Effects Research Laboratory, US Environmental Protection Agency, Research Triangle Park, North Carolina 27711, USA
    Toxicol Pathol 41:322-5. 2013
    ..Thus, the dose-response curve for any DNA-reactive chemical can be predicted from knowledge of its mode of action and the behavior of the induced key events...
  3. doi request reprint Update on linear non-threshold dose-response model and implications for diagnostic radiology procedures
    R Julian Preston
    National Health and Environmental Effects Research Laboratory, US Environmental Protection Agency, Research Triangle Park, NC 27711, USA
    Health Phys 95:541-6. 2008
    ..The major conclusion is that potential radiation risks need to be considered along with the pros and cons of the detection limits of the procedure and the impact of false positives...
  4. ncbi request reprint Epigenetic processes and cancer risk assessment
    R Julian Preston
    National Health and Environmental Effects Research Laboratory, U S Environmental Protection Agency, Research Triangle Park, NC 27711, USA
    Mutat Res 616:7-10. 2007
    ..These concepts are described and discussed...
  5. ncbi request reprint Cancer risk assessment for 1,3-butadiene: data integration opportunities
    R Julian Preston
    National Health and Environmental Effects Research Laboratory, U S Environmental Protection Agency, Research Triangle Park, NC 27711, USA
    Chem Biol Interact 166:150-5. 2007
    ..Truly informative predictors of tumor responses should be able to provide estimates of human tumor frequencies at low, environmental exposures to 1,3-butadiene...
  6. ncbi request reprint DNA-reactive carcinogens: mode of action and human cancer hazard
    R Julian Preston
    US Environmental Protection Agency, Research Triangle Park, North Carolina 27711, USA
    Crit Rev Toxicol 35:673-83. 2005
    ..In contrast, the HRF predicted that the human carcinogenic potential of dichloromethane was at best less likely than in rodents; this conclusion was supported by the available epidemiological data...
  7. ncbi request reprint Quantitation of molecular endpoints for the dose-response component of cancer risk assessment
    R Julian Preston
    Environmental Carcinogenesis Division, US Environmental Protection Agency, Research Triangle Park, North Carolina 27711, USA
    Toxicol Pathol 30:112-6. 2002
    ..This hypothesis can be addressed through whole cell molecular assessment using microarrays and quantitative PCR together with the emerging proteomic approaches. This is the world of the new computational cell biology...
  8. ncbi request reprint Bystander effects, genomic instability, adaptive response, and cancer risk assessment for radiation and chemical exposures
    R Julian Preston
    Environmental Carcinogenesis Division, National Health and Environmental Effects Research Laboratory, U S Environmental Protection Agency, Research Triangle Park, NC 27711, USA
    Toxicol Appl Pharmacol 207:550-6. 2005
    ..In addition, it is not known how widespread they are as regards inducing agents. Thus, their impact on low dose cancer risk remains to be established...
  9. ncbi request reprint Radiation biology: concepts for radiation protection
    R Julian Preston
    Environmental Carcinogenesis Division, NHEERL, U S Environmental Protection Agency, Research Triangle Park, NC 27711, USA
    Health Phys 88:545-56. 2005
    ..Thus, radiation biology research has always had a focus on how best to protect human health from radiation exposures and will continue to do so...
  10. ncbi request reprint Extrapolations are the Achilles heel of risk assessment
    R J Preston
    Environmental Carcinogenesis Division, US Environmental Protection Agency, Research Triangle Park, NC 27711, USA
    Mutat Res 589:153-7. 2005
    ..The reduction in reliance on default options and safety factors in the risk assessment process is a real possibility...
  11. ncbi request reprint Mechanistic data and cancer risk assessment: the need for quantitative molecular endpoints
    R Julian Preston
    Environmental Carcinogenesis Division, National Health and Environmental Effects Research Laboratory, U S Environmental Protection Agency, Research Triangle Park, North Carolina 27711, USA
    Environ Mol Mutagen 45:214-21. 2005
    ..e., DNA, RNA, and protein) will be the most productive for biomarker development. The rapid progress that is being made will make this tool kit even more applicable for the cancer risk assessment process...
  12. ncbi request reprint 26th Lauriston S. Taylor Lecture: developing mechanistic data for incorporation into cancer and genetic risk assessments: old problems and new approaches
    R Julian Preston
    Environmental Carcinogenesis Division, U S Environmental Protection Agency, NHEERL, Research Triangle Park, NC 27711, USA
    Health Phys 85:4-12. 2003
    ..The attention is still on the role of genetic alterations in cancer and hereditary effects and the mechanism of their formation--it is the approaches to address these that are changing...
  13. ncbi request reprint The LNT model is the best we can do--today
    R Julian Preston
    Environmental Carcinogenesis Division, National Health and Environmental Effects Research Laboratory, US Environmental Protection Agency MD B143 06, Research Triangle Park, NC 27711, USA
    J Radiol Prot 23:263-8. 2003
    ..Additional data pertinent to addressing the shape of the tumour dose-response relationship at low doses are needed...
  14. ncbi request reprint Radiation biology: concepts for radiation protection
    R Julian Preston
    Environmental Carcinogenesis Division, NHEERL, U S Environmental Protection Agency, Research Triangle Park, NC 27711, USA
    Health Phys 87:3-14. 2004
    ..Thus, radiation biology research has always had a focus on how best to protect human health from radiation exposures and will continue to do so...
  15. ncbi request reprint Molecular epidemiology: potential impacts on the assessment of public health
    R Julian Preston
    Environmental Carcinogenesis Division, National Health and Environmental Effects Research Laboratory, US Environmental Protection Agency, Research Triangle Park, NC 27711, USA
    Mutat Res 543:121-4. 2003
    ..Jim Neel would have loved to have entered into this discussion; he would have enhanced it in is own inimitable way...
  16. ncbi request reprint Children as a sensitive subpopulation for the risk assessment process
    R Julian Preston
    Environmental Carcinogenesis Division, National Health and Environmental Effects Research Laboratory, U S Environmental Protection Agency, Research Triangle Park, NC 27711, USA
    Toxicol Appl Pharmacol 199:132-41. 2004
    ..Clearly, this is an interim position that is dependent on more pertinent data being collected. A significant component of this is to conduct cancer bioassays that include early-life exposures...
  17. doi request reprint Creating context for the use of DNA adduct data in cancer risk assessment: I. Data organization
    Annie M Jarabek
    National Health and Environmental Effects Research Laboratory, on detail from National Center for Environmental Assessment, US Environmental Protection Agency, Research Triangle Park, North Carolina, USA
    Crit Rev Toxicol 39:659-78. 2009
    ..DNA adducts are considered biomarkers of exposure, whereas gene mutations and chromosomal alterations are often biomarkers of early biological effects and also can be bioindicators of the carcinogenic process...
  18. ncbi request reprint The effect of arsenicals on ultraviolet-radiation-induced growth arrest and related signaling events in human keratinocytes
    Anuradha Mudipalli
    Environmental Carcinogenesis Division, National Health and Environmental Effects Research Laboratory, ORD, US EPA, Research Triangle Park, NC 27711, USA
    Int J Oncol 27:769-78. 2005
    ..Taken together, the data suggest that both UV exposure and methylation status of the arsenicals dictate the participation of key cell cycle proteins and related signaling events in arsenical-induced cell proliferation...
  19. doi request reprint Toxicoproteomics and its application to human health risk assessment
    Yue Ge
    Environmental Carcinogenesis Division, National Health and Environmental Effects Research Laboratory, US Environmental Protection Agency, Research Triangle Park, NC, USA
    Proteomics Clin Appl 1:1613-24. 2007
    ..The discussion includes a focus on challenges and future directions...
  20. ncbi request reprint Overview: Using mode of action and life stage information to evaluate the human relevance of animal toxicity data
    Jennifer Seed
    US Environmental Protection Agency, Washington, DC, USA
    Crit Rev Toxicol 35:664-72. 2005
    ....
  21. doi request reprint Systems biology and mode of action based risk assessment
    Stephen W Edwards
    National Health and Environmental Effects Research Laboratory, U S Environmental Protection Agency, Research Triangle Park, North Carolina 27711, USA
    Toxicol Sci 106:312-8. 2008
    ..To realize the full potential of these approaches, larger integrated projects which include all these individual components are necessary...
  22. ncbi request reprint Childhood acute lymphocytic leukemia and perspectives on risk assessment of early-life stage exposures
    Andrea S Kim
    National Center for Environmental Assessment, Office of Research and Development, U S Environmental Protection Agency, 1200 Pennsylvania Avenue MC 8623D, Washington, DC 20460, USA
    Mutat Res 613:138-60. 2006
    ....
  23. pmc Reciprocal translocations in somatic and germ cells of mice chronically exposed by inhalation to ethylene oxide: implications for risk assessment
    E Maria Donner
    The Hamner Institutes for Health Sciences, Research Triangle Park, NC 27709, USA
    Mutagenesis 25:49-55. 2010
    ....
  24. pmc Impact of life stage and duration of exposure on arsenic-induced proliferative lesions and neoplasia in C3H mice
    Gene J Ahlborn
    United States Environmental Protection Agency, Office of Research and Development, National Health and Environmental Effects Research Laboratory, Research Triangle Park, NC, USA
    Toxicology 262:106-13. 2009
    ..The paradoxical nature of these effects may be related to altered lipid metabolism, the effective dose in each target organ, and/or the shorter one-year observational period...
  25. ncbi request reprint Molecular and cellular biology of moderate-dose (1-10 Gy) radiation and potential mechanisms of radiation protection: report of a workshop at Bethesda, Maryland, December 17-18, 2001
    C Norman Coleman
    Radiation Oncology Sciences Program, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland 20892, USA
    Radiat Res 159:812-34. 2003
    ..Communicate knowledge of the effects of radiation exposure to the general public and to investigators, policy makers and agencies involved in response to nuclear accidents/events and protection/treatment of the general public...
  26. ncbi request reprint 4-Aminobiphenyl and DNA reactivity: case study within the context of the 2006 IPCS Human Relevance Framework for Analysis of a cancer mode of action for humans
    Samuel M Cohen
    Department of Pathology and Microbiology and Eppley Institute for Cancer Research, University of Nebraska Medical Center, Omaha, Nebraska, USA
    Crit Rev Toxicol 36:803-19. 2006
    ..The IPCA Human Relevance Framework is useful in evaluating DNA-reactive carcinogens...
  27. pmc Cancer risks attributable to low doses of ionizing radiation: assessing what we really know
    David J Brenner
    Center for Radiological Research, Columbia University, 630 West 168th Street, New York, NY 10032, USA
    Proc Natl Acad Sci U S A 100:13761-6. 2003
    ..This linearity assumption is not necessarily the most conservative approach, and it is likely that it will result in an underestimate of some radiation-induced cancer risks and an overestimate of others...
  28. ncbi request reprint Proceedings of a workshop on DNA adducts: biological significance and applications to risk assessment Washington, DC, April 13-14, 2004
    Miriam Sander
    Page One Editorial Services, Durham, NC 27707, USA
    Toxicol Appl Pharmacol 208:1-20. 2005
    ....
  29. ncbi request reprint Comments on 'Cytogenetic effects in children treated with methylphenidate' by El-Zein et al
    R Julian Preston
    Cancer Lett 230:292-4. 2005