Research Topics
| V C MoserSummaryAffiliation: U.S. Environmental Protection Agency Country: USA Publications
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Detail Information
Publications
Differential profiles of cholinesterase inhibition and neurobehavioral effects in rats exposed to fenamiphos or profenofosKatherine L McDaniel
Neurotoxicology Division (Mail Code B105-04, National Health and Environmental Effects Research Laboratory, Office of Research and Development, U.S. Environmental Protection Agency, Research Triangle Park, NC 27711, USA
Neurotoxicol Teratol 26:407-15. 2004..Despite the low level of brain ChE inhibition, some behavioral effects of fenamiphos were centrally mediated, and there was little regional specificity of ChE inhibition that could account for the behavioral changes observed...
Impact of chemical proportions on the acute neurotoxicity of a mixture of seven carbamates in preweanling and adult ratsVirginia C Moser
Toxicity Assessment Division, US EPA, Research Triangle Park, North Carolina 27711, USA
Toxicol Sci 129:126-34. 2012..These approaches for studying pesticide mixtures can improve evaluations of potential toxicity under varying experimental conditions that may mimic human exposures...- Direct dosing of preweaning rodents in toxicity testing and research: deliberations of an ILSI RSI Expert Working GroupVirginia C Moser
Neurotoxicology Division NHEERL ORD, US Environmental Protection Agency, Research Triangle Park, NC 27711, USA
Int J Toxicol 24:87-94. 2005..Ultimately, the success of the study will depend upon careful preparation, including thorough training of the technical staff... - Neurotoxicity produced by dibromoacetic acid in drinking water of ratsV C Moser
Neurotoxicology Division, NHEERL ORD, US Environmental Protection Agency, Research Triangle Park, North Carolina, 27711, USA
Toxicol Sci 79:112-22. 2004..2 g/l, lowest concentration tested), whereas this dosage was a no-effect level for neuropathological changes. These studies suggest that neurotoxicity should be considered in the overall hazard evaluation of haloacetic acids... - Animal models of chronic pesticide neurotoxicityVirginia C Moser
Neurotoxicology Division NHEERL ORD, US Environmental Protection Agency, Research Triangle Park, NC 27711, USA
Hum Exp Toxicol 26:321-31. 2007..Future research should concentrate on analogous exposures and outcomes to facilitate interpretation... - Time-course, dose-response, and age comparative sensitivity of N-methyl carbamates in ratsVirginia C Moser
Toxicity Assessment Division, National Health and Environmental Effects Research Laboratory, Office of Research and Development, U S Environmental Protection Agency, Research Triangle Park, North Carolina 27711, USA
Toxicol Sci 114:113-23. 2010..Thus, these data show the time-course and dose-response characteristics for each carbamate and document greater sensitivity of the young for carbofuran and carbaryl... - Concentration and persistence of tin in rat brain and blood following dibutyltin exposure during developmentV C Moser
Neurotoxicology Division, National Health and Environmental Effects Research Laboratory, US Environmental Protection Agency, Research Triangle Park, North Carolina 27711, USA
J Toxicol Environ Health A 72:47-52. 2009..Furthermore, Sn is concentrated in brain compared to blood, and its elimination is protracted, on the order of days to months after exposure ends... - Neurotoxicological and statistical analyses of a mixture of five organophosphorus pesticides using a ray designV C Moser
Neurotoxicology Division, NHEERL ORD, US EPA, RTP, North Carolina 27711, USA
Toxicol Sci 86:101-15. 2005..In all cases, the deviations from additivity occurred at the lower end of the dose-response curves... - Neurotoxicological evaluation of two disinfection by-products, bromodichloromethane and dibromoacetonitrile, in ratsVirginia C Moser
Neurotoxicology Division, NHEERL ORD, U S Environmental Protection Agency, Research Triangle Park, NC 27711, USA
Toxicology 230:137-44. 2007..Lowered fluid consumption was the most sensitive and consistent endpoint in the present studies. Thus, unlike the haloacetic acids, neurotoxicity may not be a concern for toxicity of halomethanes or haloacetonitriles... - Response to open commentary, "Validity and Utility of Geotaxis" by Motz and AlbertsVirginia C Moser
Neurotoxicology Division, National Health and Environmental Effects Research Laboratory, US Environmental Protection Agency, Research Triangle Park, NC 27711, USA
Neurotoxicol Teratol 27:539-40; author reply 543-4. 2005 - Neurobehavioral evaluations of mixtures of trichloroethylene, heptachlor, and di(2-ethylhexyl)phthlate in a full-factorial designV C Moser
Neurotoxicology Division, NHEERL ORD, US Environmental Protection Agency, Research Triangle Park, NC 27711, USA
Toxicology 188:125-37. 2003..These results underscore the need for more economical approaches to evaluate the toxic effects of mixtures of chemicals... - Evaluation of developmental neurotoxicity of organotins via drinking water in rats: monomethyltinVirginia C Moser
Neurotoxicology Division, National Health and Environmental Effects Research Laboratory, Office of Research and Development, US Environmental Protection Agency, Research Triangle Park, NC 27711, United States
Neurotoxicology 27:409-20. 2006..While mild neuropathological lesions were observed in the adult offspring, the biological significance of this restricted finding is unclear... - The effects of perinatal tebuconazole exposure on adult neurological, immunological, and reproductive function in ratsV C Moser
Neurotoxicology Division and Environmental Toxicology Division, National Health and Environmental Effects Research Laboratory, U S Environmental Protection Agency, Research Triangle Park, NC 27711, USA
Toxicol Sci 62:339-52. 2001..Thus, perinatal exposure to tebuconazole produced neurobehavioral deficits and neuropathology in rats, but did not alter immunological or reproductive function... - Neurotoxicological interactions of a five-pesticide mixture in preweanling ratsVirginia C Moser
Neurotoxicology Division, National Health and Environmental Effects Research Laboratory Office of Research and Development, U S Environmental Protection Agency, Research Triangle Park, NC 27711, USA
Toxicol Sci 92:235-45. 2006..Thus, greater-than-additive responses were detected in preweanling rats with this OP mixture, and this effect can only partially be attributed to the malathion in the mixture... - Neurotoxicological outcomes of perinatal heptachlor exposure in the ratV C Moser
Neurotoxicology Division, National Health and Environmental Effects Research Laboratory, Office of Research and Development, U S EPA, Research Triangle Park, North Carolina 27711, USA
Toxicol Sci 60:315-26. 2001..Thus, perinatal exposure to heptachlor produced neurochemical and persistent neurobehavioral changes, including alterations in spatial learning and memory... - The functional observational battery in adult and developing ratsV C Moser
National Health and Environmental Effects Research Laboratory, U S Environmental Protection Agency, Research Triangle Park, NC 27711, USA
Neurotoxicology 21:989-96. 2000..This revised FOB protocol may be useful for assessing behavioral or neurological changes due to acute chemical exposure in young rats, or following gestational/lactational exposures typical of developmental neurotoxicity studies... - Functional assays for neurotoxicity testingVirginia C Moser
Neurotoxicity Branch, Toxicity Assessment Division, National Health and Environmental Effects Research Laboratory, Office of Research and Development, U S Environmental Protection Agency, Research Triangle Park, NC 27711, USA
Toxicol Pathol 39:36-45. 2011.... - Age-related differences in acute neurotoxicity produced by mevinphos, monocrotophos, dicrotophos, and phosphamidonVirginia C Moser
Neurotoxicology Branch, Toxicity Assessment Division, National Health and Environmental Effects Research Laboratory, Office of Research and Development, US Environmental Protection Agency, Research Triangle Park, NC, USA
Neurotoxicol Teratol 33:451-7. 2011..These data show that three of these four OPs were only moderately more toxic in young rats, and further support findings that age-related differences in pesticide toxicity are chemical-specific... - Esterase metabolism of cholinesterase inhibitors using rat liver in vitroV C Moser
Toxicity Assessment Division MD B105 04, National Health and Environmental Effects Research Laboratory, Office of Research and Development, US Environmental Protection Agency, Research Triangle Park, NC 27711, USA
Toxicology 281:56-62. 2011..Thus, generalizations regarding these metabolic pathways may not be appropriate. As with other aspects of AChE inhibitors, their metabolic patterns appear to be chemical-specific... - Evaluation of developmental neurotoxicity of organotins via drinking water in rats: dimethyl tinK D Ehman
Neurotoxicology Division, National Health and Environmental Effects Research Laboratory, US Environmental Protection Agency, Research Triangle Park, NC, USA
Neurotoxicol Teratol 29:622-33. 2007..Thus, developmental neurotoxicity may be produced in offspring following gestational exposure to DMT in drinking water... - Behavioral evaluation of the neurotoxicity produced by dichloroacetic acid in ratsV C Moser
Neurotoxicology Division, National Health and Environmental Effects Research Laboratory, U S Environmental Protection Agency, Research Triangle Park, NC 27711, USA
Neurotoxicol Teratol 21:719-31. 1999..Further research should take into account these marked route, age, and strain differences... - Neurobehavioral effects of chronic dietary and repeated high-level spike exposure to chlorpyrifos in ratsV C Moser
Neurotoxicology Division, National Health and Environmental Effects Research Laboratory, Office of Research and Development, US Environmental Protection Agency, Research Triangle Park, North Carolina 27711, USA
Toxicol Sci 86:375-86. 2005..Overall, dietary exposure to chlorpyrifos produced long-lasting neurobehavioral changes and also altered the response to acute challenges... - Comparison of the role of esterases in the differential age-related sensitivity to chlorpyrifos and methamidophosS Padilla
Neurotoxicology Division, U S Environmental Protection Agency, Research Triangle Park, North Carolina 27711, USA
Neurotoxicology 21:49-56. 2000.... - Influence of dosing volume on the neurotoxicity of bifenthrinM J Wolansky
U S National Research Council, U S EPA, Research Triangle Park, NC, USA
Neurotoxicol Teratol 29:377-84. 2007..Further, these data suggest that inconsistent estimates of pyrethroid potency between laboratories are at least partially due to differences in dosing volume... - Further assessment of an in vitro screen that may help identify organophosphorus pesticides that are more acutely toxic to the youngS Padilla
Neurotoxicology Division, National Health and Environmental Effects Research Laboratory, Office of Research and Development, U S Environmental Protection Agency, North Carolina 27711, USA
J Toxicol Environ Health A 67:1477-89. 2004..We conclude that our in vitro screen may prove to be a useful, quick, convenient test for identifying which organophosphorus pesticides may be more acutely toxic to the young as compared to adults... - Comparing cognitive and screening tests for neurotoxicity. Effects of acute chlorpyrifos on visual signal detection and a neurobehavioral test battery in ratsP J Bushnell
Neurotoxicology Division, National Health and Environmental Effects Research Laboratory, U S Environmental Protection Agency, MD 74B, Research Triangle Park, NC 27711, USA
Neurotoxicol Teratol 23:33-44. 2001..Thus, CPF impaired attention and altered behavior in the test battery in the same dose ranges under two very different dosing scenarios... - Dose-response and time-course of neurobehavioral changes following oral chlorpyrifos in rats of different agesV C Moser
National Health and Environmental Effects Research Laboratory, Neurotoxicology Division MD 74B, US Environmental Protection Agency, Research Triangle Park, NC 27711, USA
Neurotoxicol Teratol 22:713-23. 2000.... - Moderate developmental undernutrition: Impact on growth and cognitive function in youth and old ageM E Gilbert
Toxicity Assessment Division, U S Environmental Protection Agency, Research Triangle Park, NC, USA
Neurotoxicol Teratol 32:362-72. 2010..These findings indicate that moderate fetal undernutrition followed by neonatal adequate nutrition does not appear to lead to obesity or neurological dysfunction in young adulthood or old age... - Paraoxon toxicity is not potentiated by prior reduction in blood acetylcholinesteraseS Padilla
Neurotoxicology Division MD 74B, U S Environmental Protection Agency, Research Triangle Park, North Carolina 27711
Toxicol Appl Pharmacol 117:110-5. 1992..Thus, significant loss in blood AChE alone produced no detectable neurobehavioral deficits and did not alter the subsequent responses to paraoxon challenge... - Acute postnatal exposure to brominated diphenylether 47 delays neuromotor ontogeny and alters motor activity in miceJ R Gee
Neurotoxicology Division, National Health and Environmental Effects Research Laboratory, Office of Research and Development, US Environmental Protection Agency, Research Triangle Park, NC 27711, USA
Neurotoxicol Teratol 30:79-87. 2008..These data indicate that acute exposure to BDE 47 during postnatal development may produce subtle changes in the development of neuromotor systems that may alter adult behavior... - Neurotoxicity of carbonyl sulfide in F344 rats following inhalation exposure for up to 12 weeksDaniel L Morgan
Laboratory of Molecular Toxicology, NIEHS, Research Triangle Park, NC 27709, USA
Toxicol Appl Pharmacol 200:131-45. 2004..Our studies demonstrate that this environmental air contaminant has the potential to cause a wide spectrum of brain lesions that are dependent on the degree and duration of exposure... - Potential developmental toxicity of anatoxin-a, a cyanobacterial toxinE H Rogers
US Environmental Protection Agency, National Health and Ecological Effects Research Laboratory, Research Triangle Park, NC 27711, USA
J Appl Toxicol 25:527-34. 2005..Most notable was the occurrence of 100% mortality at the high dose in both groups 6-13 days post-exposure. The observed delay between initial exposure and death is highly unusual for anatoxin-a... - Gestational exposure to chlorpyrifos: dose response profiles for cholinesterase and carboxylesterase activityT L Lassiter
Curriculum in Toxicology, University of North Carolina, Chapel Hill, USA
Toxicol Sci 52:92-100. 1999..Both the in vivo and in vitro findings indicated that fetal liver CaE inhibition was an extremely sensitive indicator of fetal chlorpyrifos exposure... - Neurochemical effects of chronic dietary and repeated high-level acute exposure to chlorpyrifos in ratsStephanie Padilla
Neurotoxicology Division, US Environmental Protection Agency, Research Triangle Park, North Carolina 27711, USA
Toxicol Sci 88:161-71. 2005..These data indicate that, although chronic feeding with or without intermittent spiked dosages with CPF produces substantial biochemical changes in a dose- and tissue-related manner, there are no persistent biochemical changes... - Relationship between brain and plasma carbaryl levels and cholinesterase inhibitionDavid W Herr
Neurotoxicology Branch, Toxicity Assessment Division, National Health and Environmental Effects Research Laboratory, Office of Research and Development, U S EPA, Research Triangle Park, NC 27711, United States
Toxicology 276:172-83. 2010..The results of these experiments will be useful to extend physiologically-based pharmacokinetic models for carbaryl and their application in risk assessment... - Developmental exposure to a commercial PBDE mixture, DE-71: neurobehavioral, hormonal, and reproductive effectsPrasada Rao S Kodavanti
Neurotoxicology Branch, Toxicity Assessment Division, National Health and Environmental Effects Research Laboratory, Office of Research and Development, US EPA, Research Triangle Park, North Carolina 27711, USA
Toxicol Sci 116:297-312. 2010..Some of these effects are similar to those seen with PCBs, and the persistence of these changes requires further investigation... - Integrating epidemiology and toxicology in neurotoxicity risk assessmentWilliam K Boyes
National Health and Environmental Effects Research Laboratory, Office of Research and Development, US Environmental Protection Agency, Research Triangle Park, NC 27711, USA
Hum Exp Toxicol 26:283-93. 2007..An appropriate blend of scientific information from toxicology and epidemiology studies is necessary to evaluate potential human risks of exposure to neurotoxic substances... - Comparison of acute neurobehavioral and cholinesterase inhibitory effects of N-methylcarbamates in ratKatherine L McDaniel
Neurotoxicology Division, National Health and Environmental Effects Research Laboratory, Office of Research and Development, US Environmental Protection Agency, Research Triangle Park, North Carolina 27711, USA
Toxicol Sci 98:552-60. 2007..Thus, motor activity decreases are highly predictive of ChE inhibition for N-methyl carbamates, and vice versa... - Inhalational exposure to carbonyl sulfide produces altered brainstem auditory and somatosensory-evoked potentials in Fischer 344N ratsDavid W Herr
Neurotoxicology Division, MD B105 05, NHEERL, ORD, USEPA, Research Triangle Park, North Carolina 27711, USA
Toxicol Sci 95:118-35. 2007..This series of experiments demonstrates that COS produces changes in brainstem auditory and cortical somatosensory neurophysiological responses that correlate with previously described histopathological damage... - Neurobehavioral assessments of rats perinatally exposed to a commercial mixture of polychlorinated biphenylsPhilip J Bushnell
Neurobehavioral Toxicology Branch, Neurotoxicology Division, National Health and Environmental Effects Research Laboratory, U S Environmental Protection Agency, Research Triangle Park, North Carolina 27711, USA
Toxicol Sci 68:109-20. 2002..Perinatal exposure to this commercial PCB mixture had very little effect on these tests of behavior during development and in adulthood... - An alpha 2-adrenergic mode of action of chlordimeform on rat visual functionW K Boyes
Neurotoxicology Division, United States Environmental Protection Agency, Research Triangle Park, North Carolina 27711
Toxicol Appl Pharmacol 92:402-18. 1988..These results support the hypothesis that chlordimeform alters rat pattern-reversal evoked potentials through actions as a central nervous system alpha 2-adrenergic agonist... - Lack of alterations in thyroid hormones following exposure to polybrominated diphenyl ether 47 during a period of rapid brain development in miceJillian R Gee
Neurotoxicology Division, National Health and Environmental Effects Research Laboratory, Office of Research and Development, US Environmental Protection Agency, Research Triangle Park, North Carolina, USA
Drug Chem Toxicol 31:245-54. 2008..This suggests that the neurological abnormalities reported in mice exposed to PBDE-47 are not due to acute changes in circulating thyroid hormones at these observed periods... - Behavioral test methods workshopWilliam Slikker
National Center for Toxicological Research FDA, Division of Neurotoxicology, 3900 NCTR Rd Jefferson 72079, United States
Neurotoxicol Teratol 27:417-27. 2005.... - Statistical issues and techniques appropriate for developmental neurotoxicity testing: a report from the ILSI Research Foundation/Risk Science Institute expert working group on neurodevelopmental endpointsR Robert Holson
Department of Psychology, New Mexico Tech, Socorro, NM, USA
Neurotoxicol Teratol 30:326-48. 2008..This manuscript reviews many key considerations in the analysis of DNT studies with recommendations for statistical approaches and reporting of the data... - The simultaneous analysis of discrete and continuous outcomes in a dose-response study: using desirability functionsTodd Coffey
Department of Biostatistics, Virginia Commonwealth University, PO Box 980032, Richmond, VA 23298, USA
Regul Toxicol Pharmacol 48:51-8. 2007.... - Analyses of neurobehavioral screening data: dose-time-response modeling of continuous outcomesYiliang Zhu
Department of Epidemiology and Biostatistics, College of Public Health, University of South Florida, Tampa, FL 33612, USA
Regul Toxicol Pharmacol 41:240-55. 2005..Further research is needed on the types of design and data required to reliably approximate the true underlying dose-time-response... - Analyses of neurobehavioral screening data: benchmark dose estimationYiliang Zhu
Department of Epidemiology and Biostatistics, University of South Florida, Tampa, FL 33612, USA
Regul Toxicol Pharmacol 42:190-201. 2005..and the models of Zhu et al. (Zhu, Y., Wessel, M., Liu, T., Moser, V.C., 2005. Analyses of neurobehavioral screening data: dose-time-response modeling of continuous outcomes. Regul. Toxicol. Pharmacol. 41, 240-255)...