V C Moser

Summary

Affiliation: U.S. Environmental Protection Agency
Country: USA

Publications

  1. ncbi request reprint Differential profiles of cholinesterase inhibition and neurobehavioral effects in rats exposed to fenamiphos or profenofos
    Katherine L McDaniel
    Neurotoxicology Division Mail Code B105 04, National Health and Environmental Effects Research Laboratory, Office of Research and Development, U S Environmental Protection Agency, Research Triangle Park, NC 27711, USA
    Neurotoxicol Teratol 26:407-15. 2004
  2. doi request reprint Impact of chemical proportions on the acute neurotoxicity of a mixture of seven carbamates in preweanling and adult rats
    Virginia C Moser
    Toxicity Assessment Division, US EPA, Research Triangle Park, North Carolina 27711, USA
    Toxicol Sci 129:126-34. 2012
  3. ncbi request reprint Direct dosing of preweaning rodents in toxicity testing and research: deliberations of an ILSI RSI Expert Working Group
    Virginia C Moser
    Neurotoxicology Division NHEERL ORD, US Environmental Protection Agency, Research Triangle Park, NC 27711, USA
    Int J Toxicol 24:87-94. 2005
  4. ncbi request reprint Neurotoxicity produced by dibromoacetic acid in drinking water of rats
    V C Moser
    Neurotoxicology Division, NHEERL ORD, US Environmental Protection Agency, Research Triangle Park, North Carolina, 27711, USA
    Toxicol Sci 79:112-22. 2004
  5. ncbi request reprint Animal models of chronic pesticide neurotoxicity
    Virginia C Moser
    Neurotoxicology Division NHEERL ORD, US Environmental Protection Agency, Research Triangle Park, NC 27711, USA
    Hum Exp Toxicol 26:321-31. 2007
  6. doi request reprint Time-course, dose-response, and age comparative sensitivity of N-methyl carbamates in rats
    Virginia C Moser
    Toxicity Assessment Division, National Health and Environmental Effects Research Laboratory, Office of Research and Development, U S Environmental Protection Agency, Research Triangle Park, North Carolina 27711, USA
    Toxicol Sci 114:113-23. 2010
  7. doi request reprint Concentration and persistence of tin in rat brain and blood following dibutyltin exposure during development
    V C Moser
    Neurotoxicology Division, National Health and Environmental Effects Research Laboratory, US Environmental Protection Agency, Research Triangle Park, North Carolina 27711, USA
    J Toxicol Environ Health A 72:47-52. 2009
  8. ncbi request reprint Neurotoxicological and statistical analyses of a mixture of five organophosphorus pesticides using a ray design
    V C Moser
    Neurotoxicology Division, NHEERL ORD, US EPA, RTP, North Carolina 27711, USA
    Toxicol Sci 86:101-15. 2005
  9. ncbi request reprint Neurotoxicological evaluation of two disinfection by-products, bromodichloromethane and dibromoacetonitrile, in rats
    Virginia C Moser
    Neurotoxicology Division, NHEERL ORD, U S Environmental Protection Agency, Research Triangle Park, NC 27711, USA
    Toxicology 230:137-44. 2007
  10. ncbi request reprint Response to open commentary, "Validity and Utility of Geotaxis" by Motz and Alberts
    Virginia C Moser
    Neurotoxicology Division, National Health and Environmental Effects Research Laboratory, US Environmental Protection Agency, Research Triangle Park, NC 27711, USA
    Neurotoxicol Teratol 27:539-40; author reply 543-4. 2005

Detail Information

Publications47

  1. ncbi request reprint Differential profiles of cholinesterase inhibition and neurobehavioral effects in rats exposed to fenamiphos or profenofos
    Katherine L McDaniel
    Neurotoxicology Division Mail Code B105 04, National Health and Environmental Effects Research Laboratory, Office of Research and Development, U S Environmental Protection Agency, Research Triangle Park, NC 27711, USA
    Neurotoxicol Teratol 26:407-15. 2004
    ..Despite the low level of brain ChE inhibition, some behavioral effects of fenamiphos were centrally mediated, and there was little regional specificity of ChE inhibition that could account for the behavioral changes observed...
  2. doi request reprint Impact of chemical proportions on the acute neurotoxicity of a mixture of seven carbamates in preweanling and adult rats
    Virginia C Moser
    Toxicity Assessment Division, US EPA, Research Triangle Park, North Carolina 27711, USA
    Toxicol Sci 129:126-34. 2012
    ..These approaches for studying pesticide mixtures can improve evaluations of potential toxicity under varying experimental conditions that may mimic human exposures...
  3. ncbi request reprint Direct dosing of preweaning rodents in toxicity testing and research: deliberations of an ILSI RSI Expert Working Group
    Virginia C Moser
    Neurotoxicology Division NHEERL ORD, US Environmental Protection Agency, Research Triangle Park, NC 27711, USA
    Int J Toxicol 24:87-94. 2005
    ..Ultimately, the success of the study will depend upon careful preparation, including thorough training of the technical staff...
  4. ncbi request reprint Neurotoxicity produced by dibromoacetic acid in drinking water of rats
    V C Moser
    Neurotoxicology Division, NHEERL ORD, US Environmental Protection Agency, Research Triangle Park, North Carolina, 27711, USA
    Toxicol Sci 79:112-22. 2004
    ..2 g/l, lowest concentration tested), whereas this dosage was a no-effect level for neuropathological changes. These studies suggest that neurotoxicity should be considered in the overall hazard evaluation of haloacetic acids...
  5. ncbi request reprint Animal models of chronic pesticide neurotoxicity
    Virginia C Moser
    Neurotoxicology Division NHEERL ORD, US Environmental Protection Agency, Research Triangle Park, NC 27711, USA
    Hum Exp Toxicol 26:321-31. 2007
    ..Future research should concentrate on analogous exposures and outcomes to facilitate interpretation...
  6. doi request reprint Time-course, dose-response, and age comparative sensitivity of N-methyl carbamates in rats
    Virginia C Moser
    Toxicity Assessment Division, National Health and Environmental Effects Research Laboratory, Office of Research and Development, U S Environmental Protection Agency, Research Triangle Park, North Carolina 27711, USA
    Toxicol Sci 114:113-23. 2010
    ..Thus, these data show the time-course and dose-response characteristics for each carbamate and document greater sensitivity of the young for carbofuran and carbaryl...
  7. doi request reprint Concentration and persistence of tin in rat brain and blood following dibutyltin exposure during development
    V C Moser
    Neurotoxicology Division, National Health and Environmental Effects Research Laboratory, US Environmental Protection Agency, Research Triangle Park, North Carolina 27711, USA
    J Toxicol Environ Health A 72:47-52. 2009
    ..Furthermore, Sn is concentrated in brain compared to blood, and its elimination is protracted, on the order of days to months after exposure ends...
  8. ncbi request reprint Neurotoxicological and statistical analyses of a mixture of five organophosphorus pesticides using a ray design
    V C Moser
    Neurotoxicology Division, NHEERL ORD, US EPA, RTP, North Carolina 27711, USA
    Toxicol Sci 86:101-15. 2005
    ..In all cases, the deviations from additivity occurred at the lower end of the dose-response curves...
  9. ncbi request reprint Neurotoxicological evaluation of two disinfection by-products, bromodichloromethane and dibromoacetonitrile, in rats
    Virginia C Moser
    Neurotoxicology Division, NHEERL ORD, U S Environmental Protection Agency, Research Triangle Park, NC 27711, USA
    Toxicology 230:137-44. 2007
    ..Lowered fluid consumption was the most sensitive and consistent endpoint in the present studies. Thus, unlike the haloacetic acids, neurotoxicity may not be a concern for toxicity of halomethanes or haloacetonitriles...
  10. ncbi request reprint Response to open commentary, "Validity and Utility of Geotaxis" by Motz and Alberts
    Virginia C Moser
    Neurotoxicology Division, National Health and Environmental Effects Research Laboratory, US Environmental Protection Agency, Research Triangle Park, NC 27711, USA
    Neurotoxicol Teratol 27:539-40; author reply 543-4. 2005
  11. ncbi request reprint Neurobehavioral evaluations of mixtures of trichloroethylene, heptachlor, and di(2-ethylhexyl)phthlate in a full-factorial design
    V C Moser
    Neurotoxicology Division, NHEERL ORD, US Environmental Protection Agency, Research Triangle Park, NC 27711, USA
    Toxicology 188:125-37. 2003
    ..These results underscore the need for more economical approaches to evaluate the toxic effects of mixtures of chemicals...
  12. ncbi request reprint Evaluation of developmental neurotoxicity of organotins via drinking water in rats: monomethyltin
    Virginia C Moser
    Neurotoxicology Division, National Health and Environmental Effects Research Laboratory, Office of Research and Development, US Environmental Protection Agency, Research Triangle Park, NC 27711, United States
    Neurotoxicology 27:409-20. 2006
    ..While mild neuropathological lesions were observed in the adult offspring, the biological significance of this restricted finding is unclear...
  13. ncbi request reprint The effects of perinatal tebuconazole exposure on adult neurological, immunological, and reproductive function in rats
    V C Moser
    Neurotoxicology Division and Environmental Toxicology Division, National Health and Environmental Effects Research Laboratory, U S Environmental Protection Agency, Research Triangle Park, NC 27711, USA
    Toxicol Sci 62:339-52. 2001
    ..Thus, perinatal exposure to tebuconazole produced neurobehavioral deficits and neuropathology in rats, but did not alter immunological or reproductive function...
  14. ncbi request reprint Neurotoxicological interactions of a five-pesticide mixture in preweanling rats
    Virginia C Moser
    Neurotoxicology Division, National Health and Environmental Effects Research Laboratory Office of Research and Development, U S Environmental Protection Agency, Research Triangle Park, NC 27711, USA
    Toxicol Sci 92:235-45. 2006
    ..Thus, greater-than-additive responses were detected in preweanling rats with this OP mixture, and this effect can only partially be attributed to the malathion in the mixture...
  15. ncbi request reprint Neurotoxicological outcomes of perinatal heptachlor exposure in the rat
    V C Moser
    Neurotoxicology Division, National Health and Environmental Effects Research Laboratory, Office of Research and Development, U S EPA, Research Triangle Park, North Carolina 27711, USA
    Toxicol Sci 60:315-26. 2001
    ..Thus, perinatal exposure to heptachlor produced neurochemical and persistent neurobehavioral changes, including alterations in spatial learning and memory...
  16. ncbi request reprint The functional observational battery in adult and developing rats
    V C Moser
    National Health and Environmental Effects Research Laboratory, U S Environmental Protection Agency, Research Triangle Park, NC 27711, USA
    Neurotoxicology 21:989-96. 2000
    ..This revised FOB protocol may be useful for assessing behavioral or neurological changes due to acute chemical exposure in young rats, or following gestational/lactational exposures typical of developmental neurotoxicity studies...
  17. doi request reprint Functional assays for neurotoxicity testing
    Virginia C Moser
    Neurotoxicity Branch, Toxicity Assessment Division, National Health and Environmental Effects Research Laboratory, Office of Research and Development, U S Environmental Protection Agency, Research Triangle Park, NC 27711, USA
    Toxicol Pathol 39:36-45. 2011
    ....
  18. doi request reprint Age-related differences in acute neurotoxicity produced by mevinphos, monocrotophos, dicrotophos, and phosphamidon
    Virginia C Moser
    Neurotoxicology Branch, Toxicity Assessment Division, National Health and Environmental Effects Research Laboratory, Office of Research and Development, US Environmental Protection Agency, Research Triangle Park, NC, USA
    Neurotoxicol Teratol 33:451-7. 2011
    ..These data show that three of these four OPs were only moderately more toxic in young rats, and further support findings that age-related differences in pesticide toxicity are chemical-specific...
  19. doi request reprint Esterase metabolism of cholinesterase inhibitors using rat liver in vitro
    V C Moser
    Toxicity Assessment Division MD B105 04, National Health and Environmental Effects Research Laboratory, Office of Research and Development, US Environmental Protection Agency, Research Triangle Park, NC 27711, USA
    Toxicology 281:56-62. 2011
    ..Thus, generalizations regarding these metabolic pathways may not be appropriate. As with other aspects of AChE inhibitors, their metabolic patterns appear to be chemical-specific...
  20. ncbi request reprint Evaluation of developmental neurotoxicity of organotins via drinking water in rats: dimethyl tin
    K D Ehman
    Neurotoxicology Division, National Health and Environmental Effects Research Laboratory, US Environmental Protection Agency, Research Triangle Park, NC, USA
    Neurotoxicol Teratol 29:622-33. 2007
    ..Thus, developmental neurotoxicity may be produced in offspring following gestational exposure to DMT in drinking water...
  21. ncbi request reprint Behavioral evaluation of the neurotoxicity produced by dichloroacetic acid in rats
    V C Moser
    Neurotoxicology Division, National Health and Environmental Effects Research Laboratory, U S Environmental Protection Agency, Research Triangle Park, NC 27711, USA
    Neurotoxicol Teratol 21:719-31. 1999
    ..Further research should take into account these marked route, age, and strain differences...
  22. ncbi request reprint Neurobehavioral effects of chronic dietary and repeated high-level spike exposure to chlorpyrifos in rats
    V C Moser
    Neurotoxicology Division, National Health and Environmental Effects Research Laboratory, Office of Research and Development, US Environmental Protection Agency, Research Triangle Park, North Carolina 27711, USA
    Toxicol Sci 86:375-86. 2005
    ..Overall, dietary exposure to chlorpyrifos produced long-lasting neurobehavioral changes and also altered the response to acute challenges...
  23. ncbi request reprint Comparison of the role of esterases in the differential age-related sensitivity to chlorpyrifos and methamidophos
    S Padilla
    Neurotoxicology Division, U S Environmental Protection Agency, Research Triangle Park, North Carolina 27711, USA
    Neurotoxicology 21:49-56. 2000
    ....
  24. ncbi request reprint Influence of dosing volume on the neurotoxicity of bifenthrin
    M J Wolansky
    U S National Research Council, U S EPA, Research Triangle Park, NC, USA
    Neurotoxicol Teratol 29:377-84. 2007
    ..Further, these data suggest that inconsistent estimates of pyrethroid potency between laboratories are at least partially due to differences in dosing volume...
  25. ncbi request reprint Further assessment of an in vitro screen that may help identify organophosphorus pesticides that are more acutely toxic to the young
    S Padilla
    Neurotoxicology Division, National Health and Environmental Effects Research Laboratory, Office of Research and Development, U S Environmental Protection Agency, North Carolina 27711, USA
    J Toxicol Environ Health A 67:1477-89. 2004
    ..We conclude that our in vitro screen may prove to be a useful, quick, convenient test for identifying which organophosphorus pesticides may be more acutely toxic to the young as compared to adults...
  26. ncbi request reprint Comparing cognitive and screening tests for neurotoxicity. Effects of acute chlorpyrifos on visual signal detection and a neurobehavioral test battery in rats
    P J Bushnell
    Neurotoxicology Division, National Health and Environmental Effects Research Laboratory, U S Environmental Protection Agency, MD 74B, Research Triangle Park, NC 27711, USA
    Neurotoxicol Teratol 23:33-44. 2001
    ..Thus, CPF impaired attention and altered behavior in the test battery in the same dose ranges under two very different dosing scenarios...
  27. ncbi request reprint Dose-response and time-course of neurobehavioral changes following oral chlorpyrifos in rats of different ages
    V C Moser
    National Health and Environmental Effects Research Laboratory, Neurotoxicology Division MD 74B, US Environmental Protection Agency, Research Triangle Park, NC 27711, USA
    Neurotoxicol Teratol 22:713-23. 2000
    ....
  28. doi request reprint Moderate developmental undernutrition: Impact on growth and cognitive function in youth and old age
    M E Gilbert
    Toxicity Assessment Division, U S Environmental Protection Agency, Research Triangle Park, NC, USA
    Neurotoxicol Teratol 32:362-72. 2010
    ..These findings indicate that moderate fetal undernutrition followed by neonatal adequate nutrition does not appear to lead to obesity or neurological dysfunction in young adulthood or old age...
  29. ncbi request reprint Paraoxon toxicity is not potentiated by prior reduction in blood acetylcholinesterase
    S Padilla
    Neurotoxicology Division MD 74B, U S Environmental Protection Agency, Research Triangle Park, North Carolina 27711
    Toxicol Appl Pharmacol 117:110-5. 1992
    ..Thus, significant loss in blood AChE alone produced no detectable neurobehavioral deficits and did not alter the subsequent responses to paraoxon challenge...
  30. doi request reprint Acute postnatal exposure to brominated diphenylether 47 delays neuromotor ontogeny and alters motor activity in mice
    J R Gee
    Neurotoxicology Division, National Health and Environmental Effects Research Laboratory, Office of Research and Development, US Environmental Protection Agency, Research Triangle Park, NC 27711, USA
    Neurotoxicol Teratol 30:79-87. 2008
    ..These data indicate that acute exposure to BDE 47 during postnatal development may produce subtle changes in the development of neuromotor systems that may alter adult behavior...
  31. ncbi request reprint Neurotoxicity of carbonyl sulfide in F344 rats following inhalation exposure for up to 12 weeks
    Daniel L Morgan
    Laboratory of Molecular Toxicology, NIEHS, Research Triangle Park, NC 27709, USA
    Toxicol Appl Pharmacol 200:131-45. 2004
    ..Our studies demonstrate that this environmental air contaminant has the potential to cause a wide spectrum of brain lesions that are dependent on the degree and duration of exposure...
  32. ncbi request reprint Potential developmental toxicity of anatoxin-a, a cyanobacterial toxin
    E H Rogers
    US Environmental Protection Agency, National Health and Ecological Effects Research Laboratory, Research Triangle Park, NC 27711, USA
    J Appl Toxicol 25:527-34. 2005
    ..Most notable was the occurrence of 100% mortality at the high dose in both groups 6-13 days post-exposure. The observed delay between initial exposure and death is highly unusual for anatoxin-a...
  33. ncbi request reprint Gestational exposure to chlorpyrifos: dose response profiles for cholinesterase and carboxylesterase activity
    T L Lassiter
    Curriculum in Toxicology, University of North Carolina, Chapel Hill, USA
    Toxicol Sci 52:92-100. 1999
    ..Both the in vivo and in vitro findings indicated that fetal liver CaE inhibition was an extremely sensitive indicator of fetal chlorpyrifos exposure...
  34. ncbi request reprint Neurochemical effects of chronic dietary and repeated high-level acute exposure to chlorpyrifos in rats
    Stephanie Padilla
    Neurotoxicology Division, US Environmental Protection Agency, Research Triangle Park, North Carolina 27711, USA
    Toxicol Sci 88:161-71. 2005
    ..These data indicate that, although chronic feeding with or without intermittent spiked dosages with CPF produces substantial biochemical changes in a dose- and tissue-related manner, there are no persistent biochemical changes...
  35. doi request reprint Relationship between brain and plasma carbaryl levels and cholinesterase inhibition
    David W Herr
    Neurotoxicology Branch, Toxicity Assessment Division, National Health and Environmental Effects Research Laboratory, Office of Research and Development, U S EPA, Research Triangle Park, NC 27711, United States
    Toxicology 276:172-83. 2010
    ..The results of these experiments will be useful to extend physiologically-based pharmacokinetic models for carbaryl and their application in risk assessment...
  36. doi request reprint Developmental exposure to a commercial PBDE mixture, DE-71: neurobehavioral, hormonal, and reproductive effects
    Prasada Rao S Kodavanti
    Neurotoxicology Branch, Toxicity Assessment Division, National Health and Environmental Effects Research Laboratory, Office of Research and Development, US EPA, Research Triangle Park, North Carolina 27711, USA
    Toxicol Sci 116:297-312. 2010
    ..Some of these effects are similar to those seen with PCBs, and the persistence of these changes requires further investigation...
  37. ncbi request reprint Integrating epidemiology and toxicology in neurotoxicity risk assessment
    William K Boyes
    National Health and Environmental Effects Research Laboratory, Office of Research and Development, US Environmental Protection Agency, Research Triangle Park, NC 27711, USA
    Hum Exp Toxicol 26:283-93. 2007
    ..An appropriate blend of scientific information from toxicology and epidemiology studies is necessary to evaluate potential human risks of exposure to neurotoxic substances...
  38. ncbi request reprint Comparison of acute neurobehavioral and cholinesterase inhibitory effects of N-methylcarbamates in rat
    Katherine L McDaniel
    Neurotoxicology Division, National Health and Environmental Effects Research Laboratory, Office of Research and Development, US Environmental Protection Agency, Research Triangle Park, North Carolina 27711, USA
    Toxicol Sci 98:552-60. 2007
    ..Thus, motor activity decreases are highly predictive of ChE inhibition for N-methyl carbamates, and vice versa...
  39. ncbi request reprint Inhalational exposure to carbonyl sulfide produces altered brainstem auditory and somatosensory-evoked potentials in Fischer 344N rats
    David W Herr
    Neurotoxicology Division, MD B105 05, NHEERL, ORD, USEPA, Research Triangle Park, North Carolina 27711, USA
    Toxicol Sci 95:118-35. 2007
    ..This series of experiments demonstrates that COS produces changes in brainstem auditory and cortical somatosensory neurophysiological responses that correlate with previously described histopathological damage...
  40. ncbi request reprint Neurobehavioral assessments of rats perinatally exposed to a commercial mixture of polychlorinated biphenyls
    Philip J Bushnell
    Neurobehavioral Toxicology Branch, Neurotoxicology Division, National Health and Environmental Effects Research Laboratory, U S Environmental Protection Agency, Research Triangle Park, North Carolina 27711, USA
    Toxicol Sci 68:109-20. 2002
    ..Perinatal exposure to this commercial PCB mixture had very little effect on these tests of behavior during development and in adulthood...
  41. ncbi request reprint An alpha 2-adrenergic mode of action of chlordimeform on rat visual function
    W K Boyes
    Neurotoxicology Division, United States Environmental Protection Agency, Research Triangle Park, North Carolina 27711
    Toxicol Appl Pharmacol 92:402-18. 1988
    ..These results support the hypothesis that chlordimeform alters rat pattern-reversal evoked potentials through actions as a central nervous system alpha 2-adrenergic agonist...
  42. ncbi request reprint Lack of alterations in thyroid hormones following exposure to polybrominated diphenyl ether 47 during a period of rapid brain development in mice
    Jillian R Gee
    Neurotoxicology Division, National Health and Environmental Effects Research Laboratory, Office of Research and Development, US Environmental Protection Agency, Research Triangle Park, North Carolina, USA
    Drug Chem Toxicol 31:245-54. 2008
    ..This suggests that the neurological abnormalities reported in mice exposed to PBDE-47 are not due to acute changes in circulating thyroid hormones at these observed periods...
  43. ncbi request reprint Behavioral test methods workshop
    William Slikker
    National Center for Toxicological Research FDA, Division of Neurotoxicology, 3900 NCTR Rd Jefferson 72079, United States
    Neurotoxicol Teratol 27:417-27. 2005
    ....
  44. ncbi request reprint Statistical issues and techniques appropriate for developmental neurotoxicity testing: a report from the ILSI Research Foundation/Risk Science Institute expert working group on neurodevelopmental endpoints
    R Robert Holson
    Department of Psychology, New Mexico Tech, Socorro, NM, USA
    Neurotoxicol Teratol 30:326-48. 2008
    ..This manuscript reviews many key considerations in the analysis of DNT studies with recommendations for statistical approaches and reporting of the data...
  45. ncbi request reprint The simultaneous analysis of discrete and continuous outcomes in a dose-response study: using desirability functions
    Todd Coffey
    Department of Biostatistics, Virginia Commonwealth University, PO Box 980032, Richmond, VA 23298, USA
    Regul Toxicol Pharmacol 48:51-8. 2007
    ....
  46. ncbi request reprint Analyses of neurobehavioral screening data: dose-time-response modeling of continuous outcomes
    Yiliang Zhu
    Department of Epidemiology and Biostatistics, College of Public Health, University of South Florida, Tampa, FL 33612, USA
    Regul Toxicol Pharmacol 41:240-55. 2005
    ..Further research is needed on the types of design and data required to reliably approximate the true underlying dose-time-response...
  47. ncbi request reprint Analyses of neurobehavioral screening data: benchmark dose estimation
    Yiliang Zhu
    Department of Epidemiology and Biostatistics, University of South Florida, Tampa, FL 33612, USA
    Regul Toxicol Pharmacol 42:190-201. 2005
    ..and the models of Zhu et al. (Zhu, Y., Wessel, M., Liu, T., Moser, V.C., 2005. Analyses of neurobehavioral screening data: dose-time-response modeling of continuous outcomes. Regul. Toxicol. Pharmacol. 41, 240-255)...