R W Luebke

Summary

Affiliation: U.S. Environmental Protection Agency
Country: USA

Publications

  1. ncbi request reprint Aquatic pollution-induced immunotoxicity in wildlife species
    R W Luebke
    Immunotoxicology Branch, U S EPA, Research Triangle Park, North Carolina 27711, USA
    Fundam Appl Toxicol 37:1-15. 1997
  2. ncbi request reprint Effects of aging on resistance to Trichinella spiralis infection in rodents exposed to 2,3,7,8-tetrachlorodibenzo-p-dioxin
    R W Luebke
    Immunotoxicology Branch, Experimental Toxicology Division, US Environmental Protection Agency, Research Triangle Park, NC 27711, USA
    Toxicology 136:15-26. 1999
  3. ncbi request reprint Aging and resistance to Trichinella spiralis infection following xenobiotic exposure
    R W Luebke
    Immunotoxicology Branch, Experimental Toxicology Division, United States Environmental Protection Agency, Research Triangle Park, North Carolina 27711, USA
    Ann N Y Acad Sci 919:221-9. 2000
  4. pmc Immunotoxicogenomics: the potential of genomics technology in the immunotoxicity risk assessment process
    Robert W Luebke
    Experimental Toxicology Division, National Health and Environmental Effects Research Laboratory, Office of Research and Development, U S Environmental Protection Agency, Research Triangle Park, North Carolina 27711, USA
    Toxicol Sci 94:22-7. 2006
  5. ncbi request reprint Host resistance to murine malaria in mice exposed to the adenosine deaminase inhibitor, 2'-deoxycoformycin
    R W Luebke
    Health Effects Research Laboratory, U S EPA, Research Triangle Park, North Carolina
    Int J Immunopharmacol 13:987-97. 1991
  6. ncbi request reprint Immune function in mice exposed to the adenosine deaminase inhibitor 2'-deoxycoformycin during immune system development
    R W Luebke
    Perinatal Toxicology Branch, U S Environmental Protection Agency, Research Triangle Park, NC 27711
    Immunopharmacol Immunotoxicol 9:149-61. 1987
  7. ncbi request reprint Suppression of allergic immune responses to house dust mite (HDM) in rats exposed to 2,3,7,8-TCDD
    R W Luebke
    Experimental Toxicology Division, NHEERL, ORD, U S EPA, Research Triangle Park, North Carolina, USA
    Toxicol Sci 62:71-9. 2001
  8. ncbi request reprint Enhancement of natural killer cell activity and interferon production by manganese in young mice
    R J Smialowicz
    Developmental and Cellular Toxicology Division, U.S. Environmental Protection Agency, Research Triangle Park, NC 27711
    Immunopharmacol Immunotoxicol 10:93-107. 1988
  9. ncbi request reprint Nematodes as host resistance models for detection of immunotoxicity
    Robert W Luebke
    Immunotoxicology Branch, Experimental Toxicology Division, National Health and Environmental Effects Laboratory, Office of Research and Development, United States Environmental Protection Agency, Research Triangle Park, NC 27711, USA
    Methods 41:38-47. 2007
  10. ncbi request reprint The comparative immunotoxicity of five selected compounds following developmental or adult exposure
    Robert W Luebke
    Immunotoxicology Branch, Experimental Toxicology Division, National Health and Environmental Effects Research Laboratory, U S Environmental Protection Agency, Research Triangle Park, North Carolina 27711, USA
    J Toxicol Environ Health B Crit Rev 9:1-26. 2006

Detail Information

Publications15

  1. ncbi request reprint Aquatic pollution-induced immunotoxicity in wildlife species
    R W Luebke
    Immunotoxicology Branch, U S EPA, Research Triangle Park, North Carolina 27711, USA
    Fundam Appl Toxicol 37:1-15. 1997
    ....
  2. ncbi request reprint Effects of aging on resistance to Trichinella spiralis infection in rodents exposed to 2,3,7,8-tetrachlorodibenzo-p-dioxin
    R W Luebke
    Immunotoxicology Branch, Experimental Toxicology Division, US Environmental Protection Agency, Research Triangle Park, NC 27711, USA
    Toxicology 136:15-26. 1999
    ..These model-dependent results preclude acceptance or rejection of the tested hypothesis...
  3. ncbi request reprint Aging and resistance to Trichinella spiralis infection following xenobiotic exposure
    R W Luebke
    Immunotoxicology Branch, Experimental Toxicology Division, United States Environmental Protection Agency, Research Triangle Park, North Carolina 27711, USA
    Ann N Y Acad Sci 919:221-9. 2000
    ..If proven true, a given dose of an immunosuppressive xenobiotic would cause greater suppression of host resistance in an aged population...
  4. pmc Immunotoxicogenomics: the potential of genomics technology in the immunotoxicity risk assessment process
    Robert W Luebke
    Experimental Toxicology Division, National Health and Environmental Effects Research Laboratory, Office of Research and Development, U S Environmental Protection Agency, Research Triangle Park, North Carolina 27711, USA
    Toxicol Sci 94:22-7. 2006
    ..To help move the science of immunotoxicogenomics forward, a partnership of industry, academia, and government was suggested to address data gaps, validation, quality assurance, and protocol development...
  5. ncbi request reprint Host resistance to murine malaria in mice exposed to the adenosine deaminase inhibitor, 2'-deoxycoformycin
    R W Luebke
    Health Effects Research Laboratory, U S EPA, Research Triangle Park, North Carolina
    Int J Immunopharmacol 13:987-97. 1991
    ..It appears that a combination of increased macrophage activity and altered T-cell activity contributed to the delay in peak parasitemia and clearance of infection in mice exposed to 2dCF before infection with Py17XNL...
  6. ncbi request reprint Immune function in mice exposed to the adenosine deaminase inhibitor 2'-deoxycoformycin during immune system development
    R W Luebke
    Perinatal Toxicology Branch, U S Environmental Protection Agency, Research Triangle Park, NC 27711
    Immunopharmacol Immunotoxicol 9:149-61. 1987
    ....
  7. ncbi request reprint Suppression of allergic immune responses to house dust mite (HDM) in rats exposed to 2,3,7,8-TCDD
    R W Luebke
    Experimental Toxicology Division, NHEERL, ORD, U S EPA, Research Triangle Park, North Carolina, USA
    Toxicol Sci 62:71-9. 2001
    ..We therefore conclude that TCDD exposure suppressed, rather than enhanced the development of allergic immune responses and the expression of immune-mediated lung disease...
  8. ncbi request reprint Enhancement of natural killer cell activity and interferon production by manganese in young mice
    R J Smialowicz
    Developmental and Cellular Toxicology Division, U.S. Environmental Protection Agency, Research Triangle Park, NC 27711
    Immunopharmacol Immunotoxicol 10:93-107. 1988
    ..Furthermore, Mn-enhanced NK activity in these young mice appears to be mediated by the production of interferon alpha, beta...
  9. ncbi request reprint Nematodes as host resistance models for detection of immunotoxicity
    Robert W Luebke
    Immunotoxicology Branch, Experimental Toxicology Division, National Health and Environmental Effects Laboratory, Office of Research and Development, United States Environmental Protection Agency, Research Triangle Park, NC 27711, USA
    Methods 41:38-47. 2007
    ..Detailed protocols are provided for adult and larval parasite counts, female parasite fecundity, parasite antigen-driven lymphocyte proliferation and antibody responses to infection...
  10. ncbi request reprint The comparative immunotoxicity of five selected compounds following developmental or adult exposure
    Robert W Luebke
    Immunotoxicology Branch, Experimental Toxicology Division, National Health and Environmental Effects Research Laboratory, U S Environmental Protection Agency, Research Triangle Park, North Carolina 27711, USA
    J Toxicol Environ Health B Crit Rev 9:1-26. 2006
    ..For all five chemicals, the developing immune system was found to be at greater risk than that of the adult, either because lower doses produced immunotoxicity, adverse effects were more persistent, or both...
  11. ncbi request reprint Developmental atrazine exposure suppresses immune function in male, but not female Sprague-Dawley rats
    Andrew A Rooney
    College of Veterinary Medicine, Anatomy, Physiological Sciences and Radiology, North Carolina State University, Raleigh, North Carolina 27695, USA
    Toxicol Sci 76:366-75. 2003
    ..These results demonstrate that developmental exposure to ATR produced gender-specific changes in immune function in adult rats and suggest that immune changes associated with ATR are not mediated through the suppression of PRL or THs...
  12. ncbi request reprint Mortality in dioxin-exposed mice infected with influenza: mitochondrial toxicity (reye's-like syndrome) versus enhanced inflammation as the mode of action
    Robert W Luebke
    Immunotoxicology Branch, Experimental Toxicology Division, National Health and Environmental Effects Research Laboratory, Office of Research and Development, U S Environmental Protection Agency, NC 27711, USA
    Toxicol Sci 69:109-16. 2002
    ..These results suggest that RS is an unlikely explanation for increased influenza mortality in TCDD-exposed mice. Rather, constituents in BALF implicate increased pulmonary inflammation as the mode of TCDD action...
  13. ncbi request reprint Immune function is not impaired in Sprague-Dawley rats exposed to dimethyltin dichloride (DMTC) during development or adulthood
    Jamie C DeWitt
    Curriculum in Toxicology, University of North Carolina at Chapel Hill, c o U S Environmental Protection Agency, MDB143 01, 109 TW Alexander Drive, Research Triangle Park, NC 27711, USA
    Toxicology 232:303-10. 2007
    ....
  14. pmc Serum supplementation modulates the effects of dibutyltin on human natural killer cell function
    Margaret M Whalen
    Department of Chemistry, Tennessee State University, Nashville, Tennessee 37209, USA
    Toxicol Sci 104:312-9. 2008
    ..These data indicate that the model is useful in predicting potential human effects of relatively low DBTi concentrations...
  15. pmc Perfluorooctanoic acid-induced immunomodulation in adult C57BL/6J or C57BL/6N female mice
    Jamie C DeWitt
    Curriculum in Toxicology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA
    Environ Health Perspect 116:644-50. 2008
    ..Perfluorooctanoic acid (PFOA), an environmentally persistent compound of regulatory concern, has been reported to reduce antibody responses in mice at a single dose...