Research Topics
| Susan C LawsSummaryAffiliation: U.S. Environmental Protection Agency Country: USA Publications
| Collaborators |
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Publications
Chlorotriazine herbicides and metabolites activate an ACTH-dependent release of corticosterone in male Wistar ratsSusan C Laws
Reproductive Toxicology Division, National Health and Environmental Effects Research Laboratory, Office of Research and Development, U S Environmental Protection Agency, Research Triangle Park, North Carolina 27711, USA
Toxicol Sci 112:78-87. 2009..Thus, the rapid release of ACTH and subsequent activation of adrenal steroidogenesis following a single exposure to ATR, SIM, PRO, DIA, or DEA may reflect chlorotriazine-induced changes at the level of the brain and/or pituitary...
Effects of altered food intake during pubertal development in male and female wistar ratsSusan C Laws
National Health and Environmental Effects Research Laboratory, Office of Research and Development, U S Environmental Protection Agency, Research Triangle Park, North Carolina 27711, USA
Toxicol Sci 100:194-202. 2007....- The effects of atrazine on female wistar rats: an evaluation of the protocol for assessing pubertal development and thyroid functionS C Laws
National Health and Environmental Effects Research Laboratory, U S Environmental Protection Agency, Research Triangle Park, NC 27711, USA
Toxicol Sci 58:366-76. 2000..In addition, the effect on estrous cyclicity was observed in the 100 mg/kg ATR group where no significant reduction in bw was observed... - Nature of the binding interaction for 50 structurally diverse chemicals with rat estrogen receptorsSusan C Laws
Reproductive Toxicology Division, National Health and Environmental Effects Research Laboratory, Office of Research and Development, U S Environmental Protection Agency, Mail drop 72, Research Triangle Park, North Carolina 27711, USA
Toxicol Sci 94:46-56. 2006..S. EPA's Endocrine Disruptor Screening Program, as well as to support research efforts to develop computational models designed to identify chemicals with the ability to bind to ER... - Pubertal development in female Wistar rats following exposure to propazine and atrazine biotransformation by-products, diamino-S-chlorotriazine and hydroxyatrazineSusan C Laws
Endocrinology Branch, Reproductive Toxicology Division, National Health and Environmental Effects Research Laboratory, U S Environmental Protection Agency, Research Triangle Park, North Carolina 27711, USA
Toxicol Sci 76:190-200. 2003..Together, these data demonstrate that PRO and DACT can delay the onset of puberty in the female rat at doses equimolar to ATR and provide the scientific basis for the use of additivity in the upcoming risk assessments... - Assessment of DE-71, a commercial polybrominated diphenyl ether (PBDE) mixture, in the EDSP male and female pubertal protocolsTammy E Stoker
Reproductive Toxicology Division, National Health and Environmental Effects Research Laboratory, U S Environmental Protection Agency, Research Triangle Park, North Carolina 27711, USA
Toxicol Sci 78:144-55. 2004.... - Atrazine and reproductive function: mode and mechanism of action studiesRalph L Cooper
Endocrinology Branch, Reproductive Toxicology Division, National Health and Environmental Effects Research Laboratory, United States Environmental Protection Agency, Research Triangle Park, North Carolina 27711, USA
Birth Defects Res B Dev Reprod Toxicol 80:98-112. 2007..e., the mode of action for mammary tumors); 3) the potential cellular mechanisms involving adverse effects of atrazine; and 4) the range of reproductive alterations associated with this pesticide... - Characterization of the hypothalamic-pituitary-adrenal axis response to atrazine and metabolites in the female ratMelanie J P Fraites
Endocrinology Branch, Reproductive Toxicology Division, National Health and Environmental Effects Research Laboratory, Office of Research and Development, U S Environmental Protection Agency, Research Triangle Park, North Carolina 27711, USA
Toxicol Sci 112:88-99. 2009..Activation of this endocrine axis by these chlorotriazines could contribute to the induced changes of female reproductive function reported previously... - Atrazine does not induce pica behavior at doses that increase hypothalamic-pituitary-adrenal axis activation and cause conditioned taste avoidanceMichelle Gatien Hotchkiss
National Health and Environmental Effects Research Laboratory, Office of Research and Development, U S Environmental Protection Agency, Research Triangle Park, NC 27711, USA
Neurotoxicol Teratol 34:295-302. 2012.... - Xenoendocrine disrupters-tiered screening and testing: filling key data gapsL E Gray
Endocrinology Branch, Reproductive Toxicology Division, National Health Environmental Effects Research Laboratory, ORD, US Environmental Protection Agency, MD 72, Research Triangle Park, NC 27111, USA
Toxicology 181:371-82. 2002..Tier 1 and 2 also should examine relevant mixtures of EDCs. Toxicants that induce malformations in AR-dependent tissues produce cumulative effects even when two chemicals act via different mechanisms of action... - Ligand-based identification of environmental estrogensC L Waller
Experimental Toxicology Divisions, United States Environmental Protection Agency, Research Triangle Park, North Carolina 27711, USA
Chem Res Toxicol 9:1240-8. 1996..The general application of this 3D-QSAR model within a toxicological framework is, at present, limited only by the quantity and quality of biological data for relevant biomarkers of toxicity and hormonal responsiveness... - Prepubertal exposure to compounds that increase prolactin secretion in the male rat: effects on the adult prostateT E Stoker
Endocrinology Branch, Reproductive Toxicology Division, National Health and Environmental Effects Research Laboratory, U S Environmental Protection Agency, Research Triangle Park, North Carolina 27711, USA
Biol Reprod 61:1636-43. 1999..This study demonstrates that prepubertal exposures to compounds that increase PRL secretion, albeit through different mechanisms, can increase the incidence of lateral prostate inflammation in the adult... - Estrogenic activity of octylphenol, nonylphenol, bisphenol A and methoxychlor in ratsS C Laws
Endocrinology Branch, Reproductive Toxicology Division, U S Environmental Protection Agency, Research Triangle Park, North Carolina 27711, USA
Toxicol Sci 54:154-67. 2000..These data can be useful during the assessment and validation of methods for screening environmental chemicals for endocrine disrupting activity... - Assessment of estrogenicity by using the delayed implanting rat model and examplesA M Cummings
Reproductive Toxicology Division, National Health and Environmental Effects Research Laboratory, U S Environmental Protection Agency, Research Triangle Park, NC 27711, USA
Reprod Toxicol 14:111-7. 2000..These data confirm previous evidence of the availability of this model for evaluating estrogenic activity and provide estimates of the estrogenic potencies of several environmentally important chemicals... - Evaluation of ammonium perchlorate in the endocrine disruptor screening and testing program's male pubertal protocol: ability to detect effects on thyroid endpointsT E Stoker
Endocrinology Branch, Reproductive Toxicology Division, NHEERL, Office of Research and Development, United States Environmental Protection Agency, Research Triangle Park, NC 27711, USA
Toxicology 228:58-65. 2006..This study also found that perchlorate exposure during this period did not alter any of the reproductive developmental endpoints... - The effects of atrazine metabolites on puberty and thyroid function in the male Wistar ratTammy E Stoker
Gamete and Early Embryo Biology Branch, Reproductive Toxicology Division, National Health and Environmental Effects Research Laboratory, U S Environmental Protection Agency, Research Triangle Park, NC 27711, USA
Toxicol Sci 67:198-206. 2002..These data also suggest that the 3 chlorinated metabolites are similar to ATR, by affecting the CNS control of the pituitary/gonadal axis and subsequent development of the reproductive tract... - Vinclozolin does not alter progesterone receptor (PR) function in vivo despite inhibition of PR binding by its metabolites in vitroS C Laws
Endocrinology Branch, National Health and Environmental Effects Research Laboratory, U S Environmental Protection Agency, Research Triangle Park, North Carolina 27711, USA
Toxicology 112:173-82. 1996..In addition, these studies demonstrate the importance of correlating in vitro receptor binding data with in vivo studies in order to understand the physiological consequences of exposure to environmental toxicants... - Molecular modeling for screening environmental chemicals for estrogenicity: use of the toxicant-target approachJames R Rabinowitz
National Center for Computational Toxicology, U S Environmental Protection Agency, Research Triangle Park, North Carolina, USA
Chem Res Toxicol 22:1594-602. 2009..The advantage of using a pharmacophore filter suggests that the development of filters of this type for other receptors will prove valuable... - Use of the laboratory rat as a model in endocrine disruptor screening and testingL E Gray
Reproductive Toxicology Division, US Environmental Protection Agency, Research Triangle Park, NC, USA
ILAR J 45:425-37. 2004....