Susan C Laws

Summary

Affiliation: U.S. Environmental Protection Agency
Country: USA

Publications

  1. doi request reprint Chlorotriazine herbicides and metabolites activate an ACTH-dependent release of corticosterone in male Wistar rats
    Susan C Laws
    Reproductive Toxicology Division, National Health and Environmental Effects Research Laboratory, Office of Research and Development, U S Environmental Protection Agency, Research Triangle Park, North Carolina 27711, USA
    Toxicol Sci 112:78-87. 2009
  2. ncbi request reprint Effects of altered food intake during pubertal development in male and female wistar rats
    Susan C Laws
    National Health and Environmental Effects Research Laboratory, Office of Research and Development, U S Environmental Protection Agency, Research Triangle Park, North Carolina 27711, USA
    Toxicol Sci 100:194-202. 2007
  3. ncbi request reprint The effects of atrazine on female wistar rats: an evaluation of the protocol for assessing pubertal development and thyroid function
    S C Laws
    National Health and Environmental Effects Research Laboratory, U S Environmental Protection Agency, Research Triangle Park, NC 27711, USA
    Toxicol Sci 58:366-76. 2000
  4. ncbi request reprint Nature of the binding interaction for 50 structurally diverse chemicals with rat estrogen receptors
    Susan C Laws
    Reproductive Toxicology Division, National Health and Environmental Effects Research Laboratory, Office of Research and Development, U S Environmental Protection Agency, Mail drop 72, Research Triangle Park, North Carolina 27711, USA
    Toxicol Sci 94:46-56. 2006
  5. ncbi request reprint Pubertal development in female Wistar rats following exposure to propazine and atrazine biotransformation by-products, diamino-S-chlorotriazine and hydroxyatrazine
    Susan C Laws
    Endocrinology Branch, Reproductive Toxicology Division, National Health and Environmental Effects Research Laboratory, U S Environmental Protection Agency, Research Triangle Park, North Carolina 27711, USA
    Toxicol Sci 76:190-200. 2003
  6. ncbi request reprint Assessment of DE-71, a commercial polybrominated diphenyl ether (PBDE) mixture, in the EDSP male and female pubertal protocols
    Tammy E Stoker
    Reproductive Toxicology Division, National Health and Environmental Effects Research Laboratory, U S Environmental Protection Agency, Research Triangle Park, North Carolina 27711, USA
    Toxicol Sci 78:144-55. 2004
  7. ncbi request reprint Atrazine and reproductive function: mode and mechanism of action studies
    Ralph L Cooper
    Endocrinology Branch, Reproductive Toxicology Division, National Health and Environmental Effects Research Laboratory, United States Environmental Protection Agency, Research Triangle Park, North Carolina 27711, USA
    Birth Defects Res B Dev Reprod Toxicol 80:98-112. 2007
  8. doi request reprint Characterization of the hypothalamic-pituitary-adrenal axis response to atrazine and metabolites in the female rat
    Melanie J P Fraites
    Endocrinology Branch, Reproductive Toxicology Division, National Health and Environmental Effects Research Laboratory, Office of Research and Development, U S Environmental Protection Agency, Research Triangle Park, North Carolina 27711, USA
    Toxicol Sci 112:88-99. 2009
  9. doi request reprint Atrazine does not induce pica behavior at doses that increase hypothalamic-pituitary-adrenal axis activation and cause conditioned taste avoidance
    Michelle Gatien Hotchkiss
    National Health and Environmental Effects Research Laboratory, Office of Research and Development, U S Environmental Protection Agency, Research Triangle Park, NC 27711, USA
    Neurotoxicol Teratol 34:295-302. 2012
  10. ncbi request reprint Xenoendocrine disrupters-tiered screening and testing: filling key data gaps
    L E Gray
    Endocrinology Branch, Reproductive Toxicology Division, National Health Environmental Effects Research Laboratory, ORD, US Environmental Protection Agency, MD 72, Research Triangle Park, NC 27111, USA
    Toxicology 181:371-82. 2002

Detail Information

Publications19

  1. doi request reprint Chlorotriazine herbicides and metabolites activate an ACTH-dependent release of corticosterone in male Wistar rats
    Susan C Laws
    Reproductive Toxicology Division, National Health and Environmental Effects Research Laboratory, Office of Research and Development, U S Environmental Protection Agency, Research Triangle Park, North Carolina 27711, USA
    Toxicol Sci 112:78-87. 2009
    ..Thus, the rapid release of ACTH and subsequent activation of adrenal steroidogenesis following a single exposure to ATR, SIM, PRO, DIA, or DEA may reflect chlorotriazine-induced changes at the level of the brain and/or pituitary...
  2. ncbi request reprint Effects of altered food intake during pubertal development in male and female wistar rats
    Susan C Laws
    National Health and Environmental Effects Research Laboratory, Office of Research and Development, U S Environmental Protection Agency, Research Triangle Park, North Carolina 27711, USA
    Toxicol Sci 100:194-202. 2007
    ....
  3. ncbi request reprint The effects of atrazine on female wistar rats: an evaluation of the protocol for assessing pubertal development and thyroid function
    S C Laws
    National Health and Environmental Effects Research Laboratory, U S Environmental Protection Agency, Research Triangle Park, NC 27711, USA
    Toxicol Sci 58:366-76. 2000
    ..In addition, the effect on estrous cyclicity was observed in the 100 mg/kg ATR group where no significant reduction in bw was observed...
  4. ncbi request reprint Nature of the binding interaction for 50 structurally diverse chemicals with rat estrogen receptors
    Susan C Laws
    Reproductive Toxicology Division, National Health and Environmental Effects Research Laboratory, Office of Research and Development, U S Environmental Protection Agency, Mail drop 72, Research Triangle Park, North Carolina 27711, USA
    Toxicol Sci 94:46-56. 2006
    ..S. EPA's Endocrine Disruptor Screening Program, as well as to support research efforts to develop computational models designed to identify chemicals with the ability to bind to ER...
  5. ncbi request reprint Pubertal development in female Wistar rats following exposure to propazine and atrazine biotransformation by-products, diamino-S-chlorotriazine and hydroxyatrazine
    Susan C Laws
    Endocrinology Branch, Reproductive Toxicology Division, National Health and Environmental Effects Research Laboratory, U S Environmental Protection Agency, Research Triangle Park, North Carolina 27711, USA
    Toxicol Sci 76:190-200. 2003
    ..Together, these data demonstrate that PRO and DACT can delay the onset of puberty in the female rat at doses equimolar to ATR and provide the scientific basis for the use of additivity in the upcoming risk assessments...
  6. ncbi request reprint Assessment of DE-71, a commercial polybrominated diphenyl ether (PBDE) mixture, in the EDSP male and female pubertal protocols
    Tammy E Stoker
    Reproductive Toxicology Division, National Health and Environmental Effects Research Laboratory, U S Environmental Protection Agency, Research Triangle Park, North Carolina 27711, USA
    Toxicol Sci 78:144-55. 2004
    ....
  7. ncbi request reprint Atrazine and reproductive function: mode and mechanism of action studies
    Ralph L Cooper
    Endocrinology Branch, Reproductive Toxicology Division, National Health and Environmental Effects Research Laboratory, United States Environmental Protection Agency, Research Triangle Park, North Carolina 27711, USA
    Birth Defects Res B Dev Reprod Toxicol 80:98-112. 2007
    ..e., the mode of action for mammary tumors); 3) the potential cellular mechanisms involving adverse effects of atrazine; and 4) the range of reproductive alterations associated with this pesticide...
  8. doi request reprint Characterization of the hypothalamic-pituitary-adrenal axis response to atrazine and metabolites in the female rat
    Melanie J P Fraites
    Endocrinology Branch, Reproductive Toxicology Division, National Health and Environmental Effects Research Laboratory, Office of Research and Development, U S Environmental Protection Agency, Research Triangle Park, North Carolina 27711, USA
    Toxicol Sci 112:88-99. 2009
    ..Activation of this endocrine axis by these chlorotriazines could contribute to the induced changes of female reproductive function reported previously...
  9. doi request reprint Atrazine does not induce pica behavior at doses that increase hypothalamic-pituitary-adrenal axis activation and cause conditioned taste avoidance
    Michelle Gatien Hotchkiss
    National Health and Environmental Effects Research Laboratory, Office of Research and Development, U S Environmental Protection Agency, Research Triangle Park, NC 27711, USA
    Neurotoxicol Teratol 34:295-302. 2012
    ....
  10. ncbi request reprint Xenoendocrine disrupters-tiered screening and testing: filling key data gaps
    L E Gray
    Endocrinology Branch, Reproductive Toxicology Division, National Health Environmental Effects Research Laboratory, ORD, US Environmental Protection Agency, MD 72, Research Triangle Park, NC 27111, USA
    Toxicology 181:371-82. 2002
    ..Tier 1 and 2 also should examine relevant mixtures of EDCs. Toxicants that induce malformations in AR-dependent tissues produce cumulative effects even when two chemicals act via different mechanisms of action...
  11. ncbi request reprint Ligand-based identification of environmental estrogens
    C L Waller
    Experimental Toxicology Divisions, United States Environmental Protection Agency, Research Triangle Park, North Carolina 27711, USA
    Chem Res Toxicol 9:1240-8. 1996
    ..The general application of this 3D-QSAR model within a toxicological framework is, at present, limited only by the quantity and quality of biological data for relevant biomarkers of toxicity and hormonal responsiveness...
  12. ncbi request reprint Prepubertal exposure to compounds that increase prolactin secretion in the male rat: effects on the adult prostate
    T E Stoker
    Endocrinology Branch, Reproductive Toxicology Division, National Health and Environmental Effects Research Laboratory, U S Environmental Protection Agency, Research Triangle Park, North Carolina 27711, USA
    Biol Reprod 61:1636-43. 1999
    ..This study demonstrates that prepubertal exposures to compounds that increase PRL secretion, albeit through different mechanisms, can increase the incidence of lateral prostate inflammation in the adult...
  13. ncbi request reprint Estrogenic activity of octylphenol, nonylphenol, bisphenol A and methoxychlor in rats
    S C Laws
    Endocrinology Branch, Reproductive Toxicology Division, U S Environmental Protection Agency, Research Triangle Park, North Carolina 27711, USA
    Toxicol Sci 54:154-67. 2000
    ..These data can be useful during the assessment and validation of methods for screening environmental chemicals for endocrine disrupting activity...
  14. ncbi request reprint Assessment of estrogenicity by using the delayed implanting rat model and examples
    A M Cummings
    Reproductive Toxicology Division, National Health and Environmental Effects Research Laboratory, U S Environmental Protection Agency, Research Triangle Park, NC 27711, USA
    Reprod Toxicol 14:111-7. 2000
    ..These data confirm previous evidence of the availability of this model for evaluating estrogenic activity and provide estimates of the estrogenic potencies of several environmentally important chemicals...
  15. ncbi request reprint Evaluation of ammonium perchlorate in the endocrine disruptor screening and testing program's male pubertal protocol: ability to detect effects on thyroid endpoints
    T E Stoker
    Endocrinology Branch, Reproductive Toxicology Division, NHEERL, Office of Research and Development, United States Environmental Protection Agency, Research Triangle Park, NC 27711, USA
    Toxicology 228:58-65. 2006
    ..This study also found that perchlorate exposure during this period did not alter any of the reproductive developmental endpoints...
  16. ncbi request reprint The effects of atrazine metabolites on puberty and thyroid function in the male Wistar rat
    Tammy E Stoker
    Gamete and Early Embryo Biology Branch, Reproductive Toxicology Division, National Health and Environmental Effects Research Laboratory, U S Environmental Protection Agency, Research Triangle Park, NC 27711, USA
    Toxicol Sci 67:198-206. 2002
    ..These data also suggest that the 3 chlorinated metabolites are similar to ATR, by affecting the CNS control of the pituitary/gonadal axis and subsequent development of the reproductive tract...
  17. ncbi request reprint Vinclozolin does not alter progesterone receptor (PR) function in vivo despite inhibition of PR binding by its metabolites in vitro
    S C Laws
    Endocrinology Branch, National Health and Environmental Effects Research Laboratory, U S Environmental Protection Agency, Research Triangle Park, North Carolina 27711, USA
    Toxicology 112:173-82. 1996
    ..In addition, these studies demonstrate the importance of correlating in vitro receptor binding data with in vivo studies in order to understand the physiological consequences of exposure to environmental toxicants...
  18. doi request reprint Molecular modeling for screening environmental chemicals for estrogenicity: use of the toxicant-target approach
    James R Rabinowitz
    National Center for Computational Toxicology, U S Environmental Protection Agency, Research Triangle Park, North Carolina, USA
    Chem Res Toxicol 22:1594-602. 2009
    ..The advantage of using a pharmacophore filter suggests that the development of filters of this type for other receptors will prove valuable...
  19. ncbi request reprint Use of the laboratory rat as a model in endocrine disruptor screening and testing
    L E Gray
    Reproductive Toxicology Division, US Environmental Protection Agency, Research Triangle Park, NC, USA
    ILAR J 45:425-37. 2004
    ....