C Lau

Summary

Affiliation: U.S. Environmental Protection Agency
Country: USA

Publications

  1. doi request reprint Perfluorinated compounds
    Christopher Lau
    Toxicity Assessment Division, National Health and Environment Effects Research Laboratory, Office of Research and Development, U S Environmental Protection Agency, Research Triangle Park, NC, 27711, USA
    EXS 101:47-86. 2012
  2. ncbi request reprint Embryonic and fetal programming of physiological disorders in adulthood
    Christopher Lau
    Reproductive Toxicology Division, National Health and Environmental Effects Research Laboratory, Office of Research and Development, U S Environmental Protection Agency, Research Triangle Park, North Carolina 27711, USA
    Birth Defects Res C Embryo Today 72:300-12. 2004
  3. ncbi request reprint Exposure to perfluorooctane sulfonate during pregnancy in rat and mouse. II: postnatal evaluation
    Christopher Lau
    Reproductive Toxicology Division, National Health and Environmental Effects Research Laboratory, Office of Research and Development, U S Environmental Protection Agency, Research Triangle Park, North Carolina 27711, USA
    Toxicol Sci 74:382-92. 2003
  4. ncbi request reprint Effects of perfluorooctanoic acid exposure during pregnancy in the mouse
    Christopher Lau
    Reproductive Toxicology Division, National Health and Environmental Effects Research Laboratory, U S Environmental Protection Agency, Research Triangle Park, North Carolina 27711, USA
    Toxicol Sci 90:510-8. 2006
  5. ncbi request reprint Exposure-disease continuum for 2-chloro-2'-deoxyadenosine (2-CdA), a prototype teratogen: induction of lumbar hernia in the rat and species comparison for the teratogenic responses
    Christopher Lau
    Reproductive Toxicology Division, NHEERL, ORD, US Environmental Protection Agency, Research Triangle Park, North Carolina 27711, USA
    Teratology 66:6-18. 2002
  6. ncbi request reprint Toward a biologically based dose-response model for developmental toxicity of 5-fluorouracil in the rat: acquisition of experimental data
    C Lau
    Reproductive Toxicology Division and Experimental Toxicology Division, National Health and Environmental Effects Research Laboratory, U S Environmental Protection Agency, Research Triangle Park, North Carolina 27711, USA
    Toxicol Sci 59:37-48. 2001
  7. ncbi request reprint The developmental toxicity of perfluoroalkyl acids and their derivatives
    Christopher Lau
    Reproductive Toxicology Division, National Health and Environmental Effects Research Laboratory, Office of Research and Development, U S Environmental Protection Agency, Research Triangle Park, NC 27711, USA
    Toxicol Appl Pharmacol 198:231-41. 2004
  8. ncbi request reprint Toward a biologically based dose-response model for developmental toxicity of 5-fluorouracil in the rat: a mathematical construct
    R W Setzer
    Experimental Toxicology Division and Reproductive Toxicology Division, Office of Research and Development, U S Environmental Protection Agency, Research Triangle Park, North Carolina 27711, USA
    Toxicol Sci 59:49-58. 2001
  9. ncbi request reprint Exposure to perfluorooctane sulfonate during pregnancy in rat and mouse. I: maternal and prenatal evaluations
    Julie R Thibodeaux
    Reproductive Toxicology Division, National Health and Environmental Effects Research Laboratory, Office of Research and Development, U S Environmental Protection Agency, Research Triangle Park, North Carolina 27711, USA
    Toxicol Sci 74:369-81. 2003
  10. doi request reprint Toxicogenomic dissection of the perfluorooctanoic acid transcript profile in mouse liver: evidence for the involvement of nuclear receptors PPAR alpha and CAR
    Mitchell B Rosen
    NHEERL ORD, U S EPA, Research Triangle Park, North Carolina 27711, USA
    Toxicol Sci 103:46-56. 2008

Collaborators

Detail Information

Publications36

  1. doi request reprint Perfluorinated compounds
    Christopher Lau
    Toxicity Assessment Division, National Health and Environment Effects Research Laboratory, Office of Research and Development, U S Environmental Protection Agency, Research Triangle Park, NC, 27711, USA
    EXS 101:47-86. 2012
    ....
  2. ncbi request reprint Embryonic and fetal programming of physiological disorders in adulthood
    Christopher Lau
    Reproductive Toxicology Division, National Health and Environmental Effects Research Laboratory, Office of Research and Development, U S Environmental Protection Agency, Research Triangle Park, North Carolina 27711, USA
    Birth Defects Res C Embryo Today 72:300-12. 2004
    ..This article provides an overview of the Barker hypothesis, its supporting evidence, the current advances in understanding the biological mechanisms underlying this phenomenon, and its implications for developmental toxicology...
  3. ncbi request reprint Exposure to perfluorooctane sulfonate during pregnancy in rat and mouse. II: postnatal evaluation
    Christopher Lau
    Reproductive Toxicology Division, National Health and Environmental Effects Research Laboratory, Office of Research and Development, U S Environmental Protection Agency, Research Triangle Park, North Carolina 27711, USA
    Toxicol Sci 74:382-92. 2003
    ..These results indicate that in utero exposure to PFOS severely compromised postnatal survival of neonatal rats and mice, and caused delays in growth and development that were accompanied by hypothyroxinemia in the surviving rat pups...
  4. ncbi request reprint Effects of perfluorooctanoic acid exposure during pregnancy in the mouse
    Christopher Lau
    Reproductive Toxicology Division, National Health and Environmental Effects Research Laboratory, U S Environmental Protection Agency, Research Triangle Park, North Carolina 27711, USA
    Toxicol Sci 90:510-8. 2006
    ..These data indicate maternal and developmental toxicity of PFOA in the mouse, leading to early pregnancy loss, compromised postnatal survival, delays in general growth and development, and sex-specific alterations in pubertal maturation...
  5. ncbi request reprint Exposure-disease continuum for 2-chloro-2'-deoxyadenosine (2-CdA), a prototype teratogen: induction of lumbar hernia in the rat and species comparison for the teratogenic responses
    Christopher Lau
    Reproductive Toxicology Division, NHEERL, ORD, US Environmental Protection Agency, Research Triangle Park, North Carolina 27711, USA
    Teratology 66:6-18. 2002
    ..The current study examined the teratogenic potential of this drug in the rat and compared the adverse developmental outcomes with the other species...
  6. ncbi request reprint Toward a biologically based dose-response model for developmental toxicity of 5-fluorouracil in the rat: acquisition of experimental data
    C Lau
    Reproductive Toxicology Division and Experimental Toxicology Division, National Health and Environmental Effects Research Laboratory, U S Environmental Protection Agency, Research Triangle Park, North Carolina 27711, USA
    Toxicol Sci 59:37-48. 2001
    ..Such quantitative models should be instrumental to the improvement of high-to-low dose and cross-species extrapolation in health-risk assessment...
  7. ncbi request reprint The developmental toxicity of perfluoroalkyl acids and their derivatives
    Christopher Lau
    Reproductive Toxicology Division, National Health and Environmental Effects Research Laboratory, Office of Research and Development, U S Environmental Protection Agency, Research Triangle Park, NC 27711, USA
    Toxicol Appl Pharmacol 198:231-41. 2004
    ..Based on current understanding of the developmental effects of PFOS and PFOA in rodents, several avenues of research are suggested that would further support the risk assessment of these perfluorinated organic chemicals...
  8. ncbi request reprint Toward a biologically based dose-response model for developmental toxicity of 5-fluorouracil in the rat: a mathematical construct
    R W Setzer
    Experimental Toxicology Division and Reproductive Toxicology Division, Office of Research and Development, U S Environmental Protection Agency, Research Triangle Park, North Carolina 27711, USA
    Toxicol Sci 59:49-58. 2001
    ....
  9. ncbi request reprint Exposure to perfluorooctane sulfonate during pregnancy in rat and mouse. I: maternal and prenatal evaluations
    Julie R Thibodeaux
    Reproductive Toxicology Division, National Health and Environmental Effects Research Laboratory, Office of Research and Development, U S Environmental Protection Agency, Research Triangle Park, North Carolina 27711, USA
    Toxicol Sci 74:369-81. 2003
    ..Our results demonstrate both maternal and developmental toxicity of PFOS in the rat and mouse...
  10. doi request reprint Toxicogenomic dissection of the perfluorooctanoic acid transcript profile in mouse liver: evidence for the involvement of nuclear receptors PPAR alpha and CAR
    Mitchell B Rosen
    NHEERL ORD, U S EPA, Research Triangle Park, North Carolina 27711, USA
    Toxicol Sci 103:46-56. 2008
    ..These results indicate that PFOA alters most genes in wild-type mouse liver through PPAR alpha, but that a subset of genes are regulated by CAR and possibly PPAR gamma in the PPAR alpha-null mouse...
  11. ncbi request reprint Nucleoside-mediated mitigation of 5-fluorouracil-induced toxicity in synchronized murine erythroleukemic cells
    K H Elstein
    National Health and Environmental Effects Research Laboratory, U S Environmental Protection Agency, Research Triangle Park, North Carolina 27711, USA
    Toxicol Appl Pharmacol 146:29-39. 1997
    ....
  12. doi request reprint Effects of perfluorobutyrate exposure during pregnancy in the mouse
    Kaberi P Das
    Reproductive Toxicology Division, National Health and Environmental Effects Research Laboratory, Office of Research and Development, U S Environmental Protection Agency, Research Triangle Park, North Carolina 27711, USA
    Toxicol Sci 105:173-81. 2008
    ..These data suggest that exposure to PFBA during pregnancy in the mouse did not produce developmental toxicity comparable to that observed with PFOA, in part, due to rapid elimination of the chemical...
  13. ncbi request reprint Perfluoroalkyl acids and related chemistries--toxicokinetics and modes of action
    Melvin E Andersen
    The Hamner Institutes for Health Sciences, Research Triangle Park, North Carolina 27709, USA
    Toxicol Sci 102:3-14. 2008
    ..This report summarizes the discourse that occurred during the symposium...
  14. doi request reprint Gene expression profiling in the liver and lung of perfluorooctane sulfonate-exposed mouse fetuses: comparison to changes induced by exposure to perfluorooctanoic acid
    Mitchell B Rosen
    U S Environmental Protection Agency, Office of Research and Development, National Health and Environmental Effects Research Laboratory, Reproductive Toxicology Division, Research Triangle Park, NC 27711, USA
    Reprod Toxicol 27:278-88. 2009
    ....
  15. doi request reprint Developmental toxicity of perfluorooctane sulfonate (PFOS) is not dependent on expression of peroxisome proliferator activated receptor-alpha (PPAR alpha) in the mouse
    Barbara D Abbott
    Reproductive Toxicology Division, National Health and Environmental Effects Research Laboratory, Office of Research and Development, US Environmental Protection Agency, Research Triangle Park, NC 27711, USA
    Reprod Toxicol 27:258-65. 2009
    ..Because results in WT and KO were comparable, it is concluded that PFOS-induced neonatal lethality and delayed eye opening are not dependent on activation of PPAR alpha...
  16. doi request reprint Phenotypic dichotomy following developmental exposure to perfluorooctanoic acid (PFOA) in female CD-1 mice: Low doses induce elevated serum leptin and insulin, and overweight in mid-life
    Erin P Hines
    U S Environmental Protection Agency, Research Triangle Park, NC 27711, United States
    Mol Cell Endocrinol 304:97-105. 2009
    ..01mg PFOA/kg BW. The mode of action of these effects and its relevance to human health remain to be explored...
  17. doi request reprint Comparative hepatic effects of perfluorooctanoic acid and WY 14,643 in PPAR-alpha knockout and wild-type mice
    Douglas C Wolf
    Environmental Carcinogenesis Division, US Environmental Protection Agency, Research Triangle Park, North Carolina 27711, USA
    Toxicol Pathol 36:632-9. 2008
    ..These data suggest that PPAR-alpha is required for WY- and PFOA-induced cellular alterations in WT mouse liver. Hepatic enlargement observed in KO mice may be due to an accumulation of cytoplasmic vacuoles that contain PFOA...
  18. doi request reprint Gene profiling in the livers of wild-type and PPARalpha-null mice exposed to perfluorooctanoic acid
    Mitchell B Rosen
    Office of Research and Development, National Health and Environmental Effects Research Laboratory, Reproductive Toxicology Division, U S Environmental Protection Agency, Research Triangle Park, North Carolina 27711, USA
    Toxicol Pathol 36:592-607. 2008
    ....
  19. ncbi request reprint Does exposure to perfluoroalkyl acids present a risk to human health?
    Mitchell B Rosen
    Integrated Systems Toxicology Division, National Health and Environmental Effects Research Laboratory, Office of Research and Development, US Environmental Protection Agency, Research Triangle Park, North Carolina 27711, USA
    Toxicol Sci 111:1-3. 2009
  20. doi request reprint Activation of mouse and human peroxisome proliferator-activated receptor alpha by perfluoroalkyl acids of different functional groups and chain lengths
    Cynthia J Wolf
    Reproductive Toxicology Division, National Health and Environmental Effects Research Laboratory, Office of Research and Development, US Environmental Protection Agency, Research Triangle Park, North Carolina 27711, USA
    Toxicol Sci 106:162-71. 2008
    ....
  21. ncbi request reprint Perfluorooctanoic acid induced developmental toxicity in the mouse is dependent on expression of peroxisome proliferator activated receptor-alpha
    Barbara D Abbott
    Reproductive Toxicology Division, National Health and Environmental Effects Research Laboratory, US Environmental Protection Agency, 2525 East Highway 54, Durham, NC 27713, USA
    Toxicol Sci 98:571-81. 2007
    ..PPARalpha was required for PFOA-induced postnatal lethality and expression of one copy of the gene was sufficient to mediate this effect...
  22. ncbi request reprint Gene expression profiling in the lung and liver of PFOA-exposed mouse fetuses
    Mitchell B Rosen
    Reproductive Toxicology Division, National Health and Environmental Effects Research Laboratory, Office of Research and Development, US Environmental Protection Agency, Research Triangle Park, NC 27711, USA
    Toxicology 239:15-33. 2007
    ..Additional studies will be needed to more thoroughly address the role of PPARalpha, and other nuclear receptors, in PFOA mediated developmental toxicity...
  23. ncbi request reprint Toxicogenomic study of triazole fungicides and perfluoroalkyl acids in rat livers predicts toxicity and categorizes chemicals based on mechanisms of toxicity
    Matthew T Martin
    National Center for Computational Toxicology, US Environmental Protection Agency, Research Triangle Park, NC 27711, USA
    Toxicol Sci 97:595-613. 2007
    ..The concordance of in vivo observations and gene expression findings demonstrated the ability of genomics to accurately categorize chemicals, identify toxic mechanisms of action, and predict subsequent pathological responses...
  24. ncbi request reprint Perinatal exposure to polychlorinated biphenyls Aroclor 1016 or 1254 did not alter brain catecholamines nor delayed alternation performance in Long-Evans rats
    E A Zahalka
    Toxicology Curriculum, University of North Carolina, Chapel Hill, NC, USA
    Brain Res Bull 55:487-500. 2001
    ..These results indicated that development of central noradrenergic neurons was compromised by perinatal exposure to A-1254 but not A-1016, and both PCB mixtures failed to alter behavioral performances...
  25. ncbi request reprint Sample preparation and high-performance liquid chromatographic analysis of deoxyribonucleoside triphosphates in individual rat embryos
    M L Mole
    National Health and Environmental Effects Research Laboratory, United States Environmental Protection Agency, Research Triangle Park, North Carolina 27711, USA
    Anal Biochem 259:245-52. 1998
    ..The method has also been applied successfully to analysis of murine erythroleukemic cell cultures and this, when coupled with the embryo results, suggests its general utility...
  26. ncbi request reprint Lack of evidence for intergenerational reproductive effects due to prenatal and postnatal undernutrition in the female CD-1 mouse
    E H Rogers
    US Environmental Protection Agency, NHEERL, RTD, Research Triangle Park, NC 27711, USA
    Reprod Toxicol 17:519-25. 2003
    ..We conclude that body weight at birth in the CD-1 mouse is not correlated with growth through the period of weaning (PD28). We did not find any evidence for an intergenerational reproductive effect after developmental undernutrition...
  27. doi request reprint Modeling single and repeated dose pharmacokinetics of PFOA in mice
    Inchio Lou
    National Center for Computational Toxicology, US Environmental Protection Agency, Research Triangle Park, North Carolina 27711, USA
    Toxicol Sci 107:331-41. 2009
    ..These data and modeling analyses more fully characterize PFOA in mice for purposes of estimating internal exposure for use in risk assessment...
  28. ncbi request reprint Perfluoroalkyl acids: a review of monitoring and toxicological findings
    Christopher Lau
    Reproductive Toxicology Division, National Health and Environmental Effects Research Laboratory, Office of Research and Development, U S Environmental Protection Agency, Research Triangle Park, North Carolina 27711, USA
    Toxicol Sci 99:366-94. 2007
    ..Several avenues of research are proposed that would further our understanding of this class of compounds...
  29. ncbi request reprint Nutritional influences on adrenal chromaffin cell development: comparison with central neurons
    C Lau
    Northrop Environmental Sciences, Research Triangle Park, NC 27711
    Pediatr Res 24:583-7. 1988
    ..abstract truncated at 250 words)..
  30. doi request reprint Perfluorooctane sulfonate-induced changes in fetal rat liver gene expression
    James A Bjork
    Department of Biochemistry and Molecular Biology, University of Minnesota Medical School, 1035 University Drive, Duluth, MN 55812, USA
    Toxicology 251:8-20. 2008
    ....
  31. pmc Exploration and visualization of gene expression with neuroanatomy in the adult mouse brain
    Christopher Lau
    Allen Institute for Brain Science, Seattle, WA, USA
    BMC Bioinformatics 9:153. 2008
    ....
  32. ncbi request reprint Thyroid hormone status and pituitary function in adult rats given oral doses of perfluorooctanesulfonate (PFOS)
    Shu Ching Chang
    Medical Department, 3M Company, St Paul, MN 55144, United States
    Toxicology 243:330-9. 2008
    ..We undertook this study to investigate the causes for the PFOS-induced reduction of serum total thyroxine (TT4) in rats...
  33. ncbi request reprint Inhibition of gap junctional intercellular communication by perfluorinated compounds in rat liver and dolphin kidney epithelial cell lines in vitro and Sprague-Dawley rats in vivo
    Wenyue Hu
    Aquatic Toxicology Laboratory, Department of Zoology, National Food Safety and Toxicology Center and Institute of Environmental Toxicology, Michigan State University, East Lansing, Michigan 48824, USA
    Toxicol Sci 68:429-36. 2002
    ....
  34. ncbi request reprint Genome-wide atlas of gene expression in the adult mouse brain
    Ed S Lein
    Allen Institute for Brain Science, Seattle, Washington 98103, USA
    Nature 445:168-76. 2007
    ..This highly standardized atlas provides an open, primary data resource for a wide variety of further studies concerning brain organization and function...
  35. doi request reprint Comparative pharmacokinetics of perfluorobutyrate in rats, mice, monkeys, and humans and relevance to human exposure via drinking water
    Shu Ching Chang
    Medical Department, 3M Company, St Paul, Minnesota 55144, USA
    Toxicol Sci 104:40-53. 2008
    ..These findings demonstrate that PFBA is eliminated efficiently from serum with a low potential for accumulation from repeated exposure...
  36. pmc Targeted discovery of novel human exons by comparative genomics
    Adam Siepel
    Department of Biological Statistics and Computational Biology, Cornell University, Ithaca, New York 14853, USA
    Genome Res 17:1763-73. 2007
    ..However, they suggest that hundreds-not thousands-of protein-coding genes are completely missing from the current gene catalogs...