Research Topics
Species | U P KodavantiSummaryAffiliation: U.S. Environmental Protection Agency Country: USA Publications
| Collaborators
|
Detail Information
Publications
Consistent pulmonary and systemic responses from inhalation of fine concentrated ambient particles: roles of rat strains used and physicochemical propertiesUrmila P Kodavanti
Pulmonary Toxicology Branch, Experimental Toxicology Division, Office of Research and Development, U S Environmental Protection Agency, Research Triangle Park, North Carolina 27711, USA
Environ Health Perspect 113:1561-8. 2005..Biologic effects were evident in those six studies. These studies demonstrate a pattern of rat strain-specific pulmonary and systemic effects that are not linked to high mass but appear to be dependent on CAP chemical composition...- The role of particulate matter-associated zinc in cardiac injury in ratsUrmila P Kodavanti
National Health and Environmental Effects Research Laboratory, Office of Research and Development, U S Environmental Protection Agency, Research Triangle Park, NC 27710, USA
Environ Health Perspect 116:13-20. 2008..Exposure to particulate matter (PM) has been associated with increased cardiovascular morbidity; however, causative components are unknown. Zinc is a major element detected at high levels in urban air... 
Cardiopulmonary responses of intratracheally instilled tire particles and constituent metal componentsReddy R Gottipolu
National Research Council, National Health and Environmental Effects Research Laboratory, U S Environmental Protection Agency, Research Triangle Park, North Carolina, USA
Inhal Toxicol 20:473-84. 2008..The observed acute pulmonary toxicity of TP could be due to the presence of water soluble Zn and Cu. At high concentrations these metals may induce cardiac oxidative stress...
Diesel exhaust induced pulmonary and cardiovascular impairment: the role of hypertension interventionUrmila P Kodavanti
Environmental Public Health Division, National Health and Environmental Effects Research Laboratory NHEERL, Office of Research and Development ORD, U S Environmental Protection Agency EPA, Research Triangle Park, NC 27711, USA
Toxicol Appl Pharmacol 268:232-40. 2013..ET-1 was decreased by HYD. In conclusion, antihypertensive drug treatment reduces gas and DE-induced pulmonary protein leakage and expression of vascular atherogenic markers...- The spontaneously hypertensive rat: an experimental model of sulfur dioxide-induced airways diseaseUrmila P Kodavanti
Experimental Toxicology Division, National Health and Environmental Effects Research Laboratory, Office of Research and Development, U S Environmental Protection Agency, Research Triangle Park, North Carolina, 27711, USA
Toxicol Sci 94:193-205. 2006..SO(2) effects on these genes were more pronounced in SH than in SD rats. Thus, SO(2) exposure in SH rats may yield a relevant experimental model of bronchitis... - Inhaled environmental combustion particles cause myocardial injury in the Wistar Kyoto ratUrmila P Kodavanti
Experimental Toxicology Division, National Health and Environmental Effects Research Laboratory, Office of Research and Development, U S Environmental Protection Agency, Research Triangle Park, North Carolina 27709, USA
Toxicol Sci 71:237-45. 2003..These findings provide supportive evidence for the epidemiological associations of cardiovascular morbidity and ambient PM... - Temporal association between pulmonary and systemic effects of particulate matter in healthy and cardiovascular compromised ratsUrmila P Kodavanti
Experimental Toxicology Division, National Health and Environmental Effects Research Laboratory, Office of Research and Development, U S Environmental Protection Agency, Research Triangle Park, North Carolina 27711, USA
J Toxicol Environ Health A 65:1545-69. 2002..This evidence is consistent with greater cardiovascular events during acute PM episodes in compromised humans... - Pulmonary and systemic effects of zinc-containing emission particles in three rat strains: multiple exposure scenariosUrmila P Kodavanti
Pulmonary Toxicology Branch, Experimental Toxicology Division, National Health and Environmental Effects Research Laboratory, US Environmental Protection Agency, Research Triangle Park, North Carolina 27711, USA
Toxicol Sci 70:73-85. 2002..Inhalation exposures may result in particle accumulation and macrophage recruitment with potential strain differences in EPM clearance... - Vascular and cardiac impairments in rats inhaling ozone and diesel exhaust particlesUrmila P Kodavanti
Environmental Public Health Division, National Health and Environmental Effects Research Laboratory, Office of Research and Development, U S Environmental Protection Agency, Research Triangle Park, North Carolina 27709, USA
Environ Health Perspect 119:312-8. 2011..Mechanisms of cardiovascular injuries from exposure to gas and particulate air pollutants are unknown... - Rodent models of susceptibility: what is their place in inhalation toxicology?U P Kodavanti
Pulmonary Toxicology Branch, MD 82, Experimental Toxicology Division, National Health and Environmental Effects Research Laboratory, US Environmental Protection Agency, Research Triangle Park, NC 27711, USA
Respir Physiol 128:57-70. 2001..As existing models gain wider use, our understanding of the models will improve and encourage refinements/development of models that integrate both genetic and environmental factors to better mimic the human condition... - Acute lung injury from intratracheal exposure to fugitive residual oil fly ash and its constituent metals in normo- and spontaneously hypertensive ratsU P Kodavanti
Pulmonary Toxicology Branch, MD 82, Experimental Toxicology Division, National Health and Environmental Effects Research Laboratory, U S Environmental Protection Agency, Research Triangle Park, NC 27711, USA
Inhal Toxicol 13:37-54. 2001..The metallic constituents of ROFA produced these effects in a strain-specific manner such that, at the dose level used, V caused pulmonary injury only in WKY rats, whereas Ni was toxic to both strains... - Variable pulmonary responses from exposure to concentrated ambient air particles in a rat model of bronchitisU P Kodavanti
Pulmonary Toxicology Branch, Experimental Toxicology Division, National Health and Environmental Effects Research Laboratory, US Environmental Protection Agency, Research Triangle Park, North Carolina, USA
Toxicol Sci 54:441-51. 2000..Additionally, potential variability in pathology of induced bronchitis or other lung disease may decrease the ability to distinguish toxic injury due to PM... - Cardiopulmonary responses of Wistar Kyoto, spontaneously hypertensive, and stroke-prone spontaneously hypertensive rats to particulate matter (PM) exposureJ Grace Wallenborn
Department of Environmental Sciences and Engineering, University of North Carolina School of Public Health, Chapel Hill, North Carolina, USA
J Toxicol Environ Health A 70:1912-22. 2007..Preexisting cardiovascular disease may influence susceptibility to PM pulmonary and cardiac health effects in a disease-specific manner... - Vascular and thrombogenic effects of pulmonary exposure to Libby amphiboleJ H Shannahan
Curriculum in Toxicology, UNC School of Medicine, Chapel Hill, North Carolina, USA
J Toxicol Environ Health A 75:213-31. 2012..These changes were similar to those noted at baseline in SH and SHHF rats, suggesting that LA-induced pulmonary injury might increase the risk of developing cardiovascular disease in healthy individuals... - Lung injury from intratracheal and inhalation exposures to residual oil fly ash in a rat model of monocrotaline-induced pulmonary hypertensionU P Kodavanti
Pulmonary Toxicology Branch, Experimental Toxicology Division, National Health and Environmental Effects Research Laboratory, U S Environmental Protection Agency, Research Triangle Park, North Carolina 27711, USA
J Toxicol Environ Health A 57:543-63. 1999..In summary, only the bolus IT ROFA caused mortality in the rat model of lung injury/hypertension. Exacerbation of histological lesions and cytokine mRNA expression were most reflective of increased ROFA susceptibility in this model... - Systemic imbalance of essential metals and cardiac gene expression in rats following acute pulmonary zinc exposurePeter S Gilmour
Center for Environmental Medicine, Asthma and Lung Biology, School of Medicine, University of North Carolina, Chapel Hill, North Carolina, USA
J Toxicol Environ Health A 69:2011-32. 2006..Imbalance of systemic metal homeostasis as a result of pulmonary zinc exposure may underlie the cause of extrapulmonary effects... - Long-term response of rats to single intratracheal exposure of Libby amphibole or amositeJ M Cyphert
Curriculum in Toxicology, University of North Carolina School of Medicine, Chapel Hill, North Carolina, USA
J Toxicol Environ Health A 75:183-200. 2012..Data showed that LA was on a mass basis less potent than amosite... - Rodent models of cardiopulmonary disease: their potential applicability in studies of air pollutant susceptibilityU P Kodavanti
National Health and Environmental Effects Research Laboratory, U S Environmental Protection Agency, Research Triangle Park, NC 27711, USA
Environ Health Perspect 106:111-30. 1998.... - A pulmonary rat gene array for screening altered expression profiles in air pollutant-induced lung injuryS S Nadadur
Pulmonary Toxicology Branch, National Health and Environmental Effects Research Laboratory, U S Environmental Protection Agency, MD 82, Research Triangle Park, NC 27711, USA
Inhal Toxicol 12:1239-54. 2000..Developing a pulmonary rat gene array may provide a tool for screening the expression profile of tissue specific markers following exposure to toxic air contaminants... - Susceptibility of adult and senescent Brown Norway rats to repeated ozone exposure: an assessment of behavior, serum biochemistry and cardiopulmonary functionC J Gordon
Toxicity Assessment Division, National Health and Environmental Effects Research Laboratory, U S Environmental Protection Agency, Research Triangle Park, NC 27711, USA
Inhal Toxicol 25:141-59. 2013..Overall, adult rats exhibited more immediate effects of episodic O₃ than senescent rats. Residual effects were, however, obtained in both ages of rat, especially for ventilatory endpoints... - Exposure to ultrafine carbon particles at levels below detectable pulmonary inflammation affects cardiovascular performance in spontaneously hypertensive ratsSwapna Upadhyay
EPA NHEERL, Research Triangle Park, NC 27709, USA
Part Fibre Toxicol 5:19. 2008..abstract:.. - Aging and susceptibility to toluene in rats: a pharmacokinetic, biomarker, and physiological approachChristopher J Gordon
National Health and Environmental Effects Research Laboratory, ORD, U S Environmental Protection Agency, Research Triangle Park, North Carolina, USA
J Toxicol Environ Health A 73:301-18. 2010..The expression of several cardiac biochemical markers of toluene exposure in the aged may also reflect differential susceptibility to this toxicant... - Influence of acid functionalization on the cardiopulmonary toxicity of carbon nanotubes and carbon black particles in miceHaiyan Tong
Human Studies Division, National Health and Environmental Effects Research Laboratory, US Environmental Protection Agency, Research Triangle Park, NC 27711, USA
Toxicol Appl Pharmacol 239:224-32. 2009..Further experiments are needed to understand the physico-chemical processes involved in this phenomenon... - One-month diesel exhaust inhalation produces hypertensive gene expression pattern in healthy ratsReddy R Gottipolu
Experimental Toxicology Division, National Health and Environmental Effects Research Laboratory, Office of Research and Development, U S Environmental Protection Agency, Research Triangle Park, North Carolina, USA
Environ Health Perspect 117:38-46. 2009..Exposure to diesel exhaust (DE) is linked to vasoconstriction, endothelial dysfunction, and myocardial ischemia in compromised individuals... - Systemic translocation of (70)zinc: kinetics following intratracheal instillation in ratsJ Grace Wallenborn
Department of Environmental Sciences and Engineering, UNC School of Public Health, Chapel Hill, NC 27599, USA
Toxicol Appl Pharmacol 234:25-32. 2009..Our data suggests that following pulmonary exposure, zinc accumulation and subsequent changes in normal metal homeostasis in the heart and other organs could induce cardiovascular injury... - Subchronic inhalation of zinc sulfate induces cardiac changes in healthy ratsJ Grace Wallenborn
Department of Environmental Sciences and Engineering, UNC School of Public Health, Chapel Hill, NC 27599, USA
Toxicol Appl Pharmacol 232:69-77. 2008..These data indicate that inhalation of zinc at environmentally relevant levels induces cardiac effects. While changes are small in healthy rats, these may be especially relevant in individuals with pre-existent cardiovascular disease... - Altered gene expression profiles of rat lung in response to an emission particulate and its metal constituentsSrikanth S Nadadur
Pulmonary Toxicology Branch, ETD, NHEERL, ORD, U S Environmental Protection Agency, Research Triangle Park, North Carolina 27711, USA
J Toxicol Environ Health A 65:1333-50. 2002..Expression profiling using genomic approaches will aid in our understanding of toxicant-specific altered molecular pathways in lung injury and pathogenesis... - Cardiac and thermoregulatory effects of instilled particulate matter-associated transition metals in healthy and cardiopulmonary-compromised ratsMatthew J Campen
Department of Environmental Sciences and Engineering, School of Public Health, University of North Carolina, Chapel Hill, North Carolina, USA
J Toxicol Environ Health A 65:1615-31. 2002..These data suggest that the biphasic response to instilled ROFA may result from a summation of the temporally different effects of V and Ni... - Toxic responses of the lung to inhaled pollutants: benefits and limitations of lung-disease modelsDaniel L Costa
Pulmonary Toxicology Branch, MD 82, Experimental Toxicology Division, National Health and Environmental Effects Research Laboratory, US Environmental Protection Agency, Research Triangle Park, NC 27711, USA
Toxicol Lett 140:195-203. 2003..No model should be used without careful consideration of its strengths and limitations. However, when interpreted in the context of field and epidemiology findings, they may reveal generic susceptibility attributes or useful biomarkers... - Pulmonary gene expression profiles of spontaneously hypertensive rats exposed to environmental tobacco smokeSrikanth S Nadadur
Pulmonary Toxicology Branch, National Health and Environmental Effects Research Laboratory, Office of Research and Development, United States Environmental Protection Agency, Research Triangle Park, NC 27711, USA
Chest 121:83S-84S. 2002 - Hypertensive rats are susceptible to TLR4-mediated signaling following exposure to combustion source particulate matterPeter S Gilmour
Center for Environmental Medicine, Asthma and Lung Biology, School of Medicine, University of North Carolina at Chapel Hill, USA
Inhal Toxicol 16:5-18. 2004..Thus, one of the mechanisms for greater susceptibility of SH rats to PM exposure may involve an increased activation of the TLR4 signaling pathway... - Pulmonary oxidative stress, inflammation, and dysregulated iron homeostasis in rat models of cardiovascular diseaseJonathan H Shannahan
Curriculum in Toxicology, University of North Carolina, Chapel Hill, North Carolina, USA
J Toxicol Environ Health A 73:641-56. 2010.... - Inhibition of tobacco smoke-induced lung inflammation by a catalytic antioxidantKevin R Smith
Center for Health and the Environment, University of California, Davis, CA 95616, USA
Free Radic Biol Med 33:1106-14. 2002..05). We conclude that a synthetic catalytic antioxidant decreased the adverse effects of exposure to tobacco smoke... - Systemic vascular disease in male B6C3F1 mice exposed to particulate matter by inhalation: studies conducted by the National Toxicology ProgramCarolyn F Moyer
Pathology Associates, Raleigh, North Carolina 27606, USA
Toxicol Pathol 30:427-34. 2002..The results showed arteritis did not develop in the 90-day studies, suggesting that long-term chronic exposure to lower-dose metallic particulate matter may be necessary to induce or exacerbate arteritis... - Cardiovascular and blood coagulative effects of pulmonary zinc exposurePeter S Gilmour
Center for Environmental Medicine, Asthma and Lung Biology, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
Toxicol Appl Pharmacol 211:41-52. 2006..These data suggest that cardiovascular blood coagulation impairments are likely following pulmonary zinc exposure and associated pulmonary injury and inflammation... - Acute tobacco smoke-induced airways inflammation in spontaneously hypertensive ratsBei Yu
Center for Health and the Environment, University of California, Davis, California 95616, USA
Inhal Toxicol 20:623-33. 2008..The spontaneously hypertensive rat may be a more relevant animal model of acute tobacco smoke-induced airway inflammation than other laboratory rats... - Emission-particle-induced ventilatory abnormalities in a rat model of pulmonary hypertensionSarah Y Gardner
College of Veterinary Medicine, North Carolina State University, 4700 Hillsborough Street, Raleigh, NC 27606, USA
Environ Health Perspect 112:872-8. 2004..ROFA exposure induced histologic changes and abnormalities in several ventilatory parameters, many of which were enhanced by MCT treatment... - Systemic translocation of particulate matter-associated metals following a single intratracheal instillation in ratsJ Grace Wallenborn
Department of Environmental Sciences and Engineering, UNC School of Public Health, Chapel Hill, North Carolina 27599, USA
Toxicol Sci 98:231-9. 2007.... - Acute pulmonary and systemic effects of inhaled coal fly ash in rats: comparison to ambient environmental particlesKevin R Smith
Center for Health and the Environment, University of California, Davis, California 95616, USA
Toxicol Sci 93:390-9. 2006..This study furthers our understanding of possible mechanisms by which specific sources of particulate air pollution affect human health...