P R Kodavanti

Summary

Affiliation: U.S. Environmental Protection Agency
Country: USA

Publications

  1. ncbi request reprint In vitro effects of polychlorinated biphenyls and hydroxy metabolites on nitric oxide synthases in rat brain
    Rashmi Sharma
    National Research Council, National Academy of Sciences, Washington, DC, USA
    Toxicol Appl Pharmacol 178:127-36. 2002
  2. doi request reprint Gene expression profiles in the cerebellum and hippocampus following exposure to a neurotoxicant, Aroclor 1254: developmental effects
    Joyce E Royland
    Neurotoxicology Divisions, NHEERL, ORD, U S Environmental Protection Agency, Research Triangle Park, NC 27711, USA
    Toxicol Appl Pharmacol 231:165-78. 2008
  3. pmc Ontogenetic alterations in molecular and structural correlates of dendritic growth after developmental exposure to polychlorinated biphenyls
    Pamela J Lein
    Center for Research on Occupational and Environmental Toxicology, Oregon Health and Science University, Portland, Oregon, USA
    Environ Health Perspect 115:556-63. 2007
  4. doi request reprint Cell signaling and neurotoxicity: ³H-arachidonic acid release (phospholipase A₂) in cerebellar granule neurons
    Prasada Rao S Kodavanti
    Neurotoxicology Branch, National Health and Environmental Effects Research Laboratories, United States Environmental Protection Agency, Research Triangle Park, NC, USA
    Methods Mol Biol 758:321-8. 2011
  5. ncbi request reprint Differential effects of commercial polybrominated diphenyl ether and polychlorinated biphenyl mixtures on intracellular signaling in rat brain in vitro
    Prasada Rao S Kodavanti
    Cellular and Molecular Toxicology Branch, Neurotoxicology Division, NHEERL, ORD, U S Environmental Protection Agency, Research Triangle Park, North Carolina 27711, USA
    Toxicol Sci 85:952-62. 2005
  6. ncbi request reprint Polybrominated diphenyl ether (PBDE) effects in rat neuronal cultures: 14C-PBDE accumulation, biological effects, and structure-activity relationships
    Prasada Rao S Kodavanti
    Cellular and Molecular Toxicology Branch, Neurotoxicology and Experimental Toxicology Division, NHEERL, ORD, US Environmental Protection Agency, Research Triangle Park, North Carolina 27711, USA
    Toxicol Sci 88:181-92. 2005
  7. pmc Neurotoxicity of persistent organic pollutants: possible mode(s) of action and further considerations
    Prasada Rao S Kodavanti
    Cellular and Molecular Toxicology Branch, Neurotoxicology Division, NHEERL ORD, U S Environmental Protection Agency, Research Triangle Park, NC 27711, USA
    Dose Response 3:273-305. 2005
  8. doi request reprint Developmental exposure to a commercial PBDE mixture, DE-71: neurobehavioral, hormonal, and reproductive effects
    Prasada Rao S Kodavanti
    Neurotoxicology Branch, Toxicity Assessment Division, National Health and Environmental Effects Research Laboratory, Office of Research and Development, US EPA, Research Triangle Park, North Carolina 27711, USA
    Toxicol Sci 116:297-312. 2010
  9. doi request reprint Neuroendocrine actions of organohalogens: thyroid hormones, arginine vasopressin, and neuroplasticity
    Prasada Rao S Kodavanti
    Neurotoxicology Branch, Toxicity Assessment Division, B 105 06, National Health and Environmental Effects Research Laboratory, Office of Research and Development, US Environmental Protection Agency, Research Triangle Park, NC 27711, USA
    Front Neuroendocrinol 31:479-96. 2010
  10. doi request reprint Toluene effects on oxidative stress in brain regions of young-adult, middle-age, and senescent Brown Norway rats
    Prasada Rao S Kodavanti
    Neurotoxicology Branch, Toxicity Assessment Division, NHEERL, ORD, US Environmental Protection Agency, Research Triangle Park, NC 27711, USA
    Toxicol Appl Pharmacol 256:386-98. 2011

Collaborators

Detail Information

Publications32

  1. ncbi request reprint In vitro effects of polychlorinated biphenyls and hydroxy metabolites on nitric oxide synthases in rat brain
    Rashmi Sharma
    National Research Council, National Academy of Sciences, Washington, DC, USA
    Toxicol Appl Pharmacol 178:127-36. 2002
    ..The selective sensitivity of NOS to dichloro- ortho-PCB and hydroxy metabolites suggests that the inhibition of NOS could play a role in the neuroendocrine effects as well as learning and memory deficits caused by exposure to PCBs...
  2. doi request reprint Gene expression profiles in the cerebellum and hippocampus following exposure to a neurotoxicant, Aroclor 1254: developmental effects
    Joyce E Royland
    Neurotoxicology Divisions, NHEERL, ORD, U S Environmental Protection Agency, Research Triangle Park, NC 27711, USA
    Toxicol Appl Pharmacol 231:165-78. 2008
    ..Such changes may underlie learning and memory deficits observed in PCB exposed animals and humans...
  3. pmc Ontogenetic alterations in molecular and structural correlates of dendritic growth after developmental exposure to polychlorinated biphenyls
    Pamela J Lein
    Center for Research on Occupational and Environmental Toxicology, Oregon Health and Science University, Portland, Oregon, USA
    Environ Health Perspect 115:556-63. 2007
    ..It is postulated that these neuropsychological deficits reflect altered patterns of neuronal connectivity. To test this hypothesis, we examined the effects of developmental PCB exposure on dendritic growth...
  4. doi request reprint Cell signaling and neurotoxicity: ³H-arachidonic acid release (phospholipase A₂) in cerebellar granule neurons
    Prasada Rao S Kodavanti
    Neurotoxicology Branch, National Health and Environmental Effects Research Laboratories, United States Environmental Protection Agency, Research Triangle Park, NC, USA
    Methods Mol Biol 758:321-8. 2011
    ..Understanding the role of the AA signaling pathway in chemically-induced effects on the nervous system will provide specific mode of action information that can be used in assessing the compound risk...
  5. ncbi request reprint Differential effects of commercial polybrominated diphenyl ether and polychlorinated biphenyl mixtures on intracellular signaling in rat brain in vitro
    Prasada Rao S Kodavanti
    Cellular and Molecular Toxicology Branch, Neurotoxicology Division, NHEERL, ORD, U S Environmental Protection Agency, Research Triangle Park, North Carolina 27711, USA
    Toxicol Sci 85:952-62. 2005
    ..These results indicate that PBDEs perturbed intracellular signaling mechanisms in rat brain as do other organohalogen compounds and the efficacy between the commercial PCB and PBDE mixtures seem to vary with different endpoints...
  6. ncbi request reprint Polybrominated diphenyl ether (PBDE) effects in rat neuronal cultures: 14C-PBDE accumulation, biological effects, and structure-activity relationships
    Prasada Rao S Kodavanti
    Cellular and Molecular Toxicology Branch, Neurotoxicology and Experimental Toxicology Division, NHEERL, ORD, US Environmental Protection Agency, Research Triangle Park, North Carolina 27711, USA
    Toxicol Sci 88:181-92. 2005
    ....
  7. pmc Neurotoxicity of persistent organic pollutants: possible mode(s) of action and further considerations
    Prasada Rao S Kodavanti
    Cellular and Molecular Toxicology Branch, Neurotoxicology Division, NHEERL ORD, U S Environmental Protection Agency, Research Triangle Park, NC 27711, USA
    Dose Response 3:273-305. 2005
    ..This is a comprehensive review comparing molecular effects at the cellular level to the neurotoxic effects seen in the whole animal for environmentally relevant POPs...
  8. doi request reprint Developmental exposure to a commercial PBDE mixture, DE-71: neurobehavioral, hormonal, and reproductive effects
    Prasada Rao S Kodavanti
    Neurotoxicology Branch, Toxicity Assessment Division, National Health and Environmental Effects Research Laboratory, Office of Research and Development, US EPA, Research Triangle Park, North Carolina 27711, USA
    Toxicol Sci 116:297-312. 2010
    ..Some of these effects are similar to those seen with PCBs, and the persistence of these changes requires further investigation...
  9. doi request reprint Neuroendocrine actions of organohalogens: thyroid hormones, arginine vasopressin, and neuroplasticity
    Prasada Rao S Kodavanti
    Neurotoxicology Branch, Toxicity Assessment Division, B 105 06, National Health and Environmental Effects Research Laboratory, Office of Research and Development, US Environmental Protection Agency, Research Triangle Park, NC 27711, USA
    Front Neuroendocrinol 31:479-96. 2010
    ....
  10. doi request reprint Toluene effects on oxidative stress in brain regions of young-adult, middle-age, and senescent Brown Norway rats
    Prasada Rao S Kodavanti
    Neurotoxicology Branch, Toxicity Assessment Division, NHEERL, ORD, US Environmental Protection Agency, Research Triangle Park, NC 27711, USA
    Toxicol Appl Pharmacol 256:386-98. 2011
    ....
  11. doi request reprint Aroclor 1254, a developmental neurotoxicant, alters energy metabolism- and intracellular signaling-associated protein networks in rat cerebellum and hippocampus
    Prasada Rao S Kodavanti
    Neurotoxicology Branch, NHEERL, ORD, US Environmental Protection Agency, Research Triangle Park, North Carolina 27711, USA
    Toxicol Appl Pharmacol 256:290-9. 2011
    ..Results suggest that Aroclor 1254-like persistent chemicals may alter energy metabolism and intracellular signaling, which might result in developmental neurotoxicity...
  12. doi request reprint Cell signaling and neurotoxicity: protein kinase C in vitro and in vivo
    Prasada Rao S Kodavanti
    Neurotoxicology Branch, National Health and Environmental Effects Research Laboratories, United States Environmental Protection Agency, Research Triangle Park, NC, USA
    Methods Mol Biol 758:307-19. 2011
    ..Here, we show the relationship between changes in PKC (as assayed using radioactive material or by western blots) and the neurotoxic effects caused by environmental chemicals in vitro and in vivo...
  13. ncbi request reprint Increased [3H]phorbol ester binding in rat cerebellar granule cells and inhibition of 45Ca(2+) buffering in rat cerebellum by hydroxylated polychlorinated biphenyls
    Prasada Rao S Kodavanti
    Cellular and Molecular Toxicology Branch, National Health and Environmental Effects Research Laboratory, ORD, US Environmental Protection Agency, Research Triangle Park, NC 27711, USA
    Neurotoxicology 24:187-98. 2003
    ..Hydroxylated PCBs seemed to be as active as parent PCBs in vitro. These studies indicate that PCB metabolites such as hydroxy-PCBs might contribute significantly to the neurotoxic responses of PCBs...
  14. ncbi request reprint Differential effects of polybrominated diphenyl ethers and polychlorinated biphenyls on [3H]arachidonic acid release in rat cerebellar granule neurons
    Prasada Rao S Kodavanti
    Cellular and Molecular Toxicology Branch, Neurotoxicology Division, MD 74B, NHEERL, ORD, U S Environmental Protection Agency, Research Triangle Park, North Carolina 27711, USA
    Toxicol Sci 68:451-7. 2002
    ..These results indicate that PBDEs stimulated the release of [(3)H]AA by activating PLA(2), which is similar to the effect of other organohalogen mixtures...
  15. pmc Differential effects of two lots of aroclor 1254: congener-specific analysis and neurochemical end points
    P R Kodavanti
    Neurotoxicology Division, National Health and Environmental Effects Research Laboratory, U S Environmental Protection Agency, Research Triangle Park, North Carolina 27711, USA
    Environ Health Perspect 109:1153-61. 2001
    ..Because of these differential effects with different lot numbers, the composition of Aroclor mixtures used in investigations should be disclosed...
  16. ncbi request reprint Extracellular calcium is required for the polychlorinated biphenyl-induced increase of intracellular free calcium levels in cerebellar granule cell culture
    W R Mundy
    Neurotoxicology Division, National Health and Environmental Effects Research Laboratory, US Environmental Protection Agency, Research Triangle Park, NC 27711, USA
    Toxicology 136:27-39. 1999
    ....
  17. ncbi request reprint PCBs, thyroid hormones, and ototoxicity in rats: cross-fostering experiments demonstrate the impact of postnatal lactation exposure
    K M Crofton
    Neurotoxicology Division, MD 74B, National Health and Environmental Effects Research Laboratory, U S Environmental Protection Agency, Research Triangle Park, North Carolina 27711, USA
    Toxicol Sci 57:131-40. 2000
    ..This effect is consistent with the greater degree of postnatal hypothyroxinemia resulting from the greater magnitude of exposure that occurs postnatally via lactation...
  18. ncbi request reprint Neurotoxicity of environmental chemicals and their mechanism of action
    H A Tilson
    Neurotoxicology Division, US EPA, Research Triangle Park, N Carolina 27711, USA
    Toxicol Lett 102:631-5. 1998
    ..Our results are consistent with the hypothesis that developmental neurotoxicity of ARC is due, in part, to the presence of ortho-substituted PCB congeners...
  19. ncbi request reprint Aluminum potentiates glutamate-induced calcium accumulation and iron-induced oxygen free radical formation in primary neuronal cultures
    W R Mundy
    Neurotoxicology Division, US Environmental Protection Agency, Research Triangle Park, NC 27711, USA
    Mol Chem Neuropathol 32:41-57. 1997
    ..These results suggest that aluminum may facilitate increases in intracellular Ca2+ and ROS, and potentially contribute to neurotoxicity induced by other neurotoxicants...
  20. ncbi request reprint Gender-dependent behavioral and sensory effects of a commercial mixture of polychlorinated biphenyls (Aroclor 1254) in rats
    A M Geller
    Neurotoxicology Division, MD 74B, National Health and Environmental Effects Research Laboratory, U S Environmental Protection Agency, Research Triangle Park, North Carolina 27711, USA
    Toxicol Sci 59:268-77. 2001
    ..These data extend previous findings of gender-specific effects of PCBs on neurobehavioral development to measures of acquisition and sensory function...
  21. ncbi request reprint Assessing the role of ortho-substitution on polychlorinated biphenyl binding to transthyretin, a thyroxine transport protein
    K R Chauhan
    Curriculum in Toxicology, University of North Carolina, Chapel Hill, North Carolina, USA
    Toxicol Appl Pharmacol 162:10-21. 2000
    ....
  22. pmc Differential effects of two lots of aroclor 1254 on enzyme induction, thyroid hormones, and oxidative stress
    D E Burgin
    Curriculum in Toxicology, University of North Carolina, Chapel Hill, North Carolina, USA
    Environ Health Perspect 109:1163-8. 2001
    ..It is also critical that the lot number is reported in studies conducted with Aroclor 1254 because the congener composition and therefore the effects observed can be very different...
  23. doi request reprint Changes in mitogen-activated protein kinase in cerebellar granule neurons by polybrominated diphenyl ethers and polychlorinated biphenyls
    Chun Yang Fan
    US Environmental Protection Agency, Research Triangle Park, NC 27711, USA
    Toxicol Appl Pharmacol 245:1-8. 2010
    ....
  24. doi request reprint Gene expression profiles following exposure to a developmental neurotoxicant, Aroclor 1254: pathway analysis for possible mode(s) of action
    Joyce E Royland
    Cellular and Molecular Toxicology Branch, Neurotoxicology Division, NHEERL, ORD, U S Environmental Protection Agency, Research Triangle Park, NC, USA
    Toxicol Appl Pharmacol 231:179-96. 2008
    ..The genomic data suggests that PCB-induced neurotoxic effects were due to disruption of normal ontogenetic pattern of nervous system growth and development by altering intracellular signaling pathways but not by endocrine disruption...
  25. ncbi request reprint Neurobehavioral assessments of rats perinatally exposed to a commercial mixture of polychlorinated biphenyls
    Philip J Bushnell
    Neurobehavioral Toxicology Branch, Neurotoxicology Division, National Health and Environmental Effects Research Laboratory, U S Environmental Protection Agency, Research Triangle Park, North Carolina 27711, USA
    Toxicol Sci 68:109-20. 2002
    ..Perinatal exposure to this commercial PCB mixture had very little effect on these tests of behavior during development and in adulthood...
  26. ncbi request reprint Flash-, somatosensory-, and peripheral nerve-evoked potentials in rats perinatally exposed to Aroclor 1254
    D W Herr
    Neurotoxicology Division, MD 74B, National Health and Environmental Effects Research Laboratory, Office of Research and Development, U S Environmental Protection Agency, Research Triangle Park, NC 27711, USA
    Neurotoxicol Teratol 23:591-601. 2001
    ..However, subtle changes in the function of the visual or somatosensory systems cannot be disproved...
  27. ncbi request reprint In vitro effects of environmentally relevant polybrominated diphenyl ether (PBDE) congeners on calcium buffering mechanisms in rat brain
    Cary G Coburn
    Environmental Toxicology Graduate Program, University of California, Riverside, CA 92521, USA
    Neurochem Res 33:355-64. 2008
    ..These results indicate that PBDE 47 and PBDE 99 congeners perturb calcium signaling in rat brain in a manner similar to PCB congeners, suggesting a common mode of action of these persistent organic pollutants...
  28. ncbi request reprint Polybrominated diphenyl ethers and ortho-substituted polychlorinated biphenyls as neuroendocrine disruptors of vasopressin release: effects during physiological activation in vitro and structure-activity relationships
    Cary G Coburn
    Environmental Toxicology Graduate Program, University of California, Riverside, California 92521, USA
    Toxicol Sci 98:178-86. 2007
    ....
  29. ncbi request reprint Ontogenetic alterations in prototypical transcription factors in the rat cerebellum and hippocampus following perinatal exposure to a commercial PCB mixture
    Md Riyaz Basha
    Department of Biomedical Sciences and Pharmaceutical, University of Rhode Island, RI 02881, USA
    Neurotoxicology 27:118-24. 2006
    ..These distinct changes delineate the involvement of specific transduction-transcription coupling pathways that may mediate PCB-induced perturbations in developmental gene expression...
  30. ncbi request reprint Effects of PCB 84 enantiomers on [3H]-phorbol ester binding in rat cerebellar granule cells and 45Ca2+-uptake in rat cerebellum
    Hans Joachim Lehmler
    Department of Occupational and Environmental Health, College of Public Health, The University of Iowa, 100 Oakdale Campus, 124 IREH, Iowa City, IA 52242 5000, USA
    Toxicol Lett 156:391-400. 2005
    ....
  31. ncbi request reprint Alterations in brain protein kinase C isoforms following developmental exposure to a polychlorinated biphenyl mixture
    Jae Ho Yang
    National Academy of Sciences, National Research Council, Washington, DC, USA
    Brain Res Mol Brain Res 111:123-35. 2003
    ..It is believed that this is the first report successfully identifying PKC isoforms responding to PCBs during developmental exposure...
  32. ncbi request reprint Occurrence of polybrominated biphenyls, polybrominated dibenzo-p-dioxins, and polybrominated dibenzofurans as impurities in commercial polybrominated diphenyl ether mixtures
    Nobuyasu Hanari
    National Institute of Advanced Industrial Science and Technology, 16 1 Onogawa, Tsukuba, Ibaraki 305 8569, Japan
    Environ Sci Technol 40:4400-5. 2006
    ..Results of our study suggestthat PBDFs can also be formed during the production of commercial PBDE mixtures, in addition to their formation during pyrolysis of brominated flame retardants...