Thomas B Knudsen

Summary

Affiliation: U.S. Environmental Protection Agency
Country: USA

Publications

  1. ncbi request reprint Profiling the activity of environmental chemicals in prenatal developmental toxicity studies using the U.S. EPA's ToxRefDB
    Thomas B Knudsen
    National Center for Computational Toxicology, Office of Research and Development, U S Environmental Protection Agency, Research Triangle Park, NC 27711, United States
    Reprod Toxicol 28:209-19. 2009
  2. doi request reprint Activity profiles of 309 ToxCastâ„¢ chemicals evaluated across 292 biochemical targets
    Thomas B Knudsen
    National Center for Computational Toxicology B205 01, Office of Research and Development, U S Environmental Protection Agency, Research Triangle Park, NC 27711, USA
    Toxicology 282:1-15. 2011
  3. pmc Lasting effects on body weight and mammary gland gene expression in female mice upon early life exposure to n-3 but not n-6 high-fat diets
    Mirjam Luijten
    Laboratory for Health Protection Research, National Institute for Public Health and the Environment, Bilthoven, The Netherlands
    PLoS ONE 8:e55603. 2013
  4. pmc A computational model predicting disruption of blood vessel development
    Nicole Kleinstreuer
    National Center for Computational Toxicology, Office of Research and Development, U S Environmental Protection Agency, Research Triangle Park, North Carolina, USA
    PLoS Comput Biol 9:e1002996. 2013
  5. doi request reprint Disruption of embryonic vascular development in predictive toxicology
    Thomas B Knudsen
    National Center for Computational Toxicology, Office of Research and Development, U S Environmental Protection Agency, Research Triangle Park, North Carolina 27711, USA
    Birth Defects Res C Embryo Today 93:312-23. 2011
  6. ncbi request reprint The Hemimelic extra toes mouse mutant: Historical perspective on unraveling mechanisms of dysmorphogenesis
    Thomas B Knudsen
    National Center for Computational Toxicology, Office of Research and Development, U S Environmental Protection Agency, Research Triangle Park, North Carolina 27711, USA
    Birth Defects Res C Embryo Today 90:155-62. 2010
  7. doi request reprint Developmental toxicity testing for safety assessment: new approaches and technologies
    Thomas B Knudsen
    National Center for Computational Toxicology, US Environmental Protection Agency, Research Triangle Park, North Carolina 27711, USA
    Birth Defects Res B Dev Reprod Toxicol 92:413-20. 2011
  8. pmc Environmental impact on vascular development predicted by high-throughput screening
    Nicole C Kleinstreuer
    National Center for Computational Toxiciology, Office of Research and Development, U S Environmental Protection Agency, Research Triangle Park, North Carolina, USA
    Environ Health Perspect 119:1596-603. 2011
  9. doi request reprint Predictive models of prenatal developmental toxicity from ToxCast high-throughput screening data
    Nisha S Sipes
    National Center for Computational Toxicology, Office of Research and Development, U S Environmental Protection Agency, Research Triangle Park, North Carolina 27711, USA
    Toxicol Sci 124:109-27. 2011
  10. doi request reprint In vitro perturbations of targets in cancer hallmark processes predict rodent chemical carcinogenesis
    Nicole C Kleinstreuer
    National Center for Computational Toxicology, Office of Research and Development, US Environmental Protection Agency, Research Triangle Park, North Carolina 27711, USA
    Toxicol Sci 131:40-55. 2013

Collaborators

Detail Information

Publications24

  1. ncbi request reprint Profiling the activity of environmental chemicals in prenatal developmental toxicity studies using the U.S. EPA's ToxRefDB
    Thomas B Knudsen
    National Center for Computational Toxicology, Office of Research and Development, U S Environmental Protection Agency, Research Triangle Park, NC 27711, United States
    Reprod Toxicol 28:209-19. 2009
    ..This novel data model provides an important public resource for cross-scale modeling and predictive understanding of developmental processes and toxicities...
  2. doi request reprint Activity profiles of 309 ToxCastâ„¢ chemicals evaluated across 292 biochemical targets
    Thomas B Knudsen
    National Center for Computational Toxicology B205 01, Office of Research and Development, U S Environmental Protection Agency, Research Triangle Park, NC 27711, USA
    Toxicology 282:1-15. 2011
    ..The primary dataset, summary data and details on quality control checks are available for download at http://www.epa.gov/ncct/toxcast/...
  3. pmc Lasting effects on body weight and mammary gland gene expression in female mice upon early life exposure to n-3 but not n-6 high-fat diets
    Mirjam Luijten
    Laboratory for Health Protection Research, National Institute for Public Health and the Environment, Bilthoven, The Netherlands
    PLoS ONE 8:e55603. 2013
    ..Our findings suggest that diet during early life indeed has a lasting effect on the mammary gland and significantly influences postnatal body weight gain, metabolic status, and signaling networks in the mammary gland of female offspring...
  4. pmc A computational model predicting disruption of blood vessel development
    Nicole Kleinstreuer
    National Center for Computational Toxicology, Office of Research and Development, U S Environmental Protection Agency, Research Triangle Park, North Carolina, USA
    PLoS Comput Biol 9:e1002996. 2013
    ..These findings support the utility of cell agent-based models for simulating a morphogenetic series of events and for the first time demonstrate the applicability of these models for predictive toxicology...
  5. doi request reprint Disruption of embryonic vascular development in predictive toxicology
    Thomas B Knudsen
    National Center for Computational Toxicology, Office of Research and Development, U S Environmental Protection Agency, Research Triangle Park, North Carolina 27711, USA
    Birth Defects Res C Embryo Today 93:312-23. 2011
    ..As such, an adverse outcome pathway perspective of embryonic vascular development can help identify useful information for assessing adverse outcomes relevant to risk assessment and efficient use of resources for validation...
  6. ncbi request reprint The Hemimelic extra toes mouse mutant: Historical perspective on unraveling mechanisms of dysmorphogenesis
    Thomas B Knudsen
    National Center for Computational Toxicology, Office of Research and Development, U S Environmental Protection Agency, Research Triangle Park, North Carolina 27711, USA
    Birth Defects Res C Embryo Today 90:155-62. 2010
    ....
  7. doi request reprint Developmental toxicity testing for safety assessment: new approaches and technologies
    Thomas B Knudsen
    National Center for Computational Toxicology, US Environmental Protection Agency, Research Triangle Park, North Carolina 27711, USA
    Birth Defects Res B Dev Reprod Toxicol 92:413-20. 2011
    ..Though a daunting task, technologies are being developed and utilized to make that goal reachable...
  8. pmc Environmental impact on vascular development predicted by high-throughput screening
    Nicole C Kleinstreuer
    National Center for Computational Toxiciology, Office of Research and Development, U S Environmental Protection Agency, Research Triangle Park, North Carolina, USA
    Environ Health Perspect 119:1596-603. 2011
    ....
  9. doi request reprint Predictive models of prenatal developmental toxicity from ToxCast high-throughput screening data
    Nisha S Sipes
    National Center for Computational Toxicology, Office of Research and Development, U S Environmental Protection Agency, Research Triangle Park, North Carolina 27711, USA
    Toxicol Sci 124:109-27. 2011
    ..This work indicates the utility of HTS assays for developing pathway-level models predictive of developmental toxicity...
  10. doi request reprint In vitro perturbations of targets in cancer hallmark processes predict rodent chemical carcinogenesis
    Nicole C Kleinstreuer
    National Center for Computational Toxicology, Office of Research and Development, US Environmental Protection Agency, Research Triangle Park, North Carolina 27711, USA
    Toxicol Sci 131:40-55. 2013
    ..This model represents a chemical carcinogenicity prioritization tool supporting targeted testing and functional validation of cancer pathways...
  11. doi request reprint Predictive model of rat reproductive toxicity from ToxCast high throughput screening
    Matthew T Martin
    National Center for Computational Toxicology, Office of Research and Development, U S Environmental Protection Agency, Research Triangle Park, NC 27711, USA
    Biol Reprod 85:327-39. 2011
    ....
  12. pmc Using in vitro high throughput screening assays to identify potential endocrine-disrupting chemicals
    Daniel M Rotroff
    Department of Environmental Sciences and Engineering, University of North Carolina, Chapel Hill, North Carolina, USA
    Environ Health Perspect 121:7-14. 2013
    ..A need for increased throughput and efficiency motivated the development of methods using in vitro high throughput screening (HTS) assays to prioritize chemicals for EDSP Tier 1 screening (T1S)...
  13. pmc In vitro screening of environmental chemicals for targeted testing prioritization: the ToxCast project
    Richard S Judson
    National Center for Computational Toxicology, Office of Research and Development, US Environmental Protection Agency, Research Triangle Park, North Carolina 27711, USA
    Environ Health Perspect 118:485-92. 2010
    ..The U.S. Environmental Protection Agency's ToxCast program aims to address these concerns by screening and prioritizing chemicals for potential human toxicity using in vitro assays and in silico approaches...
  14. doi request reprint Economic benefits of using adaptive predictive models of reproductive toxicity in the context of a tiered testing program
    Matthew T Martin
    National Center for Computational Toxicology, Office of Research and Development, US Environmental Protection Agency, Research Triangle Park, North Carolina 27711, USA
    Syst Biol Reprod Med 58:3-9. 2012
    ....
  15. pmc Endocrine profiling and prioritization of environmental chemicals using ToxCast data
    David M Reif
    National Center for Computational Toxicology, Office of Research and Development, U S Environmental Protection Agency, Research Triangle Park, North Carolina 27711, USA
    Environ Health Perspect 118:1714-20. 2010
    ..S. EPA's Endocrine Disruptor Screening Program (EDSP) has been charged with screening pesticide chemicals and environmental contaminants for their potential to affect the endocrine systems of humans and wildlife...
  16. pmc Profiling 976 ToxCast chemicals across 331 enzymatic and receptor signaling assays
    Nisha S Sipes
    National Center for Computational Toxicology, Office of Research and Development, U S Environmental Protection Agency, Research Triangle Park, North Carolina 27711, USA
    Chem Res Toxicol 26:878-95. 2013
    ..Results from this large inventory of chemical-biological interactions can inform read-across methods as well as link potential targets to molecular initiating events in adverse outcome pathways for diverse toxicities...
  17. doi request reprint Estimating toxicity-related biological pathway altering doses for high-throughput chemical risk assessment
    Richard S Judson
    National Center for Computational Toxicology, Office of Research and Development, U S Environmental Protection Agency, Research Triangle Park, NC 27711, United States
    Chem Res Toxicol 24:451-62. 2011
    ....
  18. pmc Evaluation of 309 environmental chemicals using a mouse embryonic stem cell adherent cell differentiation and cytotoxicity assay
    Kelly J Chandler
    National Health and Environmental Effects Research Laboratory, Office of Research and Development, U S Environmental Protection Agency, Research Triangle Park, North Carolina, United States of America
    PLoS ONE 6:e18540. 2011
    ..Taken together, these results provide an initial characterization of metabolic and regulatory pathways by which some environmental chemicals may act to disrupt ES cell growth and differentiation...
  19. ncbi request reprint Phenotypic screening of the ToxCast chemical library to classify toxic and therapeutic mechanisms
    Nicole C Kleinstreuer
    National Center for Computational Toxicology, Office of Research and Development, United States Environmental Protection Agency, Research Triangle Park, North Carolina, USA
    Nat Biotechnol 32:583-91. 2014
    ..Our results demonstrate that assaying complex biological pathways in primary human cells can identify potential chemical targets, toxicological liabilities and mechanisms useful for elucidating adverse outcome pathways. ..
  20. doi request reprint Zebrafish: as an integrative model for twenty-first century toxicity testing
    Nisha S Sipes
    National Center for Computational Toxicology, U S Environmental Protection Agency, Research Triangle Park, North Carolina, USA
    Birth Defects Res C Embryo Today 93:256-67. 2011
    ..Cross-species comparisons implied a common basis for biological pathways associated with neuronal defects, extracellular matrix remodeling, and mitotic arrest...
  21. pmc Analysis of eight oil spill dispersants using rapid, in vitro tests for endocrine and other biological activity
    Richard S Judson
    National Center for Computational Toxicology, Office of Research and Development, U S Environmental Protection Agency, Research Triangle Park, North Carolina 27711, USA
    Environ Sci Technol 44:5979-85. 2010
    ..Two dispersants, JD 2000 and SAF-RON GOLD, were significantly less cytotoxic than the others with LC50 values approaching or exceeding 1000 ppm...
  22. doi request reprint Using pathway modules as targets for assay development in xenobiotic screening
    Richard S Judson
    National Center for Computational Toxicology, Office of Research and Development, US Environmental Protection Agency, Research Triangle Park, NC 27711, USA
    Mol Biosyst 8:531-42. 2012
    ..These selected genes could then form the basis for a battery to test for pathway-chemical interactions under many biological contexts using throughput expression-based assays...
  23. ncbi request reprint Exposure-disease continuum for 2-chloro-2'-deoxyadenosine (2-CdA), a prototype teratogen: induction of lumbar hernia in the rat and species comparison for the teratogenic responses
    Christopher Lau
    Reproductive Toxicology Division, NHEERL, ORD, US Environmental Protection Agency, Research Triangle Park, North Carolina 27711, USA
    Teratology 66:6-18. 2002
    ..The current study examined the teratogenic potential of this drug in the rat and compared the adverse developmental outcomes with the other species...
  24. doi request reprint High-throughput models for exposure-based chemical prioritization in the ExpoCast project
    John F Wambaugh
    National Center for Computational Toxicology, United States Environmental Protection Agency, Research Triangle Park, North Carolina 27711, United States
    Environ Sci Technol 47:8479-88. 2013
    ..Coupled with hazard HTS, exposure HTS can place risk earlier in decision processes. High-priority chemicals become targets for further data collection. ..