Robert Kavlock

Summary

Affiliation: U.S. Environmental Protection Agency
Country: USA

Publications

  1. ncbi request reprint Toxicogenomic study of triazole fungicides and perfluoroalkyl acids in rat livers predicts toxicity and categorizes chemicals based on mechanisms of toxicity
    Matthew T Martin
    National Center for Computational Toxicology, US Environmental Protection Agency, Research Triangle Park, NC 27711, USA
    Toxicol Sci 97:595-613. 2007
  2. doi request reprint Update on EPA's ToxCast program: providing high throughput decision support tools for chemical risk management
    Robert Kavlock
    National Center for Computational Toxicology, Office of Research and Development, U S Environmental Protection Agency, Research Triangle Park, NC 27711, USA
    Chem Res Toxicol 25:1287-302. 2012
  3. ncbi request reprint Computational toxicology--a state of the science mini review
    Robert J Kavlock
    National Center for Computational Toxicology, Office of Research and Development, U S Environmental Protection Agency, Research Triangle Park, NC 27711, USA
    Toxicol Sci 103:14-27. 2008
  4. ncbi request reprint Mode of action: inhibition of androgen receptor function--vinclozolin-induced malformations in reproductive development
    Robert Kavlock
    National Center for Computational Toxicology, US Environmental Protection Agency, Research Triangle Park, North Carolina 27711, USA
    Crit Rev Toxicol 35:721-6. 2005
  5. ncbi request reprint Mode of action: reduction of testosterone availability--molinate-induced inhibition of spermatogenesis
    Robert Kavlock
    US Environmental Protection Agency, Research Triangle Park, North Carolina 27711, USA
    Crit Rev Toxicol 35:685-90. 2005
  6. doi request reprint Advancing exposure characterization for chemical evaluation and risk assessment
    Elaine A Cohen Hubal
    National Center for Computational Toxicology, U S Environmental Protection Agency, Research Triangle Park, North Carolina 27711, USA
    J Toxicol Environ Health B Crit Rev 13:299-313. 2010
  7. ncbi request reprint Perspectives on validation of high-throughput assays supporting 21st century toxicity testing
    Richard Judson
    National Center for Computational Toxicology, Office of Research and Development, U S Environmental Protection Agency, Research Triangle Park, NC 27711, USA
    ALTEX 30:51-6. 2013
  8. doi request reprint Computational toxicology as implemented by the U.S. EPA: providing high throughput decision support tools for screening and assessing chemical exposure, hazard and risk
    Robert Kavlock
    National Center for Computational Toxicology, Office of Research and Development, US Environmental Protection Agency, Research Triangle Park, North Carolina 27711, USA
    J Toxicol Environ Health B Crit Rev 13:197-217. 2010
  9. doi request reprint Exposure science and the U.S. EPA National Center for Computational Toxicology
    Elaine A Cohen Hubal
    National Center for Computational Toxicology, US Environmental Protection Agency, Research Triangle Park, North Carolina 27711, USA
    J Expo Sci Environ Epidemiol 20:231-6. 2010
  10. pmc The toxicity data landscape for environmental chemicals
    Richard Judson
    National Center for Computational Toxicology, Office of Research and Development, U S Environmental Protection Agency, Research Triangle Park, North Carolina 27711, USA
    Environ Health Perspect 117:685-95. 2009

Detail Information

Publications41

  1. ncbi request reprint Toxicogenomic study of triazole fungicides and perfluoroalkyl acids in rat livers predicts toxicity and categorizes chemicals based on mechanisms of toxicity
    Matthew T Martin
    National Center for Computational Toxicology, US Environmental Protection Agency, Research Triangle Park, NC 27711, USA
    Toxicol Sci 97:595-613. 2007
    ..The concordance of in vivo observations and gene expression findings demonstrated the ability of genomics to accurately categorize chemicals, identify toxic mechanisms of action, and predict subsequent pathological responses...
  2. doi request reprint Update on EPA's ToxCast program: providing high throughput decision support tools for chemical risk management
    Robert Kavlock
    National Center for Computational Toxicology, Office of Research and Development, U S Environmental Protection Agency, Research Triangle Park, NC 27711, USA
    Chem Res Toxicol 25:1287-302. 2012
    ..This perspective provides a summary of the initial, proof of concept, Phase I of ToxCast that has laid the groundwork for the next phases and future directions of the program...
  3. ncbi request reprint Computational toxicology--a state of the science mini review
    Robert J Kavlock
    National Center for Computational Toxicology, Office of Research and Development, U S Environmental Protection Agency, Research Triangle Park, NC 27711, USA
    Toxicol Sci 103:14-27. 2008
    ..The next few years should witness the early fruits of these efforts, but as the National Research Council indicates, the paradigm shift will take a long term investment and commitment to reach full potential...
  4. ncbi request reprint Mode of action: inhibition of androgen receptor function--vinclozolin-induced malformations in reproductive development
    Robert Kavlock
    National Center for Computational Toxicology, US Environmental Protection Agency, Research Triangle Park, North Carolina 27711, USA
    Crit Rev Toxicol 35:721-6. 2005
    ..Based on what is known about kinetic and dynamic factors, confidence is high that the animal mode of action (MOA) for vinclozolin-induced malformation of the male reproductive tract is highly plausible in humans...
  5. ncbi request reprint Mode of action: reduction of testosterone availability--molinate-induced inhibition of spermatogenesis
    Robert Kavlock
    US Environmental Protection Agency, Research Triangle Park, North Carolina 27711, USA
    Crit Rev Toxicol 35:685-90. 2005
    ..For this reason, a complete MOA/human relevance analysis is not possible and, based on traditional risk assessment principles, any toxic effects are assumed to be relevant for human risk assessment...
  6. doi request reprint Advancing exposure characterization for chemical evaluation and risk assessment
    Elaine A Cohen Hubal
    National Center for Computational Toxicology, U S Environmental Protection Agency, Research Triangle Park, North Carolina 27711, USA
    J Toxicol Environ Health B Crit Rev 13:299-313. 2010
    ....
  7. ncbi request reprint Perspectives on validation of high-throughput assays supporting 21st century toxicity testing
    Richard Judson
    National Center for Computational Toxicology, Office of Research and Development, U S Environmental Protection Agency, Research Triangle Park, NC 27711, USA
    ALTEX 30:51-6. 2013
    ....
  8. doi request reprint Computational toxicology as implemented by the U.S. EPA: providing high throughput decision support tools for screening and assessing chemical exposure, hazard and risk
    Robert Kavlock
    National Center for Computational Toxicology, Office of Research and Development, US Environmental Protection Agency, Research Triangle Park, North Carolina 27711, USA
    J Toxicol Environ Health B Crit Rev 13:197-217. 2010
    ..The CTRP will be a critical component in next-generation risk assessments utilizing quantitative high-throughput data and providing a much higher capacity for assessing chemical toxicity than is currently available...
  9. doi request reprint Exposure science and the U.S. EPA National Center for Computational Toxicology
    Elaine A Cohen Hubal
    National Center for Computational Toxicology, US Environmental Protection Agency, Research Triangle Park, North Carolina 27711, USA
    J Expo Sci Environ Epidemiol 20:231-6. 2010
    ..In addition, common themes inherent throughout National Center for Computational Toxicology research activities are highlighted for emphasis as exposure science advances into the 21st century...
  10. pmc The toxicity data landscape for environmental chemicals
    Richard Judson
    National Center for Computational Toxicology, Office of Research and Development, U S Environmental Protection Agency, Research Triangle Park, North Carolina 27711, USA
    Environ Health Perspect 117:685-95. 2009
    ..The main objective of this analysis is to define a list of environmental chemicals that are candidates for the U.S. EPA screening and prioritization process, and to catalog the available toxicology information...
  11. ncbi request reprint Understanding mechanisms of toxicity: insights from drug discovery research
    Keith A Houck
    National Center for Computational Toxicology, Office Research and Development, United Stated Environmental Protection Agency, Research Triangle Park, NC 27711, USA
    Toxicol Appl Pharmacol 227:163-78. 2008
    ..Integration of successful approaches will contribute towards building a systems approach to toxicology that will provide mechanistic understanding of the effects of chemicals on biological systems and aid in rationale risk assessments...
  12. pmc Profiling chemicals based on chronic toxicity results from the U.S. EPA ToxRef Database
    Matthew T Martin
    National Center for Computational Toxicology, Office of Research and Development, U S Environmental Protection Agency, Research Triangle Park, North Carolina 27711, USA
    Environ Health Perspect 117:392-9. 2009
    ..These data are now accessible and mineable within ToxRefDB and are serving as a primary source of validation for U.S. EPA's ToxCast research program in predictive toxicology...
  13. doi request reprint Behavioral toxicology in the 21st century: challenges and opportunities for behavioral scientists. Summary of a symposium presented at the annual meeting of the neurobehavioral teratology society, June, 2009
    Philip J Bushnell
    National Health and Environmental Effects Research Laboratory, U S Environmental Protection Agency, Research Triangle Park, NC 27711, United States
    Neurotoxicol Teratol 32:313-28. 2010
    ..Initial advances will likely provide better prioritization tools so that animal resources are used more efficiently and effectively...
  14. doi request reprint Profiling the activity of environmental chemicals in prenatal developmental toxicity studies using the U.S. EPA's ToxRefDB
    Thomas B Knudsen
    National Center for Computational Toxicology, Office of Research and Development, U S Environmental Protection Agency, Research Triangle Park, NC 27711, United States
    Reprod Toxicol 28:209-19. 2009
    ..This novel data model provides an important public resource for cross-scale modeling and predictive understanding of developmental processes and toxicities...
  15. doi request reprint Profiling bioactivity of the ToxCast chemical library using BioMAP primary human cell systems
    Keith A Houck
    National Center for Computational Toxicology, Office of Research and Development, United States Environmental Protection Agency, Research Triangle Park, North Carolina, USA
    J Biomol Screen 14:1054-66. 2009
    ..This data set is being combined with additional ToxCast data sets for development of predictive toxicity models at the EPA...
  16. doi request reprint Impact of environmental chemicals on key transcription regulators and correlation to toxicity end points within EPA's ToxCast program
    Matthew T Martin
    National Center for Computational Toxicology, Office of Research and Development, US Environmental Protection Agency, Research Triangle Park, North Carolina, USA
    Chem Res Toxicol 23:578-90. 2010
    ....
  17. pmc In vitro screening of environmental chemicals for targeted testing prioritization: the ToxCast project
    Richard S Judson
    National Center for Computational Toxicology, Office of Research and Development, US Environmental Protection Agency, Research Triangle Park, North Carolina 27711, USA
    Environ Health Perspect 118:485-92. 2010
    ..The U.S. Environmental Protection Agency's ToxCast program aims to address these concerns by screening and prioritizing chemicals for potential human toxicity using in vitro assays and in silico approaches...
  18. pmc Analysis of eight oil spill dispersants using rapid, in vitro tests for endocrine and other biological activity
    Richard S Judson
    National Center for Computational Toxicology, Office of Research and Development, U S Environmental Protection Agency, Research Triangle Park, North Carolina 27711, USA
    Environ Sci Technol 44:5979-85. 2010
    ..Two dispersants, JD 2000 and SAF-RON GOLD, were significantly less cytotoxic than the others with LC50 values approaching or exceeding 1000 ppm...
  19. doi request reprint Activity profiles of 309 ToxCastâ„¢ chemicals evaluated across 292 biochemical targets
    Thomas B Knudsen
    National Center for Computational Toxicology B205 01, Office of Research and Development, U S Environmental Protection Agency, Research Triangle Park, NC 27711, USA
    Toxicology 282:1-15. 2011
    ..The primary dataset, summary data and details on quality control checks are available for download at http://www.epa.gov/ncct/toxcast/...
  20. pmc Using nuclear receptor activity to stratify hepatocarcinogens
    Imran Shah
    National Center for Computational Toxicology, Office of Research and Development, United States Environmental Protection Agency, Research Triangle Park, North Carolina, United States of America
    PLoS ONE 6:e14584. 2011
    ..Here we report on a systematic analysis of new in vitro human NR activity data on 309 environmental chemicals in relationship to their liver cancer-related chronic outcomes in rodents...
  21. doi request reprint Profiling the reproductive toxicity of chemicals from multigeneration studies in the toxicity reference database
    Matthew T Martin
    National Center for Computational Toxicology, Office of Research and Development, U S Environmental Protection Agency, Research Triangle Park, North Carolina 27711, USA
    Toxicol Sci 110:181-90. 2009
    ..Capturing this reproductive toxicity data in ToxRefDB supports ongoing retrospective analyses, test guideline revisions, and computational toxicology research...
  22. ncbi request reprint Gender-based differences in endocrine and reproductive toxicity
    Audrey M Cummings
    Reproductive Toxicology Division, National Health and Environmental Effects Research Laboratory, Office of Research and Development, United States Environmental Protection Agency, USA
    Environ Res 104:96-107. 2007
    ..It is clear that gender biases exist in the reproductive and developmental toxicity, and the biological bases for these differences need to be explored...
  23. pmc Endocrine profiling and prioritization of environmental chemicals using ToxCast data
    David M Reif
    National Center for Computational Toxicology, Office of Research and Development, U S Environmental Protection Agency, Research Triangle Park, North Carolina 27711, USA
    Environ Health Perspect 118:1714-20. 2010
    ..S. EPA's Endocrine Disruptor Screening Program (EDSP) has been charged with screening pesticide chemicals and environmental contaminants for their potential to affect the endocrine systems of humans and wildlife...
  24. ncbi request reprint DNA arrays to monitor gene expression in rat blood and uterus following 17beta-estradiol exposure: biomonitoring environmental effects using surrogate tissues
    John C Rockett
    Reproductive Toxicology Division, National Health and Environmental Effects Research Laboratory, Office of Research and Development, U S Environmental Protection Agency, Research Triangle Park, North Carolina 27711, USA
    Toxicol Sci 69:49-59. 2002
    ....
  25. ncbi request reprint Gene-environment interactions: a review of effects on reproduction and development
    Audrey M Cummings
    Reproductive Toxicology Division, National Health and Environmental Effects Research Laboratory, Office of Research and Development, U S Environmental Protection Agency, Research Triangle Park, North Carolina 27711, USA
    Crit Rev Toxicol 34:461-85. 2004
    ..As a conclusion, we offer a discussion of lessons learned and suggested research needs...
  26. ncbi request reprint The ToxCast program for prioritizing toxicity testing of environmental chemicals
    David J Dix
    National Center for Computational Toxicology D343 03, Office of Research and Development, U S Environmental Protection Agency, Research Triangle Park, North Carolina 27711, USA
    Toxicol Sci 95:5-12. 2007
    ..The resulting multidimensional data set provides an informatics challenge requiring appropriate computational methods for integrating various chemical, biological, and toxicological data into profiles and models predicting toxicity...
  27. ncbi request reprint Computational toxicology: framework, partnerships, and program development. September 29-30, 2003, Research Triangle Park, North Carolina
    Robert Kavlock
    Office of Research and Development, US Environmental Protection Agency, Washington, DC, USA
    Reprod Toxicol 19:265-80. 2005
  28. pmc Evaluation of 309 environmental chemicals using a mouse embryonic stem cell adherent cell differentiation and cytotoxicity assay
    Kelly J Chandler
    National Health and Environmental Effects Research Laboratory, Office of Research and Development, U S Environmental Protection Agency, Research Triangle Park, North Carolina, United States of America
    PLoS ONE 6:e18540. 2011
    ..Taken together, these results provide an initial characterization of metabolic and regulatory pathways by which some environmental chemicals may act to disrupt ES cell growth and differentiation...
  29. ncbi request reprint NTP-CERHR Expert Panel Update on the Reproductive and Developmental Toxicity of di(2-ethylhexyl) phthalate
    Robert Kavlock
    US Environmental Agency, Research Triangle Park, NC, USA
    Reprod Toxicol 22:291-399. 2006
  30. ncbi request reprint Overview: Using mode of action and life stage information to evaluate the human relevance of animal toxicity data
    Jennifer Seed
    US Environmental Protection Agency, Washington, DC, USA
    Crit Rev Toxicol 35:664-72. 2005
    ....
  31. ncbi request reprint A systems biology approach to developmental toxicology
    Audrey Cummings
    Reproductive Toxicology Division, National Health and Environmental Effects Research Laboratory, Office of Research and Development, U S Environmental Protection Agency, Research Triangle Park, NC 27711, USA
    Reprod Toxicol 19:281-90. 2005
    ..A hypothesis is presented regarding the role of GRN analysis in the determination of mechanisms of chemical toxicity during embryonic development. Potential for future directions and research approaches in this area is discussed...
  32. ncbi request reprint NTP Center for the Evaluation of Risks to Human Reproduction: phthalates expert panel report on the reproductive and developmental toxicity of butyl benzyl phthalate
    Robert Kavlock
    National Health and Environmental Effects Research Laboratory, USEPA, Research Triangle Park, NC, USA
    Reprod Toxicol 16:453-87. 2002
  33. ncbi request reprint NTP Center for the Evaluation of Risks to Human Reproduction: phthalates expert panel report on the reproductive and developmental toxicity of di-n-butyl phthalate
    Robert Kavlock
    National Health and Environmental Effects Research Laboratory, USEPA, Research Triangle Park, NC, USA
    Reprod Toxicol 16:489-527. 2002
  34. ncbi request reprint NTP Center for the Evaluation of Risks to Human Reproduction: phthalates expert panel report on the reproductive and developmental toxicity of di(2-ethylhexyl) phthalate
    Robert Kavlock
    National Health and Environmental Effects Research Laboratory, USEPA, Research Triangle Park, NC, USA
    Reprod Toxicol 16:529-653. 2002
  35. ncbi request reprint NTP Center for the Evaluation of Risks to Human Reproduction: phthalates expert panel report on the reproductive and developmental toxicity of di-isononyl phthalate
    Robert Kavlock
    National Health and Environmental Effects Research Laboratory USEPA, Research Triangle Park, NC, USA
    Reprod Toxicol 16:679-708. 2002
  36. ncbi request reprint NTP Center for the Evaluation of Risks to Human Reproduction: phthalates expert panel report on the reproductive and developmental toxicity of di-isodecyl phthalate
    Robert Kavlock
    National Health and Environmental Effects, Research Laboratory USEPA, Research Triangle Park, NC, USA
    Reprod Toxicol 16:655-78. 2002
  37. ncbi request reprint NTP Center for the Evaluation of Risks to Human Reproduction: phthalates expert panel report on the reproductive and developmental toxicity of di-n-hexyl phthalate
    Robert Kavlock
    National Health and Environmental Effects Research Laboratory USEPA, Research Triangle Park, NC, USA
    Reprod Toxicol 16:709-19. 2002
  38. ncbi request reprint NTP Center for the Evaluation of Risks to Human Reproduction: phthalates expert panel report on the reproductive and developmental toxicity of di-n-octyl phthalate
    Robert Kavlock
    National Health and Environmental Effects Research Laboratory USEPA, Research Triangle Park, NC, USA
    Reprod Toxicol 16:721-34. 2002
  39. ncbi request reprint Function of sexual glands and mechanism of sex differentiation
    Audrey M Cummings
    Reproductive Toxicology Division, National Health and Environmental Effects Research Laboratory, Office of Research and Development, U S Environmental Protection Agency, Research Triangle Park, NC, USA
    J Toxicol Sci 29:167-78. 2004
    ..In this chapter, we have outlined the basics of reproductive development and provided examples of adverse effects by endocrine disrupting chemicals (EDCs) on such development...
  40. ncbi request reprint Uncertainties for endocrine disrupters: our view on progress
    George P Daston
    Miami Valley Laboratories, The Procter and Gamble Company, P O Box 538707, Cincinnati, Ohio 45253, USA
    Toxicol Sci 74:245-52. 2003
    ....
  41. ncbi request reprint Defects in cervical vertebrae in boric acid-exposed rat embryos are associated with anterior shifts of hox gene expression domains
    Nathalie Wery
    Unit of Developmental Genetics, Universite Catholique de Louvain, Brussels, Belgium
    Birth Defects Res A Clin Mol Teratol 67:59-67. 2003
    ..The present study attempts to determine if these skeletal alterations could be explained by modifications of the hox code, involved in the establishment of positional information along the craniocaudal axis of the embryo...