Richard S Judson

Summary

Affiliation: U.S. Environmental Protection Agency
Country: USA

Publications

  1. pmc Using in vitro high throughput screening assays to identify potential endocrine-disrupting chemicals
    Daniel M Rotroff
    Department of Environmental Sciences and Engineering, University of North Carolina, Chapel Hill, North Carolina, USA
    Environ Health Perspect 121:7-14. 2013
  2. pmc Perspectives on validation of high-throughput assays supporting 21st century toxicity testing
    Richard Judson
    National Center for Computational Toxicology, Office of Research and Development, U S Environmental Protection Agency, Research Triangle Park, NC 27711, USA
    ALTEX 30:51-6. 2013
  3. doi request reprint Estimating toxicity-related biological pathway altering doses for high-throughput chemical risk assessment
    Richard S Judson
    National Center for Computational Toxicology, Office of Research and Development, U S Environmental Protection Agency, Research Triangle Park, NC 27711, United States
    Chem Res Toxicol 24:451-62. 2011
  4. pmc Analysis of eight oil spill dispersants using rapid, in vitro tests for endocrine and other biological activity
    Richard S Judson
    National Center for Computational Toxicology, Office of Research and Development, U S Environmental Protection Agency, Research Triangle Park, North Carolina 27711, USA
    Environ Sci Technol 44:5979-85. 2010
  5. doi request reprint Public databases supporting computational toxicology
    Richard Judson
    National Center for Computational Toxicology, Office of Research and Development, US Environmental Protection Agency, Research Triangle Park, North Carolina 27711, USA
    J Toxicol Environ Health B Crit Rev 13:218-31. 2010
  6. pmc In vitro screening of environmental chemicals for targeted testing prioritization: the ToxCast project
    Richard S Judson
    National Center for Computational Toxicology, Office of Research and Development, US Environmental Protection Agency, Research Triangle Park, North Carolina 27711, USA
    Environ Health Perspect 118:485-92. 2010
  7. pmc The toxicity data landscape for environmental chemicals
    Richard Judson
    National Center for Computational Toxicology, Office of Research and Development, U S Environmental Protection Agency, Research Triangle Park, North Carolina 27711, USA
    Environ Health Perspect 117:685-95. 2009
  8. doi request reprint Using pathway modules as targets for assay development in xenobiotic screening
    Richard S Judson
    National Center for Computational Toxicology, Office of Research and Development, US Environmental Protection Agency, Research Triangle Park, NC 27711, USA
    Mol Biosyst 8:531-42. 2012
  9. doi request reprint ACToR--Aggregated Computational Toxicology Resource
    Richard Judson
    National Center for Computational Toxicology, U S Environmental Protection Agency, 109 T W Alexander Drive, Research Triangle Park, NC 27711, USA
    Toxicol Appl Pharmacol 233:7-13. 2008
  10. pmc A comparison of machine learning algorithms for chemical toxicity classification using a simulated multi-scale data model
    Richard Judson
    National Center for Computational Toxicology, Office of Research and Development, US Environmental Protection Agency, Research Triangle Park, North Carolina 27711, USA
    BMC Bioinformatics 9:241. 2008

Collaborators

Detail Information

Publications40

  1. pmc Using in vitro high throughput screening assays to identify potential endocrine-disrupting chemicals
    Daniel M Rotroff
    Department of Environmental Sciences and Engineering, University of North Carolina, Chapel Hill, North Carolina, USA
    Environ Health Perspect 121:7-14. 2013
    ..A need for increased throughput and efficiency motivated the development of methods using in vitro high throughput screening (HTS) assays to prioritize chemicals for EDSP Tier 1 screening (T1S)...
  2. pmc Perspectives on validation of high-throughput assays supporting 21st century toxicity testing
    Richard Judson
    National Center for Computational Toxicology, Office of Research and Development, U S Environmental Protection Agency, Research Triangle Park, NC 27711, USA
    ALTEX 30:51-6. 2013
    ....
  3. doi request reprint Estimating toxicity-related biological pathway altering doses for high-throughput chemical risk assessment
    Richard S Judson
    National Center for Computational Toxicology, Office of Research and Development, U S Environmental Protection Agency, Research Triangle Park, NC 27711, United States
    Chem Res Toxicol 24:451-62. 2011
    ....
  4. pmc Analysis of eight oil spill dispersants using rapid, in vitro tests for endocrine and other biological activity
    Richard S Judson
    National Center for Computational Toxicology, Office of Research and Development, U S Environmental Protection Agency, Research Triangle Park, North Carolina 27711, USA
    Environ Sci Technol 44:5979-85. 2010
    ..Two dispersants, JD 2000 and SAF-RON GOLD, were significantly less cytotoxic than the others with LC50 values approaching or exceeding 1000 ppm...
  5. doi request reprint Public databases supporting computational toxicology
    Richard Judson
    National Center for Computational Toxicology, Office of Research and Development, US Environmental Protection Agency, Research Triangle Park, North Carolina 27711, USA
    J Toxicol Environ Health B Crit Rev 13:218-31. 2010
    ....
  6. pmc In vitro screening of environmental chemicals for targeted testing prioritization: the ToxCast project
    Richard S Judson
    National Center for Computational Toxicology, Office of Research and Development, US Environmental Protection Agency, Research Triangle Park, North Carolina 27711, USA
    Environ Health Perspect 118:485-92. 2010
    ..The U.S. Environmental Protection Agency's ToxCast program aims to address these concerns by screening and prioritizing chemicals for potential human toxicity using in vitro assays and in silico approaches...
  7. pmc The toxicity data landscape for environmental chemicals
    Richard Judson
    National Center for Computational Toxicology, Office of Research and Development, U S Environmental Protection Agency, Research Triangle Park, North Carolina 27711, USA
    Environ Health Perspect 117:685-95. 2009
    ..The main objective of this analysis is to define a list of environmental chemicals that are candidates for the U.S. EPA screening and prioritization process, and to catalog the available toxicology information...
  8. doi request reprint Using pathway modules as targets for assay development in xenobiotic screening
    Richard S Judson
    National Center for Computational Toxicology, Office of Research and Development, US Environmental Protection Agency, Research Triangle Park, NC 27711, USA
    Mol Biosyst 8:531-42. 2012
    ..These selected genes could then form the basis for a battery to test for pathway-chemical interactions under many biological contexts using throughput expression-based assays...
  9. doi request reprint ACToR--Aggregated Computational Toxicology Resource
    Richard Judson
    National Center for Computational Toxicology, U S Environmental Protection Agency, 109 T W Alexander Drive, Research Triangle Park, NC 27711, USA
    Toxicol Appl Pharmacol 233:7-13. 2008
    ..At the EPA National Center for Computational Toxicology, ACToR helps manage large data sets being used in a high-throughput environmental chemical screening and prioritization program called ToxCast...
  10. pmc A comparison of machine learning algorithms for chemical toxicity classification using a simulated multi-scale data model
    Richard Judson
    National Center for Computational Toxicology, Office of Research and Development, US Environmental Protection Agency, Research Triangle Park, North Carolina 27711, USA
    BMC Bioinformatics 9:241. 2008
    ..We present a novel model to simulate complex chemical-toxicology data sets and use this model to evaluate the relative performance of different machine learning (ML) methods...
  11. pmc Environmental impact on vascular development predicted by high-throughput screening
    Nicole C Kleinstreuer
    National Center for Computational Toxiciology, Office of Research and Development, U S Environmental Protection Agency, Research Triangle Park, North Carolina, USA
    Environ Health Perspect 119:1596-603. 2011
    ....
  12. doi request reprint Predictive models of prenatal developmental toxicity from ToxCast high-throughput screening data
    Nisha S Sipes
    National Center for Computational Toxicology, Office of Research and Development, U S Environmental Protection Agency, Research Triangle Park, North Carolina 27711, USA
    Toxicol Sci 124:109-27. 2011
    ..This work indicates the utility of HTS assays for developing pathway-level models predictive of developmental toxicity...
  13. doi request reprint In vitro perturbations of targets in cancer hallmark processes predict rodent chemical carcinogenesis
    Nicole C Kleinstreuer
    National Center for Computational Toxicology, Office of Research and Development, US Environmental Protection Agency, Research Triangle Park, North Carolina 27711, USA
    Toxicol Sci 131:40-55. 2013
    ..This model represents a chemical carcinogenicity prioritization tool supporting targeted testing and functional validation of cancer pathways...
  14. doi request reprint Predictive model of rat reproductive toxicity from ToxCast high throughput screening
    Matthew T Martin
    National Center for Computational Toxicology, Office of Research and Development, U S Environmental Protection Agency, Research Triangle Park, NC 27711, USA
    Biol Reprod 85:327-39. 2011
    ....
  15. doi request reprint Integration of dosimetry, exposure, and high-throughput screening data in chemical toxicity assessment
    Barbara A Wetmore
    The Hamner Institutes for Health Sciences, Research Triangle Park, North Carolina 27709 2137, USA
    Toxicol Sci 125:157-74. 2012
    ..The incorporation of dosimetry and exposure provide necessary context for interpretation of in vitro toxicity screening data and are important considerations in determining chemical testing priorities...
  16. ncbi request reprint Profiling the activity of environmental chemicals in prenatal developmental toxicity studies using the U.S. EPA's ToxRefDB
    Thomas B Knudsen
    National Center for Computational Toxicology, Office of Research and Development, U S Environmental Protection Agency, Research Triangle Park, NC 27711, United States
    Reprod Toxicol 28:209-19. 2009
    ..This novel data model provides an important public resource for cross-scale modeling and predictive understanding of developmental processes and toxicities...
  17. doi request reprint Economic benefits of using adaptive predictive models of reproductive toxicity in the context of a tiered testing program
    Matthew T Martin
    National Center for Computational Toxicology, Office of Research and Development, US Environmental Protection Agency, Research Triangle Park, North Carolina 27711, USA
    Syst Biol Reprod Med 58:3-9. 2012
    ....
  18. pmc Profiling 976 ToxCast chemicals across 331 enzymatic and receptor signaling assays
    Nisha S Sipes
    National Center for Computational Toxicology, Office of Research and Development, U S Environmental Protection Agency, Research Triangle Park, North Carolina 27711, USA
    Chem Res Toxicol 26:878-95. 2013
    ..Results from this large inventory of chemical-biological interactions can inform read-across methods as well as link potential targets to molecular initiating events in adverse outcome pathways for diverse toxicities...
  19. pmc Endocrine profiling and prioritization of environmental chemicals using ToxCast data
    David M Reif
    National Center for Computational Toxicology, Office of Research and Development, U S Environmental Protection Agency, Research Triangle Park, North Carolina 27711, USA
    Environ Health Perspect 118:1714-20. 2010
    ..S. EPA's Endocrine Disruptor Screening Program (EDSP) has been charged with screening pesticide chemicals and environmental contaminants for their potential to affect the endocrine systems of humans and wildlife...
  20. doi request reprint Activity profiles of 309 ToxCastâ„¢ chemicals evaluated across 292 biochemical targets
    Thomas B Knudsen
    National Center for Computational Toxicology B205 01, Office of Research and Development, U S Environmental Protection Agency, Research Triangle Park, NC 27711, USA
    Toxicology 282:1-15. 2011
    ..The primary dataset, summary data and details on quality control checks are available for download at http://www.epa.gov/ncct/toxcast/...
  21. doi request reprint Xenobiotic-metabolizing enzyme and transporter gene expression in primary cultures of human hepatocytes modulated by ToxCast chemicals
    Daniel M Rotroff
    US Environmental Protection Agency, Office of Research and Development, National Center for Computational Toxicology, Research Triangle Park, North Carolina, USA
    J Toxicol Environ Health B Crit Rev 13:329-46. 2010
    ..Significant relative risk associations with rodent in vivo chronic toxicity effects are reported for the five major receptor pathways. These gene expression data are being incorporated into the larger ToxCast predictive modeling effort...
  22. ncbi request reprint Phenotypic screening of the ToxCast chemical library to classify toxic and therapeutic mechanisms
    Nicole C Kleinstreuer
    National Center for Computational Toxicology, Office of Research and Development, United States Environmental Protection Agency, Research Triangle Park, North Carolina, USA
    Nat Biotechnol 32:583-91. 2014
    ..Our results demonstrate that assaying complex biological pathways in primary human cells can identify potential chemical targets, toxicological liabilities and mechanisms useful for elucidating adverse outcome pathways. ..
  23. doi request reprint Real-time growth kinetics measuring hormone mimicry for ToxCast chemicals in T-47D human ductal carcinoma cells
    Daniel M Rotroff
    Department of Environmental Sciences and Engineering, University of North Carolina, Chapel Hill, North Carolina 27514, United States
    Chem Res Toxicol 26:1097-107. 2013
    ..In conclusion, this cell-based assay rapidly detects chemical effects on T-47D growth and shows potential, in combination with other HTS assays, to detect environmentally relevant chemicals with potential estrogenic activity. ..
  24. doi request reprint Relative impact of incorporating pharmacokinetics on predicting in vivo hazard and mode of action from high-throughput in vitro toxicity assays
    Barbara A Wetmore
    The Hamner Institutes for Health Sciences, Research Triangle Park, North Carolina 27709 2137, USA
    Toxicol Sci 132:327-46. 2013
    ....
  25. ncbi request reprint Incorporating exposure information into the toxicological prioritization index decision support framework
    Sumit Gangwal
    National Center for Computational Toxicology NCCT, Office of Research and Development, U S Environmental Protection Agency, Research Triangle Park, NC, USA
    Sci Total Environ 435:316-25. 2012
    ..The ToxPi framework can be used to gain insight into the factors driving these rankings and aid identification of key exposure metrics. Additional exposure data is required to build confidence in exposure-based chemical prioritization...
  26. pmc Profiling chemicals based on chronic toxicity results from the U.S. EPA ToxRef Database
    Matthew T Martin
    National Center for Computational Toxicology, Office of Research and Development, U S Environmental Protection Agency, Research Triangle Park, North Carolina 27711, USA
    Environ Health Perspect 117:392-9. 2009
    ..These data are now accessible and mineable within ToxRefDB and are serving as a primary source of validation for U.S. EPA's ToxCast research program in predictive toxicology...
  27. doi request reprint Impact of environmental chemicals on key transcription regulators and correlation to toxicity end points within EPA's ToxCast program
    Matthew T Martin
    National Center for Computational Toxicology, Office of Research and Development, US Environmental Protection Agency, Research Triangle Park, North Carolina, USA
    Chem Res Toxicol 23:578-90. 2010
    ....
  28. ncbi request reprint Predictive endocrine testing in the 21st century using in vitro assays of estrogen receptor signaling responses
    Daniel M Rotroff
    Department of Environmental Sciences and Engineering, University of North Carolina, Chapel Hill, North Carolina 27514, United States
    Environ Sci Technol 48:8706-16. 2014
    ....
  29. doi request reprint Incorporating human dosimetry and exposure into high-throughput in vitro toxicity screening
    Daniel M Rotroff
    National Center for Computational Toxicology, Office of Research and Development, United States Environmental Protection Agency, Research Triangle Park, North Carolina 27711, USA
    Toxicol Sci 117:348-58. 2010
    ..Importantly, these tools are necessary to move beyond hazard rankings to estimates of possible in vivo responses based on in vitro screens...
  30. pmc Evaluation of 309 environmental chemicals using a mouse embryonic stem cell adherent cell differentiation and cytotoxicity assay
    Kelly J Chandler
    National Health and Environmental Effects Research Laboratory, Office of Research and Development, U S Environmental Protection Agency, Research Triangle Park, North Carolina, United States of America
    PLoS ONE 6:e18540. 2011
    ..Taken together, these results provide an initial characterization of metabolic and regulatory pathways by which some environmental chemicals may act to disrupt ES cell growth and differentiation...
  31. doi request reprint High-throughput models for exposure-based chemical prioritization in the ExpoCast project
    John F Wambaugh
    National Center for Computational Toxicology, United States Environmental Protection Agency, Research Triangle Park, North Carolina 27711, United States
    Environ Sci Technol 47:8479-88. 2013
    ..Coupled with hazard HTS, exposure HTS can place risk earlier in decision processes. High-priority chemicals become targets for further data collection. ..
  32. pmc Using nuclear receptor activity to stratify hepatocarcinogens
    Imran Shah
    National Center for Computational Toxicology, Office of Research and Development, United States Environmental Protection Agency, Research Triangle Park, North Carolina, United States of America
    PLoS ONE 6:e14584. 2011
    ..Here we report on a systematic analysis of new in vitro human NR activity data on 309 environmental chemicals in relationship to their liver cancer-related chronic outcomes in rodents...
  33. doi request reprint Profiling bioactivity of the ToxCast chemical library using BioMAP primary human cell systems
    Keith A Houck
    National Center for Computational Toxicology, Office of Research and Development, United States Environmental Protection Agency, Research Triangle Park, North Carolina, USA
    J Biomol Screen 14:1054-66. 2009
    ..This data set is being combined with additional ToxCast data sets for development of predictive toxicity models at the EPA...
  34. pmc Aggregating Data for Computational Toxicology Applications: The U.S. Environmental Protection Agency (EPA) Aggregated Computational Toxicology Resource (ACToR) System
    Richard S Judson
    U S EPA, National Center for Computational Toxicology, Research Triangle Park, NC 27709, USA E Mails M T M S G D M R P K D S J V A F S M E A C H A M R
    Int J Mol Sci 13:1805-31. 2012
    ..The entire system is built using open source tools and is freely available to download. This review describes the organization of the data repository and provides selected examples of use cases...
  35. doi request reprint Profiling the reproductive toxicity of chemicals from multigeneration studies in the toxicity reference database
    Matthew T Martin
    National Center for Computational Toxicology, Office of Research and Development, U S Environmental Protection Agency, Research Triangle Park, North Carolina 27711, USA
    Toxicol Sci 110:181-90. 2009
    ..Capturing this reproductive toxicity data in ToxRefDB supports ongoing retrospective analyses, test guideline revisions, and computational toxicology research...
  36. ncbi request reprint Computational toxicology--a state of the science mini review
    Robert J Kavlock
    National Center for Computational Toxicology, Office of Research and Development, U S Environmental Protection Agency, Research Triangle Park, NC 27711, USA
    Toxicol Sci 103:14-27. 2008
    ..The next few years should witness the early fruits of these efforts, but as the National Research Council indicates, the paradigm shift will take a long term investment and commitment to reach full potential...
  37. doi request reprint Binary classification of a large collection of environmental chemicals from estrogen receptor assays by quantitative structure-activity relationship and machine learning methods
    Qingda Zang
    ORISE Postdoctoral Fellow and National Center for Computational Toxicology, U S Environmental Protection Agency, Research Triangle Park, North Carolina 27711, United States
    J Chem Inf Model 53:3244-61. 2013
    ....
  38. ncbi request reprint Toxicity data informatics: supporting a new paradigm for toxicity prediction
    Ann M Richard
    National Center for Computational Toxicology, U S Environmental Protection Agency, Research Triangle Park, NC, 27711
    Toxicol Mech Methods 18:103-18. 2008
    ....
  39. ncbi request reprint Restoring value to stalled Phase II compounds: the case for developing a novel compound for depression using pharmacogenetics
    Carol Reed
    Pharmacogenomics 6:95-100. 2005
  40. ncbi request reprint How many SNPs does a genome-wide haplotype map require?
    Richard Judson
    Genaissance Pharmaceuticals, 5 Science Park, New Haven, CT 06511, USA
    Pharmacogenomics 3:379-91. 2002
    ..Finally, we estimate the experimental effort and cost required to complete a genome-wide haplotype survey...