Christopher J Johnson

Summary

Affiliation: U.S. Geological Survey
Country: USA

Publications

  1. pmc In vitro prion protein conversion suggests risk of bighorn sheep (Ovis canadensis) to transmissible spongiform encephalopathies
    Aaron R Morawski
    Department of Bacteriology, University of Wisconsin, Madison, WI, USA
    BMC Vet Res 9:157. 2013
  2. pmc Degradation of the disease-associated prion protein by a serine protease from lichens
    Christopher J Johnson
    Prion Research Laboratory, United States Geological Survey National Wildlife Health Center, Madison, Wisconsin, United States of America
    PLoS ONE 6:e19836. 2011
  3. pmc Low copper and high manganese levels in prion protein plaques
    Christopher J Johnson
    USGS National Wildlife Health Center, Madison, WI 53711, USA
    Viruses 5:654-62. 2013
  4. pmc Persistence of pathogenic prion protein during simulated wastewater treatment processes
    Glen T Hinckley
    Department of Civil and Environmental Engineering, University of Wisconsin, Madison, Wisconsin 53706, USA
    Environ Sci Technol 42:5254-9. 2008
  5. pmc Lichens: unexpected anti-prion agents?
    Cynthia M Rodriguez
    USGS National Wildlife Health Center Department of Bacteriology, University of Wisconsin, Madison, WI, USA
    Prion 6:11-6. 2012
  6. pmc Meat and bone meal and mineral feed additives may increase the risk of oral prion disease transmission
    Christopher J Johnson
    Prion Research Laboratory, USGS National Wildlife Health Center, Madison, Wisconsin, USA
    J Toxicol Environ Health A 74:161-6. 2011
  7. doi request reprint Pathogenic prion protein is degraded by a manganese oxide mineral found in soils
    Fabio Russo
    Department of Soil Science and Molecular and Environmental Toxicology Center, University of Wisconsin, Madison, WI, USA
    J Gen Virol 90:275-80. 2009
  8. pmc Chronic wasting disease (CWD) susceptibility of several North American rodents that are sympatric with cervid CWD epidemics
    Dennis M Heisey
    USGS National Wildlife Health Center, Madison, WI 53711, USA
    J Virol 84:210-5. 2010
  9. pmc Ultraviolet-ozone treatment reduces levels of disease-associated prion protein and prion infectivity
    Christopher J Johnson
    Department of Comparative Biosciences, University of Wisconsin Madison, 1656 Linden Dr, Madison, WI 53706, USA
    BMC Res Notes 2:121. 2009
  10. pmc Oral transmissibility of prion disease is enhanced by binding to soil particles
    Christopher J Johnson
    Program in Cellular and Molecular Biology, University of Wisconsin Madison, Madison, Wisconsin, United States of America
    PLoS Pathog 3:e93. 2007

Collaborators

  • Joel A Pedersen
  • Tonie E Rocke
  • Dennis M Heisey
  • Aaron R Morawski
  • Cynthia M Rodriguez
  • Fabio Russo
  • Judd M Aiken
  • Debbie McKenzie
  • Glen T Hinckley
  • Christina M Carlson
  • Haeyoon Chang
  • James P Bennett
  • Christian Bartholomay
  • Kurt H Jacobson
  • Katherine D McMahon

Detail Information

Publications11

  1. pmc In vitro prion protein conversion suggests risk of bighorn sheep (Ovis canadensis) to transmissible spongiform encephalopathies
    Aaron R Morawski
    Department of Bacteriology, University of Wisconsin, Madison, WI, USA
    BMC Vet Res 9:157. 2013
    ..No TSEs have been documented in BHS, but the susceptibility of this species to TSEs remains unknown...
  2. pmc Degradation of the disease-associated prion protein by a serine protease from lichens
    Christopher J Johnson
    Prion Research Laboratory, United States Geological Survey National Wildlife Health Center, Madison, Wisconsin, United States of America
    PLoS ONE 6:e19836. 2011
    ..Further work to clone and characterize the protease, assess its effect on TSE infectivity and determine which organism or organisms present in lichens produce or influence the protease activity is warranted...
  3. pmc Low copper and high manganese levels in prion protein plaques
    Christopher J Johnson
    USGS National Wildlife Health Center, Madison, WI 53711, USA
    Viruses 5:654-62. 2013
    ..These data provide evidence for prion plaques altering local transition metal distribution in the TSE-infected central nervous system...
  4. pmc Persistence of pathogenic prion protein during simulated wastewater treatment processes
    Glen T Hinckley
    Department of Civil and Environmental Engineering, University of Wisconsin, Madison, Wisconsin 53706, USA
    Environ Sci Technol 42:5254-9. 2008
    ..Our results suggest that if prions were to enter municipal wastewater treatment systems, most would partition to activated sludge solids, survive mesophilic anaerobic digestion, and be present in treated biosolids...
  5. pmc Lichens: unexpected anti-prion agents?
    Cynthia M Rodriguez
    USGS National Wildlife Health Center Department of Bacteriology, University of Wisconsin, Madison, WI, USA
    Prion 6:11-6. 2012
    ..In addition, lichens are frequently consumed by cervids and many other animals and the effect of dietary lichens on prion disease transmission should also be considered...
  6. pmc Meat and bone meal and mineral feed additives may increase the risk of oral prion disease transmission
    Christopher J Johnson
    Prion Research Laboratory, USGS National Wildlife Health Center, Madison, Wisconsin, USA
    J Toxicol Environ Health A 74:161-6. 2011
    ..Our data suggest that in feed or other prion-contaminated substances consumed by animals or, potentially, humans, the addition of MBM or the presence of microparticles could heighten risks of prion disease acquisition...
  7. doi request reprint Pathogenic prion protein is degraded by a manganese oxide mineral found in soils
    Fabio Russo
    Department of Soil Science and Molecular and Environmental Toxicology Center, University of Wisconsin, Madison, WI, USA
    J Gen Virol 90:275-80. 2009
    ..Exposure to 5.6 mg MnO(2) ml(-1) (PrP(TSE) : MnO(2)=1 : 110) decreased PrP(TSE) levels by > or = 4 orders of magnitude. Manganese oxides may contribute to prion degradation in soil environments rich in these minerals...
  8. pmc Chronic wasting disease (CWD) susceptibility of several North American rodents that are sympatric with cervid CWD epidemics
    Dennis M Heisey
    USGS National Wildlife Health Center, Madison, WI 53711, USA
    J Virol 84:210-5. 2010
    ....
  9. pmc Ultraviolet-ozone treatment reduces levels of disease-associated prion protein and prion infectivity
    Christopher J Johnson
    Department of Comparative Biosciences, University of Wisconsin Madison, 1656 Linden Dr, Madison, WI 53706, USA
    BMC Res Notes 2:121. 2009
    ..Using larger UV-ozone doses or combining UV-ozone treatment with other decontaminant methods may allow the sterilization of TSE-contaminated materials...
  10. pmc Oral transmissibility of prion disease is enhanced by binding to soil particles
    Christopher J Johnson
    Program in Cellular and Molecular Biology, University of Wisconsin Madison, Madison, Wisconsin, United States of America
    PLoS Pathog 3:e93. 2007
    ..Association of prions with inorganic microparticles represents a novel means by which their oral transmission is enhanced relative to unbound agent...
  11. pmc Prions adhere to soil minerals and remain infectious
    Christopher J Johnson
    Program in Cellular and Molecular Biology, University of Wisconsin Madison, Madison, Wisconsin, United States of America
    PLoS Pathog 2:e32. 2006
    ..Results from our study suggest that PrP(Sc) released into soil environments may be preserved in a bioavailable form, perpetuating prion disease epizootics and exposing other species to the infectious agent...