Research Topics
| Christopher J JohnsonSummaryAffiliation: U.S. Geological Survey Country: USA Publications
| Collaborators |
Detail Information
Publications
Ultraviolet-ozone treatment reduces levels of disease-associated prion protein and prion infectivityChristopher J Johnson
Department of Comparative Biosciences, University of Wisconsin Madison, 1656 Linden Dr, Madison, WI 53706, USA
BMC Res Notes 2:121. 2009..Using larger UV-ozone doses or combining UV-ozone treatment with other decontaminant methods may allow the sterilization of TSE-contaminated materials...
Degradation of the disease-associated prion protein by a serine protease from lichensChristopher J Johnson
Prion Research Laboratory, United States Geological Survey National Wildlife Health Center, Madison, Wisconsin, United States of America
PLoS ONE 6:e19836. 2011..Further work to clone and characterize the protease, assess its effect on TSE infectivity and determine which organism or organisms present in lichens produce or influence the protease activity is warranted...
Meat and bone meal and mineral feed additives may increase the risk of oral prion disease transmissionChristopher J Johnson
Prion Research Laboratory, USGS National Wildlife Health Center, Madison, Wisconsin, USA
J Toxicol Environ Health A 74:161-6. 2011..Our data suggest that in feed or other prion-contaminated substances consumed by animals or, potentially, humans, the addition of MBM or the presence of microparticles could heighten risks of prion disease acquisition...
Chronic wasting disease (CWD) susceptibility of several North American rodents that are sympatric with cervid CWD epidemicsDennis M Heisey
USGS National Wildlife Health Center, Madison, WI 53711, USA
J Virol 84:210-5. 2010....
Oral transmissibility of prion disease is enhanced by binding to soil particlesChristopher J Johnson
Program in Cellular and Molecular Biology, University of Wisconsin Madison, Madison, Wisconsin, United States of America
PLoS Pathog 3:e93. 2007..Association of prions with inorganic microparticles represents a novel means by which their oral transmission is enhanced relative to unbound agent...
Prions adhere to soil minerals and remain infectiousChristopher J Johnson
Program in Cellular and Molecular Biology, University of Wisconsin Madison, Madison, Wisconsin, United States of America
PLoS Pathog 2:e32. 2006..Results from our study suggest that PrP(Sc) released into soil environments may be preserved in a bioavailable form, perpetuating prion disease epizootics and exposing other species to the infectious agent...
