M F Hughes

Summary

Affiliation: U.S. Environmental Protection Agency
Country: USA

Publications

  1. ncbi request reprint Arsenic toxicity and potential mechanisms of action
    Michael F Hughes
    US Environmental Protection Agency, Office of Research and Development, National Health and Environmental Effects Research Laboratory, MD 74, Research Triangle Park, NC 27711, USA
    Toxicol Lett 133:1-16. 2002
  2. pmc Biomarkers of exposure: a case study with inorganic arsenic
    Michael F Hughes
    National Health and Environmental Effects Research Laboratory, Office of Research and Development, U S Environmental Protection Agency, Research Triangle Park, North Carolina 27711, USA
    Environ Health Perspect 114:1790-6. 2006
  3. ncbi request reprint Research approaches to address uncertainties in the risk assessment of arsenic in drinking water
    Michael F Hughes
    US Environmental Protection Agency, Office of Research and Development, National Health and Environmental Effects Research Laboratory, MD B143 01, Research Triangle Park, NC 27711, USA
    Toxicol Appl Pharmacol 222:399-404. 2007
  4. pmc Tissue dosimetry, metabolism and excretion of pentavalent and trivalent dimethylated arsenic in mice after oral administration
    Michael F Hughes
    US Environmental Protection Agency, Office of Research and Development, National Health and Environmental Effects Research Laboratory, Research Triangle Park, NC 27711, USA
    Toxicol Appl Pharmacol 227:26-35. 2008
  5. ncbi request reprint Accumulation and metabolism of arsenic in mice after repeated oral administration of arsenate
    Michael F Hughes
    U S Environmental Protection Agency, National Health and Environmental Effects Research Laboratory, Research Triangle Park, NC 27711, USA
    Toxicol Appl Pharmacol 191:202-10. 2003
  6. ncbi request reprint In vitro dermal absorption of flame retardant chemicals
    M F Hughes
    US Environmental Protection Agency, Office of Research and Development, National Health and Environmental Effects Research Laboratory, Research Triangle Park, NC 27711, USA
    Food Chem Toxicol 39:1263-70. 2001
  7. doi request reprint In vitro dermal absorption of pyrethroid pesticides in human and rat skin
    Michael F Hughes
    Integrated Systems Toxicology Division, National Health and Environmental Effects Research Laboratory, Office of Research and Development, U S Environmental Protection Agency, Research Triangle Park, NC 27711, USA
    Toxicol Appl Pharmacol 246:29-37. 2010
  8. pmc Arsenic exposure and toxicology: a historical perspective
    Michael F Hughes
    Office of Research and Development, National Health and Environmental Effects Research Laboratory, U S Environmental Protection Agency, Research Triangle Park, North Carolina 27711, USA
    Toxicol Sci 123:305-32. 2011
  9. pmc Tissue dosimetry, metabolism and excretion of pentavalent and trivalent monomethylated arsenic in mice after oral administration
    Michael F Hughes
    U S Environmental Protection Agency, Office of Research and Development, National Health and Environmental Effects Research Laboratory, Research Triangle Park, NC 27711, USA
    Toxicol Appl Pharmacol 208:186-97. 2005
  10. ncbi request reprint Dose-dependent effects on tissue distribution and metabolism of dimethylarsinic acid in the mouse after intravenous administration
    M F Hughes
    U S Environmental Protection Agency, Experimental Toxicology Division, Research Triangle Park, NC 27711, USA
    Toxicology 143:155-66. 2000

Detail Information

Publications24

  1. ncbi request reprint Arsenic toxicity and potential mechanisms of action
    Michael F Hughes
    US Environmental Protection Agency, Office of Research and Development, National Health and Environmental Effects Research Laboratory, MD 74, Research Triangle Park, NC 27711, USA
    Toxicol Lett 133:1-16. 2002
    ..A better understanding of the mechanism(s) of action of arsenic will make a more confident determination of the risks associated with exposure to this chemical...
  2. pmc Biomarkers of exposure: a case study with inorganic arsenic
    Michael F Hughes
    National Health and Environmental Effects Research Laboratory, Office of Research and Development, U S Environmental Protection Agency, Research Triangle Park, North Carolina 27711, USA
    Environ Health Perspect 114:1790-6. 2006
    ....
  3. ncbi request reprint Research approaches to address uncertainties in the risk assessment of arsenic in drinking water
    Michael F Hughes
    US Environmental Protection Agency, Office of Research and Development, National Health and Environmental Effects Research Laboratory, MD B143 01, Research Triangle Park, NC 27711, USA
    Toxicol Appl Pharmacol 222:399-404. 2007
    ..Integration of research to address these goals will better protect the health of iAs-exposed populations...
  4. pmc Tissue dosimetry, metabolism and excretion of pentavalent and trivalent dimethylated arsenic in mice after oral administration
    Michael F Hughes
    US Environmental Protection Agency, Office of Research and Development, National Health and Environmental Effects Research Laboratory, Research Triangle Park, NC 27711, USA
    Toxicol Appl Pharmacol 227:26-35. 2008
    ..TMAO was detected in tissues of the high dose DMA(V) group. The low acute toxicity of DMA(V) in the mouse appears to be due in part to its minimal retention and rapid elimination...
  5. ncbi request reprint Accumulation and metabolism of arsenic in mice after repeated oral administration of arsenate
    Michael F Hughes
    U S Environmental Protection Agency, National Health and Environmental Effects Research Laboratory, Research Triangle Park, NC 27711, USA
    Toxicol Appl Pharmacol 191:202-10. 2003
    ..A trimethylated metabolite was also detected in the liver. Tissue accumulation of arsenic after repeated po exposure to arsenate in the mouse corresponds to the known human target organs for iAs-induced carcinogenicity...
  6. ncbi request reprint In vitro dermal absorption of flame retardant chemicals
    M F Hughes
    US Environmental Protection Agency, Office of Research and Development, National Health and Environmental Effects Research Laboratory, Research Triangle Park, NC 27711, USA
    Food Chem Toxicol 39:1263-70. 2001
    ..The differences in the physico-chemical properties of these two chemicals most likely explains their dissimilar absorption through hairless mouse skin...
  7. doi request reprint In vitro dermal absorption of pyrethroid pesticides in human and rat skin
    Michael F Hughes
    Integrated Systems Toxicology Division, National Health and Environmental Effects Research Laboratory, Office of Research and Development, U S Environmental Protection Agency, Research Triangle Park, NC 27711, USA
    Toxicol Appl Pharmacol 246:29-37. 2010
    ..Therefore, consideration of the skin type used and fractions analyzed are important when using in vitro dermal absorption data for risk assessment...
  8. pmc Arsenic exposure and toxicology: a historical perspective
    Michael F Hughes
    Office of Research and Development, National Health and Environmental Effects Research Laboratory, U S Environmental Protection Agency, Research Triangle Park, North Carolina 27711, USA
    Toxicol Sci 123:305-32. 2011
    ..With advances in technology and the recent development of animal models for arsenic carcinogenicity, understanding of the toxicology of arsenic will continue to improve...
  9. pmc Tissue dosimetry, metabolism and excretion of pentavalent and trivalent monomethylated arsenic in mice after oral administration
    Michael F Hughes
    U S Environmental Protection Agency, Office of Research and Development, National Health and Environmental Effects Research Laboratory, Research Triangle Park, NC 27711, USA
    Toxicol Appl Pharmacol 208:186-97. 2005
    ..Based on urinary analysis, administered dose of MMA(V) did not affect the level of its metabolites excreted. In the tested range, dose affects the absorption, distribution and route of excretion of MMA(V) but not its metabolism...
  10. ncbi request reprint Dose-dependent effects on tissue distribution and metabolism of dimethylarsinic acid in the mouse after intravenous administration
    M F Hughes
    U S Environmental Protection Agency, Experimental Toxicology Division, Research Triangle Park, NC 27711, USA
    Toxicology 143:155-66. 2000
    ..No methylated or demethylated products of DMA were detected in blood or any organ up to 8 h post-exposure. The dose-dependent distribution of DMA in the lung may have a role in the toxic effects DMA elicits in this organ...
  11. ncbi request reprint Dose-dependent effects on the disposition of monomethylarsonic acid and dimethylarsinic acid in the mouse after intravenous administration
    M F Hughes
    National Health and Environmental Effects Research Laboratory, U S Environmental Protection Agency, Research Triangle Park, North Carolina 27711, USA
    J Toxicol Environ Health A 53:95-112. 1998
    ..The rapid elimination and low retention of MMA and DMA explain in part their low acute toxicity...
  12. ncbi request reprint Strain-dependent disposition of inorganic arsenic in the mouse
    M F Hughes
    Experimental Toxicology Division, National Health and Environmental Effects Research Laboratory, US Environmental Protection Agency, Research Triangle Park, NC 27711, USA
    Toxicology 137:95-108. 1999
    ..A better understanding of the role of phenotype in the disposition and toxicity of iAs would reduce the uncertainty in arsenic risk assessment...
  13. doi request reprint Concentration- and time-dependent genomic changes in the mouse urinary bladder following exposure to arsenate in drinking water for up to 12 weeks
    H J Clewell
    The Hamner Institutes for Health Sciences, Research Triangle Park, North Carolina 27709, USA
    Toxicol Sci 123:421-32. 2011
    ..The results of this study provide evidence of a concentration-dependent transition in the mode of action for the subchronic effects of As(i) in mouse bladder cells in the vicinity of 2 mg As(i)/l...
  14. doi request reprint Tissue distribution and urinary excretion of inorganic arsenic and its methylated metabolites in C57BL6 mice following subchronic exposure to arsenate in drinking water
    E M Kenyon
    Experimental Toxicology Division, Mail Stop B143 01, National Health and Environmental Effects Research Laboratory, Office of Research and Development, U S Environmental Protection Agency, Research Triangle Park, NC 27711, USA
    Toxicol Appl Pharmacol 232:448-55. 2008
    ....
  15. ncbi request reprint Tissue distribution and urinary excretion of inorganic arsenic and its methylated metabolites in mice following acute oral administration of arsenate
    E M Kenyon
    Experimental Toxicology Division, National Health and Environmental Effects Research Laboratory, Office of Research and Development, US Environmental Protection Agency, Research Triangle Park, North Carolina 27711, USA
    Toxicol Sci 85:468-75. 2005
    ....
  16. ncbi request reprint A concise review of the toxicity and carcinogenicity of dimethylarsinic acid
    E M Kenyon
    US Environmental Protection Agency, Office of Research and Development, National Health and Environmental Effects Research Laboratory, Experimental Toxicology Division, MD-74, Research Triangle Park, NC 27711, USA
    Toxicology 160:227-36. 2001
    ..These data collectively suggest that DMA plays a role in the carcinogenesis of inorganic arsenic...
  17. doi request reprint A physiologically based pharmacokinetic model for intravenous and ingested dimethylarsinic acid in mice
    Marina V Evans
    National Health and Environmental Effects Research Laboratory, Office of Research and Development, U S Environmental Protection Agency, Research Triangle Park, North Carolina 27711, USA
    Toxicol Sci 104:250-60. 2008
    ....
  18. ncbi request reprint An integrated pharmacokinetic and pharmacodynamic study of arsenite action 2. Heme oxygenase induction in mice
    Elaina M Kenyon
    Experimental Toxicology Division, U S Environmental Protection Agency, Office of Research and Development, National Health and Environmental Effects Research Laboratory ETD PKB, Research Triangle Park, NC 27711, USA
    Toxicology 206:389-401. 2005
    ..Thus, HO induction has potential for use as a biomarker of effect for inorganic arsenic exposure and may be used as an indicator response to further the development of a biologically-based dose response model for As...
  19. doi request reprint Arsenic (+3 oxidation state) methyltransferase genotype affects steady-state distribution and clearance of arsenic in arsenate-treated mice
    Michael F Hughes
    Pharmacokinetics Branch, Integrated Systems Toxicology Division, National Health and Environmental Effects Research Laboratory, Office of Research and Development, US Environmental Protection Agency, Research Triangle Park, NC 27711, USA
    Toxicol Appl Pharmacol 249:217-23. 2010
    ..Altered retention and tissue tropism of arsenic in As3mt knockout mice could affect the toxic or carcinogenic effects associated with exposure to this metalloid or its methylated metabolites...
  20. doi request reprint Accumulation of pyrethroid compounds in primary cultures from rat cortex
    Timothy J Shafer
    Integrated Systems Toxicology Division, National Health and Environmental Effects Research Laboratory, US Environmental Protection Agency, Research Triangle Park, NC, USA
    Toxicol In Vitro 24:2053-7. 2010
    ..This data will be useful for making comparisons between in vivo and in vitro studies regarding effective concentrations of pyrethroids...
  21. ncbi request reprint Identification of rat and human cytochrome p450 isoforms and a rat serum esterase that metabolize the pyrethroid insecticides deltamethrin and esfenvalerate
    Stephen J Godin
    United States Environmental Protection Agency, Office of Research and Development, National Health and Environmental Effects Resource Laboratory, Experimental Toxicology Division, Pharmacokinetics Branch, Research Triangle Park, NC 27711, USA
    Drug Metab Dispos 35:1664-71. 2007
    ..Furthermore, these studies show that the metabolic elimination of deltamethrin and esfenvalerate in blood may be important to their disposition in rats but not in humans...
  22. doi request reprint In vitro metabolism of pyrethroid pesticides by rat and human hepatic microsomes and cytochrome p450 isoforms
    Edward J Scollon
    United States Environmental Protection Agency, Office of Research and Development, National Health and Environmental Effects Research Laboratory, Research Triangle Park, North Carolina 27711, USA
    Drug Metab Dispos 37:221-8. 2009
    ..These species differences and isomer interactions in metabolism of pyrethroids should be considered when assessing the potential adverse health effects of pyrethroid pesticides...
  23. ncbi request reprint Liquid chromatography determination of the anti-androgen vinclozolin and its metabolites in rat serum
    Adolfo Sierra-Santoyo
    Experimental Toxicology Division, National Health and Environmental Effects Research Laboratory, Office of Research and Development, US Environmental Protection Agency, MD B143 01, Research Triangle Park, NC 27711, USA
    J Chromatogr B Analyt Technol Biomed Life Sci 809:105-10. 2004
    ..4 and rat serum, with M1 the predominant metabolite. This method was successfully applied in the analysis of V and its metabolites in the serum of a male rat after oral administration of V (100 mg/kg)...
  24. ncbi request reprint Species differences in the in vitro metabolism of deltamethrin and esfenvalerate: differential oxidative and hydrolytic metabolism by humans and rats
    Stephen J Godin
    Curriculum in Toxicology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA
    Drug Metab Dispos 34:1764-71. 2006
    ....