D W Herr
Affiliation: U.S. Environmental Protection Agency
- A comparison of the acute neuroactive effects of dichloromethane, 1,3-dichloropropane, and 1,2-dichlorobenzene on rat flash evoked potentials (FEPs)D W Herr
National Health and Environmental Effects Research Laboratory, U S Environmental Protection Agency, Research Triangle Park, North Carolina 27711, USA
Fundam Appl Toxicol 35:31-48. 1997..The results suggest that organic solvents have multiple acute effects on the function of the central nervous system, which are not predictable solely by the compound's lipid solubility...
- Flash-, somatosensory-, and peripheral nerve-evoked potentials in rats perinatally exposed to Aroclor 1254D W Herr
Neurotoxicology Division, MD 74B, National Health and Environmental Effects Research Laboratory, Office of Research and Development, U S Environmental Protection Agency, Research Triangle Park, NC 27711, USA
Neurotoxicol Teratol 23:591-601. 2001..However, subtle changes in the function of the visual or somatosensory systems cannot be disproved...
- Inhalational exposure to carbonyl sulfide produces altered brainstem auditory and somatosensory-evoked potentials in Fischer 344N ratsDavid W Herr
Neurotoxicology Division, MD B105 05, NHEERL, ORD, USEPA, Research Triangle Park, North Carolina 27711, USA
Toxicol Sci 95:118-35. 2007..This series of experiments demonstrates that COS produces changes in brainstem auditory and cortical somatosensory neurophysiological responses that correlate with previously described histopathological damage...
- Evaluation of sensory evoked potentials in Long Evans rats gestationally exposed to mercury (Hg0) vaporDavid W Herr
Neurotoxicology Division, MD B105 05, NHEERL, ORD, U S Environmental Protection Agency, 109 T W Alexander Drive, Research Triangle Park, NC 27711, USA
Toxicol Sci 82:193-206. 2004..These results indicate that gestational exposure to 4 mg/m(3) Hg(0) did not result in changes in responses evoked from peripheral nerves, or the somatosensory, auditory, or visual modalities...
- A system for simultaneous multiple subject, multiple stimulus modality, and multiple channel collection and analysis of sensory evoked potentialsC W Hamm
Neurotoxicology Division, National Health and Environmental Effects Research Laboratory, Office of Research and Development, United States Environmental Protection Agency, Research Triangle Park, NC 27711, USA
J Neurosci Methods 102:95-108. 2000..Sample data are presented from control animals for each of the sensory modalities for comparison with historical data collected from other systems...
- Possible confounding effects of strobe "clicks" on flash evoked potentials in ratsD W Herr
National Health and Environmental Effects Research Laboratory, U S Environmental Protection Agency, Research Triangle Park, NC 27711, USA
Physiol Behav 59:325-40. 1996....
- Gestational mercury vapor exposure and diet contribute to mercury accumulation in neonatal ratsDaniel L Morgan
National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, North Carolina 27709, USA
Environ Health Perspect 114:735-9. 2006..These data indicate that dietary exposure to trace amounts of Hg can result in a significantly greater accumulation of Hg in neonates than gestational exposure to high concentrations of Hg0 vapor...
- Thermoregulatory response to an organophosphate and carbamate insecticide mixture: testing the assumption of dose-additivityChristopher J Gordon
Neurotoxicology Division, National Health and Environmental Effects Research Laboratory, B105 04, U S Environmental Protection Agency, 109 S T W Alexander Drive, Research Triangle Park, NC 27711, USA
Toxicology 217:1-13. 2006..e., ChE inhibition) endpoints for the 2:1 and 1:1 mixtures studies did not coincide as expected. An interaction between CHP and CAR appears to depend on the ratio of compounds in the mixture as well as the biological endpoint...
- D-optimal experimental designs to test for departure from additivity in a fixed-ratio mixture rayTodd Coffey
Department of Biostatistics, Virginia Commonwealth University, Richmond, 23298, USA
Toxicol Sci 88:467-76. 2005..Use of a D-optimal criterion produces experimental designs with increased power, whereas standard nonoptimal designs with equally spaced dose groups may result in low power if the active range or threshold is missed...
- Contribution of magnetic resonance microscopy in the 12-week neurotoxicity evaluation of carbonyl sulfide in Fischer 344 ratsRobert C Sills
Laboratory of Experimental Pathology, NIEHS, Research Triangle Park, North Carolina 27709, USA
Toxicol Pathol 32:501-10. 2004....
- Neurotoxicity of carbonyl sulfide in F344 rats following inhalation exposure for up to 12 weeksDaniel L Morgan
Laboratory of Molecular Toxicology, NIEHS, Research Triangle Park, NC 27709, USA
Toxicol Appl Pharmacol 200:131-45. 2004..Our studies demonstrate that this environmental air contaminant has the potential to cause a wide spectrum of brain lesions that are dependent on the degree and duration of exposure...
- Depression of the photic after discharge of flash evoked potentials by physostigmine, carbaryl and propoxur, and the relationship to inhibition of brain cholinesteraseJean Claude Mwanza
National Research Council, Washington, DC 20001, United States
Neurotoxicology 29:87-100. 2008..However, the data suggest that disruption of cortical processing of visual signals related to FEP late components, as indicated by depression of the PhAD, was related to inhibition of brain ChE activity...
- Effects of gestational exposure to ethane dimethanesulfonate in CD-1 mice: microtia and preliminary hearing testsDana K Tarka-Leeds
Curriculum in Toxicology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA
Birth Defects Res B Dev Reprod Toxicol 68:383-90. 2003..We report microtia in CD-1 mice after gestational exposure to ethane dimethanesulfonate (EDS), an alkylating agent and adult rat Leydig cell toxicant...
- Disassociation of carbon disulfide-induced depression of flash-evoked potential peak N166 amplitude and norepinephrine levelsJaimie E Graff
Neurotoxicology Division, MD B105 05, National Health and Environmental Effects Research Laboratory, Office of Research and Development, U S Environmental Protection Agency, Research Triangle Park, North Carolina 27711, USA
Toxicol Sci 73:403-15. 2003..There was no apparent association between the decreases in NE levels and the reductions in amplitudes for peaks N36 and N166. The neurochemical mechanism for CS2-induced reductions in FEP peak amplitudes remains to be determined...