D W Herr

Summary

Affiliation: U.S. Environmental Protection Agency
Country: USA

Publications

  1. ncbi request reprint A comparison of the acute neuroactive effects of dichloromethane, 1,3-dichloropropane, and 1,2-dichlorobenzene on rat flash evoked potentials (FEPs)
    D W Herr
    National Health and Environmental Effects Research Laboratory, U S Environmental Protection Agency, Research Triangle Park, North Carolina 27711, USA
    Fundam Appl Toxicol 35:31-48. 1997
  2. ncbi request reprint Flash-, somatosensory-, and peripheral nerve-evoked potentials in rats perinatally exposed to Aroclor 1254
    D W Herr
    Neurotoxicology Division, MD 74B, National Health and Environmental Effects Research Laboratory, Office of Research and Development, U S Environmental Protection Agency, Research Triangle Park, NC 27711, USA
    Neurotoxicol Teratol 23:591-601. 2001
  3. ncbi request reprint Inhalational exposure to carbonyl sulfide produces altered brainstem auditory and somatosensory-evoked potentials in Fischer 344N rats
    David W Herr
    Neurotoxicology Division, MD B105 05, NHEERL, ORD, USEPA, Research Triangle Park, North Carolina 27711, USA
    Toxicol Sci 95:118-35. 2007
  4. ncbi request reprint Evaluation of sensory evoked potentials in Long Evans rats gestationally exposed to mercury (Hg0) vapor
    David W Herr
    Neurotoxicology Division, MD B105 05, NHEERL, ORD, U S Environmental Protection Agency, 109 T W Alexander Drive, Research Triangle Park, NC 27711, USA
    Toxicol Sci 82:193-206. 2004
  5. ncbi request reprint A system for simultaneous multiple subject, multiple stimulus modality, and multiple channel collection and analysis of sensory evoked potentials
    C W Hamm
    Neurotoxicology Division, National Health and Environmental Effects Research Laboratory, Office of Research and Development, United States Environmental Protection Agency, Research Triangle Park, NC 27711, USA
    J Neurosci Methods 102:95-108. 2000
  6. ncbi request reprint Possible confounding effects of strobe "clicks" on flash evoked potentials in rats
    D W Herr
    National Health and Environmental Effects Research Laboratory, U S Environmental Protection Agency, Research Triangle Park, NC 27711, USA
    Physiol Behav 59:325-40. 1996
  7. pmc Gestational mercury vapor exposure and diet contribute to mercury accumulation in neonatal rats
    Daniel L Morgan
    National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, North Carolina 27709, USA
    Environ Health Perspect 114:735-9. 2006
  8. ncbi request reprint Thermoregulatory response to an organophosphate and carbamate insecticide mixture: testing the assumption of dose-additivity
    Christopher J Gordon
    Neurotoxicology Division, National Health and Environmental Effects Research Laboratory, B105 04, U S Environmental Protection Agency, 109 S T W Alexander Drive, Research Triangle Park, NC 27711, USA
    Toxicology 217:1-13. 2006
  9. ncbi request reprint D-optimal experimental designs to test for departure from additivity in a fixed-ratio mixture ray
    Todd Coffey
    Department of Biostatistics, Virginia Commonwealth University, Richmond, 23298, USA
    Toxicol Sci 88:467-76. 2005
  10. ncbi request reprint Contribution of magnetic resonance microscopy in the 12-week neurotoxicity evaluation of carbonyl sulfide in Fischer 344 rats
    Robert C Sills
    Laboratory of Experimental Pathology, NIEHS, Research Triangle Park, North Carolina 27709, USA
    Toxicol Pathol 32:501-10. 2004

Detail Information

Publications14

  1. ncbi request reprint A comparison of the acute neuroactive effects of dichloromethane, 1,3-dichloropropane, and 1,2-dichlorobenzene on rat flash evoked potentials (FEPs)
    D W Herr
    National Health and Environmental Effects Research Laboratory, U S Environmental Protection Agency, Research Triangle Park, North Carolina 27711, USA
    Fundam Appl Toxicol 35:31-48. 1997
    ..The results suggest that organic solvents have multiple acute effects on the function of the central nervous system, which are not predictable solely by the compound's lipid solubility...
  2. ncbi request reprint Flash-, somatosensory-, and peripheral nerve-evoked potentials in rats perinatally exposed to Aroclor 1254
    D W Herr
    Neurotoxicology Division, MD 74B, National Health and Environmental Effects Research Laboratory, Office of Research and Development, U S Environmental Protection Agency, Research Triangle Park, NC 27711, USA
    Neurotoxicol Teratol 23:591-601. 2001
    ..However, subtle changes in the function of the visual or somatosensory systems cannot be disproved...
  3. ncbi request reprint Inhalational exposure to carbonyl sulfide produces altered brainstem auditory and somatosensory-evoked potentials in Fischer 344N rats
    David W Herr
    Neurotoxicology Division, MD B105 05, NHEERL, ORD, USEPA, Research Triangle Park, North Carolina 27711, USA
    Toxicol Sci 95:118-35. 2007
    ..This series of experiments demonstrates that COS produces changes in brainstem auditory and cortical somatosensory neurophysiological responses that correlate with previously described histopathological damage...
  4. ncbi request reprint Evaluation of sensory evoked potentials in Long Evans rats gestationally exposed to mercury (Hg0) vapor
    David W Herr
    Neurotoxicology Division, MD B105 05, NHEERL, ORD, U S Environmental Protection Agency, 109 T W Alexander Drive, Research Triangle Park, NC 27711, USA
    Toxicol Sci 82:193-206. 2004
    ..These results indicate that gestational exposure to 4 mg/m(3) Hg(0) did not result in changes in responses evoked from peripheral nerves, or the somatosensory, auditory, or visual modalities...
  5. ncbi request reprint A system for simultaneous multiple subject, multiple stimulus modality, and multiple channel collection and analysis of sensory evoked potentials
    C W Hamm
    Neurotoxicology Division, National Health and Environmental Effects Research Laboratory, Office of Research and Development, United States Environmental Protection Agency, Research Triangle Park, NC 27711, USA
    J Neurosci Methods 102:95-108. 2000
    ..Sample data are presented from control animals for each of the sensory modalities for comparison with historical data collected from other systems...
  6. ncbi request reprint Possible confounding effects of strobe "clicks" on flash evoked potentials in rats
    D W Herr
    National Health and Environmental Effects Research Laboratory, U S Environmental Protection Agency, Research Triangle Park, NC 27711, USA
    Physiol Behav 59:325-40. 1996
    ....
  7. pmc Gestational mercury vapor exposure and diet contribute to mercury accumulation in neonatal rats
    Daniel L Morgan
    National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, North Carolina 27709, USA
    Environ Health Perspect 114:735-9. 2006
    ..These data indicate that dietary exposure to trace amounts of Hg can result in a significantly greater accumulation of Hg in neonates than gestational exposure to high concentrations of Hg0 vapor...
  8. ncbi request reprint Thermoregulatory response to an organophosphate and carbamate insecticide mixture: testing the assumption of dose-additivity
    Christopher J Gordon
    Neurotoxicology Division, National Health and Environmental Effects Research Laboratory, B105 04, U S Environmental Protection Agency, 109 S T W Alexander Drive, Research Triangle Park, NC 27711, USA
    Toxicology 217:1-13. 2006
    ..e., ChE inhibition) endpoints for the 2:1 and 1:1 mixtures studies did not coincide as expected. An interaction between CHP and CAR appears to depend on the ratio of compounds in the mixture as well as the biological endpoint...
  9. ncbi request reprint D-optimal experimental designs to test for departure from additivity in a fixed-ratio mixture ray
    Todd Coffey
    Department of Biostatistics, Virginia Commonwealth University, Richmond, 23298, USA
    Toxicol Sci 88:467-76. 2005
    ..Use of a D-optimal criterion produces experimental designs with increased power, whereas standard nonoptimal designs with equally spaced dose groups may result in low power if the active range or threshold is missed...
  10. ncbi request reprint Contribution of magnetic resonance microscopy in the 12-week neurotoxicity evaluation of carbonyl sulfide in Fischer 344 rats
    Robert C Sills
    Laboratory of Experimental Pathology, NIEHS, Research Triangle Park, North Carolina 27709, USA
    Toxicol Pathol 32:501-10. 2004
    ....
  11. ncbi request reprint Neurotoxicity of carbonyl sulfide in F344 rats following inhalation exposure for up to 12 weeks
    Daniel L Morgan
    Laboratory of Molecular Toxicology, NIEHS, Research Triangle Park, NC 27709, USA
    Toxicol Appl Pharmacol 200:131-45. 2004
    ..Our studies demonstrate that this environmental air contaminant has the potential to cause a wide spectrum of brain lesions that are dependent on the degree and duration of exposure...
  12. ncbi request reprint Depression of the photic after discharge of flash evoked potentials by physostigmine, carbaryl and propoxur, and the relationship to inhibition of brain cholinesterase
    Jean Claude Mwanza
    National Research Council, Washington, DC 20001, United States
    Neurotoxicology 29:87-100. 2008
    ..However, the data suggest that disruption of cortical processing of visual signals related to FEP late components, as indicated by depression of the PhAD, was related to inhibition of brain ChE activity...
  13. ncbi request reprint Effects of gestational exposure to ethane dimethanesulfonate in CD-1 mice: microtia and preliminary hearing tests
    Dana K Tarka-Leeds
    Curriculum in Toxicology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA
    Birth Defects Res B Dev Reprod Toxicol 68:383-90. 2003
    ..We report microtia in CD-1 mice after gestational exposure to ethane dimethanesulfonate (EDS), an alkylating agent and adult rat Leydig cell toxicant...
  14. ncbi request reprint Disassociation of carbon disulfide-induced depression of flash-evoked potential peak N166 amplitude and norepinephrine levels
    Jaimie E Graff
    Neurotoxicology Division, MD B105 05, National Health and Environmental Effects Research Laboratory, Office of Research and Development, U S Environmental Protection Agency, Research Triangle Park, North Carolina 27711, USA
    Toxicol Sci 73:403-15. 2003
    ..There was no apparent association between the decreases in NE levels and the reductions in amplitudes for peaks N36 and N166. The neurochemical mechanism for CS2-induced reductions in FEP peak amplitudes remains to be determined...