Leon Earl Gray

Summary

Affiliation: U.S. Environmental Protection Agency
Country: USA

Publications

  1. ncbi request reprint The plasticizer diethylhexyl phthalate induces malformations by decreasing fetal testosterone synthesis during sexual differentiation in the male rat
    L G Parks
    Endocrinology Branch, MD 72, U S Environmental Protection Agency, National Health and Environmental Effects Research Laboratory, Reproductive Toxicology Division, Research Triangle Park, North Carolina 27711, USA
    Toxicol Sci 58:339-49. 2000
  2. ncbi request reprint Chronic di-n-butyl phthalate exposure in rats reduces fertility and alters ovarian function during pregnancy in female Long Evans hooded rats
    Leon Earl Gray
    Endocrinology Branch, Reproductive Toxicology Division, National Health and Environmental Effects Research Laboratory, ORD, U S Environmental Protection Agency, Research Triangle Park, North Carolina 27711, USA
    Toxicol Sci 93:189-95. 2006
  3. ncbi request reprint Adverse effects of environmental antiandrogens and androgens on reproductive development in mammals
    L Earl Gray
    MD 72, Endocrinology Branch, Reproductive Toxicology Division, NHEERL, ORD, US Environmental Protection Agency, RTP, NC 27771, USA
    Int J Androl 29:96-104; discussion 105-8. 2006
  4. ncbi request reprint Toxicant-induced hypospadias in the male rat
    L Earl Gray
    Endocrinology Branch, RTD, NHEERL, ORD, USEPA, RTP, NC 27711, USA
    Adv Exp Med Biol 545:217-41. 2004
  5. ncbi request reprint Xenoendocrine disrupters-tiered screening and testing: filling key data gaps
    L E Gray
    Endocrinology Branch, Reproductive Toxicology Division, National Health Environmental Effects Research Laboratory, ORD, US Environmental Protection Agency, MD 72, Research Triangle Park, NC 27111, USA
    Toxicology 181:371-82. 2002
  6. ncbi request reprint Effects of environmental antiandrogens on reproductive development in experimental animals
    L E Gray
    Endocrinology Branch, RTD, NHEERL, ORD, USEPA, RTP, NC, 27711, USA
    Hum Reprod Update 7:248-64. 2001
  7. ncbi request reprint Perinatal exposure to the phthalates DEHP, BBP, and DINP, but not DEP, DMP, or DOTP, alters sexual differentiation of the male rat
    L E Gray
    Endocrinology Branch, MD 72, U S Environmental Protection Agency, National Health and Environmental Effects Research Laboratory, Reproductive Toxicology Division, Research Triangle Park, North Carolina 27711, USA
    Toxicol Sci 58:350-65. 2000
  8. pmc Transgenerational effects of Di (2-ethylhexyl) phthalate in the male CRL:CD(SD) rat: added value of assessing multiple offspring per litter
    Leon Earl Gray
    Endocrinology Branch, RTD, NHEERL, ORD, USEPA, Research Triangle Park, North Carolina 27711, USA
    Toxicol Sci 110:411-25. 2009
  9. doi request reprint A mixture of five phthalate esters inhibits fetal testicular testosterone production in the sprague-dawley rat in a cumulative, dose-additive manner
    Kembra L Howdeshell
    Reproductive Toxicology Division, NHEERL, ORD, United States Environmental Protection Agency USEPA, Research Triangle Park, North Carolina 27711, USA
    Toxicol Sci 105:153-65. 2008
  10. ncbi request reprint Prochloraz inhibits testosterone production at dosages below those that affect androgen-dependent organ weights or the onset of puberty in the male Sprague Dawley rat
    Chad R Blystone
    Department of Environmental and Molecular Toxicology, North Carolina State University, Raleigh, North Carolina 27695, USA
    Toxicol Sci 97:65-74. 2007

Collaborators

Detail Information

Publications10

  1. ncbi request reprint The plasticizer diethylhexyl phthalate induces malformations by decreasing fetal testosterone synthesis during sexual differentiation in the male rat
    L G Parks
    Endocrinology Branch, MD 72, U S Environmental Protection Agency, National Health and Environmental Effects Research Laboratory, Reproductive Toxicology Division, Research Triangle Park, North Carolina 27711, USA
    Toxicol Sci 58:339-49. 2000
    ..These data indicate that DEHP disrupts male rat sexual differentiation by reducing T to female levels in the fetal male rat during a critical stage of reproductive tract differentiation...
  2. ncbi request reprint Chronic di-n-butyl phthalate exposure in rats reduces fertility and alters ovarian function during pregnancy in female Long Evans hooded rats
    Leon Earl Gray
    Endocrinology Branch, Reproductive Toxicology Division, National Health and Environmental Effects Research Laboratory, ORD, U S Environmental Protection Agency, Research Triangle Park, North Carolina 27711, USA
    Toxicol Sci 93:189-95. 2006
    ....
  3. ncbi request reprint Adverse effects of environmental antiandrogens and androgens on reproductive development in mammals
    L Earl Gray
    MD 72, Endocrinology Branch, Reproductive Toxicology Division, NHEERL, ORD, US Environmental Protection Agency, RTP, NC 27771, USA
    Int J Androl 29:96-104; discussion 105-8. 2006
    ....
  4. ncbi request reprint Toxicant-induced hypospadias in the male rat
    L Earl Gray
    Endocrinology Branch, RTD, NHEERL, ORD, USEPA, RTP, NC 27711, USA
    Adv Exp Med Biol 545:217-41. 2004
  5. ncbi request reprint Xenoendocrine disrupters-tiered screening and testing: filling key data gaps
    L E Gray
    Endocrinology Branch, Reproductive Toxicology Division, National Health Environmental Effects Research Laboratory, ORD, US Environmental Protection Agency, MD 72, Research Triangle Park, NC 27111, USA
    Toxicology 181:371-82. 2002
    ..Tier 1 and 2 also should examine relevant mixtures of EDCs. Toxicants that induce malformations in AR-dependent tissues produce cumulative effects even when two chemicals act via different mechanisms of action...
  6. ncbi request reprint Effects of environmental antiandrogens on reproductive development in experimental animals
    L E Gray
    Endocrinology Branch, RTD, NHEERL, ORD, USEPA, RTP, NC, 27711, USA
    Hum Reprod Update 7:248-64. 2001
    ..Knowledge of the tissue concentrations of the active toxicants also would provide an important link to in-vitro studies, which provide more useful mechanistic information when they are executed at relevant concentrations...
  7. ncbi request reprint Perinatal exposure to the phthalates DEHP, BBP, and DINP, but not DEP, DMP, or DOTP, alters sexual differentiation of the male rat
    L E Gray
    Endocrinology Branch, MD 72, U S Environmental Protection Agency, National Health and Environmental Effects Research Laboratory, Reproductive Toxicology Division, Research Triangle Park, North Carolina 27711, USA
    Toxicol Sci 58:350-65. 2000
    ..In summary, DEHP, BBP, and DINP all altered sexual differentiation, whereas DOTP, DEP, and DMP were ineffective at this dose. Whereas DEHP and BBP were of equivalent potency, DINP was about an order of magnitude less active...
  8. pmc Transgenerational effects of Di (2-ethylhexyl) phthalate in the male CRL:CD(SD) rat: added value of assessing multiple offspring per litter
    Leon Earl Gray
    Endocrinology Branch, RTD, NHEERL, ORD, USEPA, Research Triangle Park, North Carolina 27711, USA
    Toxicol Sci 110:411-25. 2009
    ....
  9. doi request reprint A mixture of five phthalate esters inhibits fetal testicular testosterone production in the sprague-dawley rat in a cumulative, dose-additive manner
    Kembra L Howdeshell
    Reproductive Toxicology Division, NHEERL, ORD, United States Environmental Protection Agency USEPA, Research Triangle Park, North Carolina 27711, USA
    Toxicol Sci 105:153-65. 2008
    ..These data demonstrate that individual phthalates with a similar mechanism of action can elicit cumulative, dose additive effects on fetal testosterone production and pregnancy when administered as a mixture...
  10. ncbi request reprint Prochloraz inhibits testosterone production at dosages below those that affect androgen-dependent organ weights or the onset of puberty in the male Sprague Dawley rat
    Chad R Blystone
    Department of Environmental and Molecular Toxicology, North Carolina State University, Raleigh, North Carolina 27695, USA
    Toxicol Sci 97:65-74. 2007
    ....