C J Gordon

Summary

Affiliation: U.S. Environmental Protection Agency
Country: USA

Publications

  1. ncbi request reprint Thermal stress and the physiological response to environmental toxicants
    Christopher J Gordon
    Neurotoxicology Division, National Health and Environmental Effects Research Laboratory, U S Environmental Protection Agency, Research Triangle Park, North Carolina 27711, USA
    Rev Environ Health 20:235-63. 2005
  2. ncbi request reprint Thermophysiological responses to hyperthermic drugs: extrapolating from rodent to human
    Christopher J Gordon
    Neurotoxicology Division, National Health and Environmental Effects Research Laboratory, B105 04, US Environmental Protection Agency, 109 S T W Alexander Drive, Research Triangle Park, NC 27711, USA
    Prog Brain Res 162:63-79. 2007
  3. ncbi request reprint Cardiac and thermal homeostasis in the aging Brown Norway rat
    Christopher J Gordon
    United States Environmental Protection Agency, Research Triangle Park, NC 27711, USA
    J Gerontol A Biol Sci Med Sci 63:1307-13. 2008
  4. ncbi request reprint Response of the thermoregulatory system to toxic insults
    Christopher J Gordon
    Toxicology Assessment Division, Neurotoxicology Branch, National Health Effects and Environmental Research Laboratory, US Environmental Protection Agency, Research Triangle Park, North Carolina 27711, USA
    Front Biosci (Elite Ed) 2:293-311. 2010
  5. doi request reprint Susceptibility of adult and senescent Brown Norway rats to repeated ozone exposure: an assessment of behavior, serum biochemistry and cardiopulmonary function
    C J Gordon
    Toxicity Assessment Division, National Health and Environmental Effects Research Laboratory, U S Environmental Protection Agency, Research Triangle Park, NC 27711, USA
    Inhal Toxicol 25:141-59. 2013
  6. doi request reprint Cardiovascular and thermoregulatory responses of unrestrained rats exposed to filtered or unfiltered diesel exhaust
    Christopher J Gordon
    Toxicity Assessment Division, National Health and Environmental Effects Research Laboratory, Office of Research and Development, U S Environmental Protection Agency, Research Triangle Park, NC 27709, USA
    Inhal Toxicol 24:296-309. 2012
  7. ncbi request reprint Chlorpyrifos-induced hypothermia and vasodilation in the tail of the rat: blockade by scopolamine
    C J Gordon
    Neurotoxicology Division, National Health and Environmental Effects Research Laboratory, U S Environmental Protection Agency, Research Triangle Park, North Carolina 27711, USA
    Pharmacol Toxicol 87:6-10. 2000
  8. ncbi request reprint Acute and delayed thermoregulatory response of mice exposed to brevetoxin
    C J Gordon
    Neurotoxicology Division, National Health and Environmental Effects Research Laboratory, US Environmental Protection Agency, Research Triangle Park, NC 27711, USA
    Toxicon 39:1367-74. 2001
  9. ncbi request reprint Diurnal variation in thermoregulatory response to chlorpyrifos and carbaryl in the rat
    C J Gordon
    Neurotoxicology Division, National Health and Environmental Effects Research Laboratory, US Environmental Protection Agency, MD 74B, Research Triangle Park, NC, 27711, USA
    Toxicology 169:93-105. 2001
  10. ncbi request reprint Thermoregulation and its influence on toxicity assessment
    Christopher J Gordon
    Neurotoxicology Division, National Health and Environmental Effects Research Laboratory, B105 04, U S Environmental Protection Agency, 109 S T W Alexander Drive, Research Triangle Park, NC 27711, USA
    Toxicology 244:87-97. 2008

Collaborators

Detail Information

Publications58

  1. ncbi request reprint Thermal stress and the physiological response to environmental toxicants
    Christopher J Gordon
    Neurotoxicology Division, National Health and Environmental Effects Research Laboratory, U S Environmental Protection Agency, Research Triangle Park, North Carolina 27711, USA
    Rev Environ Health 20:235-63. 2005
    ..This paper endeavors to review the issue of environmental heat stress and exercise and how they influence thermoregulatory and related pathophysiological responses to environmental toxicants, as well as exposure to drugs...
  2. ncbi request reprint Thermophysiological responses to hyperthermic drugs: extrapolating from rodent to human
    Christopher J Gordon
    Neurotoxicology Division, National Health and Environmental Effects Research Laboratory, B105 04, US Environmental Protection Agency, 109 S T W Alexander Drive, Research Triangle Park, NC 27711, USA
    Prog Brain Res 162:63-79. 2007
    ..Overall, the interaction between ambient temperature and drug-induced changes in body temperature is critical in the evaluation of hyperthermic-induced toxicity in rodent models...
  3. ncbi request reprint Cardiac and thermal homeostasis in the aging Brown Norway rat
    Christopher J Gordon
    United States Environmental Protection Agency, Research Triangle Park, NC 27711, USA
    J Gerontol A Biol Sci Med Sci 63:1307-13. 2008
    ..The elevation in daytime Tc beginning around 8 months of age may be a physiological biomarker of aging and may be an important factor to consider in studies using caloric restriction-induced hypothermia to increase longevity...
  4. ncbi request reprint Response of the thermoregulatory system to toxic insults
    Christopher J Gordon
    Toxicology Assessment Division, Neurotoxicology Branch, National Health Effects and Environmental Research Laboratory, US Environmental Protection Agency, Research Triangle Park, North Carolina 27711, USA
    Front Biosci (Elite Ed) 2:293-311. 2010
    ..g., telemetry). Overall, the universal effects of temperature on chemical toxicity call for researchers to have a better understanding of how body and ambient temperature affect the physiological response to environmental toxicants...
  5. doi request reprint Susceptibility of adult and senescent Brown Norway rats to repeated ozone exposure: an assessment of behavior, serum biochemistry and cardiopulmonary function
    C J Gordon
    Toxicity Assessment Division, National Health and Environmental Effects Research Laboratory, U S Environmental Protection Agency, Research Triangle Park, NC 27711, USA
    Inhal Toxicol 25:141-59. 2013
    ..Overall, adult rats exhibited more immediate effects of episodic O₃ than senescent rats. Residual effects were, however, obtained in both ages of rat, especially for ventilatory endpoints...
  6. doi request reprint Cardiovascular and thermoregulatory responses of unrestrained rats exposed to filtered or unfiltered diesel exhaust
    Christopher J Gordon
    Toxicity Assessment Division, National Health and Environmental Effects Research Laboratory, Office of Research and Development, U S Environmental Protection Agency, Research Triangle Park, NC 27709, USA
    Inhal Toxicol 24:296-309. 2012
    ..We found a significant decrease in CC and slight reduction in BP. Exposure to DEP and F is associated with pulmonary inflammation, and mild effects on HR, BP, and T(c) but there is a marked effect of DEP on CC...
  7. ncbi request reprint Chlorpyrifos-induced hypothermia and vasodilation in the tail of the rat: blockade by scopolamine
    C J Gordon
    Neurotoxicology Division, National Health and Environmental Effects Research Laboratory, U S Environmental Protection Agency, Research Triangle Park, North Carolina 27711, USA
    Pharmacol Toxicol 87:6-10. 2000
    ..The blockade of the response by scopolamine suggests that the hypothermic and vasodilatory response to chlorpyrifos is mediated via a cholinergic muscarinic pathway in the CNS...
  8. ncbi request reprint Acute and delayed thermoregulatory response of mice exposed to brevetoxin
    C J Gordon
    Neurotoxicology Division, National Health and Environmental Effects Research Laboratory, US Environmental Protection Agency, Research Triangle Park, NC 27711, USA
    Toxicon 39:1367-74. 2001
    ..Thermal dysthesia was not apparent, but the exaggerated hyperthermic response with a normal SFT in the temperature gradient may suggest an altered processing of thermal stimuli in mice treated with PbTx...
  9. ncbi request reprint Diurnal variation in thermoregulatory response to chlorpyrifos and carbaryl in the rat
    C J Gordon
    Neurotoxicology Division, National Health and Environmental Effects Research Laboratory, US Environmental Protection Agency, MD 74B, Research Triangle Park, NC, 27711, USA
    Toxicology 169:93-105. 2001
    ..Hence, cholinergic stimulation is probably not the only mechanism to explain the effects of the chronotoxicogical effects of some antiChE insecticides...
  10. ncbi request reprint Thermoregulation and its influence on toxicity assessment
    Christopher J Gordon
    Neurotoxicology Division, National Health and Environmental Effects Research Laboratory, B105 04, U S Environmental Protection Agency, 109 S T W Alexander Drive, Research Triangle Park, NC 27711, USA
    Toxicology 244:87-97. 2008
    ..This paper endeavors to summarize the importance of thermoregulation in the study of toxicology and propose recommendations for thermometry that researchers may utilize in their toxicological studies...
  11. ncbi request reprint Dietary exposure to chlorpyrifos alters core temperature in the rat
    Christopher J Gordon
    National Health and Environmental Effects Research Laboratory, Neurotoxicology Division, U S Environmental Protection Agency, Research Triangle Park, NC 27711, USA
    Toxicology 177:215-26. 2002
    ..This latter finding was unexpected and suggests that chronic exposure to CHP sensitizes the rat's thermoregulatory response to acute CHP exposure...
  12. ncbi request reprint Cardiovascular effects of oral toluene exposure in the rat monitored by radiotelemetry
    Christopher J Gordon
    Neurotoxicology Division, National Health and Environmental Effects Research Laboratory, U S Environmental Protection Agency, Research Triangle Park, North Carolina 27711, USA
    Neurotoxicol Teratol 29:228-35. 2007
    ..Doses of 0.8 and 1.2 g/kg elicited a mean BP elevation of 6 and 16 mm Hg, respectively, for 7-hour post-dosing. The biphasic tachycardia to toluene suggests multiple sites for eliciting the cardiotoxic effects of this toxicant...
  13. ncbi request reprint Rat tail skin temperature monitored noninvasively by radiotelemetry: characterization by examination of vasomotor responses to thermomodulatory agents
    Christopher J Gordon
    National Health and Environmental Effects Research Laboratory, Office of Research and Development, U S Environmental Protection Agency, Research Triangle Park, NC 27711, USA
    J Pharmacol Toxicol Methods 47:107-14. 2002
    ..The purpose of this study is to demonstrate the utility of a radiotelemetric probe to provide continuous, long-term measurements of T(sk) in undisturbed rats...
  14. ncbi request reprint Influence of gender on thermoregulation and cholinesterase inhibition in the long-evans rat exposed to diazinon
    Christopher J Gordon
    Neurotoxicology Division, National Health and Environmental Effects Research Laboratory, U S Environmental Protection Agency, Research Triangle Park, North Carolina 27711, USA
    J Toxicol Environ Health A 66:291-304. 2003
    ..The delayed fever and efficacy of sodium salicylate to block diazinon-induced fever are similar to the effects of OPs chlorpyrifos and diisopropyl fluoro-phosphate (DFP)...
  15. ncbi request reprint Role of environmental stress in the physiological response to chemical toxicants
    Christopher J Gordon
    Neurotoxicology Division, National Health and Environmental Effects Research Laboratory, Office of Research and Development, US Environmental Protection Agency, Research Triangle Park, NC 27711, USA
    Environ Res 92:1-7. 2003
    ....
  16. ncbi request reprint Comment on "Scaling the thermophysiological effects of radiofrequency radiation--revisited"
    Christopher J Gordon
    Neurotoxicology Division, National Health and Environmental Effects Research Laboratory, Office of Research and Development, U S Environmental Protection Agency, Research Triangle Park, North Carolina, USA
    Bioelectromagnetics 27:82-3; author reply 84-5. 2006
  17. ncbi request reprint Neurotensin analog NT77 induces regulated hypothermia in the rat
    Christopher J Gordon
    National Health and Environmental Effects Research Laboratory, U S Environmental Protection Agency, Research Triangle Park, NC 27711, USA
    Life Sci 73:2611-23. 2003
    ..Inducing a regulated hypothermic response with drugs such as NT77 may be an important therapy for ischemic disease and other insults...
  18. ncbi request reprint Thermoregulatory response to an organophosphate and carbamate insecticide mixture: testing the assumption of dose-additivity
    Christopher J Gordon
    Neurotoxicology Division, National Health and Environmental Effects Research Laboratory, B105 04, U S Environmental Protection Agency, 109 S T W Alexander Drive, Research Triangle Park, NC 27711, USA
    Toxicology 217:1-13. 2006
    ..e., ChE inhibition) endpoints for the 2:1 and 1:1 mixtures studies did not coincide as expected. An interaction between CHP and CAR appears to depend on the ratio of compounds in the mixture as well as the biological endpoint...
  19. pmc The therapeutic potential of regulated hypothermia
    C J Gordon
    Neurotoxicology Division, National Health and Environmental Effects Research Laboratory, US Environmental Protection Agency, Research Triangle Park, North Carolina 27711, USA
    Emerg Med J 18:81-9. 2001
    ..On the other hand, regulated hypothermia would seem to be the best means of achieving a therapeutic benefit because thermal homeostatic systems mediate a controlled reduction in core temperature...
  20. ncbi request reprint Effects of marine algal toxins on thermoregulation in mice
    Christopher J Gordon
    Neurotoxicology Division, National Health and Environmental Effects Research Laboratory, U S Environmental Protection Agency Research Triangle Park, NC 27711, USA
    Neurotoxicol Teratol 27:727-31. 2005
    ..A better understanding of the mechanisms of action of the toxins on thermoregulation should lead to improved methods for treating victims of ciguatera and other toxin exposures...
  21. doi request reprint Serum biomarkers of aging in the Brown Norway rat
    Christopher J Gordon
    Toxicity Assessment Division, U S Environmental Protection Agency, Research Triangle Park, NC 27711, USA
    Exp Gerontol 46:953-7. 2011
    ..The variability of CRP and MDC-2 was relatively low compared to the other analytes of the panel. It is concluded that CRP and possibly MDC-2 are candidates for biomarkers of aging in the BN rat...
  22. doi request reprint Aging and susceptibility to toluene in rats: a pharmacokinetic, biomarker, and physiological approach
    Christopher J Gordon
    National Health and Environmental Effects Research Laboratory, ORD, U S Environmental Protection Agency, Research Triangle Park, North Carolina, USA
    J Toxicol Environ Health A 73:301-18. 2010
    ..The expression of several cardiac biochemical markers of toluene exposure in the aged may also reflect differential susceptibility to this toxicant...
  23. ncbi request reprint Comparison of heat and cold stress to assess thermoregulatory dysfunction in hypothyroid rats
    C J Gordon
    Neurotoxicology Division, National Health and Environmental Effects Research Laboratory, United States Environmental Protection Agency, Research Triangle Park, North Carolina 27711, USA
    Am J Physiol Regul Integr Comp Physiol 279:R2066-71. 2000
    ..A thermoregulatory deficit is more correlated with a reduction in serum T(4) compared with T(3). Serum levels of TSH are unrelated to thermoregulatory response to heat and cold stress...
  24. doi request reprint A multianalyte profile of serum proteins to screen for toxicological effects of anticholinesterase insecticides in the rat
    Christopher J Gordon
    Neurotoxicology Division, National Health and Environmental Effects Research Laboratory, US Environmental Protection Agency, MD B105 04, 109 TW Alexander Drive, Research Triangle Park, NC 27711, United States
    Neurotoxicology 30:377-81. 2009
    ..It is concluded that the MAP is a useful tool to screen for in vivo effects of environmental toxicants and its use could lead to the discovery of novel mechanisms of action...
  25. ncbi request reprint Behavioral and autonomic thermoregulation in the rat following chlordimeform administration
    C J Gordon
    Neurotoxicology and Inhalation Toxicology, U S Environmental Protection Agency, Research Triangle Park, NC 27711
    Neurotoxicol Teratol 10:215-9. 1988
    ..The changes in temperature were concomitant with an abrupt drop in heart rate.(ABSTRACT TRUNCATED AT 250 WORDS)..
  26. ncbi request reprint Prolonged elevation in blood pressure in the unrestrained rat exposed to chlorpyrifos
    C J Gordon
    Neurotoxicology Division, National Health and Environmental Effects Research Laboratory, MD 74B, U S Environmental Protection Agency, Research Triangle Park, NC 27711, USA
    Toxicology 146:1-13. 2000
    ..Cholinergic stimulation of the CNS may explain the initial effects of CHP on BP; however, the persistent elevation suggests an involvement of neurohumoral pressor pathways...
  27. ncbi request reprint Hypothermia and delayed fever in the male and female rat exposed to chlorpyrifos
    C J Gordon
    National Health and Environmental Effects Research Laboratory, US Environmental Protection Agency, Research Triangle Park, North Carolina 27711, USA
    Toxicology 118:149-58. 1997
    ..This mechanism could be responsible for the febrile response to OP pesticides commonly observed in humans exposed to OPs...
  28. ncbi request reprint Effect of central and peripheral cholinergic antagonists on chlorpyrifos-induced changes in body temperature in the rat
    C J Gordon
    Neurotoxicology Division, National Health and Environmental Effects Research Laboratory, US Environmental Protection Agency, Research Triangle Park, North Carolina 27711, USA
    Toxicology 142:15-28. 1999
    ..The data provides a possible explanation for the persistent fever in humans exposed to OP pesticides and treated with atropine. Methyl atropine or methyl scopolamine may be a more effective therapy in the treatment of the fever...
  29. ncbi request reprint Thermoregulation in rats exposed perinatally to dioxin: core temperature stability to altered ambient temperature, behavioral thermoregulation, and febrile response to lipopolysaccharide
    C J Gordon
    Neurotoxicology Division, National Health and Environmental Effects Research Laboratory, U S Environmental Protection Agency, Research Triangle Park, North Carolina 27711, USA
    J Toxicol Environ Health A 54:647-62. 1998
    ..The accentuated fever in TCDD animals shows possible functional alterations in the neuroimmune and/or thermoregulatory axes involved in fever...
  30. ncbi request reprint Behavioral and autonomic thermoregulation in the rat following propylthiouracil-induced hypothyroidism
    C J Gordon
    Neurotoxicology Division, U S Environmental Protection Agency, Research Triangle Park, NC 27711, USA
    Pharmacol Biochem Behav 58:231-6. 1997
    ..e., decrease in the set point). A reduced set point seems to be an adaptive response that lowers the metabolic requirements for thermoregulation in the hypothyroid rat...
  31. ncbi request reprint Changes in EEG power spectra and behavioral states in rats exposed to the acetylcholinesterase inhibitor chlorpyrifos and muscarinic agonist oxotremorine
    O A Timofeeva
    Curriculum in Toxicology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA
    Brain Res 893:165-77. 2001
    ..Cortical arousal together with increased quiet waking and decreased sleep after CHP occurred independently from inhibition of motor activity and lowering of core temperature...
  32. ncbi request reprint Delayed febrile effects of chlorpyrifos: is there cross-tolerance to bacterial lipopolysaccharide?
    C J Gordon
    Neurotoxicology Division, National Health and Environmental Effects Research Laboratory, U S Environmental Protection Agency, Research Triangle Park, NC 27711, USA
    Toxicology 130:17-28. 1998
    ..Overall, the neural-immune mechanisms for LPS fever is distinct from that of CHP in view of marked difference in mechanisms of tolerance...
  33. ncbi request reprint Behavioral thermoregulatory responses of single- and group-housed mice
    C J Gordon
    Neurotoxicology Division, National Health and Environmental Effects Research Laboratory, U S Environmental Protection Agency, Research Triangle Park, NC 27711, USA
    Physiol Behav 65:255-62. 1998
    ..The results show that the typical housing conditions for single- and group-housed mice are cooler than their Ta for ideal thermal comfort...
  34. ncbi request reprint Caveats regarding the use of the laboratory rat as a model for acute toxicological studies: modulation of the toxic response via physiological and behavioral mechanisms
    W P Watkinson
    Environmental Toxicology Division, U S Environmental Protection Agency, Research Triangle Park, NC 27711
    Toxicology 81:15-31. 1993
    ..In general, the rat responds to acute intoxication by lowering its core temperature via both physiological and behavioral mechanisms, thereby attenuating the induced toxicity. Similar responses have not been reported in humans...
  35. ncbi request reprint Are circulating cytokines interleukin-6 and tumor necrosis factor alpha involved in chlorpyrifos-induced fever?
    C J Gordon
    Neurotoxicology Division, National Health and Environmental Effects Research Laboratory, US Environmental Protection Agency, Research Triangle Park, NC 27711, USA
    Toxicology 134:9-17. 1999
    ..Nonetheless, the data suggest that the delayed fever from CHP is unique, involving mechanisms other than TNF alpha and IL-6 release into the circulation characteristic of infectious fevers...
  36. ncbi request reprint Modulating effect of body temperature on the toxic response produced by the pesticide chlordimeform in rats
    W P Watkinson
    Environmental Toxicology Division, Health Effects Research Laboratory, U S Environmental Protection Agency, Research Triangle Park, North Carolina 27711
    J Toxicol Environ Health 28:483-500. 1989
    ....
  37. ncbi request reprint Behavioral thermoregulatory response to chlorpyrifos in the rat
    C J Gordon
    Neurotoxicology Division, National Health Effects and Environmental Research Laboratory, US Environmental Protection Agency, Research Triangle Park, NC 27711, USA
    Toxicology 124:165-71. 1997
    ..Overall, the CHP-induced hyperthermia is not dependent on the development of hypothermia. Behavioral thermoregulatory observations suggest that both hypothermia and hyperthermia are regulated by CNS thermoregulatory centers...
  38. ncbi request reprint Effect of cage bedding on temperature regulation and metabolism of group-housed female mice
    Christopher J Gordon
    Neurotoxicology Division, National Health and Environmental Effects Research Laboratory, MD 74B, US Environmental Protection Agency, Research Triangle Park, North Carolina 27711, USA
    Comp Med 54:63-8. 2004
    ..The effects of bedding material on temperature regulation may affect rodent health and well being. Moreover, bedding will affect variability in toxicologic and pharmacologic studies whenever an endpoint is dependent on body temperature...
  39. ncbi request reprint Effects of exercise conditioning on thermoregulatory response to anticholinesterase insecticide toxicity
    P J Rowsey
    University of North Carolina at Chapel Hill School of Nursing, USA
    Biol Res Nurs 2:267-76. 2001
    ..Training did ameliorate the febrile effects of CHP. Thus, exercise training may afford protection to the toxic effects of organophosphate insecticides...
  40. ncbi request reprint Tolerance to the hypothermic and hyperthermic effects of chlorpyrifos
    P Johnson Rowsey
    The University of North Carolina at Chapel Hill, School of Nursing, 27599 7460, USA
    Toxicology 121:215-21. 1997
    ..The data indicate that tolerance to the hypothermic and hyperthermic effects of chlorpyrifos involve separate neurochemical pathways...
  41. ncbi request reprint A peripheral mechanism of fever: differential sensitivity to the antipyretic action of methyl scopolamine
    P J Rowsey
    School of Nursing, The University of North Carolina at Chapel Hill, 27599, USA
    Auton Neurosci 85:148-55. 2000
    ..During recovery from exposure to a LPS, the fever appears to be mediated independently of peripheral cholinergic activation...
  42. ncbi request reprint Peripheral cholinergic pathway modulates hyperthermia induced by stress in rats exposed to open-field stress
    Pamela Johnson Rowsey
    School of Nursing, The University of North Carolina at Chapel Hill, 27599, USA
    J Appl Physiol 92:789-94. 2002
    ..Overall, open-field stress exacerbated the effects of MS and PYR on body T(c) and provides support for a peripheral cholinergic mechanism that mediates stress-induced hyperthermia...
  43. ncbi request reprint Effects of exercise conditioning on thermoregulatory responses to repeated administration of chlorpyrifos
    Pamela Johnson Rowsey
    School of Nursing, University of North Carolina, Chapel Hill, NC 27599, USA
    Environ Res 92:27-34. 2003
    ..Thus, the data suggest that a sedentary lifestyle may increase the sensitivity to OP insecticides. Exercise training was also associated with a more rapid recovery of plasma cholinesterase activity...
  44. ncbi request reprint Differential sensitivity to anticholinesterase insecticides in the juvenile rat: effects on thermoregulation
    Cina M Mack
    Neurotoxicology Division, National Health and Environmental Effects Research Laboratory, U S Environmental Protection Agency, Research Triangle Park, North Carolina 27711, USA
    J Toxicol Environ Health A 70:439-44. 2007
    ..Overall, it appears that during the development from preweanling to adult rat, there is a progressive attenuation in CHP-induced hypothermia. Conversely, CAR-induced hypothermia increases as a function of development...
  45. ncbi request reprint Possible role of vasopressin in the thermoregulatory response to chlorpyrifos in the rat
    Yong La Yang
    Neurotoxicology Division, National Health and Environmental Effects Research Laboratory, Office of Research and Development, U S Environmental Protection Agency, Research Triangle Park, North Carolina 27711, U S A
    Pharmacol Toxicol 90:311-6. 2002
    ..The lack of a significant increase in plasma vasopressin after chlorpyrifos suggests that localized release of vasopressin may be involved in the thermoregulatory response to chlorpyrifos...
  46. ncbi request reprint Poisons and fever
    C J Gordon
    Neurotoxicology Division, National Health Effects and Environmental Research Laboratory, US Environmental Protection Agency, Research Triangle Park, North Carolina 27711, USA
    Clin Exp Pharmacol Physiol 25:145-9. 1998
    ..Overall, the delayed hyperthermia resulting from OP exposure involves activation of thermoregulatory pathways that may be similar to infection-mediated fever...
  47. doi request reprint Extrapolating the acute behavioral effects of toluene from 1- to 24-h exposures in rats: roles of dose metric and metabolic and behavioral tolerance
    W M Oshiro
    Toxicity Assessment Division, National Health and Environmental Effects Research Laboratory, Office of Research and Development, U S Environmental Protection Agency, Research Triangle Park, North Carolina 27711, USA
    Toxicol Sci 123:180-92. 2011
    ....
  48. doi request reprint Effect of physical restraint on the limits of thermoregulation in telemetered rats
    Cenk Aydin
    Department of Physiology, Faculty of Veterinary Medicine, University of Uludag, Bursa 16059, Turkey
    Exp Physiol 96:1218-27. 2011
    ..Overall, the ideal T(a) for restrained rats appears to be 20 °C and no higher than 22 °C for the thermoregulatory system to maintain a regulated T(c) in rats well adapted to physical restraint...
  49. ncbi request reprint The Pre-Optic Anterior Hypothalamus (POAH) partially mediates the hypothermic response to hemorrhage in rats
    Justin W Brown
    Department of Physiology, 6n98, Brody School of Medicine at East Carolina University, 600 Moye Boulevard, Greenville, NC 27858 4354, USA
    Brain Res 1041:1-10. 2005
    ..Heating of the POAH significantly exacerbated the hemorrhagic hypothermic response. These data further suggest that the POAH is at least partially responsible for mediating hemorrhagic hypothermia...
  50. ncbi request reprint The effects of chlorpyrifos on blood pressure and temperature regulation in spontaneously hypertensive rats
    Edward G Smith
    Livingstone College, Department of Biological Sciences, 701 West Monroe Street, Salisbury, North Carolina 28144, USA
    Basic Clin Pharmacol Toxicol 96:503-11. 2005
    ....
  51. ncbi request reprint EEG spectra, behavioral states and motor activity in rats exposed to acetylcholinesterase inhibitor chlorpyrifos
    Olga A Timofeeva
    Curriculum in Toxicology, University of North Carolina Chapel Hill, USA
    Pharmacol Biochem Behav 72:669-79. 2002
    ..Increased wakefulness together with reduced motor activity after exposure to CHP seems to be a result of hyperactivity in brain cholinergic neuronal networks...
  52. ncbi request reprint Effects of chronic exercise conditioning on thermal responses to lipopolysaccharide and turpentine abscess in female rats
    Pamela Johnson Rowsey
    School of Nursing, The University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
    Arch Toxicol 80:81-7. 2006
    ..We conclude that the effect of exercise training and source of infection (i.e., systemic versus localized in muscle) on fever is directly linked to type of pyrogenic agent...
  53. doi request reprint Repeat exposure to ciguatoxin leads to enhanced and sustained thermoregulatory, pain threshold and motor activity responses in mice: relationship to blood ciguatoxin concentrations
    Marie Yasmine Bottein Dechraoui
    Center for Coastal Environmental Health and Biomolecular Research, NOAA National Ocean Service, Charleston, SC 29412, USA
    Toxicology 246:55-62. 2008
    ..In conclusion, a single exposure to toxin exerts a significant neurological response which may be enhanced with subsequent exposure...
  54. ncbi request reprint Thermoregulatory set point decreases after hemorrhage in rats
    Justin W Brown
    Department of Physiology, Brody School of Medicine, East Carolina University, 600 Moye Boulevard, Greenville, NC 27834, USA
    Shock 23:239-42. 2005
    ..These results indicate that a decrease in thermoregulatory set point contributes to the drop in body core temperature after hemorrhage...
  55. pmc Measurement of brevetoxin levels by radioimmunoassay of blood collection cards after acute, long-term, and low-dose exposure in mice
    Ricky Woofter
    Marine Biotoxins Program, Center for Coastal Environmental Health and Biomolecular Research, National Oceanic and Atmospheric Administration, National Ocean Service, Charleston, South Carolina 29412, USA
    Environ Health Perspect 111:1595-600. 2003
    ....
  56. ncbi request reprint Direct and indirect methods for determining plasma volume during thermoneutral and cold-water immersion
    Christopher J Gordon
    Faculty of Health Science, Australian Catholic University, Sydney, Australia
    Eur J Appl Physiol 89:471-4. 2003
    ..The assumptions inherent in the indirect method (constant F-cell ratio) appear to be violated during water immersion...
  57. doi request reprint Liver genomic responses to ciguatoxin: evidence for activation of phase I and phase II detoxification pathways following an acute hypothermic response in mice
    Jeanine S Morey
    Marine Biotoxins Program, NOAA Center for Coastal Environmental Health and Biomolecular Research, Charleston, South Carolina 29414, USA
    Toxicol Sci 103:298-310. 2008
    ..In addition to Cyps, increases in several glutathione S-transferases were observed, an indication that both phase I and phase II metabolic reactions are involved in the hepatic response to CTX in mice...
  58. ncbi request reprint Transcriptional profiling of whole blood and serum protein analysis of mice exposed to the neurotoxin Pacific Ciguatoxin-1
    James C Ryan
    Marine Biotoxins Program, NOAA Center for Coastal Environmental Health and Biomolecular Research, Charleston, SC 29412, United States
    Neurotoxicology 28:1099-109. 2007
    ..In large part, the gene expression was consistent with a Th2 immune response with interesting similarities to expression seen in asthmatic models...